DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-9 and Tlr8

DIOPT Version :9

Sequence 1:	NP_001246846.1	Gene:	Toll-9 / 40245	FlyBaseID:	FBgn0036978	Length:	900	Species:	Drosophila melanogaster
Sequence 2:	NP_001094479.1	Gene:	Tlr8 / 684440	RGDID:	1590327	Length:	1029	Species:	Rattus norvegicus

Alignment Length:	1011	Identity:	213/1011 - (21%)
Similarity:	365/1011 - (36%)	Gaps:	321/1011 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 LLDLIKDEVIWWQFPNGTLRDSTKKYAHKLYLDLSHGNL--KDDSDLFREAKLSRKVTIWR---- 131
            |.:|:.::...:..|.| |.:|.|:      |.|...|:  ...::.|....|.|....|.
  Rat   120 LTELLLEDNQLYTIPAG-LPESLKE------LSLIQNNIFQVTKNNTFGLRNLERLYLGWNCYFK 177

  Fly   132 -TEVF---SAAFNTLTAAPFRTLYSMRESLKLLSLRGNNFAELIP-------------------D 173
             .::|   ..|||.|.            :||||||..||...:.|                   .
  Rat   178 CNQIFKVEDGAFNNLI------------NLKLLSLSFNNLFSVPPKLPSSLSKLFLSNAKISTIT 230

  Fly   174 AEDFARFVNESRLEASNSVP---------HHCEL--------LLLHNTTDL-------------- 207
            .|||....:...|:.|.:.|         ..|.|        |...|.|.|
  Rat   231 QEDFKGLEHLILLDLSGNCPRCFNAPFPCESCNLSASIRIHPLAFQNLTQLRFLNLSSTSLRTIP 295

  Fly   208 ---YD-----RECYLYFNNNTNMGQSITTGRNYT------------NFI--------------KV 238
               :|     :|.:|.||   .:.|.|.:|...|            |||              .:
  Rat   296 STWFDNLTNLKELHLEFN---YLVQEIASGAFLTKLPSLQTLDLSFNFIHKEYLQYITISPNFSM 357

  Fly   239 LKDRFDQH--GSSSQSIAWATFPKMPRLVELDISNCSIEYVSK---EAFRNVSNLRRLFMSDNKI 298
            |:.....|  |...:.:....|..:..|..|...|..|.::.|   :||::..||:.:::|.|:|
  Rat   358 LRSLRKLHLKGYVFRELKKEHFKPLQNLPNLTTINLGINFIEKIDFKAFQDFPNLKVIYLSGNRI 422

  Fly   299 MTI-------------------------SHDTFYY-------VQGVQY---LDLSFTN-FLTYSY 327
            .::                         .|..||:       .|...|   ||||..| |:....
  Rat   423 ASVIDGTDHSSWRNRLRKPLSTDYDEFDPHMNFYHSTEPLIKPQCTTYGKALDLSLNNIFVIGKS 487

  Fly   328 QLQ----LPTLEMALSLIYGLKIQQNVFKYLPELIYLDLSHSKMTRNSAVAFAHLGDKLKFLSLC 388
            |.:    :..|.::.: ..|..:....|..:|.:.||||:::::..:....|:.|.|
  Rat   488 QFEGFQDIACLNLSFN-ANGQVLNGTEFSSMPHIKYLDLTNNRLDFDDNQTFSDLHD-------- 543

  Fly   389 YTAIPMVSSTIFKNTVLEGLDLSGNP-YLSYNIIDDAFDGIAN--TLKYLYFERSNIKDL--EWS 448
                            ||.||||.|. |.|...:......|.|  .||.|....:.|..|  |:.
  Rat   544 ----------------LEVLDLSHNAHYFSIAGVTHRLGFIQNLIKLKVLNLSHNGIYTLTDEYK 592

  Fly   449 KSLKNLQVLGLAGNNINALTPA-------MFQSLESLEILDLSSNHVGNWYRSAFHN-NSALRVL 505
            ...|:|:.|..:||.::.|..|       :|.|||:|..||||.|::......||.| ..:|:.|
  Rat   593 LQSKSLKELVFSGNRLDRLWNANDGKYWSIFTSLETLTRLDLSYNNLQQIPNEAFLNLPQSLQEL 657

  Fly   506 NLRSNTINMLSNEMLKDFERLDYLSLGDND--FICDCHLRAVVEVAAANNKDADCSYRLLNYSQ- 567
            ::..|.:...:..:|:.|..|..|.||.|:  |:.:|..:....:...          |||::.
  Rat   658 HINDNRLRFFNWTLLQYFPHLHVLDLGRNELYFLTNCLSKFTHSLKTL----------LLNHNHF 712

  Fly   568 NAVGEEVISLAESLIIDRKLWQSRYIPWLQRSYSNIREFNRANHIIKLRFSSEDYMVAKCSAAQP 632
            :.:....:|.|.:|:            :|..|::.|:..|:::
  Rat   713 SHLPAGFLSEARNLV------------YLDLSFNTIKMINKSS---------------------- 743

  Fly   633 YHLGDLDGDLTLKFQLLDYEASQYYCFNNTDQLQVDELNCQIRSMSDLAEELHH----------- 686
                 |..:......:||.:.:.:.|            .|.|.......||..|
  Rat   744 -----LQTETKTNLSVLDLQGNHFDC------------TCDISDFRSWLEENPHVRIPRLVDVIC 791

  Fly   687 -------------------VTNTVIAVM--------GSLVGACILGFIIYLKRWHIHYYYSSLKS 724
                               |::|..|::        .:::.|.::..:.|...|.| |:..|.|.
  Rat   792 SNPGDQRWKSVMSLDLTTCVSDTTAAILFFFTFLTTSTVLLAALVHHLFYWDVWFI-YHMCSAKL 855

  Fly   725 AALLSSASKESVNKFTNISQRDPSAVYDIFISYCQNDRT---WVLNELLPNVEETGDVSI--CLH 784
            ....||::.::              .||.:|||...|.:   ||:|||..::||:.|.|:  ||.
  Rat   856 RGYRSSSTSQT--------------FYDAYISYDTKDASVTDWVINELRYHLEESEDKSVLLCLE 906

  Fly   785 ERDFQIGVTILDNIISCMDRSYSLMLIISSKFLLSHWCQFEMYLAQHRIFEVSKEHLILVFLEDI 849
            |||:..|:.|:||::..:::|...:.:::.|:..|...:...|||..|:.:.:.:.:|.:.||.:
  Rat   907 ERDWDPGLPIIDNLMQSINQSKKTIFVLTKKYAKSWNFKTAFYLALQRLMDENMDVIIFILLEPV 971

  Fly   850 PRRKRPKTLQYLMDVKTYIKWPTAKEDRKLFWKRLK 885
            .:..:...|:..:...:.::||...:...|||:.||
  Rat   972 LQYSQYLRLRQRICKSSILQWPNNPKAENLFWQSLK 1007

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-9	NP_001246846.1	leucine-rich repeat	157..185	CDD:275380	12/46 (26%)
		LRR_8	262..322	CDD:290566	22/98 (22%)
		leucine-rich repeat	264..287	CDD:275380	7/25 (28%)
		leucine-rich repeat	288..311	CDD:275380	7/54 (13%)
		leucine-rich repeat	312..356	CDD:275380	11/51 (22%)
		LRR_8	<344..387	CDD:290566	9/42 (21%)
		leucine-rich repeat	357..381	CDD:275380	6/23 (26%)
		leucine-rich repeat	382..397	CDD:275380	0/14 (0%)
		leucine-rich repeat	405..430	CDD:275380	10/25 (40%)
		LRR_8	431..488	CDD:290566	23/65 (35%)
		leucine-rich repeat	432..453	CDD:275380	6/22 (27%)
		LRR_RI	<449..536	CDD:238064	30/96 (31%)
		leucine-rich repeat	454..477	CDD:275380	9/29 (31%)
		LRR_8	477..536	CDD:290566	19/61 (31%)
		leucine-rich repeat	478..501	CDD:275380	9/23 (39%)
		leucine-rich repeat	502..525	CDD:275380	5/22 (23%)
		TIR	751..891	CDD:214587	42/140 (30%)
Tlr8	NP_001094479.1	PRK15370	<21..>218	CDD:185268	28/116 (24%)
		leucine-rich repeat	62..85	CDD:275380
		leucine-rich repeat	86..119	CDD:275380
		leucine-rich repeat	120..140	CDD:275380	5/20 (25%)
		PLN00113	141..>664	CDD:215061	125/568 (22%)
		leucine-rich repeat	141..164	CDD:275380	5/28 (18%)
		leucine-rich repeat	165..194	CDD:275380	8/40 (20%)
		leucine-rich repeat	195..215	CDD:275380	9/19 (47%)
		leucine-rich repeat	216..239	CDD:275380	3/22 (14%)
		leucine-rich repeat	240..280	CDD:275380	7/39 (18%)
		leucine-rich repeat	281..304	CDD:275380	2/22 (9%)
		leucine-rich repeat	305..324	CDD:275380	7/21 (33%)
		leucine-rich repeat	331..387	CDD:275380	8/55 (15%)
		leucine-rich repeat	388..411	CDD:275380	6/22 (27%)
		leucine-rich repeat	467..494	CDD:275380	8/26 (31%)
		leucine-rich repeat	495..510	CDD:275380	2/15 (13%)
		leucine-rich repeat	520..543	CDD:275380	6/22 (27%)
		leucine-rich repeat	544..573	CDD:275380	11/28 (39%)
		leucine-rich repeat	574..597	CDD:275380	6/22 (27%)
		leucine-rich repeat	598..628	CDD:275380	9/29 (31%)
		PRK15370	<629..>739	CDD:185268	30/131 (23%)
		leucine-rich repeat	629..653	CDD:275380	9/23 (39%)
		leucine-rich repeat	654..677	CDD:275380	5/22 (23%)
		leucine-rich repeat	678..701	CDD:275380	7/22 (32%)
		leucine-rich repeat	702..725	CDD:275380	5/32 (16%)
		leucine-rich repeat	726..745	CDD:275380	5/57 (9%)
		PCC	730..>813	CDD:188093	13/121 (11%)
		TIR	868..1004	CDD:214587	39/135 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920