DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-9 and LOC572462

DIOPT Version :9

Sequence 1:	NP_001246846.1	Gene:	Toll-9 / 40245	FlyBaseID:	FBgn0036978	Length:	900	Species:	Drosophila melanogaster
Sequence 2:	XP_005167813.2	Gene:	LOC572462 / 572462	-ID:	-	Length:	951	Species:	Danio rerio

Alignment Length:	1080	Identity:	223/1080 - (20%)
Similarity:	365/1080 - (33%)	Gaps:	352/1080 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MCPK--YIWDVIVLVCLFLGNVREAYTEFSIQDGLIIEPDSATTSSEEAEEVSKERTDLKSLMLK 63
            :|||  |:...:...|.|..:| |.....|...|        .||..|...|:..:.||:.|...
Zfish    18 LCPKTCYVCSWLAEKCHFFSDV-EGLNIASFYHG--------KTSIAECLSVTDIKEDLRGLPTN 73

  Fly    64 YESDDGNSCLLDLIKDEVIWWQFPNGTLRDSTKKYAHKLYLDLS-HGNLKDDSDLFREAKLSRKV 127
                     ||:|:                        :.:||. ||.|..:|
Zfish    74 ---------LLNLL------------------------VQMDLHFHGVLAPNS------------ 93

  Fly   128 TIWRTEVFSAAFNTLTAAPFRTLYSMRESLKLLSLRGNNFAELIPDAEDFARFVNESRLEASNSV 192
                   || .|.:|            |:||:...    |:|:.|:|
Zfish    94 -------FS-RFGSL------------ENLKIAGC----FSEIPPEA------------------ 116

  Fly   193 PHHCELLLLHNTTDLYDRECYLYFNNNTNMGQSITTGRNYTNFIKVLKDRFDQHGSSSQSIAWAT 257
                                   ||..||:.....|..:..|..:|..|
Zfish   117 -----------------------FNGLTNVTSLTITALDSKNCCEVALD---------------- 142

  Fly   258 FPKMPRLVELDISNCSIEYVSKEAFRNVSNLRRLFMSDNKIMTISHDTFYYVQGV---------- 312
            |..:|.|..|.||:..:..::...|..:.:|:.|::....:..:| |....:..|
Zfish   143 FSHLPSLTSLFISHHDLSLLALNVFEKIPHLQWLYLDSVCLKDLS-DVLCRLANVKLLKLFSLDD 206

  Fly   313 -----QYLDLSFTNFLTYSYQLQLPTLEMALSLIYGLKIQQNVFKYLPE--LIYLDLSHSKMTRN 370
                 ||.:.|..|....|.:..:.|:::.|..:.  .|.:..||...:  |::..:|::....:
Zfish   207 WNIRLQYQNCSVFNTTDISTEFSIETVDLLLGKLE--HIDEGAFKPFGKLSLLHFSVSNTDFLED 269

  Fly   371 SAVAFAH-------LGDKLKFLSLCYTA--IPMVSSTIFKNTVLEGLDLSGN------------- 413
            .::...|       :.|.|....||..|  ..:.|..::..|:...|...|:
Zfish   270 LSLIGVHQISKISAIVDVLNVDDLCVAAKLYSVKSVDVYYKTINLSLTSKGSVGCKEIGYITLEN 334

  Fly   414 -------PYLSYNIIDDAFDGIANTLKYLYFERSNIKDLE-----WSKSLK-------------- 452
                   ..|..|.:...|..:.:...|.:..|||  |.:     :.:::|
Zfish   335 DISREIVNLLDVNSVFQIFSNLTSAAIYRHVLRSN--DFQSLCASYPQNVKQLINMVLQTIRIDK 397

  Fly   453 ----------NLQVLGLAGNNINALTPAMFQSLESLEILDLSSNHVGNWYRSAFHNNSALRVLNL 507
                      ||:.|.|..:.|:......|..|..|:.|:|..|.:.:.:|..|.....||||:|
Zfish   398 IVSHQFMCFVNLKTLKLVMSKISVFEDFAFIGLNKLKELNLHRNKISSIHRHTFSGLHELRVLDL 462

  Fly   508 RSNTINMLSNEMLKDFERLDYLSLGDNDF-----ICDCHLRAVVEVAAANNKDADCSYRL----- 562
            :.|.|..:..:....|..|....|||.:|     :...||..:..|...|..:...|..|
Zfish   463 QENPIIYIEPKSFGHFTNLSSFLLGDLNFPPNMSLIKLHLSDIFGVIPYNLSNVFISSGLRPMHL 527

  Fly   563 -------LNYSQN--AVGEEVI---------------SLAESLIIDRKLWQSRYIPWL-----QR 598
                   ||...|  ..|:.||               .:..:.:|....:..:|:|.:     |.
Zfish   528 VIGSNTTLNNGLNLHIKGQYVIVEDCNSLLLTSVFTLQIQAAYMICENEFIGKYVPSVVSLEFQS 592

  Fly   599 SYS-NIREFNRANHIIKLR------------------FSS----EDYMVAKCSAAQPYHLGDLDG 640
            .:| ||.:.:..|.::.|:                  |.:    |..::|.|.      |..|||
Zfish   593 MFSDNIGDLSVINQLVHLKTLKLEKLDLTNLPNMDIMFHNLTKLETLILANCK------LFFLDG 651

  Fly   641 DLT-----------------------------LKFQLLDYEASQYYC----------FNNTDQLQ 666
            .||                             |:|..|  |....||          ..:..:::
Zfish   652 SLTKDLKALTKLGLIPKDTVNILQTFVDHLTQLRFVYL--EDLDLYCSCDNAWLVSWIRDNRKVE 714

  Fly   667 V-------DELNCQIRSMSDLAEELHHVTNT------VIAVMGSLVGACILGFIIYLKRWHIHYY 718
            |       .:|.|...:..|....:.:||..      .:....|.|..||...::.:.:: :..|
Zfish   715 VVMSNPSMQDLKCLTDNEVDHISFVSYVTENCSFDLDFVFFACSSVFLCIFIVVVLMYKF-VGQY 778

  Fly   719 YSSLKSAALLSSASKESVNKFTNISQRDPSAVYDIFISYCQNDRTWVLNELLPNVEETGD--VSI 781
            :......|  |...:|:.........|     ||.|:||...|..||:.|||||:|:.|.  :.:
Zfish   779 FKPFYHIA--SGWFREAFRMKEKQQYR-----YDAFVSYSSKDEHWVIEELLPNLEQRGPPFLRL 836

  Fly   782 CLHERDFQIGVTILDNIISCMDRSYSLMLIISSKFLLSHWCQFEMYLAQHRIFEVSKEHLILVFL 846
            |||.||||:|..|::||...:..|...:.::|..:|.|:||..||.||.:|:....::.||||||
Zfish   837 CLHSRDFQLGHDIVENITDSIYASRRTLCLVSRNYLNSNWCSVEMQLATYRLQVEHRDILILVFL 901

  Fly   847 EDIPRR--KRPKTLQYLMDVKTYIKWPTAKEDRKLFWKRL 884
            |.||.|  .....|..|:..:||:.||...:..:.||.||
Zfish   902 ETIPSRLLSSHHRLARLVKTRTYLDWPQESKMHEAFWDRL 941

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-9	NP_001246846.1	leucine-rich repeat	157..185	CDD:275380	6/27 (22%)
		LRR_8	262..322	CDD:290566	14/74 (19%)
		leucine-rich repeat	264..287	CDD:275380	5/22 (23%)
		leucine-rich repeat	288..311	CDD:275380	4/22 (18%)
		leucine-rich repeat	312..356	CDD:275380	11/58 (19%)
		LRR_8	<344..387	CDD:290566	8/51 (16%)
		leucine-rich repeat	357..381	CDD:275380	3/30 (10%)
		leucine-rich repeat	382..397	CDD:275380	4/16 (25%)
		leucine-rich repeat	405..430	CDD:275380	5/44 (11%)
		LRR_8	431..488	CDD:290566	17/85 (20%)
		leucine-rich repeat	432..453	CDD:275380	6/49 (12%)
		LRR_RI	<449..536	CDD:238064	26/110 (24%)
		leucine-rich repeat	454..477	CDD:275380	6/22 (27%)
		LRR_8	477..536	CDD:290566	18/58 (31%)
		leucine-rich repeat	478..501	CDD:275380	6/22 (27%)
		leucine-rich repeat	502..525	CDD:275380	8/22 (36%)
		TIR	751..891	CDD:214587	57/138 (41%)
LOC572462	XP_005167813.2	leucine-rich repeat	149..172	CDD:275380	5/22 (23%)
		leucine-rich repeat	173..195	CDD:275380	4/22 (18%)
		leucine-rich repeat	196..253	CDD:275380	11/58 (19%)
		leucine-rich repeat	254..350	CDD:275380	14/95 (15%)
		LRR_8	408..467	CDD:316378	19/58 (33%)
		leucine-rich repeat	409..432	CDD:275378	6/22 (27%)
		PLN00113	<427..>516	CDD:331614	25/88 (28%)
		leucine-rich repeat	433..456	CDD:275378	6/22 (27%)
		leucine-rich repeat	457..480	CDD:275378	8/22 (36%)
		leucine-rich repeat	541..584	CDD:275380	5/42 (12%)
		leucine-rich repeat	585..609	CDD:275380	5/23 (22%)
		leucine-rich repeat	610..635	CDD:275380	2/24 (8%)
		leucine-rich repeat	636..659	CDD:275380	9/28 (32%)
		TIR	803..941	CDD:214587	56/142 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	122	1.000	Domainoid score	I5577
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920