DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-9 and Tlr5

DIOPT Version :9

Sequence 1:	NP_001246846.1	Gene:	Toll-9 / 40245	FlyBaseID:	FBgn0036978	Length:	900	Species:	Drosophila melanogaster
Sequence 2:	XP_017177186.1	Gene:	Tlr5 / 53791	MGIID:	1858171	Length:	873	Species:	Mus musculus

Alignment Length:	906	Identity:	186/906 - (20%)
Similarity:	326/906 - (35%)	Gaps:	274/906 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 TEVFSAAFNTLTAAPFRTLYSMRESLKLLSLRGNNFAELIPDAEDFARFVNESRLEASNSVPHHC 196
            ||....:||.::.. ..|.:.:.|.|:||.| |..:|.|......|....|
Mouse    63 TERLLLSFNYISMV-VATSFPLLERLQLLEL-GTQYANLTIGPGAFRNLPN-------------- 111

  Fly   197 ELLLLHNTTDLYDRECYLYFNNNTNMGQSITTGRNYTNFIKVL-KDRFDQHGSSSQSIAWATFPK 260
             |.:|                   ::|||         .|:|| :|               .|..
Mouse   112 -LRIL-------------------DLGQS---------QIEVLNRD---------------AFQG 132

  Fly   261 MPRLVELDISNCSIE--YVSKEAFRNVSNLRRLFMSDNKIMTIS-HDTFYYVQGVQYLDLSFTNF 322
            :|.|:||.:.:|.:.  .:|...|||:.:|.||.:|.|:|.::. |.:|..:..:..::.:|...
Mouse   133 LPHLLELRLFSCGLSSAVLSDGYFRNLYSLARLDLSGNQIHSLRLHSSFRELNSLSDVNFAFNQI 197

  Fly   323 LTYSYQLQLPTLEMALSLIYGLKIQ-------------QNVFKYLPELIYLDLSHSKMTRNSAVA 374
            .|.. :.:|..|:......:|||:.             :|.|:.: .|..||||.:..|.:....
Mouse   198 FTIC-EDELEPLQGKTLSFFGLKLTKLFSRVSVGWETCRNPFRGV-RLETLDLSENGWTVDITRN 260

  Fly   375 FAHL--GDKLKFLSLCYTAIPMVSSTIFKNTVLEGLDLSGNPYLSYNIID---DAFDGIANTLKY 434
            |:::  |.:             :||.|.|:.::      |..:...||.|   ..|..:|
Mouse   261 FSNIIQGSQ-------------ISSLILKHHIM------GPGFGFQNIRDPDQSTFASLA----- 301

  Fly   435 LYFERSNIKDLEWSK------------SLKNLQVLGLAGNNINALTPAMFQSLESLEILDLSSNH 487
                ||::..|:.|.            :||:|::|.||.|.||.:....|..|:||::|:||.|.
Mouse   302 ----RSSVLQLDLSHGFIFSLNPRLFGTLKDLKMLNLAFNKINKIGENAFYGLDSLQVLNLSYNL 362

  Fly   488 VGNWYRSAFHNNSALRVLNLRSNTINMLSNEMLKDFERLDYLSLGDNDFICDCHLRAVVEVAAAN 552
            :|..|.|.|:....:..::|:.|.|.::.::..:..:.|..|.|.||.......:.::..|....
Mouse   363 LGELYNSNFYGLPRVAYVDLQRNHIGIIQDQTFRLLKTLQTLDLRDNALKAIGFIPSIQMVLLGG 427

  Fly   553 NKDADCSY-------------RLLNYS-----------------QNAVGE-------------EV 574
            ||.....:             ||.|.|                 ||.:..             |.
Mouse   428 NKLVHLPHIHFTANFLELSENRLENLSDLYFLLRVPQLQFLILNQNRLSSCKAAHTPSENPSLEQ 492

  Fly   575 ISLAESLIIDRKLWQ-----------SR-YIPWLQRSYSNIREFNRANHIIKLRFSSEDYMVAKC 627
            :.|.|:::  :..|:           || .|.:|..:|.|.......|.::.||..|  ....|.
Mouse   493 LFLTENML--QLAWETGLCWDVFQGLSRLQILYLSNNYLNFLPPGIFNDLVALRMLS--LSANKL 553

  Fly   628 SAAQPYHLGDLDGDLTLKFQLLDYEASQYY-----CFNNTDQLQVDE----LNCQIRSMSDLAEE 683
            :...|       |.|....::||...:|.:     .|::...|.:..    .||::.:.
Mouse   554 TVLSP-------GSLPANLEILDISRNQLFSPDPALFSSLRVLDITHNEFVCNCELSTF------ 605

  Fly   684 LHHVTNTVIAVMGSLVGA-CILGFIIYLKRWHIHYYYSSLKSAALLSSASKES------------ 735
            :..:..|.:.:.||.... |:              |.:||...:|.:.::::.
Mouse   606 ISWLNQTNVTLFGSPADVYCM--------------YPNSLLGGSLYNISTEDCDEEEAMRSLKFS 656

  Fly   736 ------------------VNKFTNIS-----------------QRDPSAV-YDIFISYCQNDRTW 764
                              |.||..|.                 ..:|.|. ||.:..:...|..|
Mouse   657 LFILCTVTLTLFLVITLVVIKFRGICFLCYKTIQKLVFKDKVWSLEPGAYRYDAYFCFSSKDFEW 721

  Fly   765 VLNELLPNVE----ETGDVSICLHERDFQIGVTILDNIISCMDRSYSLMLIISSKFLLSHWCQFE 825
            ..|.||.:::    ....:.:|..||||..|...:.||.:.:..|...:.::|..||...||...
Mouse   722 AQNALLKHLDAHYSSRNRLRLCFEERDFIPGENHISNIQAAVWGSRKTVCLVSRHFLKDGWCLEA 786

  Fly   826 MYLAQHRIFEVSKEHLILVFLEDIPRRK--RPKTLQYLMDVKTYIKWPTAKEDRKLFWKRL 884
            ...||.|.....|..||:|.:..:.:.:  |.:|::..:..:.|::||...:|...|..:|
Mouse   787 FRYAQSRSLSDLKSILIVVVVGSLSQYQLMRHETIRGFLQKQQYLRWPEDLQDVGWFLDKL 847

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-9	NP_001246846.1	leucine-rich repeat	157..185	CDD:275380	9/27 (33%)
		LRR_8	262..322	CDD:290566	18/62 (29%)
		leucine-rich repeat	264..287	CDD:275380	8/24 (33%)
		leucine-rich repeat	288..311	CDD:275380	8/23 (35%)
		leucine-rich repeat	312..356	CDD:275380	9/56 (16%)
		LRR_8	<344..387	CDD:290566	12/57 (21%)
		leucine-rich repeat	357..381	CDD:275380	8/25 (32%)
		leucine-rich repeat	382..397	CDD:275380	0/14 (0%)
		leucine-rich repeat	405..430	CDD:275380	5/27 (19%)
		LRR_8	431..488	CDD:290566	21/68 (31%)
		leucine-rich repeat	432..453	CDD:275380	5/32 (16%)
		LRR_RI	<449..536	CDD:238064	29/98 (30%)
		leucine-rich repeat	454..477	CDD:275380	9/22 (41%)
		LRR_8	477..536	CDD:290566	18/58 (31%)
		leucine-rich repeat	478..501	CDD:275380	9/22 (41%)
		leucine-rich repeat	502..525	CDD:275380	3/22 (14%)
		TIR	751..891	CDD:214587	36/140 (26%)
Tlr5	XP_017177186.1	leucine-rich repeat	63..93	CDD:275380	10/31 (32%)
		LRR_8	<101..146	CDD:338972	17/102 (17%)
		leucine-rich repeat	112..135	CDD:275380	10/65 (15%)
		leucine-rich repeat	136..161	CDD:275380	8/24 (33%)
		leucine-rich repeat	162..186	CDD:275380	8/23 (35%)
		leucine-rich repeat	187..242	CDD:275380	9/56 (16%)
		leucine-rich repeat	243..304	CDD:275380	19/88 (22%)
		leucine-rich repeat	305..328	CDD:275380	3/22 (14%)
		LRR_8	308..363	CDD:338972	19/54 (35%)
		leucine-rich repeat	329..352	CDD:275380	9/22 (41%)
		LRR_8	352..411	CDD:338972	18/58 (31%)
		leucine-rich repeat	353..376	CDD:275380	9/22 (41%)
		leucine-rich repeat	377..400	CDD:275380	3/22 (14%)
		PRK15370	<397..>597	CDD:185268	37/210 (18%)
		leucine-rich repeat	401..429	CDD:275380	6/27 (22%)
		leucine-rich repeat	430..464	CDD:275380	4/33 (12%)
		leucine-rich repeat	465..489	CDD:275380	2/23 (9%)
		leucine-rich repeat	490..518	CDD:275380	4/29 (14%)
		leucine-rich repeat	519..542	CDD:275380	5/22 (23%)
		leucine-rich repeat	543..561	CDD:275380	6/26 (23%)
		leucine-rich repeat	565..585	CDD:275380	4/19 (21%)
		PCC	569..>647	CDD:188093	14/97 (14%)
		TIR	708..858	CDD:366714	36/140 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010