DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-9 and TLR8

DIOPT Version :9

Sequence 1:	NP_001246846.1	Gene:	Toll-9 / 40245	FlyBaseID:	FBgn0036978	Length:	900	Species:	Drosophila melanogaster
Sequence 2:	NP_057694.2	Gene:	TLR8 / 51311	HGNCID:	15632	Length:	1059	Species:	Homo sapiens

Alignment Length:	1064	Identity:	217/1064 - (20%)
Similarity:	389/1064 - (36%)	Gaps:	359/1064 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LFLGNVREAYTEFS----IQDGLIIEPDSATTSSEEAEEVSKERTDLKSLMLKYESDDGNSCLLD 75
            |.|.|:||...|.:    |..||   |:|.|       |:|..:.::.::     :.:|.|.|::
Human   140 LNLKNLRELLLEDNQLPQIPSGL---PESLT-------ELSLIQNNIYNI-----TKEGISRLIN 189

  Fly    76 LIKDEVIWWQFPNGTLRDSTKKYAHKLYLDLSHGNLKDDSDLFREAKLSRKVTIWRTEVFSAAFN 140
            | |:..:.|..           |.:|:   ....|::|  .:|.        |:...|:.|.:||
Human   190 L-KNLYLAWNC-----------YFNKV---CEKTNIED--GVFE--------TLTNLELLSLSFN 229

  Fly   141 TLTAAP------FRTLYSMRESLKLLSLRGNNFAELIPDAEDFARFVNESRLEASNSVPH----- 194
            :|:..|      .|.|:.....:|.:|            .|||...:|.:.|:.|.:.|.
Human   230 SLSHVPPKLPSSLRKLFLSNTQIKYIS------------EEDFKGLINLTLLDLSGNCPRCFNAP 282

  Fly   195 ------------HCELLLLHNTTDLYDRECYL-------------YFNN-----------NTNMG 223
                        :.:.....|.|.|.    ||             :|.|           |..:|
Human   283 FPCVPCDGGASINIDRFAFQNLTQLR----YLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVG 343

  Fly   224 QSITTGR---------------NY------------TNFIKVLKDR-FDQHGSSSQSIAWATFPK 260
            : |.:|.               ||            .||.|:|..| ....|...|.:....|..
Human   344 E-IASGAFLTMLPRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQP 407

  Fly   261 MPRLVELDISNCSIEYVSK---EAFRNVSNLRRLFMSDNKIMTISHDTFY----------YVQGV 312
            :.:|..|...|..|.::.:   :.|:|.|||..:::|:|:|..:..||..          :::..
Human   408 LMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQRHIRKR 472

  Fly   313 QYLDLSF---TNFLTYSYQLQLP-------TLEMALSLIY----------------GLKIQQNV- 350
            :..|..|   :||..::..|..|       .|:::|:.|:                .|....|.
Human   473 RSTDFEFDPHSNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQ 537

  Fly   351 ------FKYLPELIYLDLSHSKMTRNSAVAFAHLGDKLKFLSLCYTAIPMVSSTIFKNTVLEGLD 409
                  |..:|.:.||||:::::..::|.|...|.|                        ||.||
Human   538 VLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSD------------------------LEVLD 578

  Fly   410 LSGNPYLSYNIIDDAFDGIANTLKYLYFERSNI-KDLEWSKSLKNLQVLGLAGNNINALTP---- 469
            ||.|.:                    ||..:.: ..||:.::..||:||.|:.|||..||.
Human   579 LSYNSH--------------------YFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNL 623

  Fly   470 ---------------------------AMFQSLESLEILDLSSNHVGNWYRSAFHN-NSALRVLN 506
                                       ::|:.|::|..||||.|.:.:....||.| .::|..|:
Human   624 ESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELH 688

  Fly   507 LRSNTINMLSNEMLKDFERLDYLSLGDND--FICDCHLRAVVEVAAANNKDADCSYRLLNYSQNA 569
            :..|.:...:..:|:.|.||:.|.|..|.  |:.|            :..|...|.|.|..|.|.
Human   689 INDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTD------------SLSDFTSSLRTLLLSHNR 741

  Fly   570 VGEEVISLAESLIIDRKLWQSRYIP-WLQRSYSNIREFNRANHIIKLRFSSEDYMVAKCSAAQPY 633
            :.                    ::| ......|:::..:.:::::|....|.
Human   742 IS--------------------HLPSGFLSEVSSLKHLDLSSNLLKTINKSA------------- 773

  Fly   634 HLGDLDGDLTLKFQLLDYEASQYYCFNNTDQLQ--VDE-LNCQIRSMSDLA------EELHHVTN 689
                |:...|.|..:|:...:.:.|..:....:  :|| ||.:|..:.|:.      :....:.:
Human   774 ----LETKTTTKLSMLELHGNPFECTCDIGDFRRWMDEHLNVKIPRLVDVICASPGDQRGKSIVS 834

  Fly   690 TVIAVMGSLVGACILGFIIY--------------LKRWHIHYYY----SSLKSAALLSSASKESV 736
            ..:....|.|.|.||.|..:              |..|.:.:.|    :.:|....||::
Human   835 LELTTCVSDVTAVILFFFTFFITTMVMLAALAHHLFYWDVWFIYNVCLAKVKGYRSLSTS----- 894

  Fly   737 NKFTNISQRDPSAVYDIFISYCQNDRT---WVLNELLPNVEETGD--VSICLHERDFQIGVTILD 796
                       ...||.:|||...|.:   ||:|||..::||:.|  |.:||.|||:..|:.|:|
Human   895 -----------QTFYDAYISYDTKDASVTDWVINELRYHLEESRDKNVLLCLEERDWDPGLAIID 948

  Fly   797 NIISCMDRSYSLMLIISSKFLLSHWCQFEMYLAQHRIFEVSKEHLILVFLEDIPRRKRPKTLQYL 861
            |::..:::|...:.:::.|:..|...:...|||..|:.:.:.:.:|.:.||.:.:..:...|:..
Human   949 NLMQSINQSKKTVFVLTKKYAKSWNFKTAFYLALQRLMDENMDVIIFILLEPVLQHSQYLRLRQR 1013

  Fly   862 MDVKTYIKWPTAKEDRKLFWKRLK 885
            :...:.::||...:...|||:.|:
Human  1014 ICKSSILQWPDNPKAEGLFWQTLR 1037

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-9	NP_001246846.1	leucine-rich repeat	157..185	CDD:275380	6/27 (22%)
		LRR_8	262..322	CDD:290566	16/75 (21%)
		leucine-rich repeat	264..287	CDD:275380	6/25 (24%)
		leucine-rich repeat	288..311	CDD:275380	6/32 (19%)
		leucine-rich repeat	312..356	CDD:275380	12/76 (16%)
		LRR_8	<344..387	CDD:290566	12/49 (24%)
		leucine-rich repeat	357..381	CDD:275380	7/23 (30%)
		leucine-rich repeat	382..397	CDD:275380	0/14 (0%)
		leucine-rich repeat	405..430	CDD:275380	7/24 (29%)
		LRR_8	431..488	CDD:290566	22/88 (25%)
		leucine-rich repeat	432..453	CDD:275380	4/21 (19%)
		LRR_RI	<449..536	CDD:238064	31/120 (26%)
		leucine-rich repeat	454..477	CDD:275380	11/53 (21%)
		LRR_8	477..536	CDD:290566	19/61 (31%)
		leucine-rich repeat	478..501	CDD:275380	9/23 (39%)
		leucine-rich repeat	502..525	CDD:275380	5/22 (23%)
		TIR	751..891	CDD:214587	41/140 (29%)
TLR8	NP_057694.2	LRR_8	83..155	CDD:290566	6/14 (43%)
		leucine-rich repeat	83..106	CDD:275380
		leucine-rich repeat	107..144	CDD:275380	2/3 (67%)
		leucine-rich repeat	145..165	CDD:275380	7/22 (32%)
		leucine-rich repeat	166..189	CDD:275380	6/34 (18%)
		leucine-rich repeat	190..220	CDD:275380	9/54 (17%)
		leucine-rich repeat	221..241	CDD:275380	6/19 (32%)
		LRR_8	240..317	CDD:290566	16/92 (17%)
		leucine-rich repeat	242..265	CDD:275380	7/34 (21%)
		leucine-rich repeat	266..306	CDD:275380	4/39 (10%)
		LRR_8	305..367	CDD:290566	11/66 (17%)
		leucine-rich repeat	307..330	CDD:275380	5/26 (19%)
		leucine-rich repeat	331..356	CDD:275380	4/25 (16%)
		leucine-rich repeat	387..413	CDD:275380	5/25 (20%)
		LRR_8	412..>449	CDD:290566	10/36 (28%)
		leucine-rich repeat	414..437	CDD:275380	5/22 (23%)
		LRR_8	502..560	CDD:290566	11/57 (19%)
		LRR_RI	<504..719	CDD:238064	57/258 (22%)
		leucine-rich repeat	504..524	CDD:275380	3/19 (16%)
		leucine-rich repeat	525..549	CDD:275380	3/23 (13%)
		LRR_8	548..614	CDD:290566	26/109 (24%)
		leucine-rich repeat	550..573	CDD:275380	7/22 (32%)
		leucine-rich repeat	574..603	CDD:275380	11/48 (23%)
		leucine-rich repeat	604..658	CDD:275380	11/53 (21%)
		LRR_8	657..718	CDD:290566	19/60 (32%)
		leucine-rich repeat	659..683	CDD:275380	9/23 (39%)
		leucine-rich repeat	684..707	CDD:275380	5/22 (23%)
		LRR_8	706..766	CDD:290566	15/91 (16%)
		leucine-rich repeat	708..730	CDD:275380	7/33 (21%)
		leucine-rich repeat	732..755	CDD:275380	5/42 (12%)
		leucine-rich repeat	756..775	CDD:275380	2/35 (6%)
		LRRCT	790..835	CDD:214507	7/44 (16%)
		TIR	898..1040	CDD:214587	41/140 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920