DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-9 and tlr20.2

DIOPT Version :9

Sequence 1:	NP_001246846.1	Gene:	Toll-9 / 40245	FlyBaseID:	FBgn0036978	Length:	900	Species:	Drosophila melanogaster
Sequence 2:	NP_001170914.2	Gene:	tlr20.2 / 403140	ZFINID:	ZDB-GENE-040220-6	Length:	950	Species:	Danio rerio

Alignment Length:	939	Identity:	215/939 - (22%)
Similarity:	361/939 - (38%)	Gaps:	227/939 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 SEEAEEVSKERTDLKSLMLKYESDDGNSCLLDLIKDEV---IWWQFPNGTLRDST------KKYA 99
            |::..||:.:.:.|.||.....||...|.|...:.:::   .|....:..|:|.:      |...
Zfish   131 SQQCTEVAFDFSRLTSLTSLSLSDYSLSLLPSNVFEKIPQLRWLHLCSECLKDLSEVLCRLKNVK 195

  Fly   100 HKLYLDLSHGNLK----DDSDLFREAKLSRKVTIWRTEVFSAAFNTLTAAPFRT------LY--- 151
            ...||.|.:..|.    .:..:|..:::|.|..|.|.::.......:.....:.      ||
Zfish   196 SLKYLGLGNTMLTRLQYPNCSVFNVSEISTKFNIERADLLLGKLEHVDEGALKVFGKLSRLYFTV 260

  Fly   152 SMRESLKLLSLRGNNFAELIPDAEDFARFVNE----SRLEASNSVPHHCELLLLHNTTDLYDREC 212
            |.:..|:.|||.|.:...:|....|... |::    ::|.:..||....:.:.|..|:.:.| .|
Zfish   261 SSKNFLRDLSLIGVHQISVIIATVDVLN-VDDLCVAAKLYSVKSVDVDYDTINLSLTSKISD-GC 323

  Fly   213 ----YLYFNNNTNMGQSI------TTGRNYTNFIKVLKDRFDQHGSSSQSIAWATFPK-MPRLVE 266
                |:...||. .|:::      :..:.::|...|..|:.....:..||:. |:||: :.::.:
Zfish   324 KQIGYIMLENNI-FGKTVNLLDVNSLFQIFSNLTSVTIDKHVLRSNDFQSLC-ASFPQTVKKISD 386

  Fly   267 LDISNCSIEYVSKEAFRNVSNLRRLFMSDNKIMTISHDTFYYVQGVQYLDLSFTNFLTYSYQLQL 331
            :.:....|:.:....|....||:.|.::.:|...|....|..:..::.|:|       :|.::.
Zfish   387 MVLRIIRIDKIVSHQFMCFVNLKTLKLAMSKFSVIEDFAFIGLNKLKELNL-------HSNKIS- 443

  Fly   332 PTLEMALSLIYGLKIQQNVFKYLPELIYLDLSHSKMTRNSAVAFAH--------LGDKLKF---- 384
                         .|.|:.|..|.||..|||:.:.:......:|.|        ||| |.|
Zfish   444 -------------SIHQHTFSGLHELRVLDLNENPLFHIEPESFRHLINLRTLLLGD-LNFPPNM 494

  Fly   385 ------LSLCYTAIPMVSSTIF-------------KNTVL-EGLDL--SGNPYLSYNIIDDAFDG 427
                  ||..:..||...|.:|             .||.| .||:|  .|    .|.|::|
Zfish   495 SLIKLHLSDIFREIPRNLSNVFISSGLRPMHLVIGSNTTLNNGLNLHIKG----QYVIVED---- 551

  Fly   428 IANTL------------KYLYFERSNIKDLEWSKSLKNLQVLGLAGNNINALTPAMFQSLESLEI 480
             .|:|            .|:..|...|.  ::..|:.:|:...:..:||..|  ::...|..|:.
Zfish   552 -CNSLLLTSVVTLQINAAYMICENEFIG--KYVPSVVSLKFESMFSDNIGDL--SVINQLVHLKT 611

  Fly   481 LDLSSNHVGNWYRSA--FHNNSALRVLNLRSNTINMLSNEMLKDFERLDYLSLGDNDFICDCHLR 543
            |.|.:..:.|...:.  |||.:.|..|.|.:..:..|...:.||.:.|..|.|...|.:
Zfish   612 LKLENIDLTNQPNTGIMFHNLTKLETLILANCRLLFLDGSLTKDLKALTTLVLLPKDTV------ 670

  Fly   544 AVVEVAAAN--NKDADCSYRLLNY--SQNAVGEEVISLAESLIIDRKLWQSRYIPWLQRSYSNIR 604
            .:::..|.:  ..:..|.|||..|  ..||                  |   .:.|:
Zfish   671 NILQTFAVHLIQLEFVCFYRLGLYCSCDNA------------------W---LVSWI-------- 706

  Fly   605 EFNRANHIIKLRFSSEDYMVAKCSAAQPYHLGDLDGDLTLKFQLLDYEASQYYCF--NNTDQL-- 665
               |.|..:::..|:..             :.||.                  ||  |..|||
Zfish   707 ---RDNRKVEVDMSNPS-------------MHDLQ------------------CFFGNEFDQLNF 737

  Fly   666 -QVDELNCQIRSMSDLAEELHHVTNTVIAVMGSLVGACILGFIIYLKRWHIHYYYSSLKSAALLS 729
             ...:.||..    ||         ..:....|.|..||...::.:.:: :..|:......|  :
Zfish   738 VSYAKENCSF----DL---------DFVFFACSSVFLCIFIVVVLMYKF-VGQYFKPFYHIA--N 786

  Fly   730 SASKESVNKFTNISQRDPSAVYDIFISYCQNDRTWVLNELLPNVEETGD--VSICLHERDFQIGV 792
            ...:|::........|     ||.|:||...|..||:.|||||:|:.|.  :.:|||.||||:|.
Zfish   787 GWFREALRMKEKQQYR-----YDAFVSYSGKDEHWVIEELLPNLEQRGPPFLRLCLHSRDFQLGH 846

  Fly   793 TILDNIISCMDRSYSLMLIISSKFLLSHWCQFEMYLAQHRIFEVSKEHLILVFLEDIPRR--KRP 855
            .|::||...:..|...:.::|..:|.|:||..||.||.:|:....::.|||||||:||.|  ...
Zfish   847 DIVENITDSIYASRRTLCLVSRNYLNSNWCSLEMQLATYRLQVEHRDILILVFLENIPSRLLSSH 911

  Fly   856 KTLQYLMDVKTYIKWPTAKEDRKLFWKRL 884
            ..|..|:..:||:.||...|....||.||
Zfish   912 HRLARLVKTRTYLDWPQEPEMHDAFWDRL 940

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-9	NP_001246846.1	leucine-rich repeat	157..185	CDD:275380	8/31 (26%)
		LRR_8	262..322	CDD:290566	10/59 (17%)
		leucine-rich repeat	264..287	CDD:275380	2/22 (9%)
		leucine-rich repeat	288..311	CDD:275380	5/22 (23%)
		leucine-rich repeat	312..356	CDD:275380	7/43 (16%)
		LRR_8	<344..387	CDD:290566	17/60 (28%)
		leucine-rich repeat	357..381	CDD:275380	8/31 (26%)
		leucine-rich repeat	382..397	CDD:275380	6/24 (25%)
		leucine-rich repeat	405..430	CDD:275380	8/27 (30%)
		LRR_8	431..488	CDD:290566	13/68 (19%)
		leucine-rich repeat	432..453	CDD:275380	5/32 (16%)
		LRR_RI	<449..536	CDD:238064	22/88 (25%)
		leucine-rich repeat	454..477	CDD:275380	5/22 (23%)
		LRR_8	477..536	CDD:290566	16/60 (27%)
		leucine-rich repeat	478..501	CDD:275380	7/24 (29%)
		leucine-rich repeat	502..525	CDD:275380	6/22 (27%)
		TIR	751..891	CDD:214587	58/138 (42%)
tlr20.2	NP_001170914.2	leucine-rich repeat	358..383	CDD:275380	7/25 (28%)
		LRR_8	407..466	CDD:290566	18/79 (23%)
		leucine-rich repeat	408..431	CDD:275380	5/22 (23%)
		LRR_4	431..471	CDD:289563	12/60 (20%)
		leucine-rich repeat	432..455	CDD:275380	7/43 (16%)
		leucine-rich repeat	456..479	CDD:275380	6/22 (27%)
		leucine-rich repeat	496..539	CDD:275380	10/42 (24%)
		leucine-rich repeat	540..583	CDD:275380	10/53 (19%)
		leucine-rich repeat	584..608	CDD:275380	5/25 (20%)
		leucine-rich repeat	609..634	CDD:275380	7/24 (29%)
		leucine-rich repeat	635..658	CDD:275380	6/22 (27%)
		TIR	802..940	CDD:214587	57/142 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	122	1.000	Domainoid score	I5577
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	1	1.000	-	-		otm24216
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	8	7.980