DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-9 and tlr5b

DIOPT Version :9

Sequence 1:	NP_001246846.1	Gene:	Toll-9 / 40245	FlyBaseID:	FBgn0036978	Length:	900	Species:	Drosophila melanogaster
Sequence 2:	NP_001124067.2	Gene:	tlr5b / 403139	ZFINID:	ZDB-GENE-040219-15	Length:	881	Species:	Danio rerio

Alignment Length:	1020	Identity:	224/1020 - (21%)
Similarity:	360/1020 - (35%)	Gaps:	317/1020 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 CLFLGNVREAYTEFSIQDGLIIEP---------DSATTSSEEAEEVSKER-TDLKSLMLKYESDD 68
            |..:|     |....|..||...|         |.:..|..|..|.|..| .||:  .||.|.
Zfish    31 CSVIG-----YNAICINRGLHQVPELPAHVNYVDLSLNSIAELNETSFSRLQDLQ--FLKVEQ-- 86

  Fly    69 GNSCLLDLIKDEVIWWQFPNGTLRDSTKKYAHKLYLDLSHGNLKDDSDLFREAKLSRKVTIWRTE 133
                            |.|...:|::|.:....|.:      ||.|.:.|.:.:
Zfish    87 ----------------QTPGLVIRNNTFRGLSSLII------LKLDYNQFLQLE----------- 118

  Fly   134 VFSAAFNTLTAAPFRTL--------------YSMRESLKLLSLRGNNFAELIPDAEDFARFVNES 184
              :.|||.|......||              :....||::|.||.||..::.|    .:.|:|..
Zfish   119 --TGAFNGLANLEVLTLTQCNLDGAVLSGNFFKPLTSLEMLVLRDNNIKKIQP----ASFFLNMR 177

  Fly   185 RLE----ASNSVPHHCE------------LLLLHNTTDLYDRECY-------------------- 213
            |..    ..|.|...||            ||.|.:.| |.|...|
Zfish   178 RFHVLDLTFNKVKSICEEDLLNFQGKHFTLLRLSSIT-LQDMNEYWLGWEKCGNPFKNTSITTLD 241

  Fly   214 -------------------------LYFNNNTNMGQSITTGRNYTNFIKVLKDRFDQHG------ 247
                                     |..:|:.|||.|.    .:|||..  .|.|...|
Zfish   242 LSGNGFKESMAKRFFDAIAGTKIQSLILSNSYNMGSSF----GHTNFKD--PDNFTFKGLEASGV 300

  Fly   248 -----SSSQSIAW--ATFPKMPRLVELDISNCSIEYVSKEAFRNVSNLRRLFMSDNKIMTISHDT 305
                 |.|:..|.  :.|.....|.:|.::...|..:...||..:::|.:|.:|.|.:.:|....
Zfish   301 KTCDLSKSKIFALLKSVFSHFTDLEQLTLAQNEINKIDDNAFWGLTHLLKLNLSQNFLGSIDSRM 365

  Fly   306 FYYVQGVQYLDLSFTNFLTYSYQ--LQLPTLEMALSLIYGLKIQQNVFKYLPELIYLDLSHSKMT 368
            |..:..::.||||:.:......|  |.||.|. .|:|........:.|..||.|..|.|..:::
Zfish   366 FENLDKLEVLDLSYNHIRALGDQSFLGLPNLR-KLNLTGNAVESVHTFAALPNLNKLYLGKNRI- 428

  Fly   369 RNSAVAFAHLGDKLKFLSLCYTAIPMVSS--TIFKN-TVLEGLDLSGNPYLS-YN---IIDDAFD 426
             :|..:..::...|..|.|.:..:..:|.  ||.:. ..:|.:.|.||.:.| ||   |:
Zfish   429 -SSVSSLPNIAHNLSTLDLEFNKLHALSDLYTILREFPQIENIFLQGNTFSSCYNQKQIV----- 487

  Fly   427 GIANTLKYLYFERSNIKDLEWSK--------SLKNLQVLGLAGNNINALTPAMFQSLESLEILDL 483
             :::.|:.|:...|::: |.||:        .|..||.|.|..|.:.:|...:|:.|.||..|||
Zfish   488 -LSDKLQLLHLGLSSMQ-LIWSEGKCLNVFADLHQLQQLSLTANGLQSLPKDIFKDLTSLFFLDL 550

  Fly   484 SSNHVGNWYRSAFHNNSALRVLNLRSNTINMLSNEMLKDFERLDYLSLGDNDFICDCHLRAVVEV 548
            |.|.:.......|  ..:|::|||..|:|..:...:   |..|.||||.:|||.|||.|:
Zfish   551 SFNSLKYLPTDVF--PKSLQILNLDYNSIYSVDPNL---FSTLSYLSLMNNDFRCDCDLK----- 605

  Fly   549 AAANNKDADCSYRLLNYSQNAVGEEVISLAESLIIDRKLWQSRYIPWLQRSYSNIREFNRAN--- 610
                                               |.:.|                 .|:.|
Zfish   606 -----------------------------------DFQTW-----------------LNQTNVTF 618

  Fly   611 -HIIKLRFSSEDYMVAKCSAAQPYHLGDLDGDLTLKFQLLDYEASQYYCFNNTDQLQV----DEL 670
             |.|:                          |:|              |.:..||..|    ..:
Zfish   619 VHPIE--------------------------DVT--------------CASPEDQYMVPVVKSSI 643

  Fly   671 NCQIRSMSDLAEELHHVTNTVIAVMGSLVGACILGFIIYLKRWHIHYYYSSLKSAALLSSASKES 735
            .|:........|:|..|...|..|:..|..|   ..|:|:.|            ..::....|:.
Zfish   644 QCENEEEERRTEKLRLVLFIVCTVLIILFTA---STIVYISR------------RGVIFKMYKKL 693

  Fly   736 VNKFTNISQRDPSA---VYDIFISYCQNDRTWVLNELLPNVE----ETGDVSICLHERDFQIGVT 793
            :.:..:..:.:|..   :||:::.:...|..||...||..::    |...:..|..||||..|..
Zfish   694 IGELVDGKREEPDPDRFLYDVYLCFSSKDMKWVERALLKRLDSQFSEHNTLRCCFEERDFIPGED 758

  Fly   794 ILDNIISCMDRSYSLMLIISSKFLLSHWCQFEMYLAQHRIFEVSKEHLILVFLEDIP--RRKRPK 856
            .|.|:.|.:..|...:.::|..||...||.....|||.|:....::.|:::.:.:||  |..:.|
Zfish   759 HLTNMRSAIQNSRKTICVVSEHFLKDGWCLETFTLAQKRMQAELEDILVVLVVGNIPQYRLLKYK 823

  Fly   857 TLQYLMDVKTYIKWPTAKEDRKLFWKRLKRSL-EVIGIN--SREI 898
            .::..::.::|:.||...:|.:.|:.:|...: :.|.||  ::||
Zfish   824 QVRSFIENRSYLVWPDDCQDLEWFYDQLLHKIRKDIKINQTTKEI 868

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-9	NP_001246846.1	leucine-rich repeat	157..185	CDD:275380	9/27 (33%)
		LRR_8	262..322	CDD:290566	15/59 (25%)
		leucine-rich repeat	264..287	CDD:275380	5/22 (23%)
		leucine-rich repeat	288..311	CDD:275380	6/22 (27%)
		leucine-rich repeat	312..356	CDD:275380	13/45 (29%)
		LRR_8	<344..387	CDD:290566	9/42 (21%)
		leucine-rich repeat	357..381	CDD:275380	4/23 (17%)
		leucine-rich repeat	382..397	CDD:275380	3/14 (21%)
		leucine-rich repeat	405..430	CDD:275380	8/28 (29%)
		LRR_8	431..488	CDD:290566	22/64 (34%)
		leucine-rich repeat	432..453	CDD:275380	7/28 (25%)
		LRR_RI	<449..536	CDD:238064	30/94 (32%)
		leucine-rich repeat	454..477	CDD:275380	8/22 (36%)
		LRR_8	477..536	CDD:290566	21/58 (36%)
		leucine-rich repeat	478..501	CDD:275380	7/22 (32%)
		leucine-rich repeat	502..525	CDD:275380	7/22 (32%)
		TIR	751..891	CDD:214587	38/146 (26%)
tlr5b	NP_001124067.2	leucine-rich repeat	55..78	CDD:275380	6/22 (27%)
		leucine-rich repeat	79..103	CDD:275380	8/43 (19%)
		LRR_8	102..164	CDD:290566	17/80 (21%)
		leucine-rich repeat	104..127	CDD:275380	9/41 (22%)
		leucine-rich repeat	128..153	CDD:275380	2/24 (8%)
		leucine-rich repeat	154..178	CDD:275380	9/27 (33%)
		leucine-rich repeat	179..236	CDD:275380	11/57 (19%)
		LRR_RI	<224..478	CDD:238064	55/262 (21%)
		LRR_8	298..356	CDD:290566	12/57 (21%)
		leucine-rich repeat	300..323	CDD:275380	4/22 (18%)
		leucine-rich repeat	324..347	CDD:275380	5/22 (23%)
		LRR_8	346..404	CDD:290566	17/58 (29%)
		leucine-rich repeat	348..371	CDD:275380	6/22 (27%)
		leucine-rich repeat	372..395	CDD:275380	7/22 (32%)
		LRR_8	394..451	CDD:290566	14/59 (24%)
		leucine-rich repeat	396..417	CDD:275380	5/21 (24%)
		leucine-rich repeat	441..482	CDD:275380	11/40 (28%)
		leucine-rich repeat	494..520	CDD:275380	6/26 (23%)
		LRR_8	520..577	CDD:290566	21/58 (36%)
		leucine-rich repeat	521..544	CDD:275380	8/22 (36%)
		leucine-rich repeat	545..563	CDD:275380	6/17 (35%)
		leucine-rich repeat	567..587	CDD:275380	7/22 (32%)
		LRRCT	596..645	CDD:214507	19/145 (13%)
		TIR	712..846	CDD:214587	36/133 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.020