DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-9 and tlr5a

DIOPT Version :9

Sequence 1:NP_001246846.1 Gene:Toll-9 / 40245 FlyBaseID:FBgn0036978 Length:900 Species:Drosophila melanogaster
Sequence 2:XP_001919052.2 Gene:tlr5a / 403138 ZFINID:ZDB-GENE-040219-14 Length:881 Species:Danio rerio


Alignment Length:928 Identity:204/928 - (21%)
Similarity:349/928 - (37%) Gaps:271/928 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    55 TDLKSLMLKYESDDGNSCLLDLIKDEVIWWQFPNGTLRDSTKKYAHKLYLDLSHGNLKDDSDLFR 119
            :|||:|.|       ..|.||   |.::...|        .|.......||||..|::      |
Zfish   120 SDLKNLTL-------TQCGLD---DSLLSGNF--------LKPLMSLEMLDLSRNNIR------R 160

  Fly   120 EAKLSRKVTIWRTEVFSAAFN------------------TLTAAPFRTLYSMRE----------- 155
            ....|..:.:.|..|....||                  ||......||..|.|           
Zfish   161 VQPASFFLNMRRFHVLDLTFNKVKSICEEDLLNFQGKHFTLLRLSSITLQDMNEYWLGWEKCGNP 225

  Fly   156 ----SLKLLSLRGNNFAELIPDAEDFARFVNESRLEASNSVPHHCELLLLHNTTDLYDRECYLYF 216
                |:..|.|.||.|.  :..|:.|...::.:::::          |::.||..:....    .
Zfish   226 FKNTSITTLDLSGNGFN--VDMAKRFFDAISSTKIQS----------LIISNTYRIGKSS----G 274

  Fly   217 NNNTNMGQSITTGRNYTNFIKVLKDRFDQHGSSSQSIAWATFPKMPRLVELDISNCSIEYVSKEA 281
            :|:.:..:|..:|.. ::.||    .||...||..|:.::.|..:..|.::.::...|..:...|
Zfish   275 DNSKDPDKSTFSGLK-SSGIK----SFDLSNSSIFSLTYSVFSYLSDLEQITLAESQINKIENNA 334

  Fly   282 FRNVSNLRRLFMSDNKIMTISHDTFYYVQGVQYLDLSFTNFLTYSYQLQLPTLEMALSLIYGLKI 346
            |..::||.:|.:|.|.:..|...||..::|::.||||:.:                   |:.|..
Zfish   335 FLGMTNLLKLNLSKNFLGYIDFRTFQNLKGLEVLDLSYNH-------------------IWRLGS 380

  Fly   347 QQNVFKYLPELIYLDLSHSKMTRNSAVAFA--------HLGDK--------------LKFLSLCY 389
            |.  |:.||.|:.|:|:.:.:  .....||        :|||.              ||.|.|.:
Zfish   381 QS--FQGLPNLLSLNLTGNSL--GHVYTFATLPKLEKLYLGDNNIQYVYEIPNIAKHLKTLDLQF 441

  Fly   390 TAI-------------PMVSSTIFKNTVLEGLDLSGNPYLSYNI--IDDAFDGIANTLKYLYFER 439
            ..|             |.:...:|:...|.......:..||.||  :|.:|.|    |:.::.|.
Zfish   442 NQIASMSELYTILDEFPQIEEVVFRGNQLLYCPQDNHEVLSQNIQVLDLSFAG----LQVIWSEG 502

  Fly   440 S--NIKDLEWSKSLKNLQVLGLAGNNINALTPAMFQSLESLEILDLSSNHVGNWYRSAFHNNSAL 502
            .  |:.|     .|..|:||.|:.|.:.:|...:|:.|.||.|||||.|.:.......|  ...|
Zfish   503 KCLNVFD-----DLHQLEVLHLSSNLLQSLPKDIFKDLTSLLILDLSFNSLKYLPTDVF--PKTL 560

  Fly   503 RVLNLRSNTINMLSNEMLKDFERLDYLSLGDNDFICDCHLRAVVEVAAANNKDADCSYRLLNYSQ 567
            :||:|..|:|..:...:   |..|.||||.:|||.|||.|:                        
Zfish   561 QVLHLDYNSIYSVDPNL---FSTLSYLSLMNNDFRCDCDLK------------------------ 598

  Fly   568 NAVGEEVISLAESLIIDRKLWQSRYIPWLQRSYSNIREFNRANHIIKLRFSSEDYMVAKCSAAQP 632
                            |.:.|                 .|:.|  |....|.||   ..|::.:.
Zfish   599 ----------------DFQTW-----------------LNQTN--ITFVHSIED---VTCASPED 625

  Fly   633 YHLGDLDGDLTLKFQLLDYEASQYYCFNNTDQLQVDELNCQIRSMSDLAEELHHVTNTVIAVMGS 697
            .:             ::...:|...|.:..::.:.::|...:           .::.||:.::.|
Zfish   626 QY-------------MVPVVSSSIQCEDEEEERRTEKLRLVL-----------FISCTVLIILFS 666

  Fly   698 LVGACILGFIIYLKRWHIHYYYSSLKSAALLSSASKESVNKFTNISQRDPSA---VYDIFISYCQ 759
                  ...|:|:.|            ..::....|:.:.||.|..|.:|.|   :||:::.:..
Zfish   667 ------ASTIVYISR------------RGVIFKIYKKLIGKFDNKPQEEPDANGFLYDVYLCFSS 713

  Fly   760 NDRTWVLNELLPNVE----ETGDVSICLHERDFQIGVTILDNIISCMDRSYSLMLIISSKFLLSH 820
            .|..||...||..::    |...:..|..||||..|...|.|:.:.:..|...:.::|..||...
Zfish   714 RDMKWVERALLKRLDSQFSEHNTLRCCFEERDFIPGEDHLTNMRNAIQHSRKTICVVSKHFLKDG 778

  Fly   821 WCQFEMYLAQHRIFEVSKEHLILVFLEDIP--RRKRPKTLQYLMDVKTYIKWPTAKEDRKLFWKR 883
            ||.....|||.|:....|:.|:::.:.:||  |..:.:.|:..::.::|:.||...:|.:.|:.:
Zfish   779 WCLETFTLAQCRMLVELKDILVVLVVGNIPQYRLLKYEQLRSFIENRSYLVWPDDGQDLEWFYDQ 843

  Fly   884 LK----RSLEVIGINSRE 897
            |.    |:.:|...|.:|
Zfish   844 LLHKIIRNTKVKQTNIKE 861

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Toll-9NP_001246846.1 leucine-rich repeat 157..185 CDD:275380 7/27 (26%)
LRR_8 262..322 CDD:290566 17/59 (29%)
leucine-rich repeat 264..287 CDD:275380 4/22 (18%)
leucine-rich repeat 288..311 CDD:275380 7/22 (32%)
leucine-rich repeat 312..356 CDD:275380 9/43 (21%)
LRR_8 <344..387 CDD:290566 16/64 (25%)
leucine-rich repeat 357..381 CDD:275380 7/31 (23%)
leucine-rich repeat 382..397 CDD:275380 6/27 (22%)
leucine-rich repeat 405..430 CDD:275380 8/26 (31%)
LRR_8 431..488 CDD:290566 21/58 (36%)
leucine-rich repeat 432..453 CDD:275380 5/22 (23%)
LRR_RI <449..536 CDD:238064 31/86 (36%)
leucine-rich repeat 454..477 CDD:275380 8/22 (36%)
LRR_8 477..536 CDD:290566 22/58 (38%)
leucine-rich repeat 478..501 CDD:275380 8/22 (36%)
leucine-rich repeat 502..525 CDD:275380 7/22 (32%)
TIR 751..891 CDD:214587 39/149 (26%)
tlr5aXP_001919052.2 LRR_8 50..107 CDD:290566
leucine-rich repeat 50..72 CDD:275380
leucine-rich repeat 73..97 CDD:275380
LRR_8 96..158 CDD:290566 15/55 (27%)