DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-9 and tlr8a

DIOPT Version :9

Sequence 1:	NP_001246846.1	Gene:	Toll-9 / 40245	FlyBaseID:	FBgn0036978	Length:	900	Species:	Drosophila melanogaster
Sequence 2:	XP_001920594.5	Gene:	tlr8a / 403137	ZFINID:	ZDB-GENE-040219-13	Length:	1019	Species:	Danio rerio

Alignment Length:	995	Identity:	205/995 - (20%)
Similarity:	372/995 - (37%)	Gaps:	269/995 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 DLKSLMLKYESDD--GNSCLLDLIKDEVIWWQFPNGTLRDSTKKYAHKLYLDLSHGNLKDDSDLF 118
            ||..:.|||...|  .|...|.|:::::.|   .|.|..:..|..: .|||..:.......|..:
Zfish   117 DLNGIKLKYIPKDIPKNLEKLSLVENKITW---INLTTFEHVKNLS-VLYLSNNCYYWNPCSRRY 177

  Fly   119 R--EAKLSRKVTIWRTEVFSAAFNTLTAAPFRTLYSMRESLKLLSLRGNNFAELIPDAEDFARFV 181
            |  :..||..|.:.|   .:.:||.||..|.    .:..||:.|.|..|:...:  ...||....
Zfish   178 RIEKGSLSYLVNLKR---LTLSFNNLTQVPI----GLPVSLERLELGSNSLTYI--GEHDFRGLF 233

  Fly   182 NESRLEAS------NSVPHHC-------------------ELLLLHNTTDLYDRECYLYFNNNTN 221
            |.:.|:..      ::.|:.|                   .|.:||...:........:|.|.:|
Zfish   234 NLTVLKIQGNCPRCHTAPYPCIPCKNTSIEIHPQAFSDLRNLHILHLAGNSIKSINPAWFANLSN 298

  Fly   222 MGQSITTGRNYTNFIKVLKDRFDQHGSSSQSIAWATFPKMPRLVELDIS------NCSIEYVSKE 280
            :.|...   ::......:.|..|.          .....:|.|.:||:|      ...:..|...
Zfish   299 LQQLFL---SFNLLFSAITDPADT----------VFLGNLPLLTKLDLSYNFAFKTYPLTVVLSP 350

  Fly   281 AFRNVSNLRRLFMSDNKIMTISHDTF---YYVQGVQYLDLSFTNFLTY--SYQLQ-LPTLEMALS 339
            .|.|:::||.|.:.......|..|||   :.:|.:..||:. .||:.:  ||..| :..|.:|.:
Zfish   351 GFANLTSLRSLHLRGLVFRKIQKDTFKSLFDLQHLNVLDVG-VNFIVFATSYIFQHVRLLYLAEN 414

  Fly   340 LIYGLKI-------------------------------------------------QQNVFKYLP 355
            .:|.:.:                                                 :.|:|...|
Zfish   415 RLYPVTVNGELSKATFVGSNHRSIMPLMAEPLDTFDAPKNLVKSECYNAGRVLDLSRNNLFLISP 479

  Fly   356 ELI--YLDLSHSKMTRN------SAVAFAHLGDKLKFLSLCYTAIPMVSSTIFKN-TVLEGLDLS 411
            |..  |.::|...::||      :...|..| ..||:|.|.:..:.:.....|:. ..||.||
Zfish   480 EQFDTYGNISCLNLSRNGFSTAPNGSEFTSL-PNLKYLDLSFNKVDLAYDNAFRELQSLEVLD-- 541

  Fly   412 GNPYLSYNIIDDAFDGIANTLKYLYFERSNIKDLEWSKSLKNLQVLGLAGNNINALTPAMFQSLE 476
                :|||.......|:.:.:.:|.:             |.:|:||.::.|:||.||.....| :
Zfish   542 ----ISYNSHYFTVAGVTHNMMFLQY-------------LPSLKVLNMSFNSINTLTTKTMSS-K 588

  Fly   477 SLEILDLSSNHVG-------NWYRSAFHNNSALRVLNLRSNTI---------------------- 512
            ||..|....|.:|       |.|...|.|.:.|..|::.:|:|
Zfish   589 SLRELQFRGNKLGRMWRDKDNTYVMIFKNFTNLIHLDISNNSIGKIPYTVYTQLPITIQRLQMSH 653

  Fly   513 NMLSN---EMLKDFERLDYLSLGDNDFICDCHLRAVVEVAAANNKDADCSYRLLNYSQNAVGEEV 574
            |.|:|   .||:.|:.|..|.|.||:         ::|:|:..:.|.. |..|||...|.:.:..
Zfish   654 NQLANINWTMLRRFQNLRELILHDNN---------IIEIASNLSVDVP-SLELLNLQHNRISKLA 708

  Fly   575 ISLAESLIIDRKLWQSRYIPWLQRSYSNIREFNRANHIIKLRFSSEDYMVAKCSAAQPYHLGDLD 639
            |...:.::                   |::|.:          .|.:|::....:..|     .:
Zfish   709 IGFLQGVV-------------------NLKELD----------LSYNYLITVNQSTFP-----TE 739

  Fly   640 GDLTLKFQLLDYEASQYYCFNNTDQ--LQVDELNCQI---------------RSMSDLAEELHHV 687
            .||    ::|....:.::|..|..:  |.:.:.|.:|               :.::.:..::...
Zfish   740 SDL----KMLWLHGNPFHCTCNLLEFVLWILDTNVKIPRLVTGVTCTMPEERKGLAVIKFDIQEC 800

  Fly   688 TNTVIAVMGSLV-GACIL-----GFIIYLKRWHIHYYYSSLKSAALLSSASKESVNKFTNISQ-R 745
            .:..:|.:...: .|||:     ...::|..|.:.|.|..||:             :||...| .
Zfish   801 IDDQLAFVAYFISAACIICTTFAAITMHLFYWDVSYLYYYLKA-------------RFTGYQQLS 852

  Fly   746 DPSAVYDIFISYCQND---RTWVLNELLPNVEETGD--VSICLHERDFQIGVTILDNIISCMDRS 805
            ..|.:||.||:|...|   ..||||.|...:||..:  :.|||.|||:..|..:||::...:..|
Zfish   853 SESCIYDAFITYDTKDPQVSDWVLNHLRVQLEERSELFLPICLEERDWIPGSPVLDSLTQSIQNS 917

  Fly   806 YSLMLIISSKFLLSHWCQFEMYLAQHRIFEVSKEHLILVFLEDIPRRKRPKTLQYLMDVKTYIKW 870
            ...:.:::..::.|...:..::||..|:.|.:::.::|:.||.:.:......|:..:..::.::|
Zfish   918 RKTVFVLTEGYVNSGSFKLAVFLAHQRLLEENEDVIVLLLLEPVLQHSHFVRLRRRLCARSILEW 982

  Fly   871 PTAKEDRKLFWKRLKRSLEV 890
            |.:......||:.|:.::.|
Zfish   983 PHSSSAEAWFWQSLRNAIRV 1002

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-9	NP_001246846.1	leucine-rich repeat	157..185	CDD:275380	7/27 (26%)
		LRR_8	262..322	CDD:290566	18/68 (26%)
		leucine-rich repeat	264..287	CDD:275380	7/28 (25%)
		leucine-rich repeat	288..311	CDD:275380	7/25 (28%)
		leucine-rich repeat	312..356	CDD:275380	12/95 (13%)
		LRR_8	<344..387	CDD:290566	13/99 (13%)
		leucine-rich repeat	357..381	CDD:275380	6/31 (19%)
		leucine-rich repeat	382..397	CDD:275380	4/14 (29%)
		leucine-rich repeat	405..430	CDD:275380	8/24 (33%)
		LRR_8	431..488	CDD:290566	15/56 (27%)
		leucine-rich repeat	432..453	CDD:275380	2/20 (10%)
		LRR_RI	<449..536	CDD:238064	34/118 (29%)
		leucine-rich repeat	454..477	CDD:275380	9/22 (41%)
		LRR_8	477..536	CDD:290566	24/90 (27%)
		leucine-rich repeat	478..501	CDD:275380	8/29 (28%)
		leucine-rich repeat	502..525	CDD:275380	10/47 (21%)
		TIR	751..891	CDD:214587	38/145 (26%)
tlr8a	XP_001920594.5	NEL	<15..>226	CDD:330839	32/121 (26%)
		leucine-rich repeat	62..112	CDD:275380
		leucine-rich repeat	113..133	CDD:275380	6/15 (40%)
		LRR_8	133..200	CDD:316378	18/73 (25%)
		leucine-rich repeat	134..157	CDD:275380	5/25 (20%)
		leucine-rich repeat	158..189	CDD:275380	7/31 (23%)
		PLN00113	189..>702	CDD:331614	117/566 (21%)
		leucine-rich repeat	190..234	CDD:275380	13/52 (25%)
		leucine-rich repeat	235..274	CDD:275380	3/38 (8%)
		leucine-rich repeat	275..298	CDD:275380	5/22 (23%)
		leucine-rich repeat	299..327	CDD:275380	3/40 (8%)
		leucine-rich repeat	328..357	CDD:275380	7/28 (25%)
		leucine-rich repeat	358..381	CDD:275380	7/22 (32%)
		leucine-rich repeat	465..487	CDD:275380	5/21 (24%)
		leucine-rich repeat	488..512	CDD:275380	5/24 (21%)
		leucine-rich repeat	513..536	CDD:275380	5/22 (23%)
		leucine-rich repeat	537..566	CDD:275380	10/47 (21%)
		leucine-rich repeat	567..620	CDD:275380	18/53 (34%)
		leucine-rich repeat	621..645	CDD:275380	4/23 (17%)
		leucine-rich repeat	646..669	CDD:275380	6/22 (27%)
		leucine-rich repeat	670..693	CDD:275380	8/32 (25%)
		LRR_8	692..752	CDD:316378	14/98 (14%)
		leucine-rich repeat	694..717	CDD:275380	5/41 (12%)
		leucine-rich repeat	718..736	CDD:275380	3/27 (11%)
		TPKR_C2	750..>789	CDD:326558	5/38 (13%)
		TIR	858..1000	CDD:214587	37/141 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920