DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-9 and tlr8b

DIOPT Version :9

Sequence 1:NP_001246846.1 Gene:Toll-9 / 40245 FlyBaseID:FBgn0036978 Length:900 Species:Drosophila melanogaster
Sequence 2:NP_001373638.1 Gene:tlr8b / 403136 ZFINID:ZDB-GENE-040219-12 Length:1015 Species:Danio rerio


Alignment Length:910 Identity:200/910 - (21%)
Similarity:345/910 - (37%) Gaps:259/910 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    55 TDLKSLMLKYESDDGNSCLLDLIKDEVIWWQFPNGTLRD-STKKYAHKLY--LDLSHGNLKDDSD 116
            |:||.|.|.:.|      |:...:....:...|...:.| |....:.::|  |.||.|       
Zfish   289 TNLKYLYLSFNS------LISEFESGQFFSVLPQVEVVDISYNNPSERIYPRLKLSEG------- 340

  Fly   117 LFREAKLSRKVTIWRTEVFSAAFNTLTAAPFRTLYSMRESLKLLSLRGNNFAELIPDAEDFARFV 181
                  .||..::....:....|:.|:....|.|:|:| :|.:|:| ..||.:.: :...|..|.
Zfish   341 ------FSRLESLQTLHLEGYIFHKLSEDDLRPLFSLR-NLSVLNL-AVNFLQQV-NLSVFRNFH 396

  Fly   182 N-------ESRLEASNSVPHHCELLLLHNTTDLYDRECYLYFNNNTNMGQSITTGRNYTNFIKVL 239
            |       ::||..|:.:..             ::.:....|.:: |.|........:||     
Zfish   397 NLSLISLIDNRLTFSSPIRR-------------WEGQSKSGFKDD-NQGDHREGPYIHTN----- 442

  Fly   240 KDRFDQHGSSSQSIAWATFPKMPRLVELDISNCSIEYVSKEAFRNVSNLRRLFMSDNKIMTISHD 304
             :.|..:...:::...||.|      .||:|..:|.:|:...|....|:..|.:|.|.|::..:.
Zfish   443 -EEFRHYPPFTKAECLATGP------VLDLSRNNIYHVNPPLFTGAENITCLNLSSNFIVSYFNG 500

  Fly   305 T-FYYVQGVQYLDLSFTNFLTYSYQLQLPTLEMALSLIYGLKIQQNVFKYLPELIYLDLSHSKM- 367
            | |.:...::|||||......:|        :.|||.:..|::             |||||::. 
Zfish   501 TEFAHFPKLKYLDLSHNRIYMHS--------DSALSELKALEV-------------LDLSHNQHY 544

  Fly   368 -----TRNSAVAFAHLGDKLKFLSLCYTAIPMVSSTIFKNTVLEGLDLSGN-------------- 413
                 .||......:| ..||.|:|.:..|.|:::...::..|..|...||              
Zfish   545 FEVAGVRNCLTFLENL-QFLKVLNLSWNEINMLTNKTLQSDSLNELQFQGNRLDIMWKKQRGYQS 608

  Fly   414 --------PYL--SYN----IIDDAFDGIANTLKYLYFERSNIKDLEWS--KSLKNLQVLGLAGN 462
                    .||  |||    |.||.||....||:|:...|:.:.|..|.  :||..|:.|.|:.|
Zfish   609 LFKSLSNLTYLDISYNKLSEIPDDIFDYFPKTLRYISMSRNTLTDFAWEQLQSLPQLETLDLSKN 673

  Fly   463 NINALTPAMFQSLESLEILDLSSNHVGNWYRSAFHNNSALRVLNLRSNTINML--SNEMLKDFER 525
            .:..:...:.:...||::||||.|.:.....|...|..:|::||..:|.:..|  |:.......:
Zfish   674 KLRVVPRKLSKHTRSLKVLDLSHNQISKLRYSFLENVKSLQILNFANNKLKHLGASSFTTGSNHQ 738

  Fly   526 LDYLSLGDNDFICDCHLRAVVEVAAANNKDADCSYRLLNYSQNAVGEEVISLAESLIIDRKLWQS 590
            |..|.|..|...|.|:|                                        :|      
Zfish   739 LQILDLQRNPIHCTCNL----------------------------------------LD------ 757

  Fly   591 RYIPWLQRS-----------YSNIREFNRANHIIKLRFSSEDYMVAKCSAAQPYHLGDLDGDLTL 644
             :|.||::|           ..::.|..|.:.::.|.|.:.                        
Zfish   758 -FILWLEKSDTILPRLATDVLCDLPESKRGHPMVSLDFKNA------------------------ 797

  Fly   645 KFQLLDYEASQYYCFNNTDQLQVDELNCQIRSMSDLAEELHHVTNTVIA-VMGSLVGACILGFII 708
                         |.||:                 :||.|:.:|::||. ||.:.:|       |
Zfish   798 -------------CINNS-----------------IAEILYILTSSVITLVMCTTIG-------I 825

  Fly   709 YLKRWHIHYYYSSLKSAALLSSASKESVNKFTNISQRDPSAVYDIFISYCQND---RTWVLNELL 770
            ::..|.|.|.|:...:             :|.:...:....:||.|:.|...|   ..||||.|.
Zfish   826 HVFYWDISYAYNFCMA-------------RFKSYYLKTNDCIYDAFVMYDTKDPMVAEWVLNHLR 877

  Fly   771 PNVEETGD--VSICLHERDFQIGVTILDNIISCMDRSYSLMLIISSKFLLSHWCQFEMYLAQHRI 833
            ..:|:.|.  ..:||.|||:..|:.|:||:...:.||...:.:::..|:.|...:...:|||.|:
Zfish   878 LELEDRGRHVRPLCLEERDWTPGIPIMDNLNLSVHRSRKTIFVLTEGFVHSGIFKMAAFLAQQRL 942

  Fly   834 FEVSKEHLILVFLEDIPRRKRPKTLQYLMDVKTYIKWPTAKEDRKLFWKRLKRSL--EVIGINSR 896
            .|...:.::||.||.:.|:.|...|:..:...:.::||........||:.|:.::  |..|:.|:
Zfish   943 LEEGVDVMVLVLLEPVLRQSRILNLRRCLCGHSVLEWPRNPAAEGWFWQSLRNAVRFESQGVQSK 1007

  Fly   897  896
            Zfish  1008  1007

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Toll-9NP_001246846.1 leucine-rich repeat 157..185 CDD:275380 8/34 (24%)
LRR_8 262..322 CDD:290566 18/60 (30%)
leucine-rich repeat 264..287 CDD:275380 6/22 (27%)
leucine-rich repeat 288..311 CDD:275380 6/23 (26%)
leucine-rich repeat 312..356 CDD:275380 10/43 (23%)
LRR_8 <344..387 CDD:290566 12/48 (25%)
leucine-rich repeat 357..381 CDD:275380 8/29 (28%)
leucine-rich repeat 382..397 CDD:275380 6/14 (43%)
leucine-rich repeat 405..430 CDD:275380 14/52 (27%)
LRR_8 431..488 CDD:290566 19/58 (33%)
leucine-rich repeat 432..453 CDD:275380 7/22 (32%)
LRR_RI <449..536 CDD:238064 25/88 (28%)
leucine-rich repeat 454..477 CDD:275380 4/22 (18%)
LRR_8 477..536 CDD:290566 19/60 (32%)
leucine-rich repeat 478..501 CDD:275380 8/22 (36%)
leucine-rich repeat 502..525 CDD:275380 6/24 (25%)
TIR 751..891 CDD:214587 43/146 (29%)
tlr8bNP_001373638.1 leucine-rich repeat 36..57 CDD:275380
leucine-rich repeat 58..78 CDD:275380
LRR_8 64..116 CDD:404697
leucine-rich repeat 79..105 CDD:275380
leucine-rich repeat 106..121 CDD:275380
LRR_8 126..190 CDD:404697
leucine-rich repeat 127..150 CDD:275380
leucine-rich repeat 151..179 CDD:275380
PLN00113 180..>735 CDD:215061 121/515 (23%)
leucine-rich repeat 180..224 CDD:275380
leucine-rich repeat 225..266 CDD:275380