DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-9 and tlr22

DIOPT Version :9

Sequence 1:	NP_001246846.1	Gene:	Toll-9 / 40245	FlyBaseID:	FBgn0036978	Length:	900	Species:	Drosophila melanogaster
Sequence 2:	NP_001122147.2	Gene:	tlr22 / 403135	ZFINID:	ZDB-GENE-040220-5	Length:	955	Species:	Danio rerio

Alignment Length:	905	Identity:	216/905 - (23%)
Similarity:	357/905 - (39%)	Gaps:	262/905 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 YAHKLYLDLSHGNLKDDSDLFREAKLSRK-VTIWRTEVFS---AAFNTLTAAPFRTL-------- 150
            |..:||:..::.|      :|..::||.| :::.|.::.:   |||. ||...|.||
Zfish   188 YLEELYIGSNYFN------VFNSSELSTKPLSLKRLDLSNNRFAAFQ-LTNNIFPTLNHLDLSYC 245

  Fly   151 -------YSMRESLKLLSLRGNNFAEL---IPDAEDFARFVNES----------RLEASNSVPHH 195
                   :::.|...|.|::...|.::   |..|::..:..|.:          ||..::.:...
Zfish   246 GHNGTMAWNVTEKSYLASVKTLYFMDVNMSIQTADNVLQSFNNTLNKIRLNGNVRLNKTSLLLSV 310

  Fly   196 CELLL----------LHNTTDLYD-----RECYLYFNNNTNMGQSITTGRNYTNFIKVLKDRFDQ 245
            |..:|          .|.|..::|     .|..|..|..:|:.||:..|......:::..::..:
Zfish   311 CSPMLRVLRLIATKIKHLTNHMFDPCSELSELDLGGNEISNLSQSMFRGFKQLKKLQLQINKLTR 375

  Fly   246 HGSSSQSIAWATFPKMPRLVELDISNCSIEYVSKEAFRNVSNLRRLFMSDNKIMTISHDTFYYVQ 310
            ..:|.|.:....|        :|:|...|..:|...|.|::.::.|::..|||.:|....|..::
Zfish   376 VTNSFQILTSLEF--------IDLSRNHIHKLSCNDFANLTQVKTLYLYSNKISSIRSCLFKDLK 432

  Fly   311 GVQYLDLSFTNFLT----------YSYQLQLPTLEMALSLIYGLKIQQNVFKYLPELIYLDLSHS 365
            .::.|.|...|.|.          :..:|||...:::|       |:.:.|..||:|..|.|..:
Zfish   433 SLEVLRLGTNNLLKIDDVFSNGPYFLKELQLSYNKLSL-------IKSHTFGNLPQLNNLSLEDN 490

  Fly   366 KMTRNSAVAFAHLGDKLKFLSLCYTAIPMVSSTIFKNTVLEGLDLSGNPYLSYNIIDDAFDGIAN 430
            :::.....||..| :.|..|.|....|...:.|...| |..|:....|..|..|.|..|:|
Zfish   491 QISEIEGYAFGGL-ENLTSLFLSSNKITGKTLTTHPN-VFSGMPNLQNLDLFANSISFAYD---- 549

  Fly   431 TLKY-------------LYFERSNIKDLEWS--KSLKNLQVLGLAGNNINALTPAMFQSLESLEI 480
            .|||             ||.:|..|..|..:  :.|.:||:..:...|:|.|.|.:|.....|..
Zfish   550 KLKYPLFKDLKNLRELSLYSQRRGIGQLPSNLLEGLSSLQMFYIGNTNLNQLNPNLFNFTPQLWF 614

  Fly   481 LDLSSNHVGNWYR-------SAFH----------NNSALRVLN------------LRS--NTINM 514
            ||||.|.:    |       ..||          :.:.||.||            ||:  |.|:.
Zfish   615 LDLSKNAL----REDDAIPPELFHPIPNLTKLIISRTQLRSLNFLLGANLNKLSTLRASGNEIDS 675

  Fly   515 LSNEMLKDFERLDYLSLGDNDFICDCHLRAVVEVAAANNKDADCSYRLLNYSQNAVGEEVISLAE 579
            ::..::|...||..|.|.:|.|.|||           ||
Zfish   676 VNETLIKSLPRLAVLDLQNNTFTCDC-----------NN-------------------------- 703

  Fly   580 SLIIDRKLWQSRYIPWLQRSYSNIREFNRANHIIKLRFSSEDYMVAKCSAAQPYHLGDLDGDLTL 644
                      :.:|.|.:::.                 |::.|.:::.:.:.|         .||
Zfish   704 ----------AFFIDWAKKNE-----------------STQVYYLSRYTCSYP---------RTL 732

  Fly   645 K-FQLLDYEAS------QYYCFNNTDQLQVDELNCQIRSMSDLAEELHHVTNTVIAVMGSLVGAC 702
            : ..|.::...      .|.||                           |.::::.::     ..
Zfish   733 RGTSLAEFNTDSCTFNWDYICF---------------------------VCSSILVIL-----TL 765

  Fly   703 ILGFIIYLKRWHIHY-YYSSLKSAALLSSASKESVNKFTNISQRDPSAVYDIFISYCQNDRTWVL 766
            :|.||....|:.:.| ||..|  |.|..|...:|...|.          ||.||||...|..||:
Zfish   766 LLSFIWNFLRYQVVYTYYLFL--AFLYDSRRNQSGQTFQ----------YDAFISYNTLDEAWVM 818

  Fly   767 NELLPNVEETGDVSICLHERDFQIGVTILDNIISCMDRSYSLMLIISSKFLLSHWCQFEMYLAQH 831
            .||:|.:|......:|||.|||:.|..|:|||:..:..|...:.:|:..:|.|:||..|:.:|..
Zfish   819 EELIPKLEGEQGWRLCLHHRDFEPGRPIIDNIVDGIYSSRKTICLITRNYLKSNWCSSEVQVASF 883

  Fly   832 RIFEVSKEHLILVFLEDIPRRKRP--KTLQYLMDVKTYIKWPTAKEDRKLFWKRLKRSLE 889
            |:|:..|:.||||||||||..:..  ..|:.|:..:|||:||...||.|:||::||.:||
Zfish   884 RLFDEQKDVLILVFLEDIPTHQLSPYHRLRKLVKKRTYIRWPKPGEDNKIFWQKLKMALE 943

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-9	NP_001246846.1	leucine-rich repeat	157..185	CDD:275380	6/40 (15%)
		LRR_8	262..322	CDD:290566	14/59 (24%)
		leucine-rich repeat	264..287	CDD:275380	6/22 (27%)
		leucine-rich repeat	288..311	CDD:275380	6/22 (27%)
		leucine-rich repeat	312..356	CDD:275380	11/53 (21%)
		LRR_8	<344..387	CDD:290566	12/42 (29%)
		leucine-rich repeat	357..381	CDD:275380	6/23 (26%)
		leucine-rich repeat	382..397	CDD:275380	4/14 (29%)
		leucine-rich repeat	405..430	CDD:275380	7/24 (29%)
		LRR_8	431..488	CDD:290566	22/71 (31%)
		leucine-rich repeat	432..453	CDD:275380	9/35 (26%)
		LRR_RI	<449..536	CDD:238064	31/117 (26%)
		leucine-rich repeat	454..477	CDD:275380	7/22 (32%)
		LRR_8	477..536	CDD:290566	23/89 (26%)
		leucine-rich repeat	478..501	CDD:275380	9/39 (23%)
		leucine-rich repeat	502..525	CDD:275380	9/36 (25%)
		TIR	751..891	CDD:214587	61/141 (43%)
tlr22	NP_001122147.2	leucine-rich repeat	458..481	CDD:275380	7/29 (24%)
		LRR_RI	461..700	CDD:238064	68/255 (27%)
		LRR_8	480..544	CDD:290566	18/65 (28%)
		leucine-rich repeat	482..505	CDD:275380	6/23 (26%)
		leucine-rich repeat	506..533	CDD:275380	8/27 (30%)
		leucine-rich repeat	534..561	CDD:275380	9/30 (30%)
		LRR_8	560..622	CDD:290566	19/61 (31%)
		leucine-rich repeat	562..587	CDD:275380	6/24 (25%)
		leucine-rich repeat	588..606	CDD:275380	6/17 (35%)
		leucine-rich repeat	612..638	CDD:275380	9/29 (31%)
		LRR_8	637..695	CDD:290566	13/57 (23%)
		leucine-rich repeat	639..662	CDD:275380	4/22 (18%)
		leucine-rich repeat	663..686	CDD:275380	5/22 (23%)
		leucine-rich repeat	687..705	CDD:275380	10/64 (16%)
		TIR	802..945	CDD:214587	61/152 (40%)
		leucine-rich repeat	71..91	CDD:275380
		LRR_8	91..150	CDD:290566
		leucine-rich repeat	92..115	CDD:275380
		leucine-rich repeat	116..139	CDD:275380
		LRR_8	138..199	CDD:290566	3/10 (30%)
		leucine-rich repeat	140..163	CDD:275380
		leucine-rich repeat	164..213	CDD:275380	8/30 (27%)
		leucine-rich repeat	214..338	CDD:275380	23/124 (19%)
		LRR_8	337..396	CDD:290566	12/66 (18%)
		leucine-rich repeat	339..362	CDD:275380	7/22 (32%)
		LRR_RI	<363..494	CDD:238064	30/145 (21%)
		leucine-rich repeat	363..385	CDD:275380	2/21 (10%)
		LRR_8	384..444	CDD:290566	15/67 (22%)
		leucine-rich repeat	386..409	CDD:275380	7/30 (23%)
		leucine-rich repeat	410..433	CDD:275380	6/22 (27%)
		LRR_8	432..492	CDD:290566	15/66 (23%)
		leucine-rich repeat	434..457	CDD:275380	4/22 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590059
Domainoid	1	1.000	122	1.000	Domainoid score	I5577
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	1	1.000	-	-		otm24216
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.850