DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-9 and tlr19.1

DIOPT Version :9

Sequence 1:	NP_001246846.1	Gene:	Toll-9 / 40245	FlyBaseID:	FBgn0036978	Length:	900	Species:	Drosophila melanogaster
Sequence 2:	NP_001352353.1	Gene:	tlr19.1 / 403134	ZFINID:	ZDB-GENE-040220-3	Length:	958	Species:	Danio rerio

Alignment Length:	916	Identity:	215/916 - (23%)
Similarity:	332/916 - (36%)	Gaps:	309/916 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 DLKSLMLKYESDDGNSCLLDLIKDEVIWWQFPNGTLRDST------KKYAHKLYLDLSH------ 108
            :|.||.|::|.....|.           |:...|.:.|.|      |||:.. :.||.|
Zfish   262 NLSSLFLEFEGKSLGSI-----------WESGVGKVNDLTLKGKVLKKYSTN-FKDLCHLVSSLY 314

  Fly   109 ----------------GNLKDDSD-----LFREAKLSR-KVTIWRT----EVFSAAFNTLTAAPF 147
                            .:|||...     |.:.:|:.. ....|.:    :....|:..||.|||
Zfish   315 SQSLSLVYTSIDRLTAEDLKDCGTKLTKLLIQNSKIDNLDFRFWTSKLEMQALQMAYMKLTDAPF 379

  Fly   148 -----RTLYSMRESLKLLSLRGNNFAELIPDAEDFARFVNESRLEASNSVPHHCELLLLHNTTDL 207
                 .|::    ||..|.|.||:...:  :.:.||                 |...|..
Zfish   380 CFVANSTMW----SLTSLDLTGNSITNI--EGDQFA-----------------CMPFLEQ----- 416

  Fly   208 YDRECYLYFNNNTNMGQSITTGRNYTNFIKVLKDRFDQHGSSSQSIAWATFPKMPRLVELDISNC 272
                  ||.:.|.               ||.|:    .|          .|..:|||..|.:.:.
Zfish   417 ------LYLSQNA---------------IKTLQ----LH----------AFRGLPRLKILQLDSN 446

  Fly   273 SIEYVSKEAFRNVSNLRRLFMSDNKIMTISHDTFYYVQGVQYLDLSFTNFLTYSYQLQLPTLEMA 337
            .|..:|...|:|:..|..|.::||.|.||...||:..:  :..:|||.. |.|.|:|.|
Zfish   447 KIWQLSANDFKNLRALEVLLINDNIIETIETGTFWDQR--ELCELSFGR-LEYVYELHL------ 502

  Fly   338 LSLIYGLKIQQNV-FKYLPELIYLDLSHSKMTR---------NSAVAFAHLGDKLKFLSLCYTAI 392
                      :|: |::.|:|..|.:.....|.         |...|....|::|.|:. |.:.:
Zfish   503 ----------ENIFFEFPPKLQRLSIDAHYGTNIYIGNASPPNGTFALELNGERLGFVG-CDSDV 556

  Fly   393 PM------VSSTIF--KNTV-------LEGLDLSGNPY---LSYNIIDDAFDGIANTLKYLYFER 439
            .|      |:.|.|  |::.       ||.|::||...   |:|..|::     .:.||:|...|
Zfish   557 LMAVRELKVNCTYFLCKDSFMAPYFLNLESLEISGGAERAPLNYATINN-----LHHLKHLKLAR 616

  Fly   440 SNIKDLEWSKS----LKNLQVLGLAGNNINALTPAMFQSLESLEILDLSSNHVGNWYRSAFHNNS 500
            .|..:...|:|    |..||.|.:...:::.||.:||:.|.||::|.|.|:
Zfish   617 LNFPNYTESRSAFWNLTQLQTLVVVNCHLSFLTKSMFRDLTSLQLLRLYSD-------------- 667

  Fly   501 ALRVLNLRSNTINMLSNEMLKDFERLDYLSLGDNDFICDCHLRAVVEVAAANNKDADCSYRLLNY 565
              ..|.|......:|  .:||.| .||.:     ||.|.|.                 :..||::
Zfish   668 --SPLILTDGVFGVL--PVLKAF-ILDRV-----DFQCSCE-----------------NGWLLDW 705

  Fly   566 SQNAVGEEVISLAESLIIDRKLWQSRYIPWLQRSYSNIREFNRANHIIKLRFSSEDYMVAKCSAA 630
            :.:....:||.|           |.:...|               |..||.|
Zfish   706 ADSTEKVQVIYL-----------QKQQCVW---------------HYQKLNF------------- 731

  Fly   631 QPYHLGDLDGDLTLKFQLLDYEASQYYCFNNTDQLQVDELNCQIRSMSDLAEELHHVTNTVIAVM 695
                       |....:|...:| ||.|:              :.:.|.::..|........|..
Zfish   732 -----------LATMEKLCQTDA-QYICY--------------VATASSISLLLSAAVGYQFARW 770

  Fly   696 GSLVGACILGFIIYLKRWHIHYYYSSLKSAALLSSASKESVNKFTNISQRDPSAVYDIFISYCQN 760
            .|||      ..:.||.|      ...:.....:...:...:.:..|.:..    ||.|:|:|..
Zfish   771 PSLV------LFLRLKGW------MERRFGRRWNRRRRRMEDDYGEIEEMQ----YDAFVSFCSQ 819

  Fly   761 DRTWVLNELLPNVEETGD--VSICLHERDFQIGVTILDNIISCMDRSYSLMLIISSKFLLSHWCQ 823
            |..|||.|:...:||.|:  :.:|||.|||::|..|:|||...:..|...:.:||.::|.|.||.
Zfish   820 DEAWVLGEMASRLEEQGNPRLRLCLHNRDFEVGKDIMDNITDSIHNSQCTVCLISRRYLRSDWCG 884

  Fly   824 FEMYLAQHRIFEVSKEHLILVFLEDIPRRKRP------KTLQYLMDVKTYIKWPTAKEDRKLFWK 882
            .||.:|.||..|..|..|||:||:.|    .|      ..|..|:..:||:.||..:.||:.||.
Zfish   885 LEMRVATHRQLEEQKHRLILIFLQHI----SPFELSAFHRLAKLVRSRTYLDWPEEEGDREHFWD 945

  Fly   883 RLKRSL 888
            ||:|::
Zfish   946 RLRRNI 951

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-9	NP_001246846.1	leucine-rich repeat	157..185	CDD:275380	7/27 (26%)
		LRR_8	262..322	CDD:290566	20/59 (34%)
		leucine-rich repeat	264..287	CDD:275380	6/22 (27%)
		leucine-rich repeat	288..311	CDD:275380	9/22 (41%)
		leucine-rich repeat	312..356	CDD:275380	10/44 (23%)
		LRR_8	<344..387	CDD:290566	11/52 (21%)
		leucine-rich repeat	357..381	CDD:275380	6/32 (19%)
		leucine-rich repeat	382..397	CDD:275380	5/20 (25%)
		leucine-rich repeat	405..430	CDD:275380	8/27 (30%)
		LRR_8	431..488	CDD:290566	21/60 (35%)
		leucine-rich repeat	432..453	CDD:275380	8/24 (33%)
		LRR_RI	<449..536	CDD:238064	23/90 (26%)
		leucine-rich repeat	454..477	CDD:275380	8/22 (36%)
		LRR_8	477..536	CDD:290566	13/58 (22%)
		leucine-rich repeat	478..501	CDD:275380	4/22 (18%)
		leucine-rich repeat	502..525	CDD:275380	6/22 (27%)
		TIR	751..891	CDD:214587	58/146 (40%)
tlr19.1	NP_001352353.1	LRR_8	101..162	CDD:316378
		leucine-rich repeat	103..126	CDD:275380
		leucine-rich repeat	127..154	CDD:275380
		leucine-rich repeat	155..178	CDD:275380
		leucine-rich repeat	179..238	CDD:275380
		leucine-rich repeat	207..219	CDD:275378
		leucine-rich repeat	239..265	CDD:275380	1/2 (50%)
		leucine-rich repeat	340..363	CDD:275380	3/22 (14%)
		leucine-rich repeat	364..389	CDD:275380	7/28 (25%)
		LRR_8	389..448	CDD:316378	22/117 (19%)
		leucine-rich repeat	390..413	CDD:275378	8/41 (20%)
		leucine-rich repeat	414..437	CDD:275378	9/62 (15%)
		LRR_8	436..>482	CDD:316378	17/45 (38%)
		leucine-rich repeat	438..461	CDD:275378	6/22 (27%)
		leucine-rich repeat	462..485	CDD:275378	9/24 (38%)
		leucine-rich repeat	540..562	CDD:275380	5/22 (23%)
		leucine-rich repeat	563..608	CDD:275380	12/49 (24%)
		leucine-rich repeat	609..634	CDD:275380	8/24 (33%)
		leucine-rich repeat	635..658	CDD:275380	8/22 (36%)
		TIR	809..952	CDD:214587	58/151 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	3	3.070