DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-9 and tlr18

DIOPT Version :9

Sequence 1:	NP_001246846.1	Gene:	Toll-9 / 40245	FlyBaseID:	FBgn0036978	Length:	900	Species:	Drosophila melanogaster
Sequence 2:	NP_001082819.1	Gene:	tlr18 / 403133	ZFINID:	ZDB-GENE-040220-2	Length:	854	Species:	Danio rerio

Alignment Length:	908	Identity:	213/908 - (23%)
Similarity:	351/908 - (38%)	Gaps:	284/908 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 YAHKLYLDLSHGNLKDDSDLFREAKLSRKVTIWRTEVFSAAFNTLTAAPFRTLYSMRESLKLLSL 162
            |...|.|:.::.:|..| |.|:...|..::.::.        |:||..||:.|..: .:||:|.:
Zfish    77 YLRVLKLNFNNISLVLD-DAFQGNLLLEELNLFN--------NSLTEIPFKALEPL-TNLKVLEM 131

  Fly   163 RGNNFAELIPDAEDFARFVNESRLEA-SNSVPHHCELLLLHNTTDLYDRECYLYFNNNTNMGQ-S 225
            ..|.:::    |...|.|:|.::|:. |...|         ..:.|..|:.|:.  .|.::.: :
Zfish   132 SNNLYSQ----ASLGAAFLNFNQLKVLSIGGP---------LVSSLGSRDIYVL--KNISLDKFA 181

  Fly   226 ITTG---RNY-TNFIKVLKDR---FDQHGSSSQSIAWATFPK-MPRLVELDISNCSIEYVSKEAF 282
            :.||   |:| ..:.|.|..:   ||        ||:...|. :|:::: |::|.:.:
Zfish   182 VKTGTGFRDYEPGYFKSLSTKHLWFD--------IAFDKNPDLLPKMLK-DLANKTFD------- 230

  Fly   283 RNVSNLRRLFMSDNKIMTISHDTFYYVQGVQYLDLSFTNFLTYSYQLQLPTLEMALSLIYGLKIQ 347
              |...|.||  :.:..|...|.||   |:||::.....|  |..:.....:.|||.     .::
Zfish   231 --VLRFRNLF--EFQYYTGKRDIFY---GLQYVNAQTLTF--YRGKFNEEVMRMALK-----NVE 281

  Fly   348 QNVFKYLPELIYLDLSHSK-MTRNSAV-----------------------AFAHLGDKLKFL--S 386
            .:..|.| ||:.:|.:.|: .|:.|:|                       :|..|....||:  :
Zfish   282 ISPIKAL-ELLLIDFARSQNRTQGSSVKNLSLDRLVLSDISNPDIMRFDWSFTWLNHVRKFIVWN 345

  Fly   387 LCYTAIPMVSSTIFKNTVLEGLDLSGNPYLS---YN-IID--------DAFDGIANTLKYLYFER 439
            :.:.::|..|....|:  :|.||:|.|..|.   || :.|        |.|:...|.|..|....
Zfish   346 VNFNSVPCDSWPEMKS--VELLDISNNQLLDSYIYNPLCDTRNTLHKLDTFNVSHNRLTSLSDLA 408

  Fly   440 SNIKDL---------------------EWSKSLKNLQVLGLAGNNINALTPAMFQ---------- 473
            |..||.                     :|.|::  .:|:|    |.|:||...|:
Zfish   409 SLTKDFVKLTTIDMSHNQLQYLGNGACDWRKTI--TKVIG----NHNSLTSDSFKCLPTSVNFLD 467

  Fly   474 -SLESLEILD--------------LSSNHV----GNWYRSAFHNNSALRVLNLRSNTINMLSNEM 519
             |..||:.||              ||.|.:    ..|      .|..||.|.|..|:..::|.:.
Zfish   468 LSYSSLDQLDMDYFNKASELTELLLSGNKIKFIPSGW------KNRYLRTLALDGNSFGLVSMKS 526

  Fly   520 LKDFERLDYLSLGDNDFICDCHLRAVVEVAAANNKDADCSYRLLNYSQNAVGEEVISLAESLIID 584
            .||...|..|:.|:|.:.|.|.|...:                         :|..|..:..|.|
Zfish   527 FKDMLSLRVLTAGNNPYHCTCDLYTFI-------------------------QETTSKGKVTITD 566

  Fly   585 RKLWQSRYIPWLQRSYSNIREFNRANHIIKLRFSSEDYMVAKCSAAQPYHLGDLDGDLTLKFQLL 649
               |.:.|     :.|...|..|.              ||:|      |..|.|..|:||..
Zfish   567 ---WPNNY-----KCYHPERLLNT--------------MVSK------YSPGHLACDITLVI--- 600

  Fly   650 DYEASQYYCFNNTDQLQVDELNCQIRSMSDLAEELHHVTNTVIAVMGSLVGACILGFIIYLKRWH 714
                                    |.|:|..|.       .|:.:|       :|.:|.::. |:
Zfish   601 ------------------------IISVSTTAA-------VVLVIM-------LLCYIFHVP-WY 626

  Fly   715 IHYYYSSLKSAALLSSASKESVNKFTNISQRDPSAVYDIFISYCQNDRTWVLNELLPNVEET-GD 778
            :...|..:::.   ..|.||.:.:..:.:       :..||||..:|..||.|.|||.:|.. ..
Zfish   627 VKATYQIIRAK---YRAHKEGLGQGVDYA-------FHAFISYSHSDADWVRNHLLPCLENVKPP 681

  Fly   779 VSICLHERDFQIGVTILDNIISCMDRSYSLMLIISSKFLLSHWCQFEMYLAQHRIFEVSKEHLIL 843
            ..:|:|||||..|..|:||||..::.|..::.::|..|:.|.||.:|:|.||.|....:...:||
Zfish   682 YRLCIHERDFIPGKWIIDNIIENIENSRKVIFVLSHNFVNSEWCNYELYFAQQRAIGKTFSDVIL 746

  Fly   844 VFLEDIPRRKRPK---TLQYLMDVKTYIKWPTAKEDRKLFWKRLKRSLEVIG----INSREIS 899
            |..|.|.....|.   .|:.:::.|||::||....::..||.:|:   .|:|    |..|.||
Zfish   747 VVKEPIDPTSLPSKFCKLKRMLNTKTYLEWPQQPTEQNFFWIQLR---SVLGKPNSIRPRTIS 806

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-9	NP_001246846.1	leucine-rich repeat	157..185	CDD:275380	8/27 (30%)
		LRR_8	262..322	CDD:290566	14/59 (24%)
		leucine-rich repeat	264..287	CDD:275380	3/22 (14%)
		leucine-rich repeat	288..311	CDD:275380	7/22 (32%)
		leucine-rich repeat	312..356	CDD:275380	9/43 (21%)
		LRR_8	<344..387	CDD:290566	13/68 (19%)
		leucine-rich repeat	357..381	CDD:275380	8/47 (17%)
		leucine-rich repeat	382..397	CDD:275380	3/16 (19%)
		leucine-rich repeat	405..430	CDD:275380	11/36 (31%)
		LRR_8	431..488	CDD:290566	22/102 (22%)
		leucine-rich repeat	432..453	CDD:275380	7/41 (17%)
		LRR_RI	<449..536	CDD:238064	30/115 (26%)
		leucine-rich repeat	454..477	CDD:275380	8/33 (24%)
		LRR_8	477..536	CDD:290566	21/76 (28%)
		leucine-rich repeat	478..501	CDD:275380	8/40 (20%)
		leucine-rich repeat	502..525	CDD:275380	8/22 (36%)
		TIR	751..891	CDD:214587	50/143 (35%)
tlr18	NP_001082819.1	LRR_8	53..>98	CDD:316378	7/21 (33%)
		leucine-rich repeat	54..77	CDD:275380	213/908 (23%)
		leucine-rich repeat	78..101	CDD:275380	6/23 (26%)
		leucine-rich repeat	102..125	CDD:275380	6/31 (19%)
		leucine-rich repeat	126..150	CDD:275380	8/27 (30%)
		LRR	<345..>519	CDD:227223	44/187 (24%)
		leucine-rich repeat	362..390	CDD:275380	9/27 (33%)
		leucine-rich repeat	391..416	CDD:275380	8/24 (33%)
		leucine-rich repeat	417..440	CDD:275380	1/22 (5%)
		leucine-rich repeat	441..462	CDD:275380	7/26 (27%)
		leucine-rich repeat	463..486	CDD:275380	5/22 (23%)
		leucine-rich repeat	487..508	CDD:275380	5/26 (19%)
		leucine-rich repeat	509..532	CDD:275380	8/22 (36%)
		TIR	653..791	CDD:214587	49/137 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	6	5.980