Protein Alignment Toll-9 and tlr4ba

DIOPT Version :10

• Sequence 1: NP_649214.1
• Gene: Toll-9 / 40245
• FlyBaseID: FBgn0036978
• Length: 900
• Species: Drosophila melanogaster
• Sequence 2: XP_009305503.2
• Gene: tlr4ba / 403131
• ZFINID: ZDB-GENE-040219-8
• Length: 824
• Species: Danio rerio
• Alignment Length: 873
• Identity: 201/873 - (23%)
• Similarity: 334/873 - (38%)
• Gaps: 266/873 - (30%)

  Fly   212 CYLYFNNN--TNMGQSI---TTGRNYTNFIKVLKDRFDQHGSSSQSIAWA----------TFPKM 261
            ||...|..  |.:.:::   ..|||.::....:.       ||.|::.::          .||.:
Zfish    17 CYYIANGEPCTRIIENLHYSCMGRNLSSIPSSIP-------SSVQTLDFSFNFFLQLKKTIFPVL 74

  Fly   262 PRLVELDISNCSIEYVSKEAFRNVSNLRRLFMSDNKIMTISH---DTFYYVQ-------GVQYLD 316
            ..|..||:|.|.|..:..:||.||.||..||::.|.|:..:.   :|.|.:|       |::.|.
Zfish    75 SFLRVLDLSRCHIRQIENDAFYNVKNLTTLFLTGNPIIYFAPGCLNTLYNLQRLVLVDIGLESLQ 139

  Fly   317 LSFTNF---------LTYSYQLQLPTL---------------------------------EMALS 339
            |:..|.         ..|...:.||..                                 .|.|.
Zfish   140 LNINNLTKLQELNVGTNYIQSMTLPPFMTTFKDFSLLDLHANNISIIRTDHTVVLREIGRNMTLI 204

  Fly   340 LIYG--LKIQQNVFK--YLPELIYLDLSHSKMTRNSAVAFAHLGDKLKFLSLCYTAIPMVSSTIF 400
            |.:.  |.|:...||  ||.:   ||:      |::.|:|:.....||.|...     .|...||
Zfish   205 LTWNPLLHIEPGAFKDVYLRQ---LDI------RSAFVSFSAQKAALKALHGL-----NVKRLIF 255

  Fly   401 ------------KNTVLEGLDLSGNPYLSYNIIDDAFDGIA------------------------ 429
                        .|.||:||.......:||.:::.|...||
Zfish   256 GKYREDNGFHFVDNDVLDGLCCFNFQEVSYYVLESAKTTIAIFRCMINATRITVKGGNIFKMETV 320

  Fly   430 --NTLKYLYF-----------ERSNIKDLEWSK--------------SLKNLQVLGLAGN----- 462
              :..|.||.           :.|::..||..:              .|..||.:.|:.|
Zfish   321 HFHKTKELYLINNGLGTLPTKQLSHLHTLEKLEITHNSEPIFAEPFTDLPKLQYVDLSDNQLKIK 385

  Fly   463 -----------NINALTPAM----------FQSLESLEILDLSSNHVGNWYRSAFHNNSALRVLN 506
                       .||.|..::          |:.|:||||||.|...|
Zfish   386 HCCSTLLSGTPQINYLNLSLNSEISVDVGGFEGLDSLEILDFSYTRV------------------ 432

  Fly   507 LRSNTINMLSNEMLKDFERLD--YLSLGDNDFICDCHLRAV-VEVAAANNKDADCSYRLLNYSQN 568
            :|...:::|||  ||:...||  |.|:..::..|...|.:: |...|.||...:.:..:.|   |
Zfish   433 VRIGYLSVLSN--LKNLRYLDVSYSSVTFSNIFCFLGLSSLNVLKMAGNNFQGNVAKYVFN---N 492

  Fly   569 AVGEEVISLAESLIIDRKLWQSRYIPWLQRSYSNIREFN-RANHIIKLRFSSE-------DYMVA 625
            ....|.:.::...:::......:|   |||    :|..| :.|::||:.|.:.       .:.|.
Zfish   493 LTLLEHLDMSFCHLVELHTSSFKY---LQR----LRHLNVKGNYLIKIDFLTHPNLKQLTSFYVE 550

  Fly   626 KCS-AAQPYH-LGDLDGDLT---LKFQLLDYEASQ----YYCFNNTDQL-QVDELNCQIRSMS-- 678
            |.| .|.|.| |.:|..:|:   |.|..:|...||    .:..||...| |.:.:.|:..|.:
Zfish   551 KNSITAIPLHVLQNLPMNLSEFDLSFNPIDCSCSQTDFMLWIINNQRVLKQPENILCKTISPNSD 615

  Fly   679 ------DLAEELHHVTNTVIAVMGSLVGACILGFIIYLKRWHIHYYYSSLKSAALLSSASKESVN 737
                  |:...::.....::..:..:|...:|..::|..::::.|::..|:.
Zfish   616 FRVTDFDIDHCVYKKKLIIVLPVFCVVFIVVLSILVYRFQFYLRYFWILLRG------------- 667

  Fly   738 KFTNISQRDPSAVYDIFISYCQNDRTWVLNELLPNVEE-TGDVSICLHERDFQIGVTILDNIISC 801
             :.:..|::.|  ||.|:.:...|..||:|||:.|:|. ...:.:|||.||||.|.:|..|||
Zfish   668 -YRSPGQQECS--YDAFVIFSSYDEAWVMNELMENLENGVPPIQLCLHMRDFQAGKSIASNII-- 727

  Fly   802 MDR----SYSLMLIISSKFLLSHWCQFEMYLAQHRIFEVSKEHLILVFLEDIPRRKRPKTLQYLM 862
             |.    |..:::::|..|:.|.||:||..|||.|.......::|::.|||:..||..|.:....
Zfish   728 -DEGIMGSRKIIVVVSQHFIDSSWCRFEFELAQSRFLMERNANIIIIILEDVAERKTKKVIGLHK 791

  Fly   863 DVK--TYIKWPTAKEDRKLFWKRLKRSL 888
            .:|  ||:||.........||.||::::
Zfish   792 HLKKNTYLKWSRDPLSNMRFWIRLRKAI 819

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Toll-9	NP_649214.1	LRR	198..537	CDD:443914	102/486 (21%)
		leucine-rich repeat	264..287	CDD:275380	10/22 (45%)
		leucine-rich repeat	288..311	CDD:275380	8/32 (25%)
		leucine-rich repeat	312..356	CDD:275380	15/89 (17%)
		leucine-rich repeat	357..381	CDD:275380	5/23 (22%)
		leucine-rich repeat	382..397	CDD:275380	4/14 (29%)
		leucine-rich repeat	405..430	CDD:275380	8/50 (16%)
		leucine-rich repeat	432..453	CDD:275380	7/45 (16%)
		leucine-rich repeat	454..477	CDD:275380	9/48 (19%)
		leucine-rich repeat	478..501	CDD:275380	7/22 (32%)
		leucine-rich repeat	502..525	CDD:275380	6/22 (27%)
		TIR	751..891	CDD:214587	52/145 (36%)
tlr4ba	XP_009305503.2	None