DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-9 and tlr2

DIOPT Version :9

Sequence 1:	NP_001246846.1	Gene:	Toll-9 / 40245	FlyBaseID:	FBgn0036978	Length:	900	Species:	Drosophila melanogaster
Sequence 2:	XP_005170910.1	Gene:	tlr2 / 403125	ZFINID:	ZDB-GENE-040219-6	Length:	818	Species:	Danio rerio

Alignment Length:	950	Identity:	210/950 - (22%)
Similarity:	349/950 - (36%)	Gaps:	306/950 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 SSEEAEEVSKERTDLKSLMLKYESDDGNSCLLDLIK-DEVIWWQFPNGTL----RDSTKKYAHKL 102
            ||....:|....:|:..|.|.:...:..: :.||.. :|:|........|    ||:.|...:..
Zfish    68 SSNNLHQVPTVPSDVLGLDLSFNQIESIN-MTDLSSYNELIILNLHKNKLRHIHRDAFKSQHNLE 131

  Fly   103 YLDLSHGNLKDDS-DLFREAKLSRKVTIWRTEVFSAAFNTLTAAP-------FRTLY----SMRE 155
            .||||..||.:.| ..|.:.|     ::.:..:....::|:..||       .|||:    |:||
Zfish   132 VLDLSLNNLNNLSPSWFHKLK-----SLQQLNLVGNPYSTVGPAPIFKSLVNLRTLHLGSPSLRE 191

  Fly   156 ----------SLKLLSLRGNNFAELIPDAEDFARFVNESRLEASNSVPHHCELL------LLHNT 204
                      .|..::..|:|.......:...||.:....|...|......||:      :.|..
Zfish   192 LHKNGLDVLTHLDEMTFFGSNLRSYENGSLKAARPIGSVSLSLQNLFESDPELVSKVLQDVSHPE 256

  Fly   205 TDLYDRECYLYFNNNT--------------NMGQSITTGRNYTNFIKVL---------------- 239
            |.|..::..:..|.:|              ....|.||.:..|:|::.:
Zfish   257 TLLIIKDVTMKTNTSTEPFKMVKEGGTKSLTFQNSSTTDQALTSFLEFMDGSPLSFIGLEDIQFV 321

  Fly   240 ------KDRFDQHGSSSQSIAWATFPKMPRLVELD-----ISNCSIEYVSKEAFRNVSNLRRLFM 293
                  |.::..|.|...:..        |.:|::     .|...:.::.|. |.|||      :
Zfish   322 GIGEWQKAKYTHHDSLRTAYL--------RNIEIEGFFGFSSMIELGFLLKH-FHNVS------V 371

  Fly   294 SDNKIMTISHDTFYYVQGVQYLDLSFTNFLT-YSYQLQLPTLEMALSLIYGLKIQQNVFK----- 352
            .:..:..|..:|.:.::.::|:||| .|.|| .:.|..|.|...|...:..|.:.|||.|
Zfish   372 INATVFVIPKETTFLLKNLEYMDLS-QNLLTDLTIQPTLYTGSGAYQNLNMLNVSQNVLKSLGLM 435

  Fly   353 -----YLPELIYLDLSHSKMTRNSAVAFAHLGDK------LKFLSLCYTAI----PMVSSTIFKN 402
                 .|.:|.|||||::        :|..:.:|      |:||:|..|.:    |.:.|::
Zfish   436 SRLVTNLKKLKYLDLSYN--------SFVSMPEKCSWPVTLRFLNLSSTKLSTLTPCLPSSL--- 489

  Fly   403 TVLEGLDLSGNPYLSYNIIDDAFDGIANTLKYLYFERSNIKDLE-WSKSLKNLQVLGLAGNNINA 466
            ||   ||||.|                              ||: :.:...:|..|.|.||.:..
Zfish   490 TV---LDLSEN------------------------------DLKAFKQRFPHLTTLILTGNRLMK 521

  Fly   467 LTPA-MFQSLESLEILDLSSNHVGNWYRSAFHNNSALRVLNLRSNTINMLSNEMLKDFERLDYLS 530
            |... :|.||.:|.|                           :.|.:.|.:...|:.|:.|.||.
Zfish   522 LPDGKLFPSLNTLLI---------------------------QRNALRMFNQSSLRSFKTLLYLE 559

  Fly   531 LGDNDFICDCHLRAVVEVAAANNKDADCSYRLLNYSQNAVGEEVISLAESLIIDRKLWQSRYIPW 595
            .|.|:|:|.|      :..:...||.:....|.:..||.|.....:|
Zfish   560 AGANNFVCSC------KFVSFFKKDVEDLITLQDGRQNYVCNTPFTL------------------ 600

  Fly   596 LQRSYSNIREFNRANHIIKLRFS-SEDYMVAKCSAAQPYHLGDLDGDLTLKFQLLDYEASQYYCF 659
                        |.|.|..:|.| .|.||:...|.                           .||
Zfish   601 ------------RGNAIDSVRLSVFECYMIPAVSV---------------------------LCF 626

  Fly   660 NNTDQLQVDELNCQIRSMSDLAEELHHVTNTVIAVMGSLVGACILGFIIYLKRWHIHYYYSSLKS 724
            .                              :|..:|.:|..|        .:.|:.:|....|
Zfish   627 G------------------------------IITALGLVVLTC--------HKLHVIWYLQMTK- 652

  Fly   725 AALLSSASKESVNKFTNISQRDPSAV-YDIFISYCQNDRTWVLNELLPNVEET-GDVSICLHERD 787
             |.:.:..|.:|.:.       |..: ||.|:||.|:|..||...|:..:|:| ...|:|||:||
Zfish   653 -AWIQAKRKPAVGRL-------PEELRYDAFVSYSQHDAEWVEEILVAELEDTQPSFSLCLHKRD 709

  Fly   788 FQIGVTILDNIISCMDRSYSLMLIISSKFLLSHWCQFEMYLAQHRIFEVSKEHLILVFLEDIPRR 852
            |:.|..|:||||..:::||..:.::|..|:.|.||::|:..:..||.:...:..:||.||.|.:.
Zfish   710 FRPGRWIVDNIIDSIEKSYRTLFVLSEHFVSSEWCRYELDFSHFRIMDEHNDSAVLVLLEPIKKE 774

  Fly   853 KRPK---TLQYLMDVKTYIKWPTAKEDRKLFWKRLKRSLE 889
            ..||   .|:.:|:.:||::||..::.|..||..|:.:|:
Zfish   775 TIPKRFCKLRKIMNSRTYLEWPEDEDKRDEFWSNLRAALQ 814

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-9	NP_001246846.1	leucine-rich repeat	157..185	CDD:275380	5/27 (19%)
		LRR_8	262..322	CDD:290566	14/64 (22%)
		leucine-rich repeat	264..287	CDD:275380	6/27 (22%)
		leucine-rich repeat	288..311	CDD:275380	2/22 (9%)
		leucine-rich repeat	312..356	CDD:275380	17/54 (31%)
		LRR_8	<344..387	CDD:290566	17/58 (29%)
		leucine-rich repeat	357..381	CDD:275380	7/23 (30%)
		leucine-rich repeat	382..397	CDD:275380	6/18 (33%)
		leucine-rich repeat	405..430	CDD:275380	5/24 (21%)
		LRR_8	431..488	CDD:290566	13/58 (22%)
		leucine-rich repeat	432..453	CDD:275380	2/21 (10%)
		LRR_RI	<449..536	CDD:238064	20/87 (23%)
		leucine-rich repeat	454..477	CDD:275380	9/23 (39%)
		LRR_8	477..536	CDD:290566	11/58 (19%)
		leucine-rich repeat	478..501	CDD:275380	2/22 (9%)
		leucine-rich repeat	502..525	CDD:275380	4/22 (18%)
		TIR	751..891	CDD:214587	53/142 (37%)
tlr2	XP_005170910.1	leucine-rich repeat	85..105	CDD:275378	4/20 (20%)
		leucine-rich repeat	106..129	CDD:275378	5/22 (23%)
		LRR_8	108..163	CDD:290566	13/59 (22%)
		leucine-rich repeat	130..153	CDD:275378	9/27 (33%)
		leucine-rich repeat	154..178	CDD:275378	3/23 (13%)
		leucine-rich repeat	179..192	CDD:275378	5/12 (42%)
		LRR_RI	<390..501	CDD:238064	41/155 (26%)
		leucine-rich repeat	390..418	CDD:275380	11/28 (39%)
		LRR_8	418..478	CDD:290566	19/67 (28%)
		leucine-rich repeat	419..444	CDD:275380	6/24 (25%)
		leucine-rich repeat	445..467	CDD:275380	8/29 (28%)
		leucine-rich repeat	468..488	CDD:275380	6/19 (32%)
		leucine-rich repeat	489..508	CDD:275380	9/54 (17%)
		leucine-rich repeat	509..530	CDD:275380	7/20 (35%)
		leucine-rich repeat	531..554	CDD:275380	7/49 (14%)
		TIR	671..814	CDD:214587	52/142 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	7	6.980