Protein Alignment Toll-9 and tlr21

DIOPT Version :10

• Sequence 1: NP_649214.1
• Gene: Toll-9 / 40245
• FlyBaseID: FBgn0036978
• Length: 900
• Species: Drosophila melanogaster
• Sequence 2: NP_001186264.2
• Gene: tlr21 / 402884
• ZFINID: ZDB-GENE-040220-4
• Length: 989
• Species: Danio rerio
• Alignment Length: 977
• Identity: 227/977 - (23%)
• Similarity: 380/977 - (38%)
• Gaps: 280/977 - (28%)

  Fly   125 RKVTIWRTEVFSAAFNTLTAAPFRTLYSMRES------LKLLSLRGNNFAELIPDAEDFARFVNE 183
            |.:|...::||..|.| ||.:.....|...:|      |..|.|..|:...:..||.:....:..
Zfish    49 RDITAIVSDVFPTALN-LTISHSNIEYVQSQSFDHLPNLTALILDANHITNIDKDAFNNLHHLQT 112

  Fly   184 SRLEASN-SVPHHCELLLLHNTTDLYDRECYLYFNNNTNMGQSITTGRNYTNFIKVLKDRFDQHG 247
            ..|..:| |..|......|||.|.|     .|..|..||..:.:.:.......:.:.::......
Zfish   113 LNLSCNNISFLHRDVFSDLHNLTQL-----LLGSNKLTNPDEYLFSSLTNLKILDLRRNHLYNFS 172

  Fly   248 SSSQSIAWATFPKMPRLVELDIS---------------NCSIEYVSKEAFRNVS-------NLRR 290
            |..:||.     .:..|::||:|               :.::.|:.....:.:.       |:::
Zfish   173 SVVESIT-----NLTSLIKLDLSFNKLTTLQHSTHLPESLALLYLGDNKLKTLGCDKSFLMNVKK 232

  Fly   291 LFMSDNKIMTISHDTFYYVQGVQYLDLSFTN-----FLTY------------------------- 325
            |.:||||.:.........::.:.||.|.|||     .|||
Zfish   233 LDLSDNKNLASKSFLGLKLENITYLRLRFTNISIFKLLTYPNVHPWHIDFSGLKLKNSHALSSLC 297

  Fly   326 ------SYQ-LQLPTLEMALSLIYGLKIQQNVFKYLPELI-YLDLSHSKMTRNSAVAFAHLGDKL 382
                  |:: ||:|.:.:..:.|..||  .|.|:|.|.:. .:|||.:::.....:.|.|...:|
Zfish   298 VLMRNHSHEHLQIPKMLLQSNSIGALK--NNTFRYCPSITREMDLSRNELKSAGCLQFLHNQTQL 360

  Fly   383 KFLSL----------C---------------YTAIPMVSSTIFKNT-VLEGLDLSGN--PYLSY- 418
            |.|.:          |               |..|..:|...|.|| .||.|:|:.|  .|:.:
Zfish   361 KSLKMEHNHLTKLTSCNKAEIHNSLTNLSYRYNRILQISGYAFSNTPKLEILELNINIIAYMDHK 425

  Fly   419 -------------------NIIDDAFDGIANTLKYLYFERSNIKDLEWS-------KSLKNLQVL 457
                               :|.:|:|:.:.| ||.|     |:::.|.:       ::|..|.:|
Zfish   426 ALSGLKDLKTLRLDNNLLSDIYNDSFEDLTN-LKTL-----NLRNNEIAVIFNYTFQNLSKLDIL 484

  Fly   458 GLAGNNINALTPAMFQSLESLEILDLSSNHV---------------------GNWY-------RS 494
            .|.||.|:.|.|..|..|.||..|.|..||:                     ||..       .|
Zfish   485 DLGGNKISQLKPHAFDGLYSLTNLYLDRNHLKMIDVVLFGKLSGTLQVLDLQGNMIVYFTEHTHS 549

  Fly   495 AFHNNSALRVLNL---RSNTINML------------------------SNEMLKDFERLDYLSLG 532
            .|.|.|.|..|.|   :.|.||:|                        .:|...|.:.||||:|
Zfish   550 PFKNMSRLYDLKLNGQQPNGINLLPRAFFRGLTSLKSLYLTNNHIIGFGDETFDDLKNLDYLTL- 613

  Fly   533 DNDFICDCHLRAVVEVAAANNKDADC-SYRLLNYSQNAVGEEVISLAESLIIDRKLWQSRYIPWL 596
            ||.......|::.:..:....:.... :..:.::|::..|.  ::..::|.::|....|..|..|
Zfish   614 DNSCAGVAQLQSGIFKSLQKLRTLSLENMGIKSFSKDVFGN--LTGLKTLHLNRNPMMSLDISLL 676

  Fly   597 QR----SYSNIREFNRANHIIKLRFSSEDYMVAKCSAAQPYHLGDLDG----DLTLKFQLL---- 649
            ..    :|.::|                     .|..:...|..||..    :..|:|..|
Zfish   677 DNLTNLTYIDMR---------------------SCPLSCGCHNSDLQNWTIMNKRLQFPHLFNIT 720

  Fly   650 --DYEASQYYCFNNTDQLQVDELNCQIRSMSDLAEELHHVTNT-VIAVMGSLVGACILGFIIYLK 711
              |:..|.::.|        |...|.:    |:  ||:..::| .:.::.:|:.      ::|:|
Zfish   721 CPDHPGSYFHNF--------DTKVCYL----DI--ELYFFSSTSTLTILLTLIP------LLYVK 765

  Fly   712 -RWHIHYYYSSLKSAALLSSASKESVNKFTNISQRDPSAVYDIFISYCQNDRTWVLNELLPNVEE 775
             .|...|.|...:|         ....::..:..::....||.|:||...|..||:.:||||:|.
Zfish   766 LYWKFKYGYYVFRS---------WFGEQWRRLRDQEEKYNYDAFVSYNSADEDWVMEQLLPNLEG 821

  Fly   776 TGDVSICLHERDFQIGVTILDNIISCMDRSYSLMLIISSKFLLSHWCQFEMYLAQHRIFEVSKEH 840
            : ...:|||.|||::|..|:|||::.:..|...:.::|..||.|.||..|:.||.:|:|:..::.
Zfish   822 S-SFRLCLHHRDFELGRDIVDNIVAAVYGSRKTICVVSQSFLRSEWCSLEIQLASYRLFQEMQDV 885

  Fly   841 LILVFLEDIPRRKRP--KTLQYLMDVKTYIKWP--------TAKEDRKLFWKRLKRSLEVIGINS 895
            |:|||||.||.|:..  ..::.:|..|||::||        :|||   |||.:|||:|......|
Zfish   886 LLLVFLEPIPERQLSAYHRMRKVMLKKTYLQWPGSNCSDPNSAKE---LFWNQLKRALRSSNSGS 947

  Fly   896 RE 897
            ::
Zfish   948 QD 949

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Toll-9	NP_649214.1	LRR	198..537	CDD:443914	112/508 (22%)
		leucine-rich repeat	264..287	CDD:275380	5/44 (11%)
		leucine-rich repeat	288..311	CDD:275380	5/22 (23%)
		leucine-rich repeat	312..356	CDD:275380	19/80 (24%)
		leucine-rich repeat	357..381	CDD:275380	5/24 (21%)
		leucine-rich repeat	382..397	CDD:275380	6/39 (15%)
		leucine-rich repeat	405..430	CDD:275380	9/46 (20%)
		leucine-rich repeat	432..453	CDD:275380	6/27 (22%)
		leucine-rich repeat	454..477	CDD:275380	10/22 (45%)
		leucine-rich repeat	478..501	CDD:275380	10/50 (20%)
		leucine-rich repeat	502..525	CDD:275380	9/49 (18%)
		TIR	751..891	CDD:214587	61/149 (41%)
tlr21	NP_001186264.2	None