DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-9 and caps

DIOPT Version :9

Sequence 1:	NP_001246846.1	Gene:	Toll-9 / 40245	FlyBaseID:	FBgn0036978	Length:	900	Species:	Drosophila melanogaster
Sequence 2:	NP_001303391.1	Gene:	caps / 39493	FlyBaseID:	FBgn0023095	Length:	811	Species:	Drosophila melanogaster

Alignment Length:	549	Identity:	120/549 - (21%)
Similarity:	205/549 - (37%)	Gaps:	131/549 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 TLTAAPFRTLYSMRESLKLLSLRGNNFAELIPDAEDFARFV------NESRLEASNSVPHHCELL 199
            ||...|.    ::..:::.|.::.|....:....:.:|:..      |:.......|..:|.:|.
  Fly    62 TLDVLPI----ALNPAIQRLVIKNNKLKTIDSSMQFYAQLTFLDLSFNDMLTIPERSFAYHAKLQ 122

  Fly   200 LLHNTTDLYDRECYLYFNNNTNMGQSITTGRNYTNFIKVLKDRFDQHGSSSQSIAWATFPKMPRL 264
            .||     .|.......:|.|.:|.|.         |.||..|    |:....:.:.||..|.:|
  Fly   123 ELH-----LDHNKIGQVSNKTFLGLST---------ISVLNLR----GNLIAELEYRTFSPMVKL 169

  Fly   265 VELDISNCSIEYVSKEAFRNVSNLRRLFMSDNKIMTISHD-TFYYVQGVQYLDLSFTNFLTYSYQ 328
            .||::....|.::...|...:.|||.|::.||.:.|:..: ||..:..:..|.|...:|:|
  Fly   170 AELNLGQNRISHIDPHALDGLDNLRVLYLDDNTLTTVPGELTFQALHSLAELYLGTNSFMT---- 230

  Fly   329 LQLPTLEMALSLIYGLKIQQNVFKYLPELIYLDLSHSKMTRNSAVAFAHLGDKLKFLSLCYTAIP 393
                             |....|:.|..|..|||..:.:...|..|...| ..|:||.|....:|
  Fly   231 -----------------IPGGAFQDLKGLTRLDLRGAGLHNISGDALKGL-VSLRFLDLSDNRLP 277

  Fly   394 MVSSTIFKNT-VLEGLDLSGNPYLSYNIIDD-AFDGIANTLKYLYFERSNIKDLEWSKSLKNLQV 456
            .:.:..|:.. .||.|::..|   .:.:|.. ||.|:                    :.|::|::
  Fly   278 AIPTAAFQRLGRLEQLNIGQN---DFEVISSGAFSGL--------------------RELRHLEL 319

  Fly   457 LGLAGNNINALTPAMFQSLESLEILDLSSNHVGNWYRS-AFHNNSALRVLNLRSNTINMLSNEML 520
            .|  ...:..:....|....:||.|:||||...|...| |......|..:.|::|.::.| :|.|
  Fly   320 TG--AQRLRRVESGAFSGNTNLEHLNLSSNKQLNELSSIALGGLPHLSTVVLKANQLSSL-DEGL 381

  Fly   521 KDFERLDYLSLGDNDFICDCHLRAVVEVAAANNKDAD-----CSY--------------RLLNYS 566
            ..:..|..|.|.:|.|.|||.|..:..:..:.|....     |:|              .||..:
  Fly   382 VPWADLQTLDLSENPFECDCRLLWLRHLLVSRNASGQYAPVICAYPTALRDLPLAHLAEPLLGCA 446

  Fly   567 QNAVGEEVI---------SLAESLIIDRKLWQSRY-IPWLQRSYSNI----REFNRANHIIKLRF 617
            ..|..::.|         :|..:|.:  .|:..|: |..:.:.:|.:    ||:.:.       |
  Fly   447 HGAASKQAIIGILVVACAALITTLAL--VLYTCRHRIREMLKGHSALGRKEREYQKT-------F 502

  Fly   618 SSEDYM---------VAKCSAAQPYHLGD 637
            |.|:||         |...:...||..|:
  Fly   503 SDEEYMSRPPPGGGGVHPAAGGYPYIAGN 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-9	NP_001246846.1	leucine-rich repeat	157..185	CDD:275380	4/33 (12%)
		LRR_8	262..322	CDD:290566	16/60 (27%)
		leucine-rich repeat	264..287	CDD:275380	5/22 (23%)
		leucine-rich repeat	288..311	CDD:275380	8/23 (35%)
		leucine-rich repeat	312..356	CDD:275380	7/43 (16%)
		LRR_8	<344..387	CDD:290566	13/42 (31%)
		leucine-rich repeat	357..381	CDD:275380	7/23 (30%)
		leucine-rich repeat	382..397	CDD:275380	5/14 (36%)
		leucine-rich repeat	405..430	CDD:275380	8/25 (32%)
		LRR_8	431..488	CDD:290566	11/56 (20%)
		leucine-rich repeat	432..453	CDD:275380	1/20 (5%)
		LRR_RI	<449..536	CDD:238064	24/87 (28%)
		leucine-rich repeat	454..477	CDD:275380	3/22 (14%)
		LRR_8	477..536	CDD:290566	20/59 (34%)
		leucine-rich repeat	478..501	CDD:275380	10/23 (43%)
		leucine-rich repeat	502..525	CDD:275380	6/22 (27%)
		TIR	751..891	CDD:214587
caps	NP_001303391.1	leucine-rich repeat	75..96	CDD:275380	2/20 (10%)
		LRR_8	96..155	CDD:290566	16/76 (21%)
		leucine-rich repeat	97..120	CDD:275380	3/22 (14%)
		leucine-rich repeat	121..144	CDD:275380	7/27 (26%)
		LRR_8	143..201	CDD:290566	18/70 (26%)
		leucine-rich repeat	145..168	CDD:275380	8/26 (31%)
		LRR_RI	147..397	CDD:238064	73/301 (24%)
		leucine-rich repeat	169..192	CDD:275380	5/22 (23%)
		leucine-rich repeat	193..217	CDD:275380	8/23 (35%)
		LRR_8	217..276	CDD:290566	18/80 (23%)
		leucine-rich repeat	218..241	CDD:275380	7/43 (16%)
		leucine-rich repeat	242..265	CDD:275380	7/23 (30%)
		LRR_8	265..321	CDD:290566	16/78 (21%)
		leucine-rich repeat	266..289	CDD:275380	6/22 (27%)
		leucine-rich repeat	290..313	CDD:275380	8/45 (18%)
		LRR_8	312..374	CDD:290566	17/63 (27%)
		leucine-rich repeat	314..335	CDD:275380	4/22 (18%)
		leucine-rich repeat	339..363	CDD:275380	10/23 (43%)
		LRRCT	395..445	CDD:214507	11/49 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453513
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840