DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-9 and trn

DIOPT Version :9

Sequence 1:	NP_001246846.1	Gene:	Toll-9 / 40245	FlyBaseID:	FBgn0036978	Length:	900	Species:	Drosophila melanogaster
Sequence 2:	NP_001261796.1	Gene:	trn / 39491	FlyBaseID:	FBgn0010452	Length:	751	Species:	Drosophila melanogaster

Alignment Length:	583	Identity:	125/583 - (21%)
Similarity:	203/583 - (34%)	Gaps:	169/583 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 SMRESLKLLSLRGNNFAELIPDAEDFARFVNESRLEASNSVPHHCELLLLHNTTDLYDR---ECY 213
            ::..|::.|.::.|....:....:.:|..   :.|:.|::     .|:.:...|..|.:   |.:
  Fly    56 ALNPSIQRLVIKSNKIKTIDSSIQFYAEL---TFLDLSSN-----HLMTIPQRTFAYQKKLQEVH 112

  Fly   214 LYFN------NNTNMGQSITTGRNYTNFIKVLKDRFDQHGSSSQSIAWATFPKMPRLVELDISNC 272
            |..|      |.|.:|.|..|..|.             .|:....:...||..:.::.||::...
  Fly   113 LNHNKIGQISNKTFIGLSAVTVLNL-------------RGNQISELHQGTFTPLLKIEELNLGEN 164

  Fly   273 SIEYVSKEAFRNVSNLRRLFMSDNKIMTISHDTFYYVQGVQYLDLSFTNFLTYSYQLQLPTL-EM 336
            .|.|:..:||..:|.||.|::.||.:.|:.....:..                     :|:| |:
  Fly   165 RIGYLDPKAFDGLSQLRILYLDDNALTTVPDPVIFQA---------------------MPSLAEL 208

  Fly   337 ALSLIYGLKIQQNVFKYLPELIYLDLSHSKMTRNSAVAFAHLGDKLKFLSLCYTAIPMVSST-IF 400
            .|.:.....||.:.|:.|..|..|:|..:.:...|..:|..| .:|:.|.|....:..:.|. :.
  Fly   209 FLGMNTLQSIQADAFQDLKGLTRLELKGASLRNISHDSFLGL-QELRILDLSDNRLDRIPSVGLS 272

  Fly   401 KNTVLEGLDLSGNPYLSYNIIDD-AFDGIANTLKYLYFERSNIKDLEWSKSLKNLQVLGLAGNNI 464
            |...||.|.|..|   .:.:|.: ||.|:                    |.||.|:|.|..  .:
  Fly   273 KLVRLEQLSLGQN---DFEVISEGAFMGL--------------------KQLKRLEVNGAL--RL 312

  Fly   465 NALTPAMFQSLESLEILDLSSNH-VGNWYRSAFHNNSALRVLNLRSNTINMLSNEML--KDFERL 526
            ..:....|....:||.|:||||. :......|....|.|:.:.|::|.:..|:..:.  ||.:.|
  Fly   313 KRVMTGAFSDNGNLEYLNLSSNKMLLEVQEGALSGLSQLKHVVLKANALTSLAEGLFPWKDLQTL 377

  Fly   527 DYLSLGDNDFICDCHLRAVVEVAAANNKDAD------C---------SYRLLNYSQNA------- 569
            |   |.:|...|||.:..:..:..|.|...|      |         |.|.||.:...
  Fly   378 D---LSENPLSCDCRVMWLHNLLVAKNASQDDVSELLCEFPERLRGESLRHLNPAMMGCTHADPR 439

  Fly   570 ---------VGEEVISLAESLIIDR-----------KLWQSRYIPWLQRSYSNIREFNRANHIIK 614
                     ||......|.:|::.|           .||.:..:...:|.|..
  Fly   440 KQALIGALLVGSAATITALALVLYRCRHKIRETIKGGLWGNSALGRKEREYQK------------ 492

  Fly   615 LRFSSEDYMVA----KCSA----------AQPYHLG-------------DLDG-DLTLKFQLL 649
             .|..||||..    .||.          ..|:|.|             ||.. |...|||.|
  Fly   493 -TFCDEDYMSRHQHHPCSLGIHSTFPNTYTAPHHPGATHHYGMCPMPVNDLGAIDPQQKFQQL 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-9	NP_001246846.1	leucine-rich repeat	157..185	CDD:275380	3/27 (11%)
		LRR_8	262..322	CDD:290566	13/59 (22%)
		leucine-rich repeat	264..287	CDD:275380	6/22 (27%)
		leucine-rich repeat	288..311	CDD:275380	6/22 (27%)
		leucine-rich repeat	312..356	CDD:275380	8/44 (18%)
		LRR_8	<344..387	CDD:290566	12/42 (29%)
		leucine-rich repeat	357..381	CDD:275380	6/23 (26%)
		leucine-rich repeat	382..397	CDD:275380	3/14 (21%)
		leucine-rich repeat	405..430	CDD:275380	9/25 (36%)
		LRR_8	431..488	CDD:290566	14/57 (25%)
		leucine-rich repeat	432..453	CDD:275380	2/20 (10%)
		LRR_RI	<449..536	CDD:238064	26/89 (29%)
		leucine-rich repeat	454..477	CDD:275380	4/22 (18%)
		LRR_8	477..536	CDD:290566	19/61 (31%)
		leucine-rich repeat	478..501	CDD:275380	8/23 (35%)
		leucine-rich repeat	502..525	CDD:275380	6/24 (25%)
		TIR	751..891	CDD:214587
trn	NP_001261796.1	leucine-rich repeat	62..80	CDD:275380	2/17 (12%)
		LRR_8	83..142	CDD:290566	15/79 (19%)
		leucine-rich repeat	84..107	CDD:275380	5/30 (17%)
		leucine-rich repeat	108..131	CDD:275380	6/22 (27%)
		LRR_RI	129..421	CDD:238064	80/354 (23%)
		LRR_8	132..190	CDD:290566	17/70 (24%)
		leucine-rich repeat	132..155	CDD:275380	5/35 (14%)
		leucine-rich repeat	156..179	CDD:275380	6/22 (27%)
		leucine-rich repeat	180..204	CDD:275380	6/44 (14%)
		LRR_8	203..263	CDD:290566	17/60 (28%)
		leucine-rich repeat	205..228	CDD:275380	7/22 (32%)
		leucine-rich repeat	229..252	CDD:275380	6/23 (26%)
		LRR_8	252..308	CDD:290566	19/78 (24%)
		leucine-rich repeat	253..276	CDD:275380	5/22 (23%)
		leucine-rich repeat	277..300	CDD:275380	9/45 (20%)
		leucine-rich repeat	301..322	CDD:275380	6/22 (27%)
		LRR_8	325..384	CDD:290566	19/61 (31%)
		leucine-rich repeat	326..350	CDD:275380	8/23 (35%)
		leucine-rich repeat	351..373	CDD:275380	4/21 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453512
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840