DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-9 and CG32055

DIOPT Version :9

Sequence 1:	NP_001246846.1	Gene:	Toll-9 / 40245	FlyBaseID:	FBgn0036978	Length:	900	Species:	Drosophila melanogaster
Sequence 2:	NP_729599.1	Gene:	CG32055 / 39188	FlyBaseID:	FBgn0052055	Length:	534	Species:	Drosophila melanogaster

Alignment Length:	415	Identity:	101/415 - (24%)
Similarity:	157/415 - (37%)	Gaps:	88/415 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   258 FPKMPRLVELDISNCSIEYVSKEAFRNVSNLRRLFMSDNKIMTISHDTFYYVQGVQYLDLSFTNF 322
            ||....::..|:|...|..::.:......||.....|:|.|..|..:.|.:::.:::||
  Fly   118 FPNPSEMINFDVSYNDILAITTKLMSGFGNLVYANFSENLIAVIEPNAFRHMKNLRFLD------ 176

  Fly   323 LTYSYQLQLPTLEMALSLIYGLKIQQN--------VFKYLPELIYLDLSHSKMTRNSAVAFAHLG 379
            ||.:||..: ||....:|.: |.|..|        ..:.||:|..|.| ||....:..:...:..
  Fly   177 LTTNYQENI-TLGENANLRF-LSISNNNLRDFQWCHLRVLPKLEELHL-HSNWLEHLDMGIFYAL 238

  Fly   380 DKLKFLSLCYTAIPMVSSTIF----KNTVLEGLDLSGNPYLSYNIIDDAFDGIANTLKYLYFERS 440
            ..|:.|::....:..:..|:|    :...||.||.|.|   ...::||:           .|.|
  Fly   239 PNLRVLNVSNNNLFEIKRTLFMAPGEIAPLELLDYSSN---IVKVLDDS-----------VFCR- 288

  Fly   441 NIKDLEWSKSLKNLQVLGLAGNNINALTPAMFQSLESLEILDLSSNHVGNWYRSAFHNNSALRVL 505
                      ||.|:.|.|..|.||.:.|..|..|.||:.|.|..|.:.......|.|.:||..|
  Fly   289 ----------LKKLRTLNLWLNQINRIHPRAFLGLSSLQTLHLQGNKISILPDDVFANLTALEKL 343

  Fly   506 NLRSNTINMLSNEMLKD--FERLDYLSLGDNDFICDCHLRA------VVEVAAANNKDADCSYR- 561
            :|..|.|..|...:..:  ..:|.||.| .|::|.|.|..|      :.|:....|:......|
  Fly   344 DLSKNNIQKLGLRVFGERILRKLIYLDL-SNNYIADLHPLALSSMPFIKELRLRRNRLVSLDLRM 407

  Fly   562 --------LLNYSQNAVGE---EVISLAESL------------IIDRK----LWQSRYI-----P 594
                    ||..::|.:.|   |::...:.|            :.|.|    |.|.|.|     |
  Fly   408 FAPLRQLQLLTINENRLEEIDGEILDTLDRLNHLELNNNRLTFLPDLKSSQNLLQLRNITLEGNP 472

  Fly   595 WLQRSYSNIREFNRANHIIKLRFSS 619
            |.......|..:....|:...|.||
  Fly   473 WQCLCLDEITSWLNGRHVSYARPSS 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-9	NP_001246846.1	leucine-rich repeat	157..185	CDD:275380
		LRR_8	262..322	CDD:290566	12/59 (20%)
		leucine-rich repeat	264..287	CDD:275380	3/22 (14%)
		leucine-rich repeat	288..311	CDD:275380	6/22 (27%)
		leucine-rich repeat	312..356	CDD:275380	13/51 (25%)
		LRR_8	<344..387	CDD:290566	12/50 (24%)
		leucine-rich repeat	357..381	CDD:275380	5/23 (22%)
		leucine-rich repeat	382..397	CDD:275380	2/14 (14%)
		leucine-rich repeat	405..430	CDD:275380	8/24 (33%)
		LRR_8	431..488	CDD:290566	18/56 (32%)
		leucine-rich repeat	432..453	CDD:275380	3/20 (15%)
		LRR_RI	<449..536	CDD:238064	30/88 (34%)
		leucine-rich repeat	454..477	CDD:275380	9/22 (41%)
		LRR_8	477..536	CDD:290566	19/60 (32%)
		leucine-rich repeat	478..501	CDD:275380	6/22 (27%)
		leucine-rich repeat	502..525	CDD:275380	6/24 (25%)
		TIR	751..891	CDD:214587
CG32055	NP_729599.1	leucine-rich repeat	76..99	CDD:275380
		leucine-rich repeat	100..123	CDD:275380	2/4 (50%)
		LRR_8	128..180	CDD:290566	14/57 (25%)
		leucine-rich repeat	128..147	CDD:275380	3/18 (17%)
		leucine-rich repeat	148..171	CDD:275380	6/22 (27%)
		leucine-rich repeat	172..192	CDD:275380	8/26 (31%)
		LRR_RI	<187..400	CDD:238064	62/240 (26%)
		LRR_8	192..251	CDD:290566	13/60 (22%)
		leucine-rich repeat	193..216	CDD:275380	5/23 (22%)
		leucine-rich repeat	217..240	CDD:275380	5/23 (22%)
		leucine-rich repeat	241..267	CDD:275380	4/25 (16%)
		leucine-rich repeat	268..291	CDD:275380	11/47 (23%)
		LRR_8	290..350	CDD:290566	22/59 (37%)
		leucine-rich repeat	292..315	CDD:275380	9/22 (41%)
		leucine-rich repeat	316..339	CDD:275380	6/22 (27%)
		LRR_8	340..400	CDD:290566	17/60 (28%)
		leucine-rich repeat	340..365	CDD:275380	6/24 (25%)
		leucine-rich repeat	366..389	CDD:275380	9/23 (39%)
		leucine-rich repeat	390..413	CDD:275380	3/22 (14%)
		LRR_8	391..448	CDD:290566	9/56 (16%)
		leucine-rich repeat	414..437	CDD:275380	5/22 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453516
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840