DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-9 and CG6749

DIOPT Version :9

Sequence 1:	NP_001246846.1	Gene:	Toll-9 / 40245	FlyBaseID:	FBgn0036978	Length:	900	Species:	Drosophila melanogaster
Sequence 2:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster

Alignment Length:	530	Identity:	121/530 - (22%)
Similarity:	212/530 - (40%)	Gaps:	94/530 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   197 ELLLLHNTTDLYDRECYLYFNNNTNMGQSITTGRNYTNFIKVLKDRFDQHGSSSQSIAWATFPKM 261
            |:..|.:..||.....:.....|......:.:|.|..:...:|.  .|..|::..::....|..:
  Fly    41 EVASLQDLVDLGAENWHTLAIRNVQTELEVGSGENADHLANLLD--LDLTGAAPINVHTNGFSIL 103

  Fly   262 PRLVELDISNCSIEYVSKEAFRNVSNLRRLFMSDNKIMTISHDTFYYVQGVQYLDLSFTNFLTYS 326
            |.|.:|::|.|.:..:....|...|.|:|:..|.|::..:..|.|..::.:.|.:.|. |.|.
  Fly   104 PNLRQLNLSGCGLVDIRGNHFAPESALQRIDFSHNQMELLDRDFFGNLRKLIYANFSH-NALK-- 165

  Fly   327 YQLQLPTLEMALSLIYG-------------------------LKIQQNVFKYLPELIYLDLSHSK 366
             |..||.:.:...|..|                         :::..|.|:.|..|:.|.||.::
  Fly   166 -QCDLPHMPLLNRLELGHNRLVNATFGVCPQLQELILNDNQLIQLDVNAFRGLHGLLELQLSGNR 229

  Fly   367 MTRNSAVAFAHLGDKLKFLSLCYTAIPMVSSTIF---KNTV--LEGLDLSGNPYLSYNIIDDAFD 426
            ::......|..|. :|:.|:|...|:..:...:|   :|.|  |:.||||||....  :.|:.|.
  Fly   230 LSSIGLETFQPLA-QLRKLNLSQNALDALRPNVFGAVQNFVLHLQQLDLSGNRIRL--LFDNQFR 291

  Fly   427 GIANTLKYLYFERSNIKDLEWSK--SLKNLQVLGLAGNNINALTPAMFQSLESLEILDLSSNHVG 489
            .:|. |:.|...|::|..|..:.  .|.:|:.|.|..|.|..:.||.|.:|.:|:.||||.|::.
  Fly   292 VLAR-LQMLDVSRNSIASLSPAHFVGLGSLRKLYLQYNAILEIKPATFAALLNLDTLDLSYNNLE 355

  Fly   490 NWYRSAFHNNS--ALRVLNLRSNTINMLSNEMLKDFERLDYLSLGDN-----DFICDCHLRAVVE 547
            ......|..|:  .:|.|||..|.:..|..........|:||.||.|     |......:|.:.:
  Fly   356 FLEEQIFGGNTLPRMRRLNLNGNRMKHLHPLAFSSLPFLEYLKLGHNELKSLDVRMFAPMRRLQK 420

  Fly   548 VAAANNKDADCSYRLLNYSQNAVGEEVISLAESLIIDRKLWQSRYIPWLQRSYSNIRE------- 605
            :...:|        ||......|.|.:.|:.|.|:.:.:|   .::..:..|:.|::.
  Fly   421 LHLGHN--------LLEEINLDVLESLSSVQEILVDNNRL---TFLAKVNVSFPNLKRVAIEGNP 474

  Fly   606 -----FNRANH------IIKLR--------------FSSEDYMVAKCSAAQPYH-LGDLDGDLTL 644
                 |.:..|      ::.||              .::.||.:....|.:... |||..|: .:
  Fly   475 WQCPCFVKLQHWLATRDVVYLRDNTGYYKGERPLCIVTNVDYCIQNLQAVRRLGILGDFQGE-QV 538

  Fly   645 KFQLLDYEAS 654
            :....|.:||
  Fly   539 EADAFDDDAS 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-9	NP_001246846.1	leucine-rich repeat	157..185	CDD:275380
		LRR_8	262..322	CDD:290566	15/59 (25%)
		leucine-rich repeat	264..287	CDD:275380	5/22 (23%)
		leucine-rich repeat	288..311	CDD:275380	6/22 (27%)
		leucine-rich repeat	312..356	CDD:275380	12/68 (18%)
		LRR_8	<344..387	CDD:290566	11/42 (26%)
		leucine-rich repeat	357..381	CDD:275380	6/23 (26%)
		leucine-rich repeat	382..397	CDD:275380	4/14 (29%)
		leucine-rich repeat	405..430	CDD:275380	9/24 (38%)
		LRR_8	431..488	CDD:290566	21/58 (36%)
		leucine-rich repeat	432..453	CDD:275380	6/22 (27%)
		LRR_RI	<449..536	CDD:238064	30/95 (32%)
		leucine-rich repeat	454..477	CDD:275380	9/22 (41%)
		LRR_8	477..536	CDD:290566	20/65 (31%)
		leucine-rich repeat	478..501	CDD:275380	8/24 (33%)
		leucine-rich repeat	502..525	CDD:275380	6/22 (27%)
		TIR	751..891	CDD:214587
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	35/157 (22%)
		LRR_8	104..164	CDD:290566	16/60 (27%)
		leucine-rich repeat	106..129	CDD:275380	5/22 (23%)
		leucine-rich repeat	130..153	CDD:275380	6/22 (27%)
		leucine-rich repeat	154..195	CDD:275380	9/44 (20%)
		LRR_RI	194..455	CDD:238064	72/275 (26%)
		LRR_8	194..254	CDD:290566	12/60 (20%)
		leucine-rich repeat	196..219	CDD:275380	3/22 (14%)
		leucine-rich repeat	220..243	CDD:275380	6/23 (26%)
		leucine-rich repeat	244..267	CDD:275380	5/22 (23%)
		LRR_8	271..330	CDD:290566	20/61 (33%)
		leucine-rich repeat	272..295	CDD:275380	9/24 (38%)
		leucine-rich repeat	296..319	CDD:275380	6/22 (27%)
		LRR_8	319..380	CDD:290566	22/60 (37%)
		leucine-rich repeat	320..343	CDD:275380	9/22 (41%)
		leucine-rich repeat	344..369	CDD:275380	8/24 (33%)
		LRR_8	368..428	CDD:290566	15/67 (22%)
		leucine-rich repeat	370..393	CDD:275380	6/22 (27%)
		leucine-rich repeat	394..417	CDD:275380	7/22 (32%)
		leucine-rich repeat	418..441	CDD:275380	5/30 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453514
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840