DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-9 and 18w

DIOPT Version :9

Sequence 1:NP_001246846.1 Gene:Toll-9 / 40245 FlyBaseID:FBgn0036978 Length:900 Species:Drosophila melanogaster
Sequence 2:NP_476814.1 Gene:18w / 37277 FlyBaseID:FBgn0004364 Length:1385 Species:Drosophila melanogaster


Alignment Length:1144 Identity:210/1144 - (18%)
Similarity:371/1144 - (32%) Gaps:404/1144 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    58 KSLMLKYESDDGNSCLLDL------IKD--EVIWWQFPNGTLRDSTKK---------YAHKL--- 102
            |:|.|..:|..|...|.:|      |:.  |.:|...|:..|.:.|:.         ::.||   
  Fly   132 KTLELHGQSFQGLKELSELHLGDNNIRQLPEGVWCSMPSLQLLNLTQNRIRSAEFLGFSEKLCAG 196

  Fly   103 -YLDLSHGNLKDDSDLFREAKLSRKVTIWRTEVFSAAFNTLTAAPFRTLYSMRESLKLLSLRGNN 166
             .|..::|.:...|:|               :....:||.|.:.|.....|....|:.|||:.||
  Fly   197 SALSNANGAVSGGSEL---------------QTLDVSFNELRSLPDAWGASRLRRLQTLSLQHNN 246

  Fly   167 FAELIPDAEDFARFVNESRLEASN-------SVPHHC-----ELLLLH-NTTDLYD--------R 210
            .:.|.|:|     ....|.|...|       |:|...     ||..|| ...|||:        .
  Fly   247 ISTLAPNA-----LAGLSSLRVLNISYNHLVSLPSEAFAGNKELRELHLQGNDLYELPKGLLHRL 306

  Fly   211 ECYLYFNNNTNMGQSITT----GRNYTNFIKVLKDRFDQHGSSSQSIAWATFPKMPRLVELDISN 271
            |..|..:.:   |..:|:    ...:...|:::.  .:...::...|...||.::..|..||:.|
  Fly   307 EQLLVLDLS---GNQLTSHHVDNSTFAGLIRLIV--LNLSNNALTRIGSKTFKELYFLQILDMRN 366

  Fly   272 CSIEYVSKEAFRNVSNLRRLFMSDNKIMTISHDTF--YYV----------------------QGV 312
            .||.::.:.||..:.||..|.:::|::.|:.:..|  .||                      ..:
  Fly   367 NSIGHIEEGAFLPLYNLHTLNLAENRLHTLDNRIFNGLYVLTKLTLNNNLVSIVESQAFRNCSDL 431

  Fly   313 QYLDLSFTNFLTYSYQLQLPTLEMALSLIYGL--------KIQQNVFKYLPELIYLDLSHSKMTR 369
            :.|||| :|.||     ::|.....||::..|        :.:.|.|:.|.:|..|.|..:::..
  Fly   432 KELDLS-SNQLT-----EVPEAVQDLSMLKTLDLGENQISEFKNNTFRNLNQLTGLRLIDNRIGN 490

  Fly   370 NSAVAFAHLGDKLKFLSLCYTAIPMVSSTIF-KNTVLEGLDLSGNPYLSYNIIDDAFDGIANTLK 433
            .:...|..| .:|..|:|....|..:....| |||.:|.:.|..|.....|       ||..||.
  Fly   491 ITVGMFQDL-PRLSVLNLAKNRIQSIERGAFDKNTEIEAIRLDKNFLTDIN-------GIFATLA 547

  Fly   434 YLYFERSNIKDLEWSKSL---KNLQVLGLAGNNINALTPAMFQSLE------------------- 476
            .|.:...:...|.|....   .||:.|.:.||.|.||  ..:..|:                   
  Fly   548 SLLWLNLSENHLVWFDYAFIPSNLKWLDIHGNYIEAL--GNYYKLQEEIRVTTLDASHNRITEIG 610

  Fly   477 ------SLEILDLSSNHVGNWYRSAFHNNSALRVLNLRSNTINMLSNEMLK----DFER-LDYLS 530
                  |:|:|.:::|.:|....:.|.:.:.|..::|.:|.::.:|...|:    ..|: :....
  Fly   611 AMSVPNSIELLFINNNIIGQIQANTFVDKTRLARVDLYANVLSKISLNALRVAPVSAEKPVPEFY 675

  Fly   531 LGDNDFICDC------------------------------HLRA--VVEVAAANNKDADCSY--- 560
            ||.|.|.|||                              |.|:  :..:|:.:..|..|.|   
  Fly   676 LGGNPFECDCSMEWLQRINNLTTRQHPHVVDLGNIECLMPHSRSAPLRPLASLSASDFVCKYESH 740

  Fly   561 ----------------------------------------------------------------- 560
                                                                             
  Fly   741 CPPTCHCCEYEQCECEVICPGNCSCFHDATWATNIVDCGRQDLAALPNRIPQDVSDLYLDGNNMP 805

  Fly   561 ----------------------------------------------------------------- 560
                                                                             
  Fly   806 ELEVGHLTGRRNLRALYLNASNLMTLQNGSLAQLVNLRVLHLENNKLTALEGTEFRSLGLLRELY 870

  Fly   561 ---RLLNYSQNAVGEEVISLAESLIIDRKLWQSRYIPWLQRSYS----------------NIREF 606
               .:|.:..||..|.::|| |.|.:|.....|  :|.||..:|                .:||.
  Fly   871 LHNNMLTHISNATFEPLVSL-EVLRLDNNRLSS--LPHLQYRHSLQGLTLGRNAWSCRCQQLREL 932

  Fly   607 NRANHIIKLRFSSEDYMVAKCSAAQPYHLGDLDGDLTLKFQLLDYEASQYYCFNNTDQLQVDELN 671
                    .:|.|::.||.:    ..:.:..||..:..:.:|:...|:...|   :|.|.....|
  Fly   933 --------AQFVSDNAMVVR----DAHDIYCLDAGIKRELELIGNLANGPDC---SDLLDASASN 982

  Fly   672 CQIRSMSDLAEELHHVTNTVIAVMGSLVGACILGFII--YLKRWHIHYYYSSLKSAALLSSASKE 734
              |.|..|||..........:.|:..||...|:.|:.  .::.|...:|            ..:.
  Fly   983 --ISSSQDLAGGYRLPLLAAVLVLIFLVVVLIIVFVFRESVRMWLFAHY------------GVRV 1033

  Fly   735 SVNKFTNISQRDPSAVYDIFISYCQNDRTWVLNELLPNVEE-TGDVSICLHERDFQIGVTILDNI 798
            ...:|     .|...:||..|.:.:.|..:|...:...:|. .....:|:.:||.....:.| .:
  Fly  1034 CEPRF-----EDAGKLYDAIILHSEKDYEFVCRNIAAELEHGRPPFRLCIQQRDLPPQASHL-QL 1092

  Fly   799 ISCMDRSYSLMLIISSKFLLSHWCQFEMYLAQHRIFEVSKEHLILV-------FLEDIPRRKRPK 856
            :.....|..::|:::...|.:.|.:.|...|.|.......:.|:::       ..||:       
  Fly  1093 VEGARASRKIILVLTRNLLATEWNRIEFRNAFHESLRGLAQKLVIIEETSVSAEAEDV------- 1150

  Fly   857 TLQYLMDVKTYIKWPTAKEDRKL-----FWKRLKRSLEV 890
                 .::..|:|  :...:|.|     ||::|:.::.:
  Fly  1151 -----AELSPYLK--SVPSNRLLTCDRYFWEKLRYAIPI 1182

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-9NP_001246846.1 leucine-rich repeat 157..185 CDD:275380 9/27 (33%)
LRR_8 262..322 CDD:290566 20/83 (24%)
leucine-rich repeat 264..287 CDD:275380 8/22 (36%)
leucine-rich repeat 288..311 CDD:275380 7/46 (15%)
leucine-rich repeat 312..356 CDD:275380 14/51 (27%)
LRR_8 <344..387 CDD:290566 11/50 (22%)
leucine-rich repeat 357..381 CDD:275380 5/23 (22%)
leucine-rich repeat 382..397 CDD:275380 4/14 (29%)
leucine-rich repeat 405..430 CDD:275380 6/24 (25%)
LRR_8 431..488 CDD:290566 18/84 (21%)
leucine-rich repeat 432..453 CDD:275380 4/23 (17%)
LRR_RI <449..536 CDD:238064 24/119 (20%)
leucine-rich repeat 454..477 CDD:275380 8/47 (17%)
LRR_8 477..536 CDD:290566 15/63 (24%)
leucine-rich repeat 478..501 CDD:275380 5/22 (23%)
leucine-rich repeat 502..525 CDD:275380 5/26 (19%)
TIR 751..891 CDD:214587 27/153 (18%)
18wNP_476814.1 leucine-rich repeat 66..91 CDD:275380
leucine-rich repeat 92..115 CDD:275380
LRR_8 115..181 CDD:290566 13/48 (27%)
leucine-rich repeat 116..146 CDD:275380 5/13 (38%)
leucine-rich repeat 147..170 CDD:275380 5/22 (23%)
leucine-rich repeat 171..201 CDD:275380 5/29 (17%)
LRR_RI 210..464 CDD:238064 63/284 (22%)
leucine-rich repeat 212..236 CDD:275380 6/38 (16%)
LRR_8 235..295 CDD:290566 18/64 (28%)
leucine-rich repeat 237..260 CDD:275380 9/27 (33%)
leucine-rich repeat 261..284 CDD:275380 4/22 (18%)
LRR_8 283..345 CDD:290566 12/66 (18%)
leucine-rich repeat 285..308 CDD:275380 6/22 (27%)
leucine-rich repeat 309..334 CDD:275380 3/27 (11%)
LRR_8 334..393 CDD:290566 15/60 (25%)
leucine-rich repeat 335..358 CDD:275380 3/24 (13%)
leucine-rich repeat 359..382 CDD:275380 8/22 (36%)
LRR_8 382..441 CDD:290566 13/59 (22%)
leucine-rich repeat 383..406 CDD:275380 5/22 (23%)
leucine-rich repeat 407..430 CDD:275380 0/22 (0%)
LRR_8 431..488 CDD:290566 17/62 (27%)
leucine-rich repeat 431..451 CDD:275380 8/25 (32%)
leucine-rich repeat 454..477 CDD:275380 4/22 (18%)
LRR_8 477..559 CDD:290566 22/89 (25%)
leucine-rich repeat 478..499 CDD:275380 4/20 (20%)
leucine-rich repeat 502..525 CDD:275380 7/22 (32%)
leucine-rich repeat 526..548 CDD:275380 8/28 (29%)
leucine-rich repeat 590..617 CDD:275380 1/26 (4%)
leucine-rich repeat 618..641 CDD:275380 5/22 (23%)
leucine-rich repeat 642..689 CDD:275380 13/46 (28%)
LRRCT 679..736 CDD:214507 9/56 (16%)
leucine-rich repeat 775..796 CDD:275380 0/20 (0%)
LRR_8 797..852 CDD:290566 0/54 (0%)
leucine-rich repeat 797..817 CDD:275380 0/19 (0%)
leucine-rich repeat 818..841 CDD:275380 0/22 (0%)
LRR_8 841..900 CDD:290566 9/59 (15%)
leucine-rich repeat 842..865 CDD:275380 0/22 (0%)
LRR_4 866..907 CDD:289563 11/43 (26%)
leucine-rich repeat 866..889 CDD:275380 4/22 (18%)
leucine-rich repeat 890..911 CDD:275380 8/23 (35%)
TIR 1045..1183 CDD:214587 27/153 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45453681
Domainoid 1 1.000 44 1.000 Domainoid score I4673
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm24216
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X221
65.850

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