DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-9 and Tlr3

DIOPT Version :9

Sequence 1:	NP_001246846.1	Gene:	Toll-9 / 40245	FlyBaseID:	FBgn0036978	Length:	900	Species:	Drosophila melanogaster
Sequence 2:	NP_942086.2	Gene:	Tlr3 / 364594	RGDID:	735171	Length:	905	Species:	Rattus norvegicus

Alignment Length:	923	Identity:	199/923 - (21%)
Similarity:	343/923 - (37%)	Gaps:	267/923 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 LDLSHGNLKDDSDLFREAKLSRKVTIWRTEVFSAAFNTLTAAPFRTLYSM--------------- 153
            |:|.|..|...||    ...:....:....:.|.:...:.:.||:...|:
  Rat   105 LNLQHNELSQISD----QTFAFCTNLTELHLMSNSIRKIKSNPFKNQKSLIKLDLSRNGLSSTKL 165

  Fly   154 -----RESLKLLSLRGNNFAELIPDAEDFARFVNESRLE-ASNSVPHHCE----------LLLLH 202
                 .|:|:.|.|..|....|..:..||....:..:|: :||.:.....          :|||:
  Rat   166 GTGVQLENLQELLLAKNKIFALRSEELDFLGNSSLQKLDLSSNPLKEFSPGCFHAIGKLFVLLLN 230

  Fly   203 N---TTDLYDRECY---------LYFNNNTNMGQSITT--GRNYTNFIKVLKDRFDQHGSSSQSI 253
            |   ..:|.::.|:         |...||..:..|.:|  |...||...:     |...:|.:.:
  Rat   231 NAQLNLNLTEKLCWELSNTSIQNLSLANNQLLATSNSTFSGLKQTNLTSL-----DLSYNSLRYV 290

  Fly   254 AWATFPKMPRLVELDISNCSIEYVSKEAFRNVSNLR----------------------------- 289
            ....|..:|.|..|.:...:|:.::..:||.:||||
  Rat   291 GNDAFSWLPHLKYLSLEYNNIQSLTPHSFRGLSNLRYLSLKRAFTKQSVALASHPNIDDFSFQWL 355

  Fly   290 ----RLFMSDNKIMTISHDTFYYVQGVQYLDLS--FTNF----------LTYSYQLQLPTLEMAL 338
                .|.|.||.|..|..:||..:..::||.||  ||..          ||:|     |.|.:.|
  Rat   356 KCLEHLNMDDNTIPGIKSNTFTGLVSLKYLSLSKTFTGLQTLTNETFVSLTHS-----PLLTLNL 415

  Fly   339 SLIYGLKIQQNVFKYLPELIYLDLSHSKMTR-----------NSAVAFAHLGDKLKFLSLCYTAI 392
            :..:..||....|.:|.:|..|||..:::.:           |....:......|:..|..:|.:
  Rat   416 TKNHISKIASGTFSWLGQLRILDLGLNEIEQELTGQEWRGLGNIFEIYLSYNKYLQLTSKSFTLV 480

  Fly   393 PMVSSTIFKNTVLEGLDLSGNPY----------LSYNII----DDAFDGIANTLKYLYFERSNIK 443
            |.:...:.:...|:.:|:|.:|:          ||.|.|    :|..:|:.| |:.|.|:.:|:.
  Rat   481 PSLQRLMLRRVALKSVDISPSPFRPLYNLTILDLSNNNIANLNEDLLEGLEN-LEILDFQHNNLA 544

  Fly   444 DLEWS-----------KSLKNLQVLGLAGNNINALTPAMFQSLESLEILDLSSNHVGNWYRSAFH 497
            .| |.           |.|.:|.:|.|..|.::.:...:|::|..|:.::|..|::.....|.|.
  Rat   545 RL-WKHANPGGPVNFLKGLSHLHILNLESNGLDEIPVKVFKNLFELKSINLGLNNLNTLLPSIFD 608

  Fly   498 NNSALRVLNLRSNTINMLSNEML-KDFERLDYLSLGDNDFICDCHLRAVVEVAAANNKDADCSYR 561
            :.::||.|||:.|.|..:...:. ..|..|:.|.:..|.|.|.|
  Rat   609 DQTSLRSLNLQKNLITSVEKSVFGPAFHNLNSLDMSFNPFDCTC--------------------- 652

  Fly   562 LLNYSQNAVGEEVISLAESLIIDRKLWQSRYIPWLQRSYSNIREFNRANHIIKLRFSSEDYMVAK 626
                             ||:     .|   ::.||.::::||.|.            |..|:
  Rat   653 -----------------ESI-----AW---FVTWLNQTHTNIPEL------------STHYL--- 677

  Fly   627 CSAAQPYHLGDLDGDLTLKFQLLDYEASQYYCFNNTDQLQVDELNCQIRSMSDLAE-ELHHVTNT 690
            |:..|.||        .|..:|.|                       ..|..|.|. :|..:.||
  Rat   678 CNTPQRYH--------GLPVKLFD-----------------------TSSCKDSAPFQLLFIINT 711

  Fly   691 ------VIAVMGSLVGACILGFIIYLKRWHIHYYYSSLKSAALLSSASKESVNKFTNISQRDPSA 749
                  ::||:           :|:.:.|.|.:|:          :.|...:..|..|..:....
  Rat   712 STLLTFILAVL-----------LIHFEGWRISFYW----------NVSVHRILGFKEIDAQGEQF 755

  Fly   750 VYDIFISYCQNDRTWVLNELLPNVEETGDVSICLHERDFQIGVTILDNIISCMDRSYSLMLIISS 814
            .|..:|.:.|.||.||.....|..|:...:..||.||||:.||..|:.|::.:.||..::.:|:.
  Rat   756 EYTAYIIHAQKDRDWVWEHFSPMEEQDQSLKFCLEERDFEAGVLGLEAIVNSIKRSRKIIFVITH 820

  Fly   815 KFLLSHWC-QFEMYLAQHRIFEVSKEHLILVFLEDIPRRKRPKTL---QYLMDVKTYIKWPTAKE 875
            ..|....| :|:::.|..:..|.:.:.:||:||::||..|....|   :.:......:.||..||
  Rat   821 HLLKDPLCRRFKVHHAVQQAIEQNLDSIILIFLQNIPDYKLNHALCLRRGMFKSHCILNWPIQKE 885

  Fly   876 DRKLFWKRLKRSL 888
            ....|..:|:.:|
  Rat   886 RINAFHHKLQVAL 898

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-9	NP_001246846.1	leucine-rich repeat	157..185	CDD:275380	7/27 (26%)
		LRR_8	262..322	CDD:290566	24/94 (26%)
		leucine-rich repeat	264..287	CDD:275380	5/22 (23%)
		leucine-rich repeat	288..311	CDD:275380	10/55 (18%)
		leucine-rich repeat	312..356	CDD:275380	16/55 (29%)
		LRR_8	<344..387	CDD:290566	10/53 (19%)
		leucine-rich repeat	357..381	CDD:275380	5/34 (15%)
		leucine-rich repeat	382..397	CDD:275380	4/14 (29%)
		leucine-rich repeat	405..430	CDD:275380	10/38 (26%)
		LRR_8	431..488	CDD:290566	17/67 (25%)
		leucine-rich repeat	432..453	CDD:275380	8/31 (26%)
		LRR_RI	<449..536	CDD:238064	24/87 (28%)
		leucine-rich repeat	454..477	CDD:275380	6/22 (27%)
		LRR_8	477..536	CDD:290566	16/59 (27%)
		leucine-rich repeat	478..501	CDD:275380	5/22 (23%)
		leucine-rich repeat	502..525	CDD:275380	8/23 (35%)
		TIR	751..891	CDD:214587	42/142 (30%)
Tlr3	NP_942086.2	leucine-rich repeat	37..53	CDD:275380
		leucine-rich repeat	54..77	CDD:275380
		PLN00113	66..>646	CDD:215061	121/556 (22%)
		leucine-rich repeat	78..101	CDD:275380
		leucine-rich repeat	102..125	CDD:275380	6/23 (26%)
		leucine-rich repeat	126..149	CDD:275380	3/22 (14%)
		leucine-rich repeat	150..199	CDD:275380	8/48 (17%)
		leucine-rich repeat	200..250	CDD:275380	9/49 (18%)
		leucine-rich repeat	251..276	CDD:275380	6/24 (25%)
		leucine-rich repeat	277..300	CDD:275380	3/27 (11%)
		leucine-rich repeat	301..322	CDD:275380	5/20 (25%)
		leucine-rich repeat	325..381	CDD:275380	10/55 (18%)
		leucine-rich repeat	382..407	CDD:275380	7/24 (29%)
		leucine-rich repeat	410..433	CDD:275380	6/22 (27%)
		leucine-rich repeat	434..458	CDD:275380	4/23 (17%)
		leucine-rich repeat	459..482	CDD:275380	3/22 (14%)
		leucine-rich repeat	483..508	CDD:275380	4/24 (17%)
		leucine-rich repeat	509..532	CDD:275380	6/22 (27%)
		leucine-rich repeat	533..564	CDD:275380	8/31 (26%)
		leucine-rich repeat	565..586	CDD:275380	5/20 (25%)
		leucine-rich repeat	589..612	CDD:275380	5/22 (23%)
		leucine-rich repeat	613..631	CDD:275380	7/17 (41%)
		LRRCT	646..698	CDD:214507	22/143 (15%)
		Tlr3_TMD	699..731	CDD:407816	9/42 (21%)
		TIR	756..901	CDD:214587	42/143 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020