DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-9 and Tlr12

DIOPT Version :9

Sequence 1:	NP_001246846.1	Gene:	Toll-9 / 40245	FlyBaseID:	FBgn0036978	Length:	900	Species:	Drosophila melanogaster
Sequence 2:	NP_001102152.1	Gene:	Tlr12 / 362604	RGDID:	1559145	Length:	904	Species:	Rattus norvegicus

Alignment Length:	693	Identity:	158/693 - (22%)
Similarity:	269/693 - (38%)	Gaps:	202/693 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   264 LVELDISNCSIEYVSKEAFRNVSNLRRLFMSDNKIMTISHDTFYYVQGVQYLDLSFTNFLTYSYQ 328
            |..||:|...:..:....|..:.:||.|.:.||:::::        :|..:.||.
  Rat   345 LSTLDLSGNGLRILPPATFSCLPHLRELLLQDNQLLSL--------EGHPFQDLQ---------- 391

  Fly   329 LQLPTLEMALSLIYGLKIQQNVFKYLPELIYLDLSHSKMTRNSAVAF--------AHLGDKLKFL 385
             ||.||::..:.:  |.:.:|....||.|..|.|..:::..:....|        .|       |
  Rat   392 -QLETLKLDRNPL--LNLGKNCLAALPALTTLSLLDTQILHSPDAGFWGARSLHTLH-------L 446

  Fly   386 SLCYTAIPMVSSTIFKNTVLE-----GL---DLSGN--PYLSYNIID--DAFDGIAN------TL 432
            ||...:.|.|.|.....|.||     ||   .||.|  |:|....|:  ....|:.|      .|
  Rat   447 SLPPLSAPAVLSLPMYLTSLELHVTPGLKHWTLSPNIFPFLETLTINGRGLKLGVQNASEVFPAL 511

  Fly   433 KYLYFERSNI-----KDLE----WS-KSLKNLQVLGLAGNNINALTPAMFQSLESLEILDLSSNH 487
            ::|:..::::     :|..    |. ..|::|:|.| ||:|..   |.:...|.||:.|.|.|
  Rat   512 QHLFLLQNSLDAFCSQDASSIFLWQLPKLQSLKVWG-AGSNSR---PCLITGLPSLQELKLES-- 570

  Fly   488 VGNWYRSAFHNNSALRVLNLRSNT--INMLSNEMLKDFERLDYLSLGDNDFICDCHLRAVVEVAA 550
                               |:|.|  .::...|::.|..:|..|.|...         .:..::|
  Rat   571 -------------------LQSITQPRSVQLEELVGDLPQLQALQLSST---------GLKSLSA 607

  Fly   551 ANNKDADCSYRLLNYSQNAV--GEEVISLAESL------------IIDRKL-------WQSRYIP 594
            |       ::|.|:..|..|  .|:.:.|.:||            |:..||       |...::.
  Rat   608 A-------AFRRLHSLQALVLDSEKDLVLQDSLREYSPQMPRYVYILQSKLACQCANAWMELWVK 665

  Fly   595 WLQRSYSNIREFNRANHII--KLRFSSEDYMVAKCSAAQPYHLGDLDGDLTLKFQLLDYEASQYY 657
            ...::|.:||:    .|:.  ::|..:.|.:::        .|.|                   :
  Rat   666 QSTKTYVHIRD----GHLCPGEVRVPARDSLIS--------FLWD-------------------H 699

  Fly   658 CFNNTDQLQVDELNCQIRSMSDLAEELHHVTNTVIAVMGSLVGACILGFIIYLKRWHIHYYYSSL 722
            | ..|.:|::...:..:..:..:...|....||.|..:.:|       |.|:|:         .|
  Rat   700 C-PQTLELKLFLASSALVLLLIVLPLLQGARNTWIPYLRAL-------FRIWLQ---------GL 747

  Fly   723 KSAALLSSASKESVNKFTNISQRDPSAVYDIFISYCQNDRTWVLNELLPNVE---ETG-DVSICL 783
            :...              |..:|   .::|:|:|:|:.|:.|||.||||.:|   ..| .:.:||
  Rat   748 RGQG--------------NAGKR---FLFDVFVSHCRQDQGWVLEELLPALEGFLPAGLGLRLCL 795

  Fly   784 HERDFQIGVTILDNIISCMDRSYSLMLIISSKFLLSHWCQFEMYLAQHRIFEV-SKEHLILVFLE 847
            .||||:.|..::||::..|..|...:.::|...|.:..|..|:.||...:... |...|:|||||
  Rat   796 PERDFEPGKDVVDNVVDSMVSSRVTLCVLSGPALCNPRCCLELRLATSLLLAAPSPPVLLLVFLE 860

  Fly   848 DIPRRKRPK--TLQYLMDVKTYIKWPTAKEDRKLFWKRLKRSL 888
            .|.|.:.|.  .|..|:....|..||..:|.:..||..|:..|
  Rat   861 PISRHQLPSYHRLARLLRRGDYCLWPEEEERKGGFWTWLRSRL 903

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-9	NP_001246846.1	leucine-rich repeat	157..185	CDD:275380
		LRR_8	262..322	CDD:290566	13/57 (23%)
		leucine-rich repeat	264..287	CDD:275380	5/22 (23%)
		leucine-rich repeat	288..311	CDD:275380	5/22 (23%)
		leucine-rich repeat	312..356	CDD:275380	9/43 (21%)
		LRR_8	<344..387	CDD:290566	10/50 (20%)
		leucine-rich repeat	357..381	CDD:275380	5/31 (16%)
		leucine-rich repeat	382..397	CDD:275380	5/14 (36%)
		leucine-rich repeat	405..430	CDD:275380	11/36 (31%)
		LRR_8	431..488	CDD:290566	18/66 (27%)
		leucine-rich repeat	432..453	CDD:275380	5/30 (17%)
		LRR_RI	<449..536	CDD:238064	22/88 (25%)
		leucine-rich repeat	454..477	CDD:275380	8/22 (36%)
		LRR_8	477..536	CDD:290566	13/60 (22%)
		leucine-rich repeat	478..501	CDD:275380	4/22 (18%)
		leucine-rich repeat	502..525	CDD:275380	5/24 (21%)
		TIR	751..891	CDD:214587	51/145 (35%)
Tlr12	NP_001102152.1	leucine-rich repeat	71..93	CDD:275380
		leucine-rich repeat	94..116	CDD:275380
		leucine-rich repeat	117..144	CDD:275380
		leucine-rich repeat	202..225	CDD:275380
		leucine-rich repeat	226..270	CDD:275380
		leucine-rich repeat	246..259	CDD:275381
		LRR_8	270..329	CDD:290566
		leucine-rich repeat	271..294	CDD:275380
		LRR_4	294..331	CDD:289563
		leucine-rich repeat	295..318	CDD:275380
		leucine-rich repeat	319..344	CDD:275380
		LRR_8	343..403	CDD:290566	17/76 (22%)
		LRR_RI	345..547	CDD:238064	52/229 (23%)
		leucine-rich repeat	345..368	CDD:275380	5/22 (23%)
		leucine-rich repeat	369..392	CDD:275380	8/41 (20%)
		leucine-rich repeat	393..416	CDD:275380	6/24 (25%)
		leucine-rich repeat	417..437	CDD:275380	4/19 (21%)
		leucine-rich repeat	441..510	CDD:275380	20/75 (27%)
		leucine-rich repeat	511..562	CDD:275380	13/54 (24%)
		leucine-rich repeat	563..591	CDD:275380	9/48 (19%)
		leucine-rich repeat	592..615	CDD:275380	7/38 (18%)
		TIR	759..900	CDD:214587	49/140 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020