DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-9 and Toll-4

DIOPT Version :9

Sequence 1:	NP_001246846.1	Gene:	Toll-9 / 40245	FlyBaseID:	FBgn0036978	Length:	900	Species:	Drosophila melanogaster
Sequence 2:	NP_523519.2	Gene:	Toll-4 / 34235	FlyBaseID:	FBgn0032095	Length:	1125	Species:	Drosophila melanogaster

Alignment Length:	1119	Identity:	220/1119 - (19%)
Similarity:	370/1119 - (33%)	Gaps:	342/1119 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LGNVREAYTEFSIQDGLIIEPDSATTSSEEAEEVSKERTDLKSLMLKYE---------------- 65
            |||:||.|.|..:.     |.....|.|....||:.|...:|.:.||.|
  Fly    85 LGNIREDYCEIYLD-----ELGENGTCSIANNEVTTEDYQMKLVFLKLEINWTSPVFHGWNIFKI 144

  Fly    66 --SDDGNSCLLDL--IKDEVIWWQFP---------------------------------NGT--- 90
              ..|....::.:  |:.||.....|                                 ||.
  Fly   145 CNETDYELVIISVLGIRSEVDMRISPAVQYLSLLGIREISGYDIYLPSVLITEMDVHHANGPKMV 209

  Fly    91 ----LRDST--------------------KKYAHKLY--------LDLSHGNLKDDSDLFREAKL 123
                |.|||                    |.|.|..:        .::.||..|..:.:|...|:
  Fly   210 TFKYLYDSTVNSVITNNYIRKTMNNTEKIKIYYHNTFEKTTLTMEKNIFHGKNKMSALIFNGLKI 274

  Fly   124 S-------RKVTIWRTEVFSAAFNTLTAAPFRTLYSMRESLKLLSLRGNNFAELIPDAEDFARFV 181
            .       ..:|...|.:|...|  |....|....:::.||....::.:|..:|    :.|.:|.
  Fly   275 KGLTNNTFENLTSLNTLIFDNVF--LKDLSFLRSSTLQSSLTYCIMKVDNMVDL----KSFEKFT 333

  Fly   182 NESRLEASN-----------SVPH--HCELLLLHNTTDLYDRECYLYFNNNTNMGQSITTGRNYT 233
            |...:|.|.           ..|:  ||:..|..|.. ....:|...:|.:.:..:.....:|.|
  Fly   334 NLEIIEVSQYKGFKNFTAFICEPYKSHCKFTLGINEV-ACPLKCNCSYNRDKSQLEIDCWQKNLT 397

  Fly   234 NF--IKVLKDRFDQHGSSS---QSIAWATFPK-----MPRLVELDISNCSIEYVSKEAFRNVSNL 288
            ..  :.|.|     .|||:   ||...|..|.     ...|..||:|...:..:|....  ..:|
  Fly   398 TIPSLPVPK-----KGSSALVFQSNLLAELPDNSLEGYHNLKSLDVSYNQLTSLSVSQL--PESL 455

  Fly   289 RRLFMSDNKIMTISHDTFYYVQGVQ-----------YLD-LSFTNFLTYSYQL------QLPTLE 335
            ..|.:..|||.|:|.....|:..|.           |.| .....|..|..:|      :..|:.
  Fly   456 HYLDIRHNKITTLSPQVVEYLYSVNVFNQYGNKWSIYCDEYHLQEFFWYKAKLLRIKTSKFQTIM 520

  Fly   336 MALSLIYGLKIQQNVFKYLPELIYLDLSHSKMTRNSAVAFAHLGDK---LKFLSLCYTAIPMVSS 397
            ..:.|.......:|.|....:.:||:.:..::..    ||.. .||   ||.:.....||.:.|.
  Fly   521 EYIELSSKGSFVENFFVQNIDQLYLEANEDEIID----AFGP-SDKYFNLKLMEALNHAIWLFSG 580

  Fly   398 TIFKNTVLEGLDLSGNPYL---------------SYNIIDDAFDGIANTLKY---LYFERSNIKD 444
            . |...:|..|: |..||.               ..|:..|.:..:.|::.|   ||.:|:.|
  Fly   581 E-FDEIILHHLN-SPCPYRCSCCFEWHTGEFLINCRNLSLDIYPRLPNSIPYKTTLYLDRNEI-- 641

  Fly   445 LEWSKSLKNLQVLGLAGNNINALTPAMFQSLESLEILDLSSNHVGNWYRSAFHNNSALRVLNLRS 509
                :.|.|.:.|.:||:             .|:..|.:|.|.:..........|  :..|::|:
  Fly   642 ----RKLTNTESLVVAGH-------------ASIHKLHMSQNLLRELPLHLLPEN--ITYLDVRN 687

  Fly   510 NTINMLSN---EMLKDFERLDYLSLGDNDFICDCHLRAVV----------------EVAAANNK- 554
            |.:..|.:   ..|:..|.:..:.|..|.:.|:|..:|.:                .|...::|
  Fly   688 NLLKYLDDGVIAFLEYRENITKIELSGNPWECNCKAKAFLSFLRRHEPMEYETVLRRVEITDDKC 752

  Fly   555 --DADCSYRLLN-----YSQNAVGEEVISLAE---------SLIIDR---KLWQSRYIPWLQRSY 600
              |..|.....|     |..:..|:|:..:.:         :|:.:|   |.|.|..:|    .|
  Fly   753 PEDCICCVDTSNSDSLAYVVDCSGKELSEIPQLPTPTYGQTTLVFERNSLKKWPSSLLP----GY 813

  Fly   601 SNIREFNRANHIIKLRFSSEDYMVAKCSAAQPYHLGDLDGDLTLKFQLLDYEASQYYCFN----- 660
            |::..|..|::                      .|.|:| .|..|.:.||...:.:...:
  Fly   814 SSVTRFYLAHN----------------------RLSDID-QLPDKLEYLDISNNNFSALDDRVRG 855

  Fly   661 ------NTDQLQV----DELNCQIRSMSDLA---EELHHVTN----------------------- 689
                  |:.|||:    :...|:......|.   |:..::.|
  Fly   856 FLQKRMNSSQLQLSLFGNPWTCRCEDKDFLVFVKEQAKNIANASAIQCIDTGRSLIEVEETDICP 920

  Fly   690 ------TVIAVMGSLVGACILGFIIYLKRWHIHYYYSSLKSAALLSSASKESVNKFTNISQRDPS 748
                  |.:||...::...|..||.:.:...|.:|...:    .||.|::..:         |..
  Fly   921 SVLIYYTSLAVSLLIIALSINVFICFRQPIMIWFYEHEI----CLSLAARREL---------DED 972

  Fly   749 AVYDIFISYCQNDRTWVLNELLPNVEE-TGDVSICLHERDFQIGVTILDNIISCMDRSYSLMLII 812
            ..||.|:|:...|.. ::.|.:..:|. .....:|.:.||:.:|.:|.|.|...:..|..:::::
  Fly   973 KKYDAFLSFTHKDED-LIEEFVDRLENGRHKFRLCFYLRDWLVGESIPDCINQSVKGSRRIIILM 1036

  Fly   813 SSKFLLSHWCQFEMYLAQHRIFEVSKEHLILVFLEDIPR-RKRPKTLQYLMDVKTYIKWPTAKED 876
            :..||.|.|.:.|..||.|.......:.||:|...|:.. ......|:..|.:.||:       |
  Fly  1037 TKNFLKSTWGRLEFRLALHATSRDRCKRLIVVLYPDVEHFDDLDSELRAYMVLNTYL-------D 1094

  Fly   877 RK--LFWKRLKRSL 888
            |.  .||.:|..|:
  Fly  1095 RNNPNFWNKLMYSM 1108

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-9	NP_001246846.1	leucine-rich repeat	157..185	CDD:275380	6/27 (22%)
		LRR_8	262..322	CDD:290566	16/71 (23%)
		leucine-rich repeat	264..287	CDD:275380	5/22 (23%)
		leucine-rich repeat	288..311	CDD:275380	8/22 (36%)
		leucine-rich repeat	312..356	CDD:275380	10/61 (16%)
		LRR_8	<344..387	CDD:290566	10/45 (22%)
		leucine-rich repeat	357..381	CDD:275380	4/23 (17%)
		leucine-rich repeat	382..397	CDD:275380	4/14 (29%)
		leucine-rich repeat	405..430	CDD:275380	7/39 (18%)
		LRR_8	431..488	CDD:290566	14/59 (24%)
		leucine-rich repeat	432..453	CDD:275380	6/23 (26%)
		LRR_RI	<449..536	CDD:238064	18/89 (20%)
		leucine-rich repeat	454..477	CDD:275380	3/22 (14%)
		LRR_8	477..536	CDD:290566	13/61 (21%)
		leucine-rich repeat	478..501	CDD:275380	4/22 (18%)
		leucine-rich repeat	502..525	CDD:275380	5/25 (20%)
		TIR	751..891	CDD:214587	37/142 (26%)
Toll-4	NP_523519.2	leucine-rich repeat	264..287	CDD:275380	2/22 (9%)
		leucine-rich repeat	288..308	CDD:275380	5/21 (24%)
		leucine-rich repeat	309..334	CDD:275380	6/28 (21%)
		leucine-rich repeat	335..386	CDD:275380	9/51 (18%)
		leucine-rich repeat	388..408	CDD:275380	4/24 (17%)
		LRR_8	412..465	CDD:290566	12/54 (22%)
		leucine-rich repeat	412..432	CDD:275378	4/19 (21%)
		LRR_4	432..470	CDD:289563	11/39 (28%)
		leucine-rich repeat	433..454	CDD:275378	5/22 (23%)
		leucine-rich repeat	455..478	CDD:275378	8/22 (36%)
		leucine-rich repeat	479..490	CDD:275378	1/10 (10%)
		leucine-rich repeat	632..657	CDD:275378	9/43 (21%)
		leucine-rich repeat	658..679	CDD:275378	3/20 (15%)
		leucine-rich repeat	680..706	CDD:275378	5/25 (20%)
		leucine-rich repeat	707..719	CDD:275378	2/11 (18%)
		leucine-rich repeat	771..791	CDD:275380	2/19 (11%)
		leucine-rich repeat	793..815	CDD:275378	7/25 (28%)
		leucine-rich repeat	816..835	CDD:275378	6/41 (15%)
		leucine-rich repeat	836..859	CDD:275378	2/22 (9%)
		TIR	974..1110	CDD:214587	37/143 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453678
Domainoid	1	1.000	44	1.000	Domainoid score	I4673
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	182	1.000	Inparanoid score	I3846
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X221
	8	8.000