DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Toll-9 and kek5

DIOPT Version :9

Sequence 1:NP_001246846.1 Gene:Toll-9 / 40245 FlyBaseID:FBgn0036978 Length:900 Species:Drosophila melanogaster
Sequence 2:NP_001245746.1 Gene:kek5 / 32930 FlyBaseID:FBgn0031016 Length:931 Species:Drosophila melanogaster


Alignment Length:279 Identity:67/279 - (24%)
Similarity:102/279 - (36%) Gaps:63/279 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   345 KIQQNVFKYLPELIYLDLSHSKM--TRNSAVAFAHLGDKLK-FLSLCYTAIPMVSSTIFKNT-VL 405
            ||.|::..   |:..||.:|:::  .|......|.|.:..| ||..|  .|..|....||.. :|
  Fly    66 KIPQDMSN---EMQVLDFAHNQIPELRREEFLLAGLPNVHKIFLRNC--TIQEVHREAFKGLHIL 125

  Fly   406 EGLDLSGNPYLSYNIIDDAFDGIANTLKYLYFERSNIKDLE--WSKSLKNLQVLGLAGNNINALT 468
            ..||||||                           .|::|.  ....|:.|:.:.:..|.|..|.
  Fly   126 IELDLSGN---------------------------RIRELHPGTFAGLEKLRNVIINNNEIEVLP 163

  Fly   469 PAMFQSLESLEILDLSSNHVGNWYRSAFHNNSALRVLNLRSNTINMLSNEMLKDFERLDYLSLGD 533
            ..:|.:|..|..::..:|.:.......|....||..::|..|.::.|..|..||.::|.:|||..
  Fly   164 NHLFVNLSFLSRIEFRNNRLRQVQLHVFAGTMALSAISLEQNRLSHLHKETFKDLQKLMHLSLQG 228

  Fly   534 NDFICDCHLRAVVEVAAAN---NKDADCSYRLLNYSQNAVGEEVISLAESLIIDRKLWQ---SRY 592
            |.:.|.|.|:...:.|.:.   ....||.                   |...:..|||.   |..
  Fly   229 NAWNCSCELQDFRDFAISKRLYTPPTDCQ-------------------EPPQLRGKLWSEVPSEN 274

  Fly   593 IPWLQRSYSNIREFNRANH 611
            .....|...::|.|..|||
  Fly   275 FACRPRILGSVRSFIEANH 293

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-9NP_001246846.1 leucine-rich repeat 157..185 CDD:275380
LRR_8 262..322 CDD:290566
leucine-rich repeat 264..287 CDD:275380
leucine-rich repeat 288..311 CDD:275380
leucine-rich repeat 312..356 CDD:275380 3/10 (30%)
LRR_8 <344..387 CDD:290566 13/44 (30%)
leucine-rich repeat 357..381 CDD:275380 6/25 (24%)
leucine-rich repeat 382..397 CDD:275380 6/15 (40%)
leucine-rich repeat 405..430 CDD:275380 7/24 (29%)
LRR_8 431..488 CDD:290566 11/58 (19%)
leucine-rich repeat 432..453 CDD:275380 3/22 (14%)
LRR_RI <449..536 CDD:238064 23/86 (27%)
leucine-rich repeat 454..477 CDD:275380 6/22 (27%)
LRR_8 477..536 CDD:290566 16/58 (28%)
leucine-rich repeat 478..501 CDD:275380 3/22 (14%)
leucine-rich repeat 502..525 CDD:275380 7/22 (32%)
TIR 751..891 CDD:214587
kek5NP_001245746.1 LRR_RI <76..160 CDD:238064 26/112 (23%)
leucine-rich repeat 76..100 CDD:275380 6/23 (26%)
LRR_8 99..159 CDD:290566 20/88 (23%)
leucine-rich repeat 101..124 CDD:275380 8/24 (33%)
LRR 122..145 CDD:197688 9/49 (18%)
leucine-rich repeat 125..148 CDD:275380 10/49 (20%)
LRR_8 148..207 CDD:290566 13/58 (22%)
leucine-rich repeat 149..172 CDD:275380 6/22 (27%)
leucine-rich repeat 173..196 CDD:275380 3/22 (14%)
LRR_8 197..>229 CDD:290566 11/31 (35%)
leucine-rich repeat 197..220 CDD:275380 7/22 (32%)
LRRCT 229..277 CDD:214507 12/66 (18%)
Ig 296..376 CDD:143165
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45453676
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
10.930

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