DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-9 and Tlr2

DIOPT Version :9

Sequence 1:	NP_001246846.1	Gene:	Toll-9 / 40245	FlyBaseID:	FBgn0036978	Length:	900	Species:	Drosophila melanogaster
Sequence 2:	XP_008759324.3	Gene:	Tlr2 / 310553	RGDID:	735138	Length:	831	Species:	Rattus norvegicus

Alignment Length:	948	Identity:	201/948 - (21%)
Similarity:	345/948 - (36%)	Gaps:	356/948 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 PNGTLRDSTKKYAHKLYLDLS--------HGNLKDDSDLFREAKLSRKVTIWRTEVFSAAFNTLT 143
            |:| |..:|||      ||||        ||:|:...:|       |.:|:     .|:..||:.
  Rat    94 PSG-LTANTKK------LDLSFNKITYIGHGDLRACVNL-------RVLTL-----ESSGINTIE 139

  Fly   144 AAPFRTLYSMR--------------------ESLKLLSLRGNNFAELIPDAEDFARFVNESRLEA 188
            ...|.:|.|:.                    .|||.|:|.||.:           |.:.|:.|
  Rat   140 GDAFYSLGSLEHLDLSNNHLSSLSSSWFRPLSSLKYLNLMGNPY-----------RTLGETSL-- 191

  Fly   189 SNSVPHHCELLLLHNTTDLYDRECYLYFNNNTNMGQSITTGRNYTNFIKVLKDRFDQHGSSSQSI 253
                                       |:|.||: |::..| |...|.::  .|.|..|.:|
  Rat   192 ---------------------------FSNLTNL-QNLRVG-NVDTFSEI--RRIDFAGLTS--- 222

  Fly   254 AWATFPKMPRLVELDISNCSI---EYVSKEAFRNVSNLRRLFMSDNK-IMTISHDTFYYVQGVQY 314
                      |.||:|...|:   |..|.::.|::.:| .|.:|::. ::.|..|   .:..|:|
  Rat   223 ----------LNELEIQVLSLGNYESRSLQSIRDIYHL-TLHLSESAFLLGIFAD---ILSSVRY 273

  Fly   315 LDLSFTNFLTYSY------QLQLPTLEMAL--------SLIYGLKIQQNVFKYLPELIYLDLSHS 365
            |:|..||...:.:      ::..|..::|.        |....||:    .:|:.||:.::..|.
  Rat   274 LELRDTNLARFQFSELSVDEINSPMKKLAFRNADLTDKSFNELLKL----LRYILELMEVEFDHC 334

  Fly   366 KM-------------------TRNSAVAFAHLGDKLKF--LSLCYTAIPMVSSTIFKNT------ 403
            .:                   .....:...|:.....|  ||..|:.:..|.....:|:
  Rat   335 TLNGVGNFNPSESDVVRELGKVETVTIRSLHIPQFYLFYDLSTVYSLLEKVKRITVENSKVFLVP 399

  Fly   404 --------VLEGLDLSGNPYLSYNIIDDAFDGIANTLKYLYFERSNIKDL----EWSKSLKNLQV 456
                    .||.||||.|..:...:.:.|.:|...:|:.|...:::::.:    |...:||||..
  Rat   400 CSFSQHLKSLEFLDLSENLMVEEYLKNSACEGGWPSLQSLVLSQNHLRSIRKTAEILLTLKNLTA 464

  Fly   457 LGLAGNNINALT-----PAMFQSL---------------ESLEILDLSSNHVGNWYRSAF----- 496
            |.::.|:...:.     |...:.|               ::||:||:|:|::.::  |.|
  Rat   465 LDISKNSFQPMPDSCQWPGKMRFLNLSSTGIQAVKTCIPQTLEVLDVSNNNLDSF--SLFLPRLQ 527

  Fly   497 -----HNN----------SALRVLNLRSNTINMLSNEMLKDFERLDYLSLGDNDFICDCHLRAVV 546
                 .|.          ..|:|:.:|.|.|:..|.:.|..|.:|:.|..|||.|||.|.|.
  Rat   528 ELYISRNKLKTLPEASLFPVLQVMKIRENAISTFSKDQLGSFPKLETLEAGDNHFICSCELL--- 589

  Fly   547 EVAAANNKDADCSYRLLNYSQNAVGEEVISLAESLIIDRKLWQSRYIPWLQRSYSNIREFNRANH 611
                                             |.|::|.......:.|
  Rat   590 ---------------------------------SFILERPALVHVLVDW---------------- 605

  Fly   612 IIKLRFSSEDYMVAKCSAAQPYHLGDLDGDLTLKFQLLDYEASQYYCFNNTDQLQVDELNCQIRS 676
                   .:.|:   |.:....|     |.     :|.|...|...|.
  Rat   606 -------PDSYL---CDSPPRLH-----GQ-----RLQDARPSVLECH----------------- 633

  Fly   677 MSDLAEELHHVTNTVIAVMGSLV-GAC--------ILGFIIYLKRWHIH-YYYSSLKSAALLSSA 731
                              ..:|| |.|        :||.:.|    |.| .:|..:..|.|.
  Rat   634 ------------------QAALVSGVCCALLLLILLLGALCY----HFHGLWYLRMMWAWLR--- 673

  Fly   732 SKESVNKFTNISQRDPSAV------YDIFISYCQNDRTWVLNELLPNVEETG-DVSICLHERDFQ 789
                       ::|.|...      ||.|:||.:.|..||.|.::..:|.:. ...:|||:|||.
  Rat   674 -----------AKRKPKKAPCRDLCYDAFVSYSEQDSYWVENLMVQQLENSDPPFKLCLHKRDFV 727

  Fly   790 IGVTILDNIISCMDRSYSLMLIISSKFLLSHWCQFEMYLAQHRIFEVSKEHLILVFLEDIPRRKR 854
            .|..|:||||..:::|:..:.::|..|:.|.||::|:..:..|:|:.:.:..|||.||.|.::..
  Rat   728 PGKWIIDNIIDSIEKSHKTVFVLSENFVRSEWCKYELDFSHFRLFDENNDAAILVLLEPIEKKAI 792

  Fly   855 PK---TLQYLMDVKTYIKWPTAKEDRKLFWKRLKRSLE 889
            |:   .|:.:|:.|||::||..:..|::||..|:.:::
  Rat   793 PQRFCKLRKIMNTKTYLEWPLDEGQREVFWANLRTAIK 830

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-9	NP_001246846.1	leucine-rich repeat	157..185	CDD:275380	8/27 (30%)
		LRR_8	262..322	CDD:290566	18/63 (29%)
		leucine-rich repeat	264..287	CDD:275380	8/25 (32%)
		leucine-rich repeat	288..311	CDD:275380	5/23 (22%)
		leucine-rich repeat	312..356	CDD:275380	12/57 (21%)
		LRR_8	<344..387	CDD:290566	9/63 (14%)
		leucine-rich repeat	357..381	CDD:275380	3/42 (7%)
		leucine-rich repeat	382..397	CDD:275380	5/16 (31%)
		leucine-rich repeat	405..430	CDD:275380	9/24 (38%)
		LRR_8	431..488	CDD:290566	17/80 (21%)
		leucine-rich repeat	432..453	CDD:275380	4/24 (17%)
		LRR_RI	<449..536	CDD:238064	30/126 (24%)
		leucine-rich repeat	454..477	CDD:275380	5/42 (12%)
		LRR_8	477..536	CDD:290566	22/78 (28%)
		leucine-rich repeat	478..501	CDD:275380	9/42 (21%)
		leucine-rich repeat	502..525	CDD:275380	8/22 (36%)
		TIR	751..891	CDD:214587	49/143 (34%)
Tlr2	XP_008759324.3	leucine-rich repeat	101..124	CDD:275378	10/28 (36%)
		LRR_8	124..182	CDD:404697	15/69 (22%)
		leucine-rich repeat	125..148	CDD:275378	8/34 (24%)
		leucine-rich repeat	149..172	CDD:275378	0/22 (0%)
		leucine-rich repeat	173..197	CDD:275378	11/63 (17%)
		leucine-rich repeat	229..249	CDD:275380	4/19 (21%)
		leucine-rich repeat	250..270	CDD:275380	5/23 (22%)
		PRK15370	<387..>605	CDD:185268	51/255 (20%)
		leucine-rich repeat	409..435	CDD:275380	9/25 (36%)
		leucine-rich repeat	436..461	CDD:275380	4/24 (17%)
		leucine-rich repeat	462..484	CDD:275380	4/21 (19%)
		leucine-rich repeat	485..505	CDD:275380	1/19 (5%)
		leucine-rich repeat	506..525	CDD:275380	8/20 (40%)
		leucine-rich repeat	526..547	CDD:275380	1/20 (5%)
		leucine-rich repeat	548..571	CDD:275380	8/22 (36%)
		LRRCT	580..633	CDD:214507	17/124 (14%)
		TIR	687..831	CDD:214587	49/144 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	113	1.000	Domainoid score	I5971
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I4128
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	8.030