DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-9 and Tlr4

DIOPT Version :9

Sequence 1:NP_001246846.1 Gene:Toll-9 / 40245 FlyBaseID:FBgn0036978 Length:900 Species:Drosophila melanogaster
Sequence 2:NP_062051.2 Gene:Tlr4 / 29260 RGDID:3870 Length:835 Species:Rattus norvegicus


Alignment Length:927 Identity:204/927 - (22%)
Similarity:345/927 - (37%) Gaps:247/927 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    70 NSCLLDLIKDEVIWWQFPNGT---LRDSTKKYAHKL-----YLDLSHGNLKDDSDLFREAKLSRK 126
            |.|:      ||:    ||.|   :..:..|..|.:     .||||...||    :.|....|..
  Rat    26 NPCI------EVL----PNITYQCMDQNLSKIPHDIPYSTKNLDLSFNPLK----ILRSYSFSNF 76

  Fly   127 VTIWRTEVFSAAFNTLTAAPFRTLYSMRESLKLLSLRGNNFAELIPDAEDFARFVNESRLEASNS 191
            ..:...::......|:....:..|    ..|..|.|.||......|.:  |:...|...|.|..:
  Rat    77 SQLQWLDLSRCEIETIEDKAWHGL----NQLSTLVLTGNPIKSFSPGS--FSGLTNLENLVAVET 135

  Fly   192 VP------HHCELLLL------HNTTDLYDRECYLYFNNNTNMGQSITTGRNYTNFIKVLKDRF- 243
            ..      |..:|:.|      ||.  ::..:...||:|.||: :.:....||...|.|...:| 
  Rat   136 KMTSLEGFHIGQLISLKKLNVAHNL--IHSFKLPEYFSNLTNL-EHVDLSYNYIQTISVKDLQFL 197

  Fly   244 ----------DQHGSSSQSIAWATFPKMPRLVELDI-SNCSIEYVSKEAFRNVSNL--------- 288
                      |...:...||....|..: ||.||.: ||.:...|.|...:|::.|         
  Rat   198 RENPQVNLSLDLSLNPIDSIQAQAFQGI-RLHELTLRSNFNSSNVLKMCLQNMTGLHVHRLILGE 261

  Fly   289 ----RRLFMSDNKIM----TISHDTF------YYVQGVQYLD-------LSFT------------ 320
                |.|...|..:|    .:|.|.|      ::...:..|:       :|||            
  Rat   262 FKNERNLESFDRSVMEGLCNVSIDEFRLTYINHFSDDIYNLNCLANISAMSFTGVHIKHIADVPR 326

  Fly   321 NFLTYSYQL------QLPTLEMALSLIYGLKIQQNVFKY----LPELIYLDLSHSKMTRNSAVAF 375
            :|...|..:      ..|.|.:.....:.|...:....:    ||.|.|||||.:.|:.....::
  Rat   327 HFKWQSLSIIRCHLKPFPKLSLPFLKSWTLTTNREDISFGQLALPSLRYLDLSRNAMSFRGCCSY 391

  Fly   376 AHLG-DKLKFLSLCYTAIPMVSSTIFKNTVLEGLDLSGNPYLSYNIIDDAFDGIANTLKYLYFER 439
            :..| :.||:|.|.:..:.::|:...      ||:                     .|:||.|:.
  Rat   392 SDFGTNNLKYLDLSFNGVILMSANFM------GLE---------------------ELEYLDFQH 429

  Fly   440 SNIKDL-EWS--KSLKNLQVLGLAGNNINALTPAMFQSLESLEILDLSSNHV-GNWYRSAFHNNS 500
            |.:|.: |:|  .||:.|..|.::..|.......:|..|.||..|.::.|.. .|...:.|.|.:
  Rat   430 STLKKVTEFSVFLSLEKLLYLDISYTNTKIDFDGIFLGLISLNTLKMAGNSFKDNTLSNVFTNTT 494

  Fly   501 ALRVLNLRSNTINMLSNEMLKDFERLDYLSLGDND--FICDCHLRAVVEVAAANNKDADCSYRLL 563
            .|..|:|....:..:|..:.....||..|::..|:  |:...|.:.:..:     :..|||:..:
  Rat   495 NLTFLDLSKCQLEQISRGVFDTLYRLQLLNMSHNNLLFLDPSHYKQLYSL-----RTLDCSFNRI 554

  Fly   564 NYSQNAVGEEVISLAESLIIDRKLWQSRYIPWLQRSYSNIREFNRANHIIKLRFSSEDYM----- 623
            ..|:..                          ||....::..||..|:.:......::::     
  Rat   555 ETSKGI--------------------------LQHFPKSLAVFNLTNNSVACICEYQNFLQWVKD 593

  Fly   624 -------VAKCSAAQPYHLGDLDGDLTLKFQLLDYEASQYYCFNNTDQLQVDELNCQIRSMSDLA 681
                   |.:...|.|                :|.:||....|.|:        .|         
  Rat   594 QKMFLVNVEQMKCASP----------------IDMKASLVLDFTNS--------TC--------- 625

  Fly   682 EELHHVTNTVIAV-MGSLVGACILGFIIYLKRWHIHYYYSSLKSAALLSSASKESVNKFTNISQR 745
                ::..|:|:| :.|::....:.|:||      |:|:..:    |::...|.|..:       
  Rat   626 ----YIYKTIISVSVVSVLVVATVAFLIY------HFYFHLI----LIAGCKKYSRGE------- 669

  Fly   746 DPSAVYDIFISYCQNDRTWVLNELLPNVEE-TGDVSICLHERDFQIGVTILDNII-SCMDRSYSL 808
               ::||.|:.|...:..||.|||:.|:|| .....:|||.|||..||.|..||| ....:|..:
  Rat   670 ---SIYDAFVIYSSQNEDWVRNELVKNLEEGVPRFQLCLHYRDFIPGVAIAANIIQEGFHKSRKV 731

  Fly   809 MLIISSKFLLSHWCQFEMYLAQHRIFEVSKEHLILVFLEDIPRR--KRPKTLQYLMDVKTYIKWP 871
            ::::|..|:.|.||.||..:||...|..|:..:|.:.||.:.:.  ::...|..|:...||::|.
  Rat   732 IVVVSRHFIQSRWCIFEYEIAQTWQFLSSRSGIIFIVLEKVEKSLLRQQVELYRLLSRNTYLEWE 796

  Fly   872 TAKEDRKLFWKRLKRSL 888
            .....|.:||:|||::|
  Rat   797 DNALGRHIFWRRLKKAL 813

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-9NP_001246846.1 leucine-rich repeat 157..185 CDD:275380 8/27 (30%)
LRR_8 262..322 CDD:290566 21/102 (21%)
leucine-rich repeat 264..287 CDD:275380 8/23 (35%)
leucine-rich repeat 288..311 CDD:275380 8/45 (18%)
leucine-rich repeat 312..356 CDD:275380 10/72 (14%)
LRR_8 <344..387 CDD:290566 14/47 (30%)
leucine-rich repeat 357..381 CDD:275380 8/24 (33%)
leucine-rich repeat 382..397 CDD:275380 4/14 (29%)
leucine-rich repeat 405..430 CDD:275380 2/24 (8%)
LRR_8 431..488 CDD:290566 19/59 (32%)
leucine-rich repeat 432..453 CDD:275380 10/23 (43%)
LRR_RI <449..536 CDD:238064 22/89 (25%)
leucine-rich repeat 454..477 CDD:275380 5/22 (23%)
LRR_8 477..536 CDD:290566 15/61 (25%)
leucine-rich repeat 478..501 CDD:275380 6/23 (26%)
leucine-rich repeat 502..525 CDD:275380 4/22 (18%)
TIR 751..891 CDD:214587 51/142 (36%)
Tlr4NP_062051.2 PLN00113 23..>456 CDD:215061 103/480 (21%)
LRR 1 54..75 7/24 (29%)
leucine-rich repeat 58..78 CDD:275380 8/23 (35%)
LRR 2 78..99 1/20 (5%)
leucine-rich repeat 79..102 CDD:275380 2/26 (8%)
LRR 3 102..123 7/22 (32%)
leucine-rich repeat 103..126 CDD:275380 7/24 (29%)
LRR 4 126..147 4/20 (20%)
leucine-rich repeat 127..150 CDD:275380 4/22 (18%)
LRR 5 150..171 4/22 (18%)
leucine-rich repeat 151..175 CDD:275380 6/25 (24%)
LRR 6 175..198 6/23 (26%)
leucine-rich repeat 176..204 CDD:275380 5/28 (18%)
LRR 7 204..224 4/19 (21%)
leucine-rich repeat 205..226 CDD:275380 4/21 (19%)
LRR 8 226..247 8/20 (40%)
leucine-rich repeat 256..310 CDD:275380 8/53 (15%)
LRR 9 372..381 6/8 (75%)
leucine-rich repeat 373..398 CDD:275380 8/24 (33%)
LRR 10 398..420 6/27 (22%)
leucine-rich repeat 399..421 CDD:275380 7/48 (15%)
LRR 11 421..442 8/20 (40%)
leucine-rich repeat 422..446 CDD:275380 10/23 (43%)
LRR 12 446..467 4/20 (20%)
leucine-rich repeat 447..470 CDD:275380 5/22 (23%)
LRR 13 470..491 5/20 (25%)
leucine-rich repeat 471..495 CDD:275380 6/23 (26%)
LRR_8 494..554 CDD:404697 13/64 (20%)
LRR 14 495..516 4/20 (20%)
leucine-rich repeat 496..519 CDD:275380 4/22 (18%)
LRR 15 519..540 6/20 (30%)
leucine-rich repeat 520..543 CDD:275380 5/22 (23%)
LRR 16 543..564 6/51 (12%)
leucine-rich repeat 544..567 CDD:275380 6/53 (11%)
TIR 672..813 CDD:214587 50/140 (36%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24365
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
33.020

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