DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-9 and GP1BA

DIOPT Version :9

Sequence 1:NP_001246846.1 Gene:Toll-9 / 40245 FlyBaseID:FBgn0036978 Length:900 Species:Drosophila melanogaster
Sequence 2:NP_000164.5 Gene:GP1BA / 2811 HGNCID:4439 Length:652 Species:Homo sapiens


Alignment Length:397 Identity:78/397 - (19%)
Similarity:147/397 - (37%) Gaps:118/397 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   390 TAIPMVSSTIFKNTVLEGLDLSGNPYLSYNIIDDAFDGIANTLKY-----LYFERSNIKDLEWSK 449
            ||:|   ..:.|:|.:  |.||.|...:::        :|..:.|     |..:|..:..|:...
Human    39 TALP---PDLPKDTTI--LHLSENLLYTFS--------LATLMPYTRLTQLNLDRCELTKLQVDG 90

  Fly   450 SLKNLQVLGLAGNNINALTPAMFQSLESLEILDLSSNHVGNWYRSAFHNNSALRVLNLRSNTINM 514
            :|..|..|.|:.|.:.:| |.:.|:|.:|.:||:|.|.:.:....|......|:.|.|:.|.:..
Human    91 TLPVLGTLDLSHNQLQSL-PLLGQTLPALTVLDVSFNRLTSLPLGALRGLGELQELYLKGNELKT 154

  Fly   515 LSNEMLKDFERLDYLSLGDNDFICDCHLRAVVEVAAANNKDADCSYRLLNYSQNAVGEEVISLAE 579
            |...:|....:|:.|||.:|:         :.|:.|.          |||..:|.   :.:.|.|
Human   155 LPPGLLTPTPKLEKLSLANNN---------LTELPAG----------LLNGLENL---DTLLLQE 197

  Fly   580 SLI--IDRKLWQSRYIP--------------------WLQRSYSNIREFNRANHIIKLRFSSEDY 622
            :.:  |.:..:.|..:|                    |||.:..|:..:.:.   :.::..:.:.
Human   198 NSLYTIPKGFFGSHLLPFAFLHGNPWLCNCEILYFRRWLQDNAENVYVWKQG---VDVKAMTSNV 259

  Fly   623 MVAKCSAAQPY-----------HLGDLDGDLTLKFQLLDYEASQYYCFNNTDQLQVDELNCQIRS 676
            ...:|..:..:           .||| :||..|      |:   ||...:|:..:|         
Human   260 ASVQCDNSDKFPVYKYPGKGCPTLGD-EGDTDL------YD---YYPEEDTEGDKV--------- 305

  Fly   677 MSDLAEELHHVTNTVIAVMGSLVGACILGFIIYLKRWHIHYYYSSLKSAALLSSA---SKESVNK 738
                     ..|.||:.....          .:...|.:.|.:|:....:.:.|:   ::||..:
Human   306 ---------RATRTVVKFPTK----------AHTTPWGLFYSWSTASLDSQMPSSLHPTQESTKE 351

  Fly   739 FTNISQR 745
            .|....|
Human   352 QTTFPPR 358

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-9NP_001246846.1 leucine-rich repeat 157..185 CDD:275380
LRR_8 262..322 CDD:290566
leucine-rich repeat 264..287 CDD:275380
leucine-rich repeat 288..311 CDD:275380
leucine-rich repeat 312..356 CDD:275380
LRR_8 <344..387 CDD:290566
leucine-rich repeat 357..381 CDD:275380
leucine-rich repeat 382..397 CDD:275380 3/6 (50%)
leucine-rich repeat 405..430 CDD:275380 4/24 (17%)
LRR_8 431..488 CDD:290566 18/61 (30%)
leucine-rich repeat 432..453 CDD:275380 5/25 (20%)
LRR_RI <449..536 CDD:238064 26/86 (30%)
leucine-rich repeat 454..477 CDD:275380 8/22 (36%)
LRR_8 477..536 CDD:290566 17/58 (29%)
leucine-rich repeat 478..501 CDD:275380 6/22 (27%)
leucine-rich repeat 502..525 CDD:275380 6/22 (27%)
TIR 751..891 CDD:214587
GP1BANP_000164.5 LRRNT 19..50 CDD:214470 4/13 (31%)
leucine-rich repeat 30..48 CDD:275380 3/11 (27%)
LRR 1 48..68 6/29 (21%)
leucine-rich repeat 49..72 CDD:275380 7/32 (22%)
LRR_RI <51..200 CDD:238064 43/181 (24%)
LRR_8 71..128 CDD:290566 17/57 (30%)
LRR 2 72..93 3/20 (15%)
leucine-rich repeat 73..94 CDD:275380 4/20 (20%)
LRR 3 94..115 7/21 (33%)
leucine-rich repeat 95..117 CDD:275380 8/22 (36%)
LRR_8 116..176 CDD:290566 17/68 (25%)
LRR 4 117..137 6/19 (32%)
leucine-rich repeat 118..141 CDD:275380 6/22 (27%)
LRR 5 141..162 6/20 (30%)
leucine-rich repeat 142..165 CDD:275380 6/22 (27%)
LRR_8 164..222 CDD:290566 16/79 (20%)
LRR 6 165..186 9/39 (23%)
leucine-rich repeat 166..189 CDD:275380 10/41 (24%)
LRR 7 189..210 4/23 (17%)
leucine-rich repeat 190..210 CDD:275380 3/22 (14%)
leucine-rich repeat 213..225 CDD:275378 1/11 (9%)
LRRCT 221..281 CDD:214507 5/62 (8%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 336..459 5/23 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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