DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-9 and Tlr13

DIOPT Version :9

Sequence 1:	NP_001246846.1	Gene:	Toll-9 / 40245	FlyBaseID:	FBgn0036978	Length:	900	Species:	Drosophila melanogaster
Sequence 2:	NP_991389.1	Gene:	Tlr13 / 279572	MGIID:	3045213	Length:	991	Species:	Mus musculus

Alignment Length:	1056	Identity:	241/1056 - (22%)
Similarity:	402/1056 - (38%)	Gaps:	323/1056 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 CPKYIWDVIVLVCL--FLGNVREAYTEF------------SIQDGLIIEPDSATTSSEEAEEVSK 52
            |.:|.:|:..::|:  .:.|:.||.::.            .||   ::.|.|.|..|.
Mouse    74 CTQYEFDIHHVLCIRKKITNLTEAISDIPRYTTHLNLTHNEIQ---VLPPWSFTNLSA------- 128

  Fly    53 ERTDLKSLMLKYES----DDG------NSCLLDLIKDEVIWWQFPNG---------TLRDSTKKY 98
                |..|.|::.|    |:|      |..||:|:::::   |..|.         ||..|..:.
Mouse   129 ----LVDLRLEWNSIWKIDEGAFRGLENLTLLNLVENKI---QSVNNSFEGLSSLKTLLLSHNQI 186

  Fly    99 AH----------KL-YLDLSHGNLKDDSDLFREAKLSRKVTIWRTEVFSAAFNTLTAAPFRTLYS 152
            .|          || ||.||..|:.|.|.:. || :.....:.|.::.:.:...|..:| |:|.|
Mouse   187 THIHKDAFTPLIKLKYLSLSRNNISDFSGIL-EA-VQHLPCLERLDLTNNSIMYLDHSP-RSLVS 248

  Fly   153 MRESLKLLSLRGNNFAELIPDAEDFARFVNESRLEASNSVPHHCEL---------------LLLH 202
            :..    ||..||...||...|.......|.|.....|.|..:..|               :.|.
Mouse   249 LTH----LSFEGNKLRELNFSALSLPNLTNLSASRNGNKVIQNVYLKTLPQLKSLNLSGTVIKLE 309

  Fly   203 NTT----------DLYDRE-----------CYLYFNNNTNMGQSITTGRNYTN------FIKVLK 240
            |.:          ||.:.|           |:|.  .|....:::...:|.||      ..|..:
Mouse   310 NLSAKHLQNLRAMDLSNWELRHGHLDMKTVCHLL--GNLPKLETLVFQKNVTNAEGIKQLAKCTR 372

  Fly   241 DRFDQHGSSSQSIAW--ATFPKMPRLVELDISNCSIEYVSKEAFRNVSNLRRLFMSDNKIMTISH 303
            ..|...|.:|..|..  :.|..:|.|.:|:::.|.:.:::...:.::.||..|.:|.||..:...
Mouse   373 LLFLDLGQNSDLIYLNDSEFNALPSLQKLNLNKCQLSFINNRTWSSLQNLTSLDLSHNKFKSFPD 437

  Fly   304 DTFYYVQGVQYLDLSFT-----NFLTYSYQLQLPTLEMALSLIYGLKIQQNVFKYLPELIYLDLS 363
            ..|..::.:::|.||..     |.|.:|....|..|.:|...|  :.|.:..|...|.|..|||.
Mouse   438 FAFSPLKHLEFLSLSRNPITELNNLAFSGLFALKELNLAACWI--VTIDRYSFTQFPNLEVLDLG 500

  Fly   364 HSKMTRNSAVAFAHLGDKLKFLSLCYTAIPMVSSTIFKN-TVLEGLDLSGNPYLSYNIIDDAFDG 427
            .:.:...:...|..| .||:.|.|.:..:.::....|.. |.|..|||..|. ||| ..:..|.|
Mouse   501 DNNIRTLNHGTFRPL-KKLQSLILSHNCLKILEPNSFSGLTNLRSLDLMYNS-LSY-FHEHLFSG 562

  Fly   428 I-----------------ANTLKY-LYFERSNIKDLEWSKSLKNLQV--------LG-----LAG 461
            :                 ..||:| .:.:..::|.|........:||        ||     |.|
Mouse   563 LEKLLILKLGFNKITYETTRTLQYPPFIKLKSLKQLNLEGQRHGIQVVPSNFFQGLGSLQELLLG 627

  Fly   462 NN-------------INA----------------LTPAMFQSLESLEILDLSSNHVGNWYRSAFH 497
            .|             ||.                |..::||:|:.|:||.|.:|::.:.....|.
Mouse   628 KNPSVFLDHHQFDPLINLTKLDISGTKDGDRSLYLNASLFQNLKRLKILRLENNNLESLVPDMFS 692

  Fly   498 NNSALRVLNLRSNTINMLSNEMLKDFERLDYLSLGDNDFICDCHLRAVVEVAAANNKDADCSYRL 562
            :..:|:|.:||.|.:.:::...||:.:.|.:..:..|...|.|.                 :...
Mouse   693 SLQSLQVFSLRFNNLKVINQSHLKNLKSLMFFDVYGNKLQCTCD-----------------NLWF 740

  Fly   563 LNYSQNAVGEEVISLAESLIIDRKLWQSRYIPWLQRSYSNIREFNRANHIIKLRFSSEDYMVAKC 627
            .|:|.|.  |||                 :||:| |||                         .|
Mouse   741 KNWSMNT--EEV-----------------HIPFL-RSY-------------------------PC 760

  Fly   628 SAAQPYHLGDLDGDLTLKFQLLDYEASQYYCFNNTDQLQVDELNCQIRSMSDLAE-----ELHHV 687
            .  ||       |..:|   |:|:                |:..|..    ||.:     ....|
Mouse   761 Q--QP-------GSQSL---LIDF----------------DDAMCNF----DLGKVYFLCSFSMV 793

  Fly   688 TNTVIAVMGS--LVGACILGFII----YLKRWHIHYYYSSLKSAALLSSASKESVNKFTNISQRD 746
            .:|::....|  ::.:...|..|    ||.:||                   ::..||
Mouse   794 LSTMVFSWFSTKMIASLWYGLYICRAWYLTKWH-------------------KTEKKF------- 832

  Fly   747 PSAVYDIFISYCQNDRTWVLNELLPNVEETGDVS--ICLHERDFQIGVTILDNIISCMDRSYSLM 809
               :||.|:|:...|..||..||:|.:|:....:  :|||:|||:.|:.|.:||.:.::.|...:
Mouse   833 ---LYDAFVSFSATDEAWVYKELVPALEQGSQTTFKLCLHQRDFEPGIDIFENIQNAINTSRKTL 894

  Fly   810 LIISSKFLLSHWCQFEMYLAQHRIFEVSKEHLILVFLEDIPRRKRPK--TLQYLMDVKTYIKWPT 872
            .::|:.:|.|.||:.|:.||..::|...|:.:||:|||:||..|...  .|:.|::.:|:|.||.
Mouse   895 CVVSNHYLHSEWCRLEVQLASMKMFYEHKDVIILIFLEEIPNYKLSSYHRLRKLINKQTFITWPD 959

  Fly   873 AKEDRKLFWKRLKRSL 888
            :...:.|||.|::.:|
Mouse   960 SVHQQPLFWARIRNAL 975

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-9	NP_001246846.1	leucine-rich repeat	157..185	CDD:275380	8/27 (30%)
		LRR_8	262..322	CDD:290566	14/64 (22%)
		leucine-rich repeat	264..287	CDD:275380	3/22 (14%)
		leucine-rich repeat	288..311	CDD:275380	6/22 (27%)
		leucine-rich repeat	312..356	CDD:275380	12/48 (25%)
		LRR_8	<344..387	CDD:290566	12/42 (29%)
		leucine-rich repeat	357..381	CDD:275380	6/23 (26%)
		leucine-rich repeat	382..397	CDD:275380	3/14 (21%)
		leucine-rich repeat	405..430	CDD:275380	10/41 (24%)
		LRR_8	431..488	CDD:290566	23/99 (23%)
		leucine-rich repeat	432..453	CDD:275380	4/21 (19%)
		LRR_RI	<449..536	CDD:238064	28/128 (22%)
		leucine-rich repeat	454..477	CDD:275380	13/64 (20%)
		LRR_8	477..536	CDD:290566	15/58 (26%)
		leucine-rich repeat	478..501	CDD:275380	6/22 (27%)
		leucine-rich repeat	502..525	CDD:275380	7/22 (32%)
		TIR	751..891	CDD:214587	51/142 (36%)
Tlr13	NP_991389.1	LRR 1	104..125		4/23 (17%)
		leucine-rich repeat	105..128	CDD:275380	5/25 (20%)
		LRR_8	106..163	CDD:290566	16/70 (23%)
		LRR 2	128..149		6/31 (19%)
		leucine-rich repeat	129..152	CDD:275380	6/22 (27%)
		LRR 3	152..174		6/24 (25%)
		leucine-rich repeat	153..175	CDD:275380	5/24 (21%)
		LRR 4	175..196		4/20 (20%)
		leucine-rich repeat	176..199	CDD:275380	4/22 (18%)
		LRR_8	183..236	CDD:290566	13/54 (24%)
		LRR_RI	<192..405	CDD:238064	49/221 (22%)
		LRR 5	199..220		11/22 (50%)
		leucine-rich repeat	200..225	CDD:275380	10/26 (38%)
		LRR 6	225..246		4/21 (19%)
		leucine-rich repeat	226..248	CDD:275380	5/22 (23%)
		LRR 7	248..268		8/23 (35%)
		leucine-rich repeat	249..271	CDD:275380	7/25 (28%)
		LRR 8	271..292		5/20 (25%)
		leucine-rich repeat	272..295	CDD:275380	5/22 (23%)
		LRR 9	295..315		2/19 (11%)
		leucine-rich repeat	296..319	CDD:275380	2/22 (9%)
		LRR 10	318..338		3/19 (16%)
		LRR 11	348..368		3/19 (16%)
		LRR 12	372..394		5/21 (24%)
		leucine-rich repeat	373..397	CDD:275380	5/23 (22%)
		LRR_8	396..456	CDD:290566	14/59 (24%)
		LRR 13	397..418		3/20 (15%)
		leucine-rich repeat	398..421	CDD:275380	3/22 (14%)
		LRR_4	420..463	CDD:289563	11/42 (26%)
		LRR 14	421..442		7/20 (35%)
		leucine-rich repeat	422..445	CDD:275380	6/22 (27%)
		LRR 15	445..466		5/20 (25%)
		leucine-rich repeat	446..469	CDD:275380	6/22 (27%)
		LRR 16	469..490		6/22 (27%)
		leucine-rich repeat	470..493	CDD:275380	6/24 (25%)
		LRR_8	492..552	CDD:290566	18/61 (30%)
		LRR 17	493..514		5/20 (25%)
		leucine-rich repeat	494..517	CDD:275380	6/23 (26%)
		LRR 18	517..538		5/20 (25%)
		leucine-rich repeat	518..541	CDD:275380	4/22 (18%)
		LRR_8	540..602	CDD:290566	16/63 (25%)
		LRR 19	541..562		9/22 (41%)
		leucine-rich repeat	542..565	CDD:275380	10/24 (42%)
		LRR 20	565..585		1/19 (5%)
		leucine-rich repeat	566..585	CDD:275380	1/18 (6%)
		LRR 21	594..617		4/22 (18%)
		LRR 22	620..641		3/20 (15%)
		LRR 23	644..665		2/20 (10%)
		LRR_8	671..731	CDD:290566	15/59 (25%)
		LRR 24	672..693		6/20 (30%)
		leucine-rich repeat	673..696	CDD:275380	6/22 (27%)
		LRR 25	696..716		5/19 (26%)
		leucine-rich repeat	697..718	CDD:275380	7/20 (35%)
		TIR	834..976	CDD:214587	51/142 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	1	1.000	-	-		otm43917
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020