DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-9 and Tlr11

DIOPT Version :9

Sequence 1:	NP_001246846.1	Gene:	Toll-9 / 40245	FlyBaseID:	FBgn0036978	Length:	900	Species:	Drosophila melanogaster
Sequence 2:	NP_991388.2	Gene:	Tlr11 / 239081	MGIID:	3045226	Length:	931	Species:	Mus musculus

Alignment Length:	1026	Identity:	224/1026 - (21%)
Similarity:	365/1026 - (35%)	Gaps:	290/1026 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 LKSLMLKYESDDGNSCLLDLIKDEVI------W-WQFPNGTLRDS----TKKY-------AHKLY 103
            ||..|.:.|.....|.||.||...::      | |..|:..:.||    ...|       |..|:
Mouse     2 LKESMPRMERHQFCSVLLILILLTLVSLTLTGWAWTIPDCIIADSLLFPNLSYYIPFCTSAPGLH 66

  Fly   104 LDLSHGNLKDDSDLFREAKLSRKVTIWRTEVFSAAFNTLTAAPFRTLYSMRESLKLLSLRGNNFA 168
            |..|..|:|:.:                        .||...|..|        ::|.|:|
Mouse    67 LLASCSNVKNLN------------------------QTLKRVPRNT--------EVLCLQG---- 95

  Fly   169 ELIP--DAEDFARFVNESRLEASNSVPHHCELLLLH-NTTDL-------YDRECYLYFNNNTNMG 223
             ::|  .|:.|.||             |..:||.|. .||.:       .|:..||:|:::....
Mouse    96 -MVPTLPAKAFIRF-------------HSLQLLRLQLRTTSVTSRTFQGLDQLQYLFFDHHAPCC 146

  Fly   224 QSITTGRNYTNFIKVLKDRFDQHG---SSSQSIAWATFPKMPRLVELDISN-CSIEYVSKEAFRN 284
            .|:....|....::.|.....| |   :.||||...|     .|..|.:.| |..::
Mouse   147 LSLFLSPNCFESLRSLSSLSFQ-GYCLTYSQSIYLPT-----SLRHLTLRNSCLTKF-------- 197

  Fly   285 VSNLRRLFMSDNKIMTISHDTFYYVQGVQYLDLSFTNFLTYSYQLQLPTLEMALSLIYGLKIQQN 349
             .:|:|||..   ::..:..|.....|..:|:.     |..||.|||.  :..:..:|||.:...
Mouse   198 -QDLQRLFPD---LLLSTSSTPNIKPGAPFLET-----LDLSYNLQLK--QAGVRDLYGLTLHSL 251

  Fly   350 VFKYLPELIYLDLSHSKMTRNSAVAFAHLGDKLKFLSLCYTAIPMVSSTIFKNTVLEGLDLSGNP 414
            :....| |..|||:.|.:..            |.||||..|.|..|.:::...:.|..|||..|.
Mouse   252 ILDGTP-LKALDLTDSGLLH------------LHFLSLVGTGIEKVPASLTGYSELRALDLGKNQ 303

  Fly   415 YLSYNIIDDA-------------FDGIANTL--KYLY------------------------FERS 440
            .  .||:::.             .|....||  ::|:                        ...:
Mouse   304 I--QNILENGEIPGYKALEFLSLHDNHLQTLPTRFLHTLPQLQKLNLSMNKLGPILELPEGLFST 366

  Fly   441 NIKDLEWSKS------------LKNLQVLGLAGNNINALTPAMFQSLESLEILDLSSNHVGNWYR 493
            |:|.|:.|.:            |..||.|.|:||||::|:....|.|..|..||||.|.:.....
Mouse   367 NLKVLDLSYNQLCDVPHGALSLLSQLQELWLSGNNISSLSNESLQGLRQLRTLDLSWNQIKVLKP 431

  Fly   494 SAFHNNSALRVLNLRSNTINMLSNEMLKDFERLDYLSLGDNDFICDCHLRAVVEVAAANNKDADC 558
            ....:..||..|||....:..:....|:..:.|.:|.||... |.|.:......:.:...:...|
Mouse   432 GWLSHLPALTTLNLLGTYLEYILGIQLQGPKMLRHLQLGSYP-ILDIYPPWPPTLLSLEIQAESC 495

  Fly   559 SYRLLNYSQNAVGEEVISLAESLIIDRKLWQSRYIPWLQ----RSYSNIREFNRANHIIKLRFSS 619
            ...:::..|..:..|.::|..|:::.:....:.:.|.|:    |.||.|...::.......:...
Mouse   496 IQFMIHSGQPFLFLENLTLETSILLLKPDNITIHFPSLRRLTLRGYSFIFSTSQLQRFFPQQLPL 560

  Fly   620 EDYMVAKCS---AAQPY----------HLGDLD---GDLTLKFQLLDYEASQYYCFNNTDQLQV- 667
            .::....|.   |...|          .||.|:   ...|:|.::|         .....||||
Mouse   561 LEHFFIWCENSYAVDLYLFGMPRLRVLELGYLNFFYESSTMKLEML---------LKEVPQLQVL 616

  Fly   668 --DELNCQ------IRSMSDL---------AEELHHVTNTVIAVMGSLVGACILGFII-----YL 710
              ..||.:      .:|:.||         |.|::......|..|...|....:.|..     :|
Mouse   617 ALSHLNLRNLSVSSFKSLQDLKLLLFNSERALEMNSNLQEFIPQMPQYVYFSDVTFTCQCEASWL 681

  Fly   711 KRWHIH----YYYSSLKSAALLSSASKESVNKFTNISQRDPSAV--------------------- 750
            :.|...    :.|...||..:.:::.......|:.::...|...
Mouse   682 ESWATRAPNTFVYGLEKSICIANASDYSKTLLFSFLATNCPHGTEFWGFLTSFILLLLLIILPLI 746

  Fly   751 --------------------------------YDIFISYCQNDRTWVLNELLPNVE----ETGDV 779
                                            ||:|||||:.|:.|||.||:|.:|    |...:
Mouse   747 SCPKWSWLHHLWTLFHTCWWKLCGHRLRGQFNYDVFISYCEEDQAWVLEELVPVLEKAPPEGEGL 811

  Fly   780 SICLHERDFQIGVTILDNIISCMDRSYSLMLIISSKFLLSHWCQFEMYLA-QHRIFEVSKEHLIL 843
            .:||..|||.||...::::|:.|.:|.:.:.:::.:.|.|.||..|:.|| .|.:......||:|
Mouse   812 RLCLPARDFGIGNDRMESMIASMGKSRATLCVLTGQALASPWCNLELRLATYHLVARPGTTHLLL 876

  Fly   844 VFLEDIPRRKRPK--TLQYLMDVKTYIKWPTAKEDRKLFWKRLKRSLEVIG 892
            :|||.:.|::...  .|...:..:.|......|.:...|.::|||.|...|
Mouse   877 LFLEPLDRQRLHSYHRLSRWLQKEDYFDLSQGKVEWNSFCEQLKRRLSKAG 927

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-9	NP_001246846.1	leucine-rich repeat	157..185	CDD:275380	8/29 (28%)
		LRR_8	262..322	CDD:290566	11/60 (18%)
		leucine-rich repeat	264..287	CDD:275380	4/23 (17%)
		leucine-rich repeat	288..311	CDD:275380	5/22 (23%)
		leucine-rich repeat	312..356	CDD:275380	10/43 (23%)
		LRR_8	<344..387	CDD:290566	10/42 (24%)
		leucine-rich repeat	357..381	CDD:275380	5/23 (22%)
		leucine-rich repeat	382..397	CDD:275380	8/14 (57%)
		leucine-rich repeat	405..430	CDD:275380	8/37 (22%)
		LRR_8	431..488	CDD:290566	25/94 (27%)
		leucine-rich repeat	432..453	CDD:275380	7/58 (12%)
		LRR_RI	<449..536	CDD:238064	28/98 (29%)
		leucine-rich repeat	454..477	CDD:275380	11/22 (50%)
		LRR_8	477..536	CDD:290566	16/58 (28%)
		leucine-rich repeat	478..501	CDD:275380	6/22 (27%)
		leucine-rich repeat	502..525	CDD:275380	5/22 (23%)
		TIR	751..891	CDD:214587	49/146 (34%)
Tlr11	NP_991388.2	LRR_RI	<184..427	CDD:238064	67/276 (24%)
		leucine-rich repeat	224..246	CDD:275380	8/28 (29%)
		leucine-rich repeat	248..270	CDD:275380	6/22 (27%)
		leucine-rich repeat	271..293	CDD:275380	8/21 (38%)
		leucine-rich repeat	294..318	CDD:275380	7/25 (28%)
		LRR_8	319..378	CDD:290566	8/58 (14%)
		leucine-rich repeat	319..342	CDD:275380	4/22 (18%)
		leucine-rich repeat	343..367	CDD:275380	0/23 (0%)
		LRR_8	366..426	CDD:290566	22/59 (37%)
		leucine-rich repeat	368..391	CDD:275380	4/22 (18%)
		leucine-rich repeat	392..415	CDD:275380	11/22 (50%)
		LRR_8	414..471	CDD:290566	15/56 (27%)
		leucine-rich repeat	416..437	CDD:275380	6/20 (30%)
		leucine-rich repeat	440..463	CDD:275380	5/22 (23%)
		TIR_2	781..>861	CDD:290400	29/79 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020