DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-9 and Tlr6

DIOPT Version :9

Sequence 1:	NP_001246846.1	Gene:	Toll-9 / 40245	FlyBaseID:	FBgn0036978	Length:	900	Species:	Drosophila melanogaster
Sequence 2:	XP_030110224.1	Gene:	Tlr6 / 21899	MGIID:	1341296	Length:	806	Species:	Mus musculus

Alignment Length:	890	Identity:	197/890 - (22%)
Similarity:	334/890 - (37%)	Gaps:	294/890 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 YLDLSHGNLKDDS----DLFREAKLSRKVTIWRTEVFSAAFNTLTAAPFRTLYSMRESLKLLSLR 163
            |||:||..|::.|    ...|...||              ||.....|....:.....|..|.|.
Mouse   115 YLDVSHNRLQNISCCPMASLRHLDLS--------------FNDFDVLPVCKEFGNLTKLTFLGLS 165

  Fly   164 GNNF--AELIPDAEDFARFVNESRLEAS----NSVPHH-----CELLLLHNTTDLYDRECYLYFN 217
            ...|  .:|:|.|          .|..|    :.|.:|     .|.|.:.|||.|     :|.|:
Mouse   166 AAKFRQLDLLPVA----------HLHLSCILLDLVSYHIKGGETESLQIPNTTVL-----HLVFH 215

  Fly   218 NNTNMGQSITTGRNYTNFIKVLKDRFDQHGSSSQSIAWATFPKMPRLVELDISN------CSIEY 276
            .|:.....:....|....:::...:.:...........:...:.|.|:.:.:.:      ||:
Mouse   216 PNSLFSVQVNMSVNALGHLQLSNIKLNDENCQRLMTFLSELTRGPTLLNVTLQHIETTWKCSV-- 278

  Fly   277 VSKEAFRNVSNLRRLFMSDNKIMTISHDTFYYVQGVQYL---DLSFTNFL-----TYSYQLQLPT 333
                         :||.            |::.:.|:||   :|:.|..:     |||
Mouse   279 -------------KLFQ------------FFWPRPVEYLNIYNLTITERIDREEFTYS------- 311

  Fly   334 LEMALSLIYGLKIQQNVFKYLPELIYLDLS--HSKMTRNSAVAFAHLGDKLKFLSLCYTAIPMVS 396
             |.||..:....::..||.:..|.:|...:  :.||...|...|.|:        :|   .|..|
Mouse   312 -ETALKSLMIEHVKNQVFLFSKEALYSVFAEMNIKMLSISDTPFIHM--------VC---PPSPS 364

  Fly   397 STIFKNTVLEGLDLSGNPYLSYNII-DDAFDGIANTLK---YLYFERSNIKDL----EWSKSLKN 453
            |..|.|             .:.|:. |..|.| .:|||   .|..:|:.:|:.    ..:|::.:
Mouse   365 SFTFLN-------------FTQNVFTDSVFQG-CSTLKRLQTLILQRNGLKNFFKVALMTKNMSS 415

  Fly   454 LQVLGLAGNNINA----LTPAMFQSLESLEILDLSSNHV-GNWYRSA--------FHNN------ 499
            |:.|.::.|::|:    .|.|.   .||:.:|:||||.: |:.:|..        .|||
Mouse   416 LETLDVSLNSLNSHAYDRTCAW---AESILVLNLSSNMLTGSVFRCLPPKVKVLDLHNNRIMSIP 477

  Fly   500 ------SALRVLNLRSNTINML----------------------SNEMLKDFERLDYLSLGDNDF 536
                  .||:.||:.||::..|                      |.:..:..:.:..|:.|:|.|
Mouse   478 KDVTHLQALQELNVASNSLTDLPGCGAFSSLSVLVIDHNSVSHPSEDFFQSCQNIRSLTAGNNPF 542

  Fly   537 ICDCHLRAVVEVAAANNKDADCSYRLLNYSQNAVGEEVISLAESLIIDRKLWQSRYIPWLQRSYS 601
            .|.|.||..|:                  :...|..||:          :.|...|
Mouse   543 QCTCELRDFVK------------------NIGWVAREVV----------EGWPDSY--------- 570

  Fly   602 NIREFNRANHIIKLRFSSEDY-MVAKCSAAQPYHLGDLDGDLTLKFQLLDYEASQYYCFNNTDQL 665
                  |.           || ..:|.:|.:.:|:..|..|..|
Mouse   571 ------RC-----------DYPESSKGTALRDFHMSPLSCDTVL--------------------- 597

  Fly   666 QVDELNCQIRSMSDLAEELHHVTNTVIAVMGSLVGACILGFIIYLKRWHIHY--YYSSLKSAALL 728
                |...|.:           |..|:||.|:.:  |    :.:...|::..  .::..:..|
Mouse   598 ----LTVTIGA-----------TMLVLAVTGAFL--C----LYFDLPWYVRMLCQWTQTRHRA-- 639

  Fly   729 SSASKESVNKFTNISQRDPSAVYDIFISYCQNDRTWVLNELLPNVEETGDVSICLHERDFQIGVT 793
                     :...:.:...:..:..|:||.::|..||.||||||:|: .|:.:|||||:|..|.:
Mouse   640 ---------RHIPLEELQRNLQFHAFVSYSEHDSAWVKNELLPNLEK-DDIRVCLHERNFVPGKS 694

  Fly   794 ILDNIISCMDRSYSLMLIISSKFLLSHWCQFEMYLAQHRIFEVSKEHLILVFLEDIPRRKRPK-- 856
            |::|||:.:::||..:.::|..|:.|.||.:|:|.|.|.:|....::|||:.||.|.:...|.
Mouse   695 IVENIINFIEKSYKAIFVLSPHFIQSEWCHYELYFAHHNLFHEGSDNLILILLEPILQNNIPSRY 759

  Fly   857 -TLQYLMDVKTYIKWPTAKEDRKLFWKRLKRS--LEVIGINSREI 898
             .|:.||..:||::|||.|..|.|||..|:.|  :::..:|..::
Mouse   760 HKLRALMAQRTYLEWPTEKGKRGLFWANLRASFIMKLALVNEDDV 804

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-9	NP_001246846.1	leucine-rich repeat	157..185	CDD:275380	7/29 (24%)
		LRR_8	262..322	CDD:290566	12/68 (18%)
		leucine-rich repeat	264..287	CDD:275380	3/28 (11%)
		leucine-rich repeat	288..311	CDD:275380	3/22 (14%)
		leucine-rich repeat	312..356	CDD:275380	13/51 (25%)
		LRR_8	<344..387	CDD:290566	9/44 (20%)
		leucine-rich repeat	357..381	CDD:275380	6/25 (24%)
		leucine-rich repeat	382..397	CDD:275380	2/14 (14%)
		leucine-rich repeat	405..430	CDD:275380	4/25 (16%)
		LRR_8	431..488	CDD:290566	20/67 (30%)
		leucine-rich repeat	432..453	CDD:275380	6/27 (22%)
		LRR_RI	<449..536	CDD:238064	30/133 (23%)
		leucine-rich repeat	454..477	CDD:275380	6/26 (23%)
		LRR_8	477..536	CDD:290566	22/101 (22%)
		leucine-rich repeat	478..501	CDD:275380	10/43 (23%)
		leucine-rich repeat	502..525	CDD:275380	7/44 (16%)
		TIR	751..891	CDD:214587	59/144 (41%)
Tlr6	XP_030110224.1	leucine-rich repeat	47..64	CDD:275380
		PLN00113	50..>540	CDD:215061	106/516 (21%)
		leucine-rich repeat	65..88	CDD:275378
		LRR_8	87..144	CDD:404697	12/42 (29%)
		leucine-rich repeat	89..112	CDD:275378
		leucine-rich repeat	113..133	CDD:275378	7/17 (41%)
		leucine-rich repeat	134..158	CDD:275378	6/37 (16%)
		leucine-rich repeat	184..206	CDD:275380	4/21 (19%)
		leucine-rich repeat	207..230	CDD:275380	6/27 (22%)
		leucine-rich repeat	290..314	CDD:275380	8/31 (26%)
		leucine-rich repeat	315..343	CDD:275380	5/27 (19%)
		leucine-rich repeat	344..365	CDD:275380	7/31 (23%)
		leucine-rich repeat	390..415	CDD:275380	4/24 (17%)
		leucine-rich repeat	416..440	CDD:275380	6/26 (23%)
		leucine-rich repeat	441..462	CDD:275380	7/20 (35%)
		leucine-rich repeat	463..485	CDD:275380	3/21 (14%)
		leucine-rich repeat	486..508	CDD:275380	6/21 (29%)
		leucine-rich repeat	510..531	CDD:275380	1/20 (5%)
		LRRCT	540..594	CDD:214507	19/107 (18%)
		TIR	652..791	CDD:214587	58/139 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	128	1.000	Domainoid score	I5290
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	205	1.000	Inparanoid score	I3722
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.070