DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-9 and Tlr4

DIOPT Version :10

Sequence 1:NP_649214.1 Gene:Toll-9 / 40245 FlyBaseID:FBgn0036978 Length:900 Species:Drosophila melanogaster
Sequence 2:NP_067272.1 Gene:Tlr4 / 21898 MGIID:96824 Length:835 Species:Mus musculus


Alignment Length:1003 Identity:210/1003 - (20%)
Similarity:370/1003 - (36%) Gaps:305/1003 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MCPKYIWDVIVLVCLFLGNVREAYTEFSIQDGLIIEPDSATTSSEEAEEVSKERTDL----KSLM 61
            |.|.::....:::.||.    ...|..|:...:.:.|:......:  :::||...|:    |::.
Mouse     1 MMPPWLLARTLIMALFF----SCLTPGSLNPCIEVVPNITYQCMD--QKLSKVPDDIPSSTKNID 59

  Fly    62 LKYESDDGNSCLLDLIKDEVIWWQFPNGTLRDSTKKYAHKLYLDLSHGNLK--DDSDLFREAKLS 124
            |.:..       |.::|.    :.|.|         ::...:||||...::  :|........||
Mouse    60 LSFNP-------LKILKS----YSFSN---------FSELQWLDLSRCEIETIEDKAWHGLHHLS 104

  Fly   125 RKVTIWRTEVFSAAFNTLTAAPFRTL----YSMRESLKLLSLRGNNFAELIPDAEDF--ARFVNE 183
            ..:              ||..|.::.    :|...||:.|.......|.|    |.|  .:.:..
Mouse   105 NLI--------------LTGNPIQSFSPGSFSGLTSLENLVAVETKLASL----ESFPIGQLITL 151

  Fly   184 SRLEASNSVPHHCELLLLHNTTDLYDRECYLYFNNNTNMGQSITTGRNYTNFIKVLKDRFDQHGS 248
            .:|..:::..|.|:|              ..||:|.||: ..:....||...|.|...:|     
Mouse   152 KKLNVAHNFIHSCKL--------------PAYFSNLTNL-VHVDLSYNYIQTITVNDLQF----- 196

  Fly   249 SSQSIAWATFPKMPRL-VELDISNCSIEYVSKEAFR-------------NVSNL----------- 288
                     ..:.|:: :.||:|...|:::..:||:             |.||:           
Mouse   197 ---------LRENPQVNLSLDMSLNPIDFIQDQAFQGIKLHELTLRGNFNSSNIMKTCLQNLAGL 252

  Fly   289 --RRLFMSDNK-----------IM------TISHDTFYYVQ-----------------------G 311
              .||.:.:.|           ||      ||......|..                       .
Mouse   253 HVHRLILGEFKDERNLEIFEPSIMEGLCDVTIDEFRLTYTNDFSDDIVKFHCLANVSAMSLAGVS 317

  Fly   312 VQYLDLSFTNFLTYSYQL------QLPTLEMALSLIYGLKIQQN----VFK--YLPELIYLDLSH 364
            ::||:....:|...|..:      |.|||:  |..:..|.:..|    .||  .||.|.|||||.
Mouse   318 IKYLEDVPKHFKWQSLSIIRCQLKQFPTLD--LPFLKSLTLTMNKGSISFKKVALPSLSYLDLSR 380

  Fly   365 SKMTRNSAVAFAHLGDKLKFLSLCYTAIPMVSSTIFKNTVLEGLDLSGNPYLSYNIIDDAFDGIA 429
            :.::.:...:::.||                      ...|..||||.|..:   |:...|.|: 
Mouse   381 NALSFSGCCSYSDLG----------------------TNSLRHLDLSFNGAI---IMSANFMGL- 419

  Fly   430 NTLKYLYFERSNIKDL-EWSK--SLKNLQVLGLAGNNINALTPAMFQSLESLEILDLSSNHV-GN 490
            ..|::|.|:.|.:|.: |:|.  ||:.|..|.::..|.......:|..|.||..|.::.|.. .|
Mouse   420 EELQHLDFQHSTLKRVTEFSAFLSLEKLLYLDISYTNTKIDFDGIFLGLTSLNTLKMAGNSFKDN 484

  Fly   491 WYRSAFHNNSALRVLNLRSNTINMLSNEMLKDFERLDYLSLGDND--FICDCHLRAVVEVAAANN 553
            ...:.|.|.:.|..|:|....:..:|..:.....||..|::..|:  |:...|...:..::.   
Mouse   485 TLSNVFANTTNLTFLDLSKCQLEQISWGVFDTLHRLQLLNMSHNNLLFLDSSHYNQLYSLST--- 546

  Fly   554 KDADCSYRLLNYSQ-------------NAVGEEVISLAESLIIDRKLWQSRYIPWLQRSYSNIRE 605
              .|||:..:..|:             |.....|..:.|         ..:::.|::..    ::
Mouse   547 --LDCSFNRIETSKGILQHFPKSLAFFNLTNNSVACICE---------HQKFLQWVKEQ----KQ 596

  Fly   606 FNRANHIIKLRFSSEDYMVAKCSAAQPYHLGDLDGDLTLKFQLLDYEASQYYCFNNTDQLQVDEL 670
            |     ::.         |.:.:.|.|.   :::..|.|.             |||:        
Mouse   597 F-----LVN---------VEQMTCATPV---EMNTSLVLD-------------FNNS-------- 623

  Fly   671 NCQIRSMSDLAEELHHVTNTVIAV-MGSLVGACILGFIIYLKRWHIHYYYSSLKSAALLSSASKE 734
            .|             ::..|:|:| :.|::....:.|:||      |:|:..:    |::...|.
Mouse   624 TC-------------YMYKTIISVSVVSVIVVSTVAFLIY------HFYFHLI----LIAGCKKY 665

  Fly   735 SVNKFTNISQRDPSAVYDIFISYCQNDRTWVLNELLPNVEE-TGDVSICLHERDFQIGVTILDNI 798
            |..:          ::||.|:.|...:..||.|||:.|:|| .....:|||.|||..||.|..||
Mouse   666 SRGE----------SIYDAFVIYSSQNEDWVRNELVKNLEEGVPRFHLCLHYRDFIPGVAIAANI 720

  Fly   799 I-SCMDRSYSLMLIISSKFLLSHWCQFEMYLAQHRIFEVSKEHLILVFLEDIPRR--KRPKTLQY 860
            | ....:|..:::::|..|:.|.||.||..:||...|..|:..:|.:.||.:.:.  ::...|..
Mouse   721 IQEGFHKSRKVIVVVSRHFIQSRWCIFEYEIAQTWQFLSSRSGIIFIVLEKVEKSLLRQQVELYR 785

  Fly   861 LMDVKTYIKWPTAKEDRKLFWKRLKRSL 888
            |:...||::|......|.:||:|||.:|
Mouse   786 LLSRNTYLEWEDNPLGRHIFWRRLKNAL 813

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-9NP_649214.1 LRR 198..537 CDD:443914 90/423 (21%)
leucine-rich repeat 264..287 CDD:275380 7/36 (19%)
leucine-rich repeat 288..311 CDD:275380 8/75 (11%)
leucine-rich repeat 312..356 CDD:275380 14/55 (25%)
leucine-rich repeat 357..381 CDD:275380 8/23 (35%)
leucine-rich repeat 382..397 CDD:275380 0/14 (0%)
leucine-rich repeat 405..430 CDD:275380 9/24 (38%)
leucine-rich repeat 432..453 CDD:275380 9/23 (39%)
leucine-rich repeat 454..477 CDD:275380 5/22 (23%)
leucine-rich repeat 478..501 CDD:275380 6/23 (26%)
leucine-rich repeat 502..525 CDD:275380 4/22 (18%)
TIR 751..891 CDD:214587 51/142 (36%)
Tlr4NP_067272.1 LRR <53..298 CDD:443914 56/311 (18%)
LRR 1. /evidence=ECO:0000255 54..75 5/31 (16%)
leucine-rich repeat 58..78 CDD:275380 5/39 (13%)
LRR 2. /evidence=ECO:0000255 78..99 5/20 (25%)
leucine-rich repeat 79..102 CDD:275380 5/22 (23%)
LRR 3. /evidence=ECO:0000255 102..123 5/34 (15%)
leucine-rich repeat 103..126 CDD:275380 6/36 (17%)
LRR 4. /evidence=ECO:0000255 126..147 7/24 (29%)
leucine-rich repeat 127..150 CDD:275380 6/26 (23%)
LRR 5. /evidence=ECO:0000255 150..171 5/34 (15%)
leucine-rich repeat 151..175 CDD:275380 7/37 (19%)
LRR 6. /evidence=ECO:0000255 175..198 6/37 (16%)
leucine-rich repeat 176..204 CDD:275380 6/42 (14%)
LRR 7. /evidence=ECO:0000255 204..224 6/19 (32%)
leucine-rich repeat 205..226 CDD:275380 6/20 (30%)
LRR 8. /evidence=ECO:0000255 226..247 3/20 (15%)
LRR 9. /evidence=ECO:0000255 248..269 3/20 (15%)
LRR 10. /evidence=ECO:0000255 329..349 5/21 (24%)
leucine-rich repeat 331..350 CDD:275380 6/20 (30%)
LRR <347..>580 CDD:443914 61/265 (23%)
LRR 11. /evidence=ECO:0000255 350..370 4/19 (21%)
leucine-rich repeat 351..372 CDD:275380 5/20 (25%)
LRR 12. /evidence=ECO:0000255 372..392 6/19 (32%)
leucine-rich repeat 373..398 CDD:275380 8/46 (17%)
LRR 13. /evidence=ECO:0000255 398..420 9/25 (36%)
leucine-rich repeat 399..421 CDD:275380 9/25 (36%)
LRR 14. /evidence=ECO:0000255 421..442 7/20 (35%)
leucine-rich repeat 422..446 CDD:275380 9/23 (39%)
LRR 15. /evidence=ECO:0000255 446..467 4/20 (20%)
leucine-rich repeat 447..470 CDD:275380 5/22 (23%)
LRR 16. /evidence=ECO:0000255 470..490 5/19 (26%)
leucine-rich repeat 471..495 CDD:275380 6/23 (26%)
LRR 17. /evidence=ECO:0000255 495..516 4/20 (20%)
leucine-rich repeat 496..519 CDD:275380 4/22 (18%)
LRR 18. /evidence=ECO:0000255 519..540 6/20 (30%)
leucine-rich repeat 520..543 CDD:275380 5/22 (23%)
LRR 19. /evidence=ECO:0000255 543..564 4/25 (16%)
Interaction with SCIMP. /evidence=ECO:0000269|PubMed:28098138 670..835 51/144 (35%)
TIR 672..813 CDD:214587 50/140 (36%)

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