DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-9 and Tlr1

DIOPT Version :9

Sequence 1:	NP_001246846.1	Gene:	Toll-9 / 40245	FlyBaseID:	FBgn0036978	Length:	900	Species:	Drosophila melanogaster
Sequence 2:	NP_001263374.1	Gene:	Tlr1 / 21897	MGIID:	1341295	Length:	795	Species:	Mus musculus

Alignment Length:	986	Identity:	210/986 - (21%)
Similarity:	360/986 - (36%)	Gaps:	302/986 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 IVLVCLFLGNVREAYTEFSIQDGLIIEPDSATTSSEEAEEVSKE---RTDLKSLMLKYESDDGNS 71
            ::..|:.:..:.....:.|.:..|||:..:|..:     .|.|:   :|....|.....|:...|
Mouse     7 LIFYCIIVLGLTLMKIQLSEECELIIKRPNANLT-----RVPKDLPLQTTTLDLSQNNISELQTS 66

  Fly    72 CLLDLIKDEVIWWQFPN-GTLRDSTKKYAHKL-YLDLSHGNLKDDSDLFREAKLSRKVTIWRTEV 134
            .:|.|.|..|:...:.. ..|..|..|:..:| ||||||..|              ||.:....|
Mouse    67 DILSLSKLRVLIMSYNRLQYLNISVFKFNTELEYLDLSHNEL--------------KVILCHPTV 117

  Fly   135 ----FSAAFNTLTAAPFRTLYSMRESLKLLSLRGNNFAELIPDAEDFARFVNESRLEASNSVPHH 195
                ...:||...|.|....:.....|:.|.|.|                   ||:: |:||.
Mouse   118 SLKHLDLSFNAFDALPICKEFGNMSQLQFLGLSG-------------------SRVQ-SSSVQ-- 160

  Fly   196 CELLLLHNTTDLYDRECYLYFNNNTNMGQSITTGRNYTNFIKVLKDRFDQHGSSSQSIAWATFPK 260
               |:.|                              .|..|||....|.:|....       |:
Mouse   161 ---LIAH------------------------------LNISKVLLVLGDAYGEKED-------PE 185

  Fly   261 MPRLVELDISNCSIEYVSKEAFR-----NVSNLRRLFMSDNKIMTISHDTFYYVQGVQYL--DLS 318
            ..|.|..:  ...|.:.||..||     :||....|.:|:.|.:.......|:::.:..|  :|.
Mouse   186 SLRHVSTE--TLHIVFPSKREFRFLLDVSVSTTIGLELSNIKCVLEDQGCSYFLRALSKLGKNLK 248

  Fly   319 FTNFLTYSYQLQLPTLEMALSLIYGLKIQQNVFKYLPELIYLDLSHSKMTRNSAVAFAHLGD-KL 382
            .:|....:.:....:....|.:::...::           |..:|:.|:....|....:..| .|
Mouse   249 LSNLTLNNVETTWNSFINILQIVWHTPVK-----------YFSISNVKLQGQLAFRMFNYSDTSL 302

  Fly   383 KFLSLCYTAIPMVS------STIFKNTVLEGLDLSG------------NPYLSYNIIDD-----A 424
            |.||:......:.|      .:||.|..::...:||            :|:|..:..|:     .
Mouse   303 KALSIHQVVTDVFSFPQSYIYSIFANMNIQNFTMSGTHMVHMLCPSQVSPFLHVDFTDNLLTDMV 367

  Fly   425 FDGIAN--TLKYLYFERSNIKDLE----WSKSLKNLQVLGLAGNNI------------------- 464
            |....|  .||.|..:::.:|:||    .|..:.:||.|.::.|::
Mouse   368 FKDCRNLVRLKTLSLQKNQLKNLENIILTSAKMTSLQKLDISQNSLRYSDGGIPCAWTQSLLVLN 432

  Fly   465 ---NALTPAMFQSL-ESLEILDLSSNHVGNWYRSAFHNNSALRVLNLRSNTINML---------- 515
               |.||.::|:.| ..:::|||.:|.:.:..:...| ..||:.||:.||::..|
Mouse   433 LSSNMLTGSVFRCLPPKVKVLDLHNNRIMSIPKDVTH-LQALQELNVASNSLTDLPGCGAFSSLS 496

  Fly   516 ------------SNEMLKDFERLDYLSLGDNDFICDCHLRAVVEVAAANNKDADCSYRLLNYSQN 568
                        |.:..:..:.:..|:.|:|.|.|.|.||..|:
Mouse   497 VLVIDHNSVSHPSEDFFQSCQNIRSLTAGNNPFQCTCELRDFVK--------------------- 540

  Fly   569 AVGEEVISLAESLIIDRKLWQSRYI--PWLQRSYSNIREFNRANHIIKLRFSSEDYMVAKCSAAQ 631
            .:|                |.:|.:  .|......:..|.:|.                  :|.:
Mouse   541 NIG----------------WVAREVVEGWPDSYRCDYPESSRG------------------TALR 571

  Fly   632 PYHLGDLDGDLTLKFQLLDYEASQYYCFNNTDQLQVDELNCQIRSMSDLAEELHHVTNTVIAVMG 696
            .:|:..|..|..|                         |...|.:           |..|:||.|
Mouse   572 DFHMSPLSCDTVL-------------------------LTVTIGA-----------TMLVLAVTG 600

  Fly   697 SLVGACILGFIIYLKRWHIHY--YYSSLKSAALLSSASKESVNKFTNISQRDPSAVYDIFISYCQ 759
            :.:  |    :.:...|::..  .::..:..|           :...:.:...:..:..|:||..
Mouse   601 AFL--C----LYFDLPWYVRMLCQWTQTRHRA-----------RHIPLEELQRNLQFHAFVSYSG 648

  Fly   760 NDRTWVLNELLPNVEETGDVSICLHERDFQIGVTILDNIISCMDRSYSLMLIISSKFLLSHWCQF 824
            :|..||.||||||:|: .|:.||||||:|..|.:|::|||:.:::||..:.::|..|:.|.||.:
Mouse   649 HDSAWVKNELLPNLEK-DDIQICLHERNFVPGKSIVENIINFIEKSYKSIFVLSPHFIQSEWCHY 712

  Fly   825 EMYLAQHRIFEVSKEHLILVFLEDIPRRKRPKT---LQYLMDVKTYIKWPTAKEDRKLFWKRLKR 886
            |:|.|.|.:|....::|||:.|..||:...|..   |:.||..:||::|||.|....|||..|:.
Mouse   713 ELYFAHHNLFHEGSDNLILILLAPIPQYSIPTNYHKLKTLMSRRTYLEWPTEKNKHGLFWANLRA 777

  Fly   887 SLEVIGINSRE 897
            |:.|..:|..|
Mouse   778 SINVKLVNQAE 788

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-9	NP_001246846.1	leucine-rich repeat	157..185	CDD:275380	4/27 (15%)
		LRR_8	262..322	CDD:290566	15/66 (23%)
		leucine-rich repeat	264..287	CDD:275380	7/27 (26%)
		leucine-rich repeat	288..311	CDD:275380	4/22 (18%)
		leucine-rich repeat	312..356	CDD:275380	4/45 (9%)
		LRR_8	<344..387	CDD:290566	8/43 (19%)
		leucine-rich repeat	357..381	CDD:275380	5/24 (21%)
		leucine-rich repeat	382..397	CDD:275380	5/20 (25%)
		leucine-rich repeat	405..430	CDD:275380	6/41 (15%)
		LRR_8	431..488	CDD:290566	20/83 (24%)
		leucine-rich repeat	432..453	CDD:275380	7/24 (29%)
		LRR_RI	<449..536	CDD:238064	25/131 (19%)
		leucine-rich repeat	454..477	CDD:275380	9/45 (20%)
		LRR_8	477..536	CDD:290566	16/80 (20%)
		leucine-rich repeat	478..501	CDD:275380	5/22 (23%)
		leucine-rich repeat	502..525	CDD:275380	7/44 (16%)
		TIR	751..891	CDD:214587	59/142 (42%)
Tlr1	NP_001263374.1	PRK15370	<38..>133	CDD:185268	27/113 (24%)
		LRR	<48..317	CDD:227223	70/357 (20%)
		leucine-rich repeat	50..73	CDD:275378	6/22 (27%)
		LRR 1	54..77		6/22 (27%)
		leucine-rich repeat	74..97	CDD:275378	4/22 (18%)
		LRR 2	78..101		4/22 (18%)
		leucine-rich repeat	98..118	CDD:275378	10/33 (30%)
		LRR 3	102..125		8/36 (22%)
		leucine-rich repeat	119..143	CDD:275378	4/23 (17%)
		LRR 4	126..150		6/23 (26%)
		leucine-rich repeat	144..156	CDD:275378	6/31 (19%)
		LRR 5	151..175		12/78 (15%)
		LRR 6	176..199		6/31 (19%)
		LRR 7	200..223		7/22 (32%)
		LRR 8	224..250		4/25 (16%)
		LRR 9	251..278		2/37 (5%)
		LRR 10	279..308		8/28 (29%)
		LRR 11	309..337		4/27 (15%)
		Interaction with bacterial lipopeptide. /evidence=ECO:0000250	316..319		1/2 (50%)
		LRR 12	338..361		3/22 (14%)
		leucine-rich repeat	355..376	CDD:275380	3/20 (15%)
		LRR 13	362..388		5/25 (20%)
		PRK15370	<377..>487	CDD:185268	27/110 (25%)
		leucine-rich repeat	377..402	CDD:275380	7/24 (29%)
		LRR 14	389..414		7/24 (29%)
		leucine-rich repeat	403..427	CDD:275380	4/23 (17%)
		LRR 15	415..437		0/21 (0%)
		leucine-rich repeat	428..449	CDD:275380	5/20 (25%)
		LRR 16	438..457		7/18 (39%)
		leucine-rich repeat	450..472	CDD:275380	5/22 (23%)
		LRR 17	458..478		5/20 (25%)
		leucine-rich repeat	473..494	CDD:275380	6/20 (30%)
		LRR 18	479..500		3/20 (15%)
		leucine-rich repeat	495..518	CDD:275380	1/22 (5%)
		LRR 19	501..524		2/22 (9%)
		LRRCT	527..581	CDD:214507	16/108 (15%)
		TIR	639..782	CDD:214587	59/143 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	128	1.000	Domainoid score	I5290
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	205	1.000	Inparanoid score	I3722
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	1	1.000	-	-		otm43917
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	9.030