DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-9 and lron-5

DIOPT Version :9

Sequence 1:	NP_001246846.1	Gene:	Toll-9 / 40245	FlyBaseID:	FBgn0036978	Length:	900	Species:	Drosophila melanogaster
Sequence 2:	NP_497943.2	Gene:	lron-5 / 184307	WormBaseID:	WBGene00008656	Length:	656	Species:	Caenorhabditis elegans

Alignment Length:	597	Identity:	123/597 - (20%)
Similarity:	223/597 - (37%)	Gaps:	155/597 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   236 IKVLK-DRFDQHGSSSQSIAWATFPKMPRLVELDISNCSIEYVSKEAFRNVSNLRRLFMSDNKIM 299
            ::||: .|...|     .|..:||..:|.|..:|:||..:|.:.....|::..||.|.:|:|::.
Worm    73 LRVLRMSRCGMH-----EIPGSTFLPLPGLEVIDLSNNHLETLPPTVLRSLKFLRVLILSNNRLS 132

  Fly   300 TISHDTFYYVQGV--QYLDLS------FTNFLTYSYQLQL------------------------- 331
            .:...|:....||  :.||||      .|:...:....||
Worm   133 NLDQLTWILAPGVVLEQLDLSGNPIAIATSMTVFPPVRQLFLSDTRMESVNETAIMFKKLPGKCD 197

  Fly   332 -------PTLEMALSLI--------YGLKIQQNVFKYLPELIYLDLSHSKMTRNSAVAF---AHL 378
                   |...:.:|:|        ..|:|............|:|||::::    .|.|   ...
Worm   198 RDVCRHIPIHNLNVSIITTIDFSSNRDLEIDSGALDVFSNATYVDLSNTRL----PVGFEEWLER 258

  Fly   379 GDKLKFLSLCYTAIPMVSST-IFKNTVLEGLDLSG---------------NPYLSYNIIDDAF-D 426
            ..::|.|::.:..:|:...| ......|..||:||               :.:...|:|...: |
Worm   259 KSRVKSLNISHCQLPLHEDTWTACGQFLHSLDISGIGAKRLRFSRFCPIRSVFARDNLISSVYID 323

  Fly   427 GIANTLKYLYFERSNIKDLEW---SKSLKNLQVLGLAGNNINALTPAMFQSLESLEILDLSSNHV 488
            .:  :::.|:.||:...:...   ...|..|..|||:.|.:.:|.|...||..:|:..|:|||.:
Worm   324 AV--SMESLHLERNMFSEFPIPPPGVELTELHTLGLSHNLMTSLPPHALQSYPNLQHFDVSSNQL 386

  Fly   489 GNWYRSAFHN-NSALRVLNLRSNTINMLSNEMLKDFERLDY----LSLGDNDFICDCHLRAVVEV 548
            ......||.: ...|..|:|.||.::.|.:.:|.....||.    :|..|..|.....:...:.:
Worm   387 SEIDPQAFPSIGLGLISLDLSSNQLSSLPHPILPSLLLLDLSFNTISHLDPHFFTGLPMLQQLRI 451

  Fly   549 AA-------ANNKDADCSYRLLNYSQNAVGEEVISLAE---------------------SLII-- 583
            |:       ..|:|:.|      :|.:.  :|:.||.:                     |||:
Worm   452 ASNPTLFSRCPNRDSPC------WSDHL--DELTSLVDLDISNSGLEFSLHWRHLRTLKSLILRG 508

  Fly   584 -DRKLWQSRYIPWLQRSYSNIR-------------EFNRANHIIKLRFSSEDYMVAKCSAAQPYH 634
             :.::..|:.:|      .|:|             .|::..|:..||.   |....:|..:
Worm   509 NEIRIIDSKSLP------ENLRTLDLGENRVQFTSNFSKLEHLRDLRV---DQNPLRCDCS---- 560

  Fly   635 LGDLDGDLTLKFQLLDYEASQYYCFNNTDQLQVDELNCQIRSMSDLAEELHHVTNTVIAVMGSLV 699
            |.|:...|..:.|:.|  ...||||:.:.|..:......::...|.....:.:..|...:..::|
Worm   561 LYDIVPHLLNQSQISD--PLLYYCFSGSWQYPLLPYLASVKPCVDTTRNFYSILITTFIIAFAIV 623

  Fly   700 GACILGFIIYLK 711
            ...|.||::|.|
Worm   624 AGLIGGFLVYRK 635

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-9	NP_001246846.1	leucine-rich repeat	157..185	CDD:275380
		LRR_8	262..322	CDD:290566	20/67 (30%)
		leucine-rich repeat	264..287	CDD:275380	6/22 (27%)
		leucine-rich repeat	288..311	CDD:275380	6/22 (27%)
		leucine-rich repeat	312..356	CDD:275380	13/91 (14%)
		LRR_8	<344..387	CDD:290566	10/45 (22%)
		leucine-rich repeat	357..381	CDD:275380	6/26 (23%)
		leucine-rich repeat	382..397	CDD:275380	3/14 (21%)
		leucine-rich repeat	405..430	CDD:275380	8/40 (20%)
		LRR_8	431..488	CDD:290566	18/59 (31%)
		leucine-rich repeat	432..453	CDD:275380	4/23 (17%)
		LRR_RI	<449..536	CDD:238064	28/91 (31%)
		leucine-rich repeat	454..477	CDD:275380	9/22 (41%)
		LRR_8	477..536	CDD:290566	18/63 (29%)
		leucine-rich repeat	478..501	CDD:275380	7/23 (30%)
		leucine-rich repeat	502..525	CDD:275380	7/22 (32%)
		TIR	751..891	CDD:214587
lron-5	NP_497943.2	leucine-rich repeat	51..72	CDD:275380
		LRR_8	72..131	CDD:338972	19/62 (31%)
		leucine-rich repeat	73..96	CDD:275380	7/27 (26%)
		LRR	<92..>272	CDD:227223	35/183 (19%)
		leucine-rich repeat	97..120	CDD:275380	6/22 (27%)
		leucine-rich repeat	121..146	CDD:275380	7/24 (29%)
		leucine-rich repeat	147..168	CDD:275380	5/20 (25%)
		leucine-rich repeat	169..208	CDD:275380	3/38 (8%)
		leucine-rich repeat	209..237	CDD:275380	4/27 (15%)
		leucine-rich repeat	238..284	CDD:275380	10/49 (20%)
		leucine-rich repeat	327..351	CDD:275380	4/23 (17%)
		internalin_A	345..>576	CDD:380193	54/251 (22%)
		leucine-rich repeat	352..375	CDD:275380	9/22 (41%)
		leucine-rich repeat	376..391	CDD:275380	5/14 (36%)
		leucine-rich repeat	401..445	CDD:275380	12/43 (28%)
		leucine-rich repeat	446..478	CDD:275380	6/39 (15%)
		leucine-rich repeat	479..500	CDD:275380	1/20 (5%)
		leucine-rich repeat	501..522	CDD:275380	5/26 (19%)
		leucine-rich repeat	523..544	CDD:275380	2/20 (10%)
		LRRCT	553..601	CDD:214507	11/53 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910