DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-9 and tol-1

DIOPT Version :10

Sequence 1:NP_649214.1 Gene:Toll-9 / 40245 FlyBaseID:FBgn0036978 Length:900 Species:Drosophila melanogaster
Sequence 2:NP_001020983.1 Gene:tol-1 / 171635 WormBaseID:WBGene00006593 Length:1221 Species:Caenorhabditis elegans


Alignment Length:1151 Identity:229/1151 - (19%)
Similarity:392/1151 - (34%) Gaps:390/1151 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    39 SATTSSEEAEEVSKERTDLKSLML----KYESDDGNSC------LLDLIKDEVIWWQFPNGTLRD 93
            :|:||.|..|:|......|:...|    ..|......|      :|::..:|:       .:||.
 Worm   130 TASTSFEMTEDVLMPLARLEKFSLTRSRNIELPQRLLCSLPHLQVLNISSNEL-------PSLRR 187

  Fly    94 STKKYAHKLYL-DLSHGNLKDDSDLFREAKLSRKVTIWRTEVFSAAFNTLT------AAPFR--- 148
            .....|.:|.: |||...|.:.....|.....|::        |.|:|::.      |.||.   
 Worm   188 EESCVAQQLLIVDLSRNRLTNIEQFLRGIPAIRQI--------SVAYNSIAELDLSLATPFLQQL 244

  Fly   149 --------TLYSMRESLKLLSLRGNNFAELIPDA-EDFARFV--NESR--LEASN-SVPHHCELL 199
                    .|.|:..::..::|.||.. :.:||| .:.|..|  |.||  :||.| ||....||.
 Worm   245 DAEANRIVDLTSLPGTVVHVNLAGNAL-KRVPDAVAELASLVALNVSRNEIEAGNSSVFSSPELE 308

  Fly   200 LLHNTTDLYD------------RECYLYFNNNTNMGQSITTG--RNYTNF---------IKVLKD 241
            :|..:.:..|            |..:|:..:|:.  :.:|.|  .|.||.         ::|.:|
 Worm   309 MLDASYNKLDSLPVEWLQKCEKRIAHLHLEHNSI--EQLTGGVLANATNLQTLDLSSNQLRVFRD 371

  Fly   242 RFDQHGSSSQSIAWATFPKMPRLVELDISNCSIEYVSKEAFRNVSNLRRLFMSDNKIMTISHDTF 306
            .              ..|:..::..|.:||.|:|.:...:...: .|..|.:|.||:..:. ...
 Worm   372 E--------------VLPENSKIGNLRLSNNSLELLEPSSLSGL-KLESLDLSHNKLTEVP-AAI 420

  Fly   307 YYVQGVQYLDLSFTNFL-TYSYQL----QLPTLEMALSLIYGLKIQQNVFKYLPELIYLDLSHSK 366
            ..|:.::.:|||..... .|.|.|    ||.|::::.:.:.  .|...:|....||..||:|:::
 Worm   421 GKVEQLKKVDLSHNRIAKVYQYVLNKIKQLHTVDLSNNQLQ--SIGPYIFSDSSELHSLDVSNNE 483

  Fly   367 MTRNSAVAFAHLGDKLKFLSLCYTAIPMVSSTIFKNTVLEGLDLSGNPYLSYNIIDDAFDGIANT 431
            ::.....|||.. .||:.:|:....|..:...:.:.:.|..||:|.|..|.              
 Worm   484 ISLLFKDAFARC-PKLRKISMKMNKIKSLDEGLTEASGLRRLDVSHNEILV-------------- 533

  Fly   432 LKYLYFERSNIKDLEWSKSLKNLQVLGLAGNNINALTPAMF-----------------------Q 473
                         |:||...:||::|....|:||.||.|..                       |
 Worm   534 -------------LKWSALPENLEILNADNNDINLLTAASMSPSTANLKSVSLSNNGITIMNADQ 585

  Fly   474 SLESLEILDLSSNHVGNWYRSAFHNNSALRVLNLRSNTINMLSNEMLKDFERLDYL--SLGDNDF 536
            ...|||.||:|:|.:....::|....|.||.|||:.|.:.:::.|.:|..|.:..|  .:.:|..
 Worm   586 IPNSLESLDVSNNRLAKLGKTALAAKSQLRRLNLKGNLLTVVATESMKVVEAVHPLKVEISENPL 650

  Fly   537 ICDCHL----------------------RAV----VEVAAANNKDADCSY--------------- 560
            ||||.:                      .||    :::.:.:.||..|.|               
 Worm   651 ICDCQMGWMIGGAKPKVLIQDSETASCSHAVDGHQIQIQSLSKKDLLCPYKSVCEPECICCQYGN 715

  Fly   561 ----------------------------------------------------------------- 560
                                                                             
 Worm   716 CDCKSVCPANCRCFRDDQFNINIVRCHGNSSMVPKREFVVSELPVSATEIILSGVTLPQLRTHSF 780

  Fly   561 ------------------------------RLLNYSQNAV----GEEVISLAE------------ 579
                                          :.|:.|.|::    |||.:...|            
 Worm   781 IGRLRLQRLHINGTGLRSIQPKAFHTLPALKTLDLSDNSLISLSGEEFLKCGEVSQLFLNGNRFS 845

  Fly   580 --SLIIDRKLWQSRYIPWLQRSYSNIREFNRANHIIKLRFSSEDYMVAKCSAAQPYHLGDLDGDL 642
              |..|..||...:|:.....|..:|.:...:..:.|:..||.. :...||.....||.......
 Worm   846 TLSRGIFEKLPNLKYLTLHNNSLEDIPQVLHSTALSKISLSSNP-LRCDCSGGSQQHLHHRRDPK 909

  Fly   643 TLKFQLLDYEASQYY--------------CFNN------TDQLQVDELNCQIRSMSD------LA 681
            ...|  .::.|::::              |:.|      |:...|  |:....:|.:      :.
 Worm   910 AHPF--WEHNAAEWFSLHRHLVVDFPKVECWENVTKAFLTNDTTV--LSAYPPNMGNDVFVMPIE 970

  Fly   682 EELHHVTNT--------------------VIAVMGSLVGACILGF--IIYLKRWHIHYYYSSLKS 724
            |.|....:|                    ||..:...|..|:|..  |.::::.|........|:
 Worm   971 EFLRDYNSTICVPFSSGFFGQDPQNSILFVIITISIAVLLCVLVILAISFIRKSHDAINQRRYKA 1035

  Fly   725 AALLSSASKESVNKFTNISQRDPSAV----YDIFISYCQNDRTWVLNELLPNVEETGDVSICLHE 785
            ::|..|.|..|          .|..|    |..|:||.:.|...|:::|...:|:. |..:||..
 Worm  1036 SSLNCSTSAGS----------SPLPVPLLSYHAFVSYSKKDEKMVIDQLCRPLEDE-DYQLCLLH 1089

  Fly   786 RDFQIGVT-------ILDNIISCMDRSYSLMLIISSKFLLSHWCQFEMYLAQHRIFEVSKEHLIL 843
            ||   |.|       |.|.:|:.||.|..|:|:::..||.:.|...:: ...|::|..::...::
 Worm  1090 RD---GPTYCSNLHAISDELIAQMDSSQCLILVLTKHFLENEWKTLQI-KTSHQLFAKNRAKRVI 1150

  Fly   844 VFLED-IPRRKRPKTLQYLMDVKTYIKWPTAKEDRKLFWKRLKRSL 888
            ..|.| :........|..::...|.|:..:     .|||..|..||
 Worm  1151 AVLGDGVDANLLDDELGQILRKHTRIEMRS-----HLFWTLLHSSL 1191

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-9NP_649214.1 LRR 198..537 CDD:443914 87/391 (22%)
leucine-rich repeat 264..287 CDD:275380 5/22 (23%)
leucine-rich repeat 288..311 CDD:275380 6/22 (27%)
leucine-rich repeat 312..356 CDD:275380 11/48 (23%)
leucine-rich repeat 357..381 CDD:275380 7/23 (30%)
leucine-rich repeat 382..397 CDD:275380 3/14 (21%)
leucine-rich repeat 405..430 CDD:275380 6/24 (25%)
leucine-rich repeat 432..453 CDD:275380 3/20 (15%)
leucine-rich repeat 454..477 CDD:275380 9/45 (20%)
leucine-rich repeat 478..501 CDD:275380 7/22 (32%)
leucine-rich repeat 502..525 CDD:275380 8/22 (36%)
TIR 751..891 CDD:214587 39/146 (27%)
tol-1NP_001020983.1 leucine-rich repeat 71..95 CDD:275380
leucine-rich repeat 96..119 CDD:275380
leucine-rich repeat 120..171 CDD:275380 10/40 (25%)
PLN00113 <166..>460 CDD:215061 72/327 (22%)
leucine-rich repeat 172..195 CDD:275380 5/29 (17%)
leucine-rich repeat 196..283 CDD:275380 21/95 (22%)
leucine-rich repeat 219..240 CDD:275378 5/28 (18%)
leucine-rich repeat 241..258 CDD:275378 2/16 (13%)
leucine-rich repeat 287..306 CDD:275380 8/18 (44%)
leucine-rich repeat 307..331 CDD:275380 3/23 (13%)
leucine-rich repeat 332..355 CDD:275380 5/24 (21%)
LRR 337..653 CDD:443914 83/363 (23%)
leucine-rich repeat 356..379 CDD:275380 3/36 (8%)
leucine-rich repeat 380..395 CDD:275380 5/14 (36%)
leucine-rich repeat 403..425 CDD:275380 6/22 (27%)
leucine-rich repeat 426..449 CDD:275380 6/22 (27%)
leucine-rich repeat 450..473 CDD:275380 4/24 (17%)
leucine-rich repeat 474..497 CDD:275380 7/23 (30%)
leucine-rich repeat 498..520 CDD:275380 3/21 (14%)
leucine-rich repeat 543..567 CDD:275380 8/23 (35%)
leucine-rich repeat 568..589 CDD:275380 1/20 (5%)
leucine-rich repeat 590..613 CDD:275380 7/22 (32%)
leucine-rich repeat 614..633 CDD:275380 7/18 (39%)
leucine-rich repeat 763..785 CDD:275378 0/21 (0%)
LRR <779..>891 CDD:443914 17/112 (15%)
leucine-rich repeat 786..809 CDD:275378 0/22 (0%)
leucine-rich repeat 810..833 CDD:275378 6/22 (27%)
leucine-rich repeat 834..857 CDD:275378 4/22 (18%)
leucine-rich repeat 858..879 CDD:275378 3/20 (15%)
leucine-rich repeat 880..892 CDD:275378 3/12 (25%)
SEFIR 1056..1194 CDD:474043 39/146 (27%)
Blue background indicates that the domain is not in the aligned region.

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