DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-9 and Cd180

DIOPT Version :9

Sequence 1:NP_001246846.1 Gene:Toll-9 / 40245 FlyBaseID:FBgn0036978 Length:900 Species:Drosophila melanogaster
Sequence 2:NP_032559.2 Gene:Cd180 / 17079 MGIID:1194924 Length:661 Species:Mus musculus


Alignment Length:659 Identity:143/659 - (21%)
Similarity:246/659 - (37%) Gaps:215/659 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 LVCLFLGNVREAYTEFSIQDGLIIEPDSATTSSEE---AEEVSK--------------------- 52
            ||.|||.:.|                  |||||::   .:||:|                     
Mouse    10 LVALFLASCR------------------ATTSSDQKCIEKEVNKTYNCENLGLNEIPGTLPNSTE 56

  Fly    53 ------------ERTDLKSLMLKYESDDGNSCLLDLIKDEVIWWQFPNGTLRDSTKKYAHKL-YL 104
                        :.|....|:        |...|||.:.::.|       :.:.|.:..|:| .|
Mouse    57 CLEFSFNVLPTIQNTTFSRLI--------NLTFLDLTRCQIYW-------IHEDTFQSQHRLDTL 106

  Fly   105 DLSHGNLKDDSDLF-REAKLSRKVTIWRTEVFSAAFNTLTAAPFRTLYSMRESLKLLSLRGNNFA 168
            .|:...|     :| .|..||....:..........:::...|...    :::|:.|.|..|:.:
Mouse   107 VLTANPL-----IFMAETALSGPKALKHLFFIQTGISSIDFIPLHN----QKTLESLYLGSNHIS 162

  Fly   169 EL-IPDAEDFARFVNESR--LEASNSVPHHC---ELLLLHNTTDLYDRECYLYFNNNTNMG---- 223
            .: :|..     |..|..  |:..|:..|:.   ::..|...|:|     .|..|.|...|    
Mouse   163 SIKLPKG-----FPTEKLKVLDFQNNAIHYLSKEDMSSLQQATNL-----SLNLNGNDIAGIELG 217

  Fly   224 -------QSITTG--RNYTNFIKVLKDRFDQHGSSSQSIAWATFPKMPRLVELDISNCSIEYVSK 279
                   ||:..|  :|.....|.||:      |:.||:...||..|.   :.|||....|.:.:
Mouse   218 AFDSAVFQSLNFGGTQNLLVIFKGLKN------STIQSLWLGTFEDMD---DEDISPAVFEGLCE 273

  Fly   280 EAFRNVSNLRRLFMSDNKIMTISHDTFYYVQGVQYLDLSFTNFLTYSYQLQLPTLEMALSLIYGL 344
            .:..:::..:..|.:      ||.:||:...|:|.|||:.|:.      .:||:..:.||.:..|
Mouse   274 MSVESINLQKHYFFN------ISSNTFHCFSGLQELDLTATHL------SELPSGLVGLSTLKKL 326

  Fly   345 KIQQNVFKYL--------PELIY-------------------------LDLSHSKM--------- 367
            .:..|.|:.|        |.|.:                         |||||..:         
Mouse   327 VLSANKFENLCQISASNFPSLTHLSIKGNTKRLELGTGCLENLENLRELDLSHDDIETSDCCNLQ 391

  Fly   368 TRNSAVAFAHLGDKLKFLSLCYTAIPMVSSTIFKN-TVLEGLDL---------SGNPY------- 415
            .||    .:|    |:.|:|.|.....:.:..||. ..||.|||         :.:|:       
Mouse   392 LRN----LSH----LQSLNLSYNEPLSLKTEAFKECPQLELLDLAFTRLKVKDAQSPFQNLHLLK 448

  Fly   416 ---LSYNIID----DAFDGIANTLKYL-----YFERSNIKDLEWSKSLKNLQVLGLAGNNINALT 468
               ||::::|    ..|||:. .|::|     :|.:.||:.....::|..|::|.|:..:::::.
Mouse   449 VLNLSHSLLDISSEQLFDGLP-ALQHLNLQGNHFPKGNIQKTNSLQTLGRLEILVLSFCDLSSID 512

  Fly   469 PAMFQSLESLEILDLSSNHVGNWYRSAFHNNSALR--VLNLRSNTINMLSNEMLKDFERLDYLSL 531
            ...|.||:.:..:|||.|.:.:   |:....|.|:  .|||.||.|:::...:|....:...::|
Mouse   513 QHAFTSLKMMNHVDLSHNRLTS---SSIEALSHLKGIYLNLASNRISIILPSLLPILSQQRTINL 574

  Fly   532 GDNDFICDC 540
            ..|...|.|
Mouse   575 RQNPLDCTC 583

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-9NP_001246846.1 leucine-rich repeat 157..185 CDD:275380 7/28 (25%)
LRR_8 262..322 CDD:290566 15/59 (25%)
leucine-rich repeat 264..287 CDD:275380 4/22 (18%)
leucine-rich repeat 288..311 CDD:275380 5/22 (23%)
leucine-rich repeat 312..356 CDD:275380 13/51 (25%)
LRR_8 <344..387 CDD:290566 16/84 (19%)
leucine-rich repeat 357..381 CDD:275380 9/57 (16%)
leucine-rich repeat 382..397 CDD:275380 4/14 (29%)
leucine-rich repeat 405..430 CDD:275380 12/47 (26%)
LRR_8 431..488 CDD:290566 16/61 (26%)
leucine-rich repeat 432..453 CDD:275380 6/25 (24%)
LRR_RI <449..536 CDD:238064 23/88 (26%)
leucine-rich repeat 454..477 CDD:275380 6/22 (27%)
LRR_8 477..536 CDD:290566 16/60 (27%)
leucine-rich repeat 478..501 CDD:275380 5/22 (23%)
leucine-rich repeat 502..525 CDD:275380 8/24 (33%)
TIR 751..891 CDD:214587
Cd180NP_032559.2 leucine-rich repeat 38..57 CDD:275380 0/18 (0%)
LRR 1 54..75 1/20 (5%)
leucine-rich repeat 58..78 CDD:275380 2/27 (7%)
LRR 2 78..99 6/27 (22%)
leucine-rich repeat 79..102 CDD:275380 5/29 (17%)
LRR 3 102..123 7/25 (28%)
leucine-rich repeat 103..126 CDD:275380 8/27 (30%)
LRR 4 126..147 1/20 (5%)
leucine-rich repeat 127..150 CDD:275380 1/26 (4%)
LRR 5 150..171 5/25 (20%)
leucine-rich repeat 151..174 CDD:275380 6/27 (22%)
LRR 6 174..195 3/20 (15%)
leucine-rich repeat 175..201 CDD:275380 4/25 (16%)
LRR 7 201..221 5/24 (21%)
leucine-rich repeat 224..275 CDD:275380 17/59 (29%)
LRR 8 275..296 5/26 (19%)
leucine-rich repeat 276..299 CDD:275380 5/28 (18%)
LRR 9 299..321 8/27 (30%)
leucine-rich repeat 300..322 CDD:275380 8/27 (30%)
LRR_8 321..382 CDD:290566 12/60 (20%)
LRR 10 322..343 4/20 (20%)
leucine-rich repeat 323..346 CDD:275380 4/22 (18%)
LRR_RI 345..>541 CDD:238064 45/207 (22%)
LRR 11 346..366 1/19 (5%)
leucine-rich repeat 347..371 CDD:275380 1/23 (4%)
LRR_8 371..432 CDD:290566 19/68 (28%)
LRR 12 371..391 5/19 (26%)
leucine-rich repeat 372..397 CDD:275380 7/28 (25%)
LRR 13 397..418 6/24 (25%)
leucine-rich repeat 398..421 CDD:275380 6/22 (27%)
LRR_8 420..481 CDD:290566 14/61 (23%)
LRR 14 421..442 6/20 (30%)
leucine-rich repeat 422..446 CDD:275380 6/23 (26%)
LRR 15 446..466 3/19 (16%)
leucine-rich repeat 447..470 CDD:275380 6/23 (26%)
LRR 16 470..493 5/22 (23%)
leucine-rich repeat 471..497 CDD:275380 6/25 (24%)
LRR_8 497..555 CDD:290566 18/60 (30%)
LRR 17 497..518 4/20 (20%)
leucine-rich repeat 498..521 CDD:275380 6/22 (27%)
LRR 18 521..544 6/25 (24%)
leucine-rich repeat 522..545 CDD:275380 7/25 (28%)
LRR 19 546..566 7/19 (37%)
LRRCT 577..626 CDD:214507 3/7 (43%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.920

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