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Protein Alignment Toll-9 and Tlr3

DIOPT Version :10

Sequence 1:	NP_649214.1	Gene:	Toll-9 / 40245	FlyBaseID:	FBgn0036978	Length:	900	Species:	Drosophila melanogaster
Sequence 2:	NP_569054.2	Gene:	Tlr3 / 142980	MGIID:	2156367	Length:	905	Species:	Mus musculus

Alignment Length:	889	Identity:	201/889 - (22%)
Similarity:	348/889 - (39%)	Gaps:	231/889 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 KKYAHKLYLDLSHGNLKDDSDLFREAKLSRKVTIWRTEVFSAAFNTLTAAPFRTL-YSMRESLKL 159
            |...:.:.|||||..|.       ..||...|.:...:....|.|.:.|.....| :....||:.
Mouse   145 KNQKNLIKLDLSHNGLS-------STKLGTGVQLENLQELLLAKNKILALRSEELEFLGNSSLRK 202

  Fly   160 LSLRGNNFAELIPD-----AEDFARFVNESRLEASNSVPHHCELLL--LHNTTDLYDRECYLYFN 217
            |.|..|...|..|.     .:.||..:|.::|.     ||..|.|.  |.||:..     .|...
Mouse   203 LDLSSNPLKEFSPGCFQTIGKLFALLLNNAQLN-----PHLTEKLCWELSNTSIQ-----NLSLA 257

  Fly   218 NNTNMGQSITT--GRNYTNFIKVLKDRFDQHGSSSQSIAWATFPKMPRLVELDISNCSIEYVSKE 280
            ||..:..|.:|  |..:||..::     |...::...:...:|..:|.|..|.:...:|:.:|..
Mouse   258 NNQLLATSESTFSGLKWTNLTQL-----DLSYNNLHDVGNGSFSYLPSLRYLSLEYNNIQRLSPR 317

  Fly   281 AFRNVSNLR-----RLF----------------------------MSDNKIMTISHDTFYYVQGV 312
            :|..:||||     |.|                            |.||.|.:...:||..:..:
Mouse   318 SFYGLSNLRYLSLKRAFTKQSVSLASHPNIDDFSFQWLKYLEYLNMDDNNIPSTKSNTFTGLVSL 382

  Fly   313 QYLDLS--FTNFLTYSYQ-----LQLPTLEMALSLIYGLKIQQNVFKYLPELIYLDLSHSKM--- 367
            :||.||  ||:..|.:.:     ...|.|.:.|:..:..||....|.:|.:|..|||..:::
Mouse   383 KYLSLSKTFTSLQTLTNETFVSLAHSPLLTLNLTKNHISKIANGTFSWLGQLRILDLGLNEIEQK 447

  Fly   368 --------TRNSAVAFAHLGDKLKFLSLCYTAIPMVSSTIFKNTVLEGLDLSGNPY--------- 415
                    .||....:......|:..:..:..:|.:...:.:...|:.:|:|.:|:
Mouse   448 LSGQEWRGLRNIFEIYLSYNKYLQLSTSSFALVPSLQRLMLRRVALKNVDISPSPFRPLRNLTIL 512

  Fly   416 -LS----YNIIDDAFDGIANTLKYLYFERSNIKDLEWS-----------KSLKNLQVLGLAGNNI 464
             ||    .||.:|..:|:.| |:.|.|:.:|:..| |.           |.|.:|.:|.|..|.:
Mouse   513 DLSNNNIANINEDLLEGLEN-LEILDFQHNNLARL-WKRANPGGPVNFLKGLSHLHILNLESNGL 575

  Fly   465 NALTPAMFQSLESLEILDLSSNHVGNWYRSAFHNNSALRVLNLRSNTINMLSNEML-KDFERLDY 528
            :.:...:|::|..|:.::|..|::.......|.:.::||.|||:.|.|..:..::. ..|:.|:.
Mouse   576 DEIPVGVFKNLFELKSINLGLNNLNKLEPFIFDDQTSLRSLNLQKNLITSVEKDVFGPPFQNLNS 640

  Fly   529 LSLGDNDFICDCHLRAVVEVAAANNKDADCSYRLLNYSQNAVGEEVISLAESLIIDRKLWQSRYI 593
            |.:..|.|.|.|                                |.||           |   ::
Mouse   641 LDMRFNPFDCTC--------------------------------ESIS-----------W---FV 659

  Fly   594 PWLQRSYSNIREFNRANHIIKLRFSSEDYMVAKCSAAQPYHLGDLDGDLTLKFQLLDYEASQYYC 658
            .|:.::::||.|.            |..|:   |:.  |:|                     ||.
Mouse   660 NWINQTHTNISEL------------STHYL---CNT--PHH---------------------YYG 686

  Fly   659 FNNTDQLQV-DELNCQIRSMSDLAE-ELHHVTNTVIAVMGSLVGACILGFIIYLKRWHIHYYYSS 721
            |    .|:: |..:|:     |.|. ||..:.:|.:.::..||   :|  :|:::.|.|.:|::
Mouse   687 F----PLKLFDTSSCK-----DSAPFELLFIISTSMLLVFILV---VL--LIHIEGWRISFYWN- 736

  Fly   722 LKSAALLSSASKESVNKFTNISQRDPSA---VYDIFISYCQNDRTWVLNELLPNVEETGDVSICL 783
                        .||::.....:.|..|   .|..:|.:...||.||.....|..|:...:..||
Mouse   737 ------------VSVHRILGFKEIDTQAEQFEYTAYIIHAHKDRDWVWEHFSPMEEQDQSLKFCL 789

  Fly   784 HERDFQIGVTILDNIISCMDRSYSLMLIISSKFLLSHWC-QFEMYLAQHRIFEVSKEHLILVFLE 847
            .||||:.||..|:.|::.:.||..::.:|:...|....| :|:::.|..:..|.:.:.:||:||:
Mouse   790 EERDFEAGVLGLEAIVNSIKRSRKIIFVITHHLLKDPLCRRFKVHHAVQQAIEQNLDSIILIFLQ 854

  Fly   848 DIPRRKRPKTL---QYLMDVKTYIKWPTAKEDRKLFWKRLKRSL 888
            :||..|....|   :.:......:.||..||....|..:|:.:|
Mouse   855 NIPDYKLNHALCLRRGMFKSHCILNWPVQKERINAFHHKLQVAL 898

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.