Protein Alignment Toll-9 and Toll-7

DIOPT Version :10

• Sequence 1: NP_649214.1
• Gene: Toll-9 / 40245
• FlyBaseID: FBgn0036978
• Length: 900
• Species: Drosophila melanogaster
• Sequence 2: XP_320221.5
• Gene: Toll-7 / 1280374
• VectorBaseID: AGAMI1_009495
• Length: 1328
• Species: Anopheles gambiae
• Alignment Length: 1085
• Identity: 213/1085 - (19%)
• Similarity: 362/1085 - (33%)
• Gaps: 356/1085 - (32%)

  Fly   104 LDLSHGNLKD-----------------DSDLFREAK---LSRKVTIWRTEV--FSAAFNTLTAAP 146
            ||||..|::.                 .::.||.|:   |:.|.....:|:  .:.|:|.|.:.|
Mosquito   151 LDLSDNNIRALPDGFLCPLTGLKVLNLTNNRFRSAEALGLAEKSCPGGSELQALNLAYNELRSVP 215

  Fly   147 FRTLYSMRESLKLLSLRGNNFAELIPDAEDFARFVNESRLEASNSVPHHCELL---LLHNTTDLY 208
            .....|....|:.|:|..||.:|:..||     ......|...|...:|.|.|   |...:.||
Mosquito   216 TGWGVSKLRRLQHLNLEFNNISEVHGDA-----LAGLGSLRTLNLSYNHLETLPGGLFAGSRDL- 274

  Fly   209 DRECYLYFNNNTNMGQSITTGRNYTNFIKVLKDRFDQHGSSSQSIAWATFPKMPRLVE------- 266
             ||.:|..|....:.:.:     :....::|.....::..||..:...||..:.|||.
Mosquito   275 -REIHLQGNQIYELPRGL-----FHRLEQLLVLDLSRNQLSSHHVDNGTFSGLIRLVVLNLAHNA 333

  Fly   267 -----------------LDISNCSIEYVSKEAFRNVSNLRRLFMSDNKIMT-------------- 300
                             ||:.|.||.|:...||..|.||..|.:::|::.|
Mosquito   334 LTRIDARTFAELYFLQILDLRNNSIGYIEDNAFLPVYNLHTLNLAENRLHTLDDRLFNGLFVLSK 398

  Fly   301 ----------ISHDTFYYVQGVQYLDLSFTNFLTYSYQLQLPTLEMALSLIYGL--------KIQ 347
                      :..:.|.....::.|||| :|.||     ::|.....||::..|        :|:
Mosquito   399 LTLNNNLISIVEPNVFRNCSDLKELDLS-SNQLT-----EVPYAIRDLSMLRALDLGENQIARIE 457

  Fly   348 QNVFKYLPELIYLDLSHSKMTRNSAVAFAHLGDKLKFLSLCYTAIPMVSSTIF-KNTVLEGLDLS 411
            ...|..|.:|..|.|..:::...:...||.| .:|..|:|....:..:....| :|..:|.:.|.
Mosquito   458 NGTFANLNQLTGLRLIDNQIENVTVGMFADL-PRLSVLNLAKNRVQNIERGSFDRNLDIEAIRLD 521

  Fly   412 GNPYLSYNIIDDAFDGIANTLKYLY---------------FERSNIKDLE----WSKSLKN---- 453
            ||.....|       ||..||..|.               |..||:|.|:    :.:||.|
Mosquito   522 GNFLTDIN-------GIFATLASLLWLNLAENHLVWFDYAFIPSNLKWLDIHGNYIESLGNYYKL 579

  Fly   454 -----LQVLGLAGNNINALTPAMFQSLESLEILDLSSNHVGNWYRSAFHNNSALRVLNLRSNTIN 513
                 ::.|..:.|.:..|.|....:  |:|:|.::.||:|..:.:.|.:...|..::|.:|.:.
Mosquito   580 QEEIKVKTLDASHNRLTDLGPMNVPN--SVELLFVNDNHIGTIHANTFIDKVNLARVDLYANALK 642

  Fly   514 MLSNEMLK------DFER-LDYLSLGDNDFICDC------------------------------H 541
            .|....|:      ..|| |....||.|.|.|||                              |
Mosquito   643 KLQLHQLRVAPAPPTTERPLPEFYLGGNPFECDCSMEWMQRVNNLTTRQHPKIMDLPNVECIMPH 707

  Fly   542 LRA--VVEVAAANNKD--------------------ADCS---------YRLLNYSQNAV----- 570
            .|.  :..:.:...||                    .||.         |....:..|.|
Mosquito   708 ARGSPIRPIVSLQPKDFLCRYETHCFALCHCCDFDACDCEMTCPSNCTCYHDQTWGTNVVDCGNQ 772

  Fly   571 -----------------------GEEVISLAESLIIDRKLWQSRY-----IPWLQ-RSYSNIR-- 604
                                   |.::..|...:.|.||..:..|     |..:| |:::.:.
Mosquito   773 GAAAAAAGGLRPVPMDATEVYLDGNDIPELQHHVFIGRKNLKVLYANASRIATIQNRTFAGLTAL 837

  Fly   605 -----EFNRANHIIKLRFSS-----EDYM-------VAKCSAAQPYHLG--DLDGDLTLKFQLLD 650
                 |.|....|....|.:     |.|:       :|..|.|..|.|.  .|||:..:...|..
Mosquito   838 QALHLEDNALQRIHGYEFENLALLRELYLQNNGLQSIANGSFAPLYSLRVLRLDGNRLVTMPLFQ 902

  Fly   651 YEASQYYCFNNTDQLQVDEL-----NCQIRSMSDLA--------------------EELHH---- 686
            .:|:|    .|...||...|     :|:.|.:.:|.                    :.:|.
Mosquito   903 LQAAQ----GNLQALQSLSLGRNPWSCRCRFLPELTAFVADNAVIVQDPQDVYCADDGVHRELDF 963

  Fly   687 --------------------VTNTVIAVMG-SLVGAC--ILGFIIYLKRWHIHYYYSSLKSAALL 728
                                :..|.|.:|. ::|..|  :|..::::.|..:.::..|.....:.
Mosquito   964 NVSAACSDFYAGRSVLPGDGLPETYIMLMALAVVLVCLLLLAVLMFVFREPLRFWLFSRYGVRVF 1028

  Fly   729 SSASKESVNKFTNISQRDPSAVYDIFISYCQNDRTWVLNELLPNVEE-TGDVSICLHERDFQIGV 792
            ....::|            ..:||..:.|...|...|...:...:|. ...:.:||..||.....
Mosquito  1029 GPRCEDS------------EKLYDAILLYSAKDAELVARSIAGELENGRPPLRLCLQHRDLPEDA 1081

  Fly   793 TILDNIISCMDRSYSLMLIISSKFLLSHWCQFEMYLAQHRIFEVSKEHLIL------VFLE---D 848
            :.| .::.....|..:::::|..||.:.|.:.|:..|.|.........|::      |.||   |
Mosquito  1082 SHL-QLLEASRASRRIVVLLSRNFLQTEWSRCELRRAVHDALRGRPHKLVVVEEGGGVLLEAEND 1145

  Fly   849 IPRRKRPKTLQYLMDVKTYIKWPTAKEDR---KLFWKRLKRSLEV 890
            :             ::..|:|..|....|   :.||::|:.:|.|
Mosquito  1146 V-------------ELVPYLKTTTVTRVRRGDRHFWEKLRYALPV 1177

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Toll-9	NP_649214.1	LRR	198..537	CDD:443914	96/433 (22%)
		leucine-rich repeat	264..287	CDD:275380	11/46 (24%)
		leucine-rich repeat	288..311	CDD:275380	5/46 (11%)
		leucine-rich repeat	312..356	CDD:275380	14/51 (27%)
		leucine-rich repeat	357..381	CDD:275380	6/23 (26%)
		leucine-rich repeat	382..397	CDD:275380	3/14 (21%)
		leucine-rich repeat	405..430	CDD:275380	7/24 (29%)
		leucine-rich repeat	432..453	CDD:275380	9/39 (23%)
		leucine-rich repeat	454..477	CDD:275380	4/22 (18%)
		leucine-rich repeat	478..501	CDD:275380	6/22 (27%)
		leucine-rich repeat	502..525	CDD:275380	5/28 (18%)
		TIR	751..891	CDD:214587	33/153 (22%)
Toll-7	XP_320221.5	None