Protein Alignment Toll-9 and LOC1270739

DIOPT Version :10

• Sequence 1: NP_649214.1
• Gene: Toll-9 / 40245
• FlyBaseID: FBgn0036978
• Length: 900
• Species: Drosophila melanogaster
• Sequence 2: XP_309458.5
• Gene: LOC1270739 / 1270739
• VectorBaseID: AGAMI1_013532
• Length: 1347
• Species: Anopheles gambiae
• Alignment Length: 1024
• Identity: 200/1024 - (19%)
• Similarity: 336/1024 - (32%)
• Gaps: 369/1024 - (36%)

  Fly   104 LDLSHGNLKDD---SDLFREAKLSRKVTIWRTEVFSAAFNTLTAAP---FRTLYSMRESLKLLSL 162
            |||||..|..:   .:.|...|        |..|...|.|.||...   ||.||    ||::|:|
Mosquito   329 LDLSHNELTSEWVKRNTFAGMK--------RLVVLEIAHNALTKIDRHVFRELY----SLQILNL 381

  Fly   163 RGNNFAELIPDA-EDFARFV----NESRLEASNSVPHH-CELLLLH------------------N 203
            ..|....:..:| .|....|    :.:||:....  || .||.:|:                  |
Mosquito   382 EANQIESIADNAFSDLKNLVALTLSHNRLKRIEQ--HHFSELYVLNQLYVESNLIESMHGRALEN 444

  Fly   204 TTDLYDRECYLYFNNNTNMGQSITTGRNYTNFIKVLKDRFDQHGSSSQSIAWATFPKMPRLVELD 268
            .|:|.|      .|.|.|....|..|.....|:|                            .||
Mosquito   445 LTNLND------LNLNDNRLTEIPEGLGKLRFLK----------------------------SLD 475

  Fly   269 ISNCSIEYVSKEAFRNVSNLRRLFMSDNKIMTISHDTFYYVQGVQYLDLSFTNFLTYSYQLQL-- 331
            :....|..||..:|..:..|..|.:.:|:|..||.|.|..:..:..|:|: :|.:.:..|...
Mosquito   476 LGKNRISAVSNASFEGLEQLLGLRLVENRITNISRDAFVTLSSLHVLNLA-SNQIRHIDQSAFSS 539

  Fly   332 -PTLEMALSLIYGLKIQQN-------VFKYLPELIYLDLSHSK-----------------MTRNS 371
             ||       |..:::..|       ||..||.|::|::|.::                 |.:|:
Mosquito   540 NPT-------IRAIRLDNNELEDISGVFTSLPALVFLNVSDNQIRLFDYSHFPVSLEWLDMHQNN 597

  Fly   372 AVAFAHLGD----KLKFLSLCYT--------AIPMVSSTIFKNT---------------VLEGLD 409
            .....:..|    ::|.|.:.:.        .||....|:|.|.               .||.:.
Mosquito   598 ITELGNYYDLNNLQIKMLDVSFNRLTSVDAKCIPDSIETLFLNNNALEEVAAGTFLSKRSLEKVV 662

  Fly   410 LSGNPYLS---------YNIIDD----AF----------------DGIANTLKYLYFERSNIKDL 445
            |.|| ||.         ..:.||    ||                .|| |.|.:|. :...:.||
Mosquito   663 LYGN-YLRKLEIGALALTRVADDREVPAFYLGDNPIHCDCTMEWLQGI-NKLAHLR-QHPRVMDL 724

  Fly   446 E--------------------------------------------------------------WS 448
            :                                                              |.
Mosquito   725 DTVLCTMEHERGASIRPLMDLRPHDFLCRYETHCFATCHCCEFDACDCKMTCPDRCSCYHDHTWK 789

  Fly   449 KSL----------------KNLQVLGLAGNNINALTPAMFQSLESLEILDLSSNHVGNWYRSAFH 497
            .::                .:...:.|.||.:..|....|...:.||:|.|:.:::.:.:...|:
Mosquito   790 ANIVDCGSADYTEVPEHIPMDASTIYLDGNELRQLASHQFIGKKKLEVLYLNGSNIRDVHNRTFN 854

  Fly   498 NNSALRVLNLRSNTINMLS----------NEMLKDFERLDYLSLGDNDFICDCHLRAVVEVAAAN 552
            ...:||||:|.:|.||.|.          ||:..|...:.|  :|:..|.   .||.:..|:.::
Mosquito   855 GIPSLRVLHLENNYINELRGFEFDQLTNLNELYLDHNAIAY--VGERTFE---SLRFLEVVSLSD 914

  Fly   553 NKDADCSYRLLNYSQNAVGEEVISLAESLIIDRKLWQ------SRYIPWLQRSYSNIREFNRA-- 609
            |:.::  :|  .:...|...|..|||. :.:|...|:      .|...|: |:.|...|..|.
Mosquito   915 NRISE--FR--PWQAFAAAGETGSLAR-VALDGNRWRCDCESLRRMQRWI-RTVSGNFELQRMIC 973

  Fly   610 --NHIIKLRFSSEDYMVAKCSAAQ-------PYHLGDLDGD--------LTLKFQLLDYEASQYY 657
              :.::.       ..:|.|.:.|       ...:|::|||        :.|...|:   ...|
Mosquito   974 ADSRVVA-------DAIASCDSRQGGGVFGAGAEVGEVDGDGPPAVHRTVLLGHGLI---GGGY- 1027

  Fly   658 CFNNTDQLQVDELNCQIRSMSDLAEELHHVTNTVIAVMGSLVG-------ACILGFIIYLKRW-H 714
                                          ...:.|::.:::|       ||:  |...::.| |
Mosquito  1028 ------------------------------VPLLAAILVAIIGTALIVALACV--FRQDVRLWAH 1060

  Fly   715 IHYYYSSLKSAALLSSASKESVNKFTNISQRDPSAVYDIFISYCQNDRTWVLNELLPNVEETGDV 779
            ..|....:|...::...           .:.|...:||.::.:..:|..:| ..||....:....
Mosquito  1061 ARYGVRLVKDPIIVGGR-----------KEPDSDRLYDCYLVHSVHDSDFV-GRLLGAELQLHGY 1113

  Fly   780 SICLHERDFQIGVTILDNIISCMDRSYSLMLIISSKFLLSHWCQFEMYLAQHRIFE----VSKEH 840
            |:|.|.||...|..:.|::.|..|.:..|:|::|..||.:.|.|.:..:|...:.|    ..:.|
Mosquito  1114 SVCQHHRDVHPGAFLADSLQSAADSARKLLLVVSMNFLQTEWSQPQFRVALQSVIESIRPAHRRH 1178

  Fly   841 -LILVFLEDIPRRKRPKTLQYLMDVKTYIKWPTAKEDRKLFWKRLKRSL 888
             ::||....:........:..|:...|...|...|     ||.:|:.:|
Mosquito  1179 KIVLVLTAPVEIVAMDPIMHLLIRTCTVACWGERK-----FWDKLRYAL 1222

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Toll-9	NP_649214.1	LRR	198..537	CDD:443914	95/527 (18%)
		leucine-rich repeat	264..287	CDD:275380	6/22 (27%)
		leucine-rich repeat	288..311	CDD:275380	8/22 (36%)
		leucine-rich repeat	312..356	CDD:275380	11/53 (21%)
		leucine-rich repeat	357..381	CDD:275380	6/44 (14%)
		leucine-rich repeat	382..397	CDD:275380	4/22 (18%)
		leucine-rich repeat	405..430	CDD:275380	13/53 (25%)
		leucine-rich repeat	432..453	CDD:275380	5/98 (5%)
		leucine-rich repeat	454..477	CDD:275380	5/22 (23%)
		leucine-rich repeat	478..501	CDD:275380	5/22 (23%)
		leucine-rich repeat	502..525	CDD:275380	12/32 (38%)
		TIR	751..891	CDD:214587	35/143 (24%)
LOC1270739	XP_309458.5	None