DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-9 and TLR6

DIOPT Version :9

Sequence 1:	NP_001246846.1	Gene:	Toll-9 / 40245	FlyBaseID:	FBgn0036978	Length:	900	Species:	Drosophila melanogaster
Sequence 2:	NP_001381482.1	Gene:	TLR6 / 10333	HGNCID:	16711	Length:	796	Species:	Homo sapiens

Alignment Length:	893	Identity:	189/893 - (21%)
Similarity:	332/893 - (37%)	Gaps:	318/893 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 YLDLSHGNLKDDS----DLFREAKLSRKVTIWRTEVFSAAFNTLTAAP------------FRTLY 151
            ||||||..|:..|    ..||...||              ||...|.|            |..|.
Human   104 YLDLSHNQLQKISCHPIVSFRHLDLS--------------FNDFKALPICKEFGNLSQLNFLGLS 154

  Fly   152 SMR-ESLKLLSLRGNNFAELIPDAEDFARFVNESR-LEASNSVPHHCELLLLHNTTDLYDRECYL 214
            :|: :.|.||.:...:.:.::.|..::....||:. |:..|:...|   |:.|.|:
Human   155 AMKLQKLDLLPIAHLHLSYILLDLRNYYIKENETESLQILNAKTLH---LVFHPTS--------- 207

  Fly   215 YFNNNTNMGQSITTGRNYTNFIKVLKDRFDQHGSSSQSIAWATFPKMPRLVELDISNCS--IEYV 277
            .|....|:..:.......||                              ::|:..||.  |:::
Human   208 LFAIQVNISVNTLGCLQLTN------------------------------IKLNDDNCQVFIKFL 242

  Fly   278 SKEAFRNVSNLRRLFMSDNKIMTISH-DT----------FYYVQGVQYLDLSFTNFLTYSYQLQL 331
            | |..|..:.|.         .|::| :|          |.:.:.|:||:
Human   243 S-ELTRGSTLLN---------FTLNHIETTWKCLVRVFQFLWPKPVEYLN--------------- 282

  Fly   332 PTLEMALSLIYGLKIQQNVFKYLPELIYLDLSHSKMTRNSAVAFAHLGDKLKFLSLCYTAIPMVS 396
                     ||.|.|.:::.:.       |.::||.|. .|:...|:.:::...|  .||:
Human   283 ---------IYNLTIIESIREE-------DFTYSKTTL-KALTIEHITNQVFLFS--QTAL---- 324

  Fly   397 STIFKNTVLEGLDLSGNPYL----------------SYNIIDDAFDGIANT---LKYLYFERSNI 442
            .|:|....:..|.:|..|::                :.|:..|:.....:|   |:.|..:::.:
Human   325 YTVFSEMNIMMLTISDTPFIHMLCPHAPSTFKFLNFTQNVFTDSIFEKCSTLVKLETLILQKNGL 389

  Fly   443 KDL----EWSKSLKNLQVLGLAGNNI----------------------NALTPAMFQSL-ESLEI 480
            |||    ..:|.:.:|::|.::.|::                      |.||.::|:.| ..:::
Human   390 KDLFKVGLMTKDMPSLEILDVSWNSLESGRHKENCTWVESIVVLNLSSNMLTDSVFRCLPPRIKV 454

  Fly   481 LDLSSNHVGNWYRS------------AFH---------NNSALRVLNLRSNTINMLSNEMLKDFE 524
            |||.||.:.:..:.            ||:         :.|:|.||.:..|:::..|.:..:..:
Human   455 LDLHSNKIKSVPKQVVKLEALQELNVAFNSLTDLPGCGSFSSLSVLIIDHNSVSHPSADFFQSCQ 519

  Fly   525 RLDYLSLGDNDFICDCHLRAVVEVAAANNKDADCSYRLLNYSQNAVGEEVISLAESLIIDRKLWQ 589
            ::..:..|||.|.|.|.||..|:                |..|  |..||:          :.|.
Human   520 KMRSIKAGDNPFQCTCELREFVK----------------NIDQ--VSSEVL----------EGWP 556

  Fly   590 SRYIPWLQRSYSNIREFNRANHIIKLRFSSEDYMVAKCSAAQPYHLGDLDGDLTLKFQLLDYEAS 654
            ..|                                 ||...:.|....|.          |:..|
Human   557 DSY---------------------------------KCDYPESYRGSPLK----------DFHMS 578

  Fly   655 QYYCFNNTDQLQVDELNCQIRSMSDLAEELHHVTNTVIAVMGS---LVGACILGFIIYLK-RWHI 715
                          ||:|.|              ..:|..:|:   ::...:....|||. .|::
Human   579 --------------ELSCNI--------------TLLIVTIGATMLVLAVTVTSLCIYLDLPWYL 615

  Fly   716 HYYYSSLKSAALLSSASKESVNKFTNISQRDPSAVYDIFISYCQNDRTWVLNELLPNVEETGDVS 780
            .......::.....:...|.:.:  |:.       :..||||.::|..||.:||:|.:|:. |:.
Human   616 RMVCQWTQTRRRARNIPLEELQR--NLQ-------FHAFISYSEHDSAWVKSELVPYLEKE-DIQ 670

  Fly   781 ICLHERDFQIGVTILDNIISCMDRSYSLMLIISSKFLLSHWCQFEMYLAQHRIFEVSKEHLILVF 845
            ||||||:|..|.:|::|||:|:::||..:.::|..|:.|.||.:|:|.|.|.:|.....:|||:.
Human   671 ICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFHEGSNNLILIL 735

  Fly   846 LEDIPRRKRPK---TLQYLMDVKTYIKWPTAKEDRKLFWKRLKRSLEV 890
            ||.||:...|.   .|:.||..:||::||..|..|.|||..::.:..:
Human   736 LEPIPQNSIPNKYHKLKALMTQRTYLQWPKEKSKRGLFWANIRAAFNM 783

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-9	NP_001246846.1	leucine-rich repeat	157..185	CDD:275380	6/27 (22%)
		LRR_8	262..322	CDD:290566	15/72 (21%)
		leucine-rich repeat	264..287	CDD:275380	7/24 (29%)
		leucine-rich repeat	288..311	CDD:275380	5/33 (15%)
		leucine-rich repeat	312..356	CDD:275380	7/43 (16%)
		LRR_8	<344..387	CDD:290566	8/42 (19%)
		leucine-rich repeat	357..381	CDD:275380	6/23 (26%)
		leucine-rich repeat	382..397	CDD:275380	3/14 (21%)
		leucine-rich repeat	405..430	CDD:275380	5/40 (13%)
		LRR_8	431..488	CDD:290566	20/86 (23%)
		leucine-rich repeat	432..453	CDD:275380	6/24 (25%)
		LRR_RI	<449..536	CDD:238064	25/130 (19%)
		leucine-rich repeat	454..477	CDD:275380	8/45 (18%)
		LRR_8	477..536	CDD:290566	16/79 (20%)
		leucine-rich repeat	478..501	CDD:275380	7/43 (16%)
		leucine-rich repeat	502..525	CDD:275380	5/22 (23%)
		TIR	751..891	CDD:214587	57/143 (40%)
TLR6	NP_001381482.1	LRR 1	54..77
		LRR 2	78..101
		LRR 3	102..122		8/17 (47%)
		LRR 4	123..147		8/37 (22%)
		LRR 5	148..168		6/19 (32%)
		LRR 6	169..196		4/26 (15%)
		LRR 7	197..219		6/33 (18%)
		LRR 8	220..250		9/60 (15%)
		LRR 9	251..277		5/34 (15%)
		LRR 10	278..303		10/55 (18%)
		LRR 11	304..330		7/32 (22%)
		LRR 12	331..354		3/22 (14%)
		LRR 13	355..378		3/22 (14%)
		LRR 14	379..404		6/24 (25%)
		LRR 15	405..429		3/23 (13%)
		LRR 16	430..450		5/19 (26%)
		LRR 17	451..474		5/22 (23%)
		LRR 18	475..496		2/20 (10%)
		LRR 19	497..520		5/22 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	131	1.000	Domainoid score	I5140
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	213	1.000	Inparanoid score	I3640
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	1	1.000	-	-		otm41867
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	9.030