DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Toll-9 and cd180

DIOPT Version :9

Sequence 1:	NP_001246846.1	Gene:	Toll-9 / 40245	FlyBaseID:	FBgn0036978	Length:	900	Species:	Drosophila melanogaster
Sequence 2:	NP_001297419.1	Gene:	cd180 / 101885327	ZFINID:	ZDB-GENE-070705-323	Length:	665	Species:	Danio rerio

Alignment Length:	741	Identity:	155/741 - (20%)
Similarity:	263/741 - (35%)	Gaps:	189/741 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 EASNSVPHHCELLLLHNTTDLYDRECYLYFNNNTNMGQSITTGRNYTNFIKVLKDRFDQHGSSSQ 251
            ||:.....||:.:     |..||  |     |:.:: |||..  ...|.:::|:..|:...:...
Zfish    23 EATPWARRHCQQI-----TKGYD--C-----NDMDL-QSIPD--EIPNSVQILQFSFNYLPALYN 72

  Fly   252 SIAWATFPKMPRLVELDISNCSIEYVSKEAFRNVSNLRRLFMSDNKIMTISHDTFYYVQGVQYLD 316
            |    ||.::..|..||::.|||.::.::.|....:|..|.::.|.::.|:...|.....::||.
Zfish    73 S----TFQRLKSLRSLDVTRCSITFIYEDVFTYQPHLEVLLLTGNPLVFIASTAFSGPLALKYLS 133

  Fly   317 LSFTNFLTYSYQLQLPTLEMALSLIYGLKIQQNVFKYLPELIYLDLSHSKM-TRNSAVAFAHLGD 380
            |..:.....|   .:|:..:|               ||.   .|||..|.: :.|....|.  ..
Zfish   134 LVQSKIKQLS---DIPSENLA---------------YLE---VLDLRGSNIRSLNGLSNFR--WQ 175

  Fly   381 KLKFLSLCYTAIPMVSST---IFKNTVLEGLDLSGNPYL--------SYNIIDDAFDGIANTLKY 434
            .||.|.|....|..:|..   .|.|.....:...||.::        |.|:....|.|..|.:..
Zfish   176 NLKSLQLDLNFIDRISFNDLQPFSNLAGVSISFKGNDFIYIEPGAFHSLNLSSLDFSGCLNKMNI 240

  Fly   435 LYFERSNIKDLEWSKSLKNLQVLGLAGNNINA-LTPAMFQSLESLEI--LDLSSNHVGNWYRSAF 496
                .|.:|.||..|:  |...|||...:.|. :..|..||..::.:  ||....|..:...|.|
Zfish   241 ----SSLLKGLEGIKT--NRLNLGLYETDSNVYIASAALQSFCNIFVSDLDFQLQHFLDLNNSTF 299

  Fly   497 HNNSALRVLNLRSNTINMLSNEMLKDFERLDYLSLGDNDF--ICDCHLR---AVVEVAAANNKDA 556
            |....|:.|:|....:|.|... ......|.:|.|.:|.|  :|..:.|   .:..::.:.|
Zfish   300 HCLEGLKKLDLTRAHLNALPLN-TTGLSTLSHLILDENQFKDVCQSNTRNFPMLTHLSISGN--- 360

  Fly   557 DCSYRLLNYSQNAVGE----EVISLAESLIIDRKLWQSRYIPWLQRSYSNIREFNRANHIIKLRF 617
               .:.|.:|...:..    |.:.|:.||:..|:       |........:.|..    ::.|.:
Zfish   361 ---LKKLTFSNRCLDSLGLLEELDLSVSLVNPRE-------PCCNNQLFGLGELK----LLNLSY 411

  Fly   618 SSEDYMVAKCSAAQPYHLGDLDGDLTLKFQLLDYEASQYYC------FNNTDQLQVDELNCQIRS 676
            .|..:..:|     |:       ::|.|.:.||:..|.|..      |:|...|:...|:.   |
Zfish   412 GSPMFWSSK-----PF-------NVTPKLEHLDFSHSVYTLLNDSSPFSNLQSLRTLNLSW---S 461

  Fly   677 MSDLA--------EELHHVTNTVIAVMGS-----------------LVGAC-ILGFIIYLKRWHI 715
            .:||.        :.|.|:.....|:.|.                 ::.|| |..|...|.:...
Zfish   462 NTDLTNVHLFVGLKALQHLNLRGNAIQGEVLTQTELFKCVPLLETLVLSACKITSFDENLFKGLR 526

  Fly   716 HYYYSSLKSAALLSSASKESVNKFTNISQRDPSAVYDIFISYCQNDRTWVLNELLPNVEETGDVS 780
            |..:..|            |.|||..:|.....::..:.:::.:||.|.|....:.::.|.|.|
Zfish   527 HLNHIDL------------SENKFVKLSTSGFYSLDFLKLNFARNDITTVDVASVADLGEEGSV- 578

  Fly   781 ICLHERDFQIGVTILDNIISCMDRSYSLMLIISSKFLLSHWCQFEMYLAQHRIFEVSKEHLILVF 845
                                  |.||:.::...|.|...||.:..         :|..:||:..|
Zfish   579 ----------------------DLSYNPLVCNCSNFEFIHWVKKN---------KVKVKHLMETF 612

  Fly   846 LEDIPRRKRPKTLQYLMDVKTYIKWP 871
            ......|        ::|.|.....|
Zfish   613 CNGTGTR--------IIDAKLQCDLP 630

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-9	NP_001246846.1	leucine-rich repeat	157..185	CDD:275380
		LRR_8	262..322	CDD:290566	15/59 (25%)
		leucine-rich repeat	264..287	CDD:275380	7/22 (32%)
		leucine-rich repeat	288..311	CDD:275380	5/22 (23%)
		leucine-rich repeat	312..356	CDD:275380	8/43 (19%)
		LRR_8	<344..387	CDD:290566	11/43 (26%)
		leucine-rich repeat	357..381	CDD:275380	6/24 (25%)
		leucine-rich repeat	382..397	CDD:275380	5/14 (36%)
		leucine-rich repeat	405..430	CDD:275380	6/32 (19%)
		LRR_8	431..488	CDD:290566	15/59 (25%)
		leucine-rich repeat	432..453	CDD:275380	5/20 (25%)
		LRR_RI	<449..536	CDD:238064	24/89 (27%)
		leucine-rich repeat	454..477	CDD:275380	7/23 (30%)
		LRR_8	477..536	CDD:290566	15/60 (25%)
		leucine-rich repeat	478..501	CDD:275380	6/24 (25%)
		leucine-rich repeat	502..525	CDD:275380	5/22 (23%)
		TIR	751..891	CDD:214587	22/121 (18%)
cd180	NP_001297419.1	leucine-rich repeat	40..56	CDD:275380	6/25 (24%)
		LRR_8	56..115	CDD:316378	15/62 (24%)
		leucine-rich repeat	57..80	CDD:275380	5/26 (19%)
		leucine-rich repeat	81..104	CDD:275380	7/22 (32%)
		LRR_8	103..163	CDD:316378	17/80 (21%)
		leucine-rich repeat	105..128	CDD:275380	5/22 (23%)
		leucine-rich repeat	153..176	CDD:275380	7/27 (26%)
		leucine-rich repeat	177..200	CDD:275380	7/22 (32%)
		leucine-rich repeat	201..225	CDD:275380	3/23 (13%)
		leucine-rich repeat	226..247	CDD:275380	5/24 (21%)
		leucine-rich repeat	284..304	CDD:275378	6/19 (32%)
		leucine-rich repeat	305..327	CDD:275380	5/22 (23%)
		leucine-rich repeat	328..351	CDD:275380	7/22 (32%)
		leucine-rich repeat	352..376	CDD:275380	3/29 (10%)
		leucine-rich repeat	404..427	CDD:275380	5/38 (13%)
		LRR_8	426..487	CDD:316378	14/63 (22%)
		leucine-rich repeat	428..452	CDD:275380	6/23 (26%)
		leucine-rich repeat	453..476	CDD:275380	5/25 (20%)
		leucine-rich repeat	477..503	CDD:275380	4/25 (16%)
		LRR_8	502..561	CDD:316378	13/70 (19%)
		leucine-rich repeat	504..527	CDD:275380	5/22 (23%)
		leucine-rich repeat	528..549	CDD:275380	6/32 (19%)
		leucine-rich repeat	552..574	CDD:275380	4/21 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920