DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-9 and tlr7

DIOPT Version :9

Sequence 1:	NP_001246846.1	Gene:	Toll-9 / 40245	FlyBaseID:	FBgn0036978	Length:	900	Species:	Drosophila melanogaster
Sequence 2:	XP_021334735.1	Gene:	tlr7 / 100534776	ZFINID:	ZDB-GENE-040219-11	Length:	1036	Species:	Danio rerio

Alignment Length:	913	Identity:	208/913 - (22%)
Similarity:	339/913 - (37%)	Gaps:	282/913 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 KERTDLKSLMLKYESDDGNSCLLDLIKDEVIWWQFPNGTLRDSTKKYAHKLYLDLSHGNLKDDSD 116
            |...:||:|.|...|       |..|..|  |:|    :|.|.|       .|||| .|.
Zfish   279 KTLRNLKTLRLHSNS-------LTNIPPE--WFQ----SLADLT-------LLDLS-SNF----- 317

  Fly   117 LFREAKLSRKVT-------IWRTEVFSAAFN-TLTAAP----FRTLYSMRESLKLLSLRGNNFAE 169
                  |::::|       :.:.|....:|| .|...|    ....:|..:||::|.:||..|.|
Zfish   318 ------LAKEITCTSFPSLLPKLEELDLSFNYELQVYPASLSLSESFSQLKSLRVLRIRGYVFQE 376

  Fly   170 L-IPDAEDFARFVNESRLEASNSVPHHCELLLLHN-----TTDLYDR------ECYLYFNNNTN- 221
            | :.|.:..........|:...:.....:|.:|.|     ..:|.|.      |....|:|:..
Zfish   377 LKLQDIQPLTNLTYLEFLDLGTNFIKIAQLSILKNLKNFKIINLSDNKISVPSEGEFSFSNHREA 441

  Fly   222 -MGQSITTGRNYTN-FIK----VLKDRFDQHGSSSQSIAW---------ATFPKMPRLVELDISN 271
             .|..::.|..|.| .:|    .|.|.|.:.........|         ::|.|     .||||.
Zfish   442 YYGSPMSQGAQYHNGEVKDMHYFLYDEFARSCKYKDKELWIPSPFNNDCSSFGK-----TLDISR 501

  Fly   272 CSIEYVSKEAFRNVSNLRRLFMSDNKI-MTISHDTFYYVQGVQYLDLSFTNFLTYSYQLQLPTLE 335
            .:|.::..: |.|:..||.|.:|.|.: .:::...|..:..:||||  ||              :
Zfish   502 NNIFFLHSK-FLNLGELRCLNLSGNAMSQSLNGSEFVQLTNLQYLD--FT--------------D 549

  Fly   336 MALSLIYGLKIQQNVFKYLPELIYLDLSHSKMTRNS----AVAFAHLGD------KLKFLSLCYT 390
            ..|.|:|     .:.|:.|..|:.||:|     |||    |....|:.:      ||:.|.:...
Zfish   550 NRLDLMY-----PSAFQELSNLVVLDIS-----RNSHYFVAEGLTHMLNFTENLSKLRKLIMNDN 604

  Fly   391 AIPMVSSTIFKNTVLEGLDLSGN-----------PYLSY-----------------NIID-DAFD 426
            .|...::|..|:..||.|:..||           .|::|                 |.|. ..|.
Zfish   605 QISTSTNTEMKSYKLEHLEFKGNRLDMLWRDGDTRYVNYFKNLMSLKTLDISRNNLNFIPLVVFQ 669

  Fly   427 GIANTLKYLYFERSNIKDLEWS--KSLKNLQVLGLAGNNINALTPAMFQSLESLEILDLSSNHV- 488
            |:.|||..||...:.:|..:|.  ..||:|.:|.|.||.:..:...:....:|::.|.||.|.:
Zfish   670 GLPNTLTKLYITDNKLKLFKWEGLVYLKSLLLLDLTGNLLTEVPSCLSNYTKSIQTLVLSKNKIV 734

  Fly   489 ---GNWYRSAFHNNSALRVLNLRSNTINMLSNEMLKD--FERLDYLSLGDNDFICDCHLRAVVEV 548
               .|:.:.||    :|::|:|..|:|..:......:  .:.|..|.|.:|.|:|.|
Zfish   735 KLSPNFLKDAF----SLKILDLSYNSIQFIDESSFPENVIDHLQTLYLNNNMFVCSC-------- 787

  Fly   549 AAANNKDADCSYRLLNYSQNAVGEEVISLAESLIIDRKLWQSRYIPWLQRSYSNIREFNRANHII 613
                               ||.                 |..|   |:.|:..||...
Zfish   788 -------------------NAT-----------------WLVR---WINRTSVNIPRL------- 806

  Fly   614 KLRFSSEDYMVAKCSAAQPYHLGDLDGDLTLKFQLLDYEASQYYCFNNTDQLQVDELNCQIRSMS 678
                 :.|...|..||                      :..|...|.|   ||.    ||
Zfish   807 -----ASDVTCASPSA----------------------QKGQSVIFLN---LQA----CQ----- 832

  Fly   679 DLAEELHHVTNTVIAVMGSLVGACILGFII--YLKRWHIHYYY----SSLKSAALLSSASKESVN 737
                  |:..:.::.:..:.:...||...|  :|..|.:.|.|    :.||....|||
Zfish   833 ------HNSLSIILCIFQTTLILTILTLTISSHLFLWDVWYIYHFCLAKLKGYRRLSS------- 884

  Fly   738 KFTNISQRDPSAVYDIFISYCQND---RTWVLNELLPNVEETGD--VSICLHERDFQIGVTILDN 797
                     .|||||.|:.|...|   :.||:.||..::|:.||  :::||.|||:..|..:::|
Zfish   885 ---------NSAVYDAFVIYDTTDPAVQEWVMQELRVHLEDKGDPRMNLCLEERDWVPGCPLIEN 940

  Fly   798 IISCMDRSYSLMLIISSKFLLSHWCQFEMYLAQHRIFEVSKEHLILVFLEDIPRRKRPKTLQYLM 862
            :...:..|...:.|::.:::.|...:...|||..|:.:...:.::|:|||.:|...:...|:..:
Zfish   941 LSQSIQLSQRTVFILTERYIRSGSFRTAFYLAHQRLMDERNDVIVLIFLERMPCHSKYLRLRKRL 1005

  Fly   863 DVK 865
            .:|
Zfish  1006 CIK 1008

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-9	NP_001246846.1	leucine-rich repeat	157..185	CDD:275380	8/28 (29%)
		LRR_8	262..322	CDD:290566	19/60 (32%)
		leucine-rich repeat	264..287	CDD:275380	7/22 (32%)
		leucine-rich repeat	288..311	CDD:275380	6/23 (26%)
		leucine-rich repeat	312..356	CDD:275380	11/43 (26%)
		LRR_8	<344..387	CDD:290566	14/52 (27%)
		leucine-rich repeat	357..381	CDD:275380	9/33 (27%)
		leucine-rich repeat	382..397	CDD:275380	3/14 (21%)
		leucine-rich repeat	405..430	CDD:275380	11/53 (21%)
		LRR_8	431..488	CDD:290566	18/58 (31%)
		leucine-rich repeat	432..453	CDD:275380	6/22 (27%)
		LRR_RI	<449..536	CDD:238064	24/92 (26%)
		leucine-rich repeat	454..477	CDD:275380	5/22 (23%)
		LRR_8	477..536	CDD:290566	17/64 (27%)
		leucine-rich repeat	478..501	CDD:275380	7/26 (27%)
		leucine-rich repeat	502..525	CDD:275380	5/24 (21%)
		TIR	751..891	CDD:214587	33/120 (28%)
tlr7	XP_021334735.1	LRR_8	67..131	CDD:316378
		leucine-rich repeat	83..120	CDD:275380
		PLN00113	107..>574	CDD:331614	84/358 (23%)
		leucine-rich repeat	121..165	CDD:275380
		leucine-rich repeat	142..157	CDD:275380
		leucine-rich repeat	166..197	CDD:275380
		leucine-rich repeat	199..218	CDD:275380
		leucine-rich repeat	219..242	CDD:275380
		leucine-rich repeat	243..283	CDD:275380	1/3 (33%)
		leucine-rich repeat	284..307	CDD:275380	11/35 (31%)
		leucine-rich repeat	308..333	CDD:275380	8/43 (19%)
		leucine-rich repeat	334..363	CDD:275380	6/28 (21%)
		leucine-rich repeat	364..390	CDD:275380	8/25 (32%)
		leucine-rich repeat	391..414	CDD:275380	4/22 (18%)
		leucine-rich repeat	415..434	CDD:275380	3/18 (17%)
		leucine-rich repeat	495..516	CDD:275380	8/26 (31%)
		leucine-rich repeat	517..541	CDD:275380	6/23 (26%)
		leucine-rich repeat	542..565	CDD:275380	11/43 (26%)
		leucine-rich repeat	566..595	CDD:275380	9/33 (27%)
		leucine-rich repeat	596..616	CDD:275380	4/19 (21%)
		leucine-rich repeat	619..649	CDD:275380	7/29 (24%)
		LRR_8	<644..685	CDD:316378	9/40 (23%)
		leucine-rich repeat	650..673	CDD:275380	4/22 (18%)
		leucine-rich repeat	675..722	CDD:275380	12/46 (26%)
		LRR_8	722..781	CDD:316378	16/62 (26%)
		leucine-rich repeat	723..746	CDD:275380	7/26 (27%)
		leucine-rich repeat	747..765	CDD:275380	5/17 (29%)
		PCC	751..>828	CDD:188093	25/160 (16%)
		TIR	889..>993	CDD:214587	30/103 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010