DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-9 and LOC100498493

DIOPT Version :9

Sequence 1:	NP_001246846.1	Gene:	Toll-9 / 40245	FlyBaseID:	FBgn0036978	Length:	900	Species:	Drosophila melanogaster
Sequence 2:	XP_002941870.2	Gene:	LOC100498493 / 100498493	XenbaseID:	XB-GENE-5824069	Length:	936	Species:	Xenopus tropicalis

Alignment Length:	974	Identity:	210/974 - (21%)
Similarity:	329/974 - (33%)	Gaps:	325/974 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 FRTLYSMRESLKLLSLRGNNFAELIPDAEDFARFVNESRLEASNS-VPHHCELLLLHNTTDLYDR 210
            |.|..|:.::...|:|.| |...:..|..|....:|...|..||: :|
Frog    50 FATRCSLYKNATSLALCG-NITNITADISDVPSTINILCLSGSNTFIP----------------- 96

  Fly   211 ECYLYFNNNTNMGQSITTGRNYTNF--IKVLKDRFDQHGSSSQSIAWATFPKMPRLVELDISNCS 273
                              |..:.||  ||.|                  |.||| ||.
Frog    97 ------------------GGTFANFKRIKYL------------------FMKMP-LVR------- 117

  Fly   274 IEYVSKEAFRNVSNLRRL---FMSDNKI--MTISHDTF---YYVQGVQYLDLSFTNF-------- 322
               :...||:.:.:|..|   |:..:|.  ::|..|.|   ||::     |||...|
Frog   118 ---IYPNAFKGLESLESLAISFLGHSKCNNLSIPTDAFSNLYYLR-----DLSIEGFKLVKSMLI 174

  Fly   323 -LTYS---YQLQLPT---------------------LEMALSLIYGLKIQQNVFKYLPELIYLDL 362
             |.:|   |.|.|||                     |::..:.|..:.:|.::...||.:..|.|
Frog   175 HLPFSTSLYSLSLPTNCITDLFHVFHIFQNLIFIHNLDVGSNKIERVSLQHDLNISLPNITELVL 239

  Fly   363 SHSKMTRNSAVAFAHLG---------------------DKLKFLSL---CYTAIPMVSS--TIFK 401
            ..:.:......|.|..|                     :.||.|||   |..||....:  :|.:
Frog   240 EKNPLILIQQNALARFGIHLLNLGFTKLNLEDILNAGVENLKSLSLTSACRRAINKTHTLCSIAQ 304

  Fly   402 NTVLEGLDLSGNPYLSYNIIDDAFDGI-------ANTLKYLYFERSNI--------------KDL 445
            ...|:.|....|          .|.||       .::|::|....::|              |:|
Frog   305 RFQLKSLSAPVN----------RFSGIYTKDFLGCSSLEFLNLNHNHIHIVDPDLLYTLPKLKEL 359

  Fly   446 EWSKSL---------------KNLQVLGLAGNNINALTPAMFQSLESLEILDLSSNHVGNWYRSA 495
            ..|.||               .:::.|...||.|..|....|..:..|..|.|:.|.:.:...||
Frog   360 HLSYSLLHMNLCPLSYQDNFTSSVEALYFIGNRITVLKNKQFFCMTKLTDLLLARNGIEHIEESA 424

  Fly   496 FHNNSALRVLNLRSNTINMLSNEMLKDFERLDYLSLGDNDFICDCHLRAVVEVAAANNKDADCSY 560
            |...:.||||:||:|.:..|....|.....|..|.|.:|          |:|.....:.......
Frog   425 FWGLNDLRVLDLRNNRLTSLQISSLSGLSNLMELYLQNN----------VMESMQRYSLKWQTKL 479

  Fly   561 RL--LNYSQNAVGEEVISLAESLIIDRKLWQSRYIPWLQRS------------------------ 599
            ||  :.:...:|..|:....|:|.|..   ..:||......
Frog   480 RLVKIGFVSVSVSFELFPNTETLDIQT---TGKYITVFMNETAASSLKSLSVNGSHVELDIKCGH 541

  Fly   600 --YSNIREFNRANHIIKLRFSSEDYMVAKCSAAQ--PYHLGDLDGDLTLKFQ------------- 647
              :|.:||....|:...:..|...|.:......:  .||.........:.|.
Frog   542 QFFSTLRELKVINNNGLISCSHYGYQLEHFENLENIQYHFSGAPLTRNVNFSNIANLRSLEVENL 606

  Fly   648 --LLDYEASQYYCFNNTDQLQVDEL-NCQIRSMSD-LAEELHHV------TNTVIAVMGSLVGAC 702
              .||........|:...:|:|.:| ||..:.|:. |.:::..:      ...::||...|....
Frog   607 ATALDPNVPPNDLFHKLHKLEVLKLFNCGFKYMTTALLKDMRSLRVLVMKNQMILAVDPGLQNTL 671

  Fly   703 I-LGFIIYL---------KRWHI-------HYYYSSLKSAALLSSASKESVNKFTNISQR----- 745
            . |.||.::         ..|.:       |.:.|.:.|...|....|.::..|:..|.|
Frog   672 SPLEFIYFIDVTFQCDCDNSWFVTWALEDKHTFVSGICSLFCLQLNKKFNLVNFSESSCRQEIDF 736

  Fly   746 ----------------------------------------------DPSAV-YDIFISYCQNDRT 763
                                                          :|.|. ||.|:|||..|:.
Frog   737 MLFVITFTSLLLFIVLTMLCNIFNSDIIQLFYVFQIWLKKLRGKTNNPIAYEYDAFVSYCSRDQG 801

  Fly   764 WVLNELLPNVEETG--DVSICLHERDFQIGVTILDNIISCMDRSYSLMLIISSKFLLSHWCQFEM 826
            ||:|.|:||:||.|  .:.:|||.|||.:|..|:|||:..:.:|...:.:||..:|.|.||..||
Frog   802 WVVNYLVPNLEEKGRNTIKLCLHNRDFLVGKDIVDNIMDSIYKSRKTICLISYNYLQSDWCSLEM 866

  Fly   827 YLAQHRIFEVSKEHLILVFLEDIP--RRKRPKTLQYLMDVKTYIKWPTAKEDRKLFWKRLKRSL 888
            .:|.:::.....:.|||||||.|.  .......|..::..||||.||..:.::..||:||:.::
Frog   867 RMATYKLLAEKNDDLILVFLESISGYHLSAYHRLARIVRKKTYIDWPQEENEQAEFWERLRMTV 930

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-9	NP_001246846.1	leucine-rich repeat	157..185	CDD:275380	7/27 (26%)
		LRR_8	262..322	CDD:290566	17/67 (25%)
		leucine-rich repeat	264..287	CDD:275380	4/22 (18%)
		leucine-rich repeat	288..311	CDD:275380	9/30 (30%)
		leucine-rich repeat	312..356	CDD:275380	15/76 (20%)
		LRR_8	<344..387	CDD:290566	11/63 (17%)
		leucine-rich repeat	357..381	CDD:275380	5/44 (11%)
		leucine-rich repeat	382..397	CDD:275380	8/17 (47%)
		leucine-rich repeat	405..430	CDD:275380	6/31 (19%)
		LRR_8	431..488	CDD:290566	18/85 (21%)
		leucine-rich repeat	432..453	CDD:275380	8/49 (16%)
		LRR_RI	<449..536	CDD:238064	28/101 (28%)
		leucine-rich repeat	454..477	CDD:275380	6/22 (27%)
		LRR_8	477..536	CDD:290566	20/58 (34%)
		leucine-rich repeat	478..501	CDD:275380	7/22 (32%)
		leucine-rich repeat	502..525	CDD:275380	9/22 (41%)
		TIR	751..891	CDD:214587	56/142 (39%)
LOC100498493	XP_002941870.2	leucine-rich repeat	60..82	CDD:275380	6/22 (27%)
		leucine-rich repeat	83..105	CDD:275380	8/56 (14%)
		leucine-rich repeat	106..128	CDD:275380	11/50 (22%)
		internalin_A	143..>394	CDD:380193	52/265 (20%)
		leucine-rich repeat	182..207	CDD:275380	5/24 (21%)
		leucine-rich repeat	208..233	CDD:275380	4/24 (17%)
		leucine-rich repeat	234..279	CDD:275380	5/44 (11%)
		leucine-rich repeat	308..331	CDD:275380	6/32 (19%)
		leucine-rich repeat	332..355	CDD:275380	3/22 (14%)
		leucine-rich repeat	356..382	CDD:275380	5/25 (20%)
		leucine-rich repeat	383..406	CDD:275380	6/22 (27%)
		LRR_8	405..463	CDD:404697	19/57 (33%)
		leucine-rich repeat	407..430	CDD:275380	7/22 (32%)
		leucine-rich repeat	431..454	CDD:275380	9/22 (41%)
		leucine-rich repeat	455..478	CDD:275380	6/32 (19%)
		TIR	788..930	CDD:214587	56/141 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010