DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-9 and tlr21

DIOPT Version :9

Sequence 1:	NP_001246846.1	Gene:	Toll-9 / 40245	FlyBaseID:	FBgn0036978	Length:	900	Species:	Drosophila melanogaster
Sequence 2:	XP_002936443.3	Gene:	tlr21 / 100497009	XenbaseID:	XB-GENE-5956980	Length:	937	Species:	Xenopus tropicalis

Alignment Length:	911	Identity:	209/911 - (22%)
Similarity:	335/911 - (36%)	Gaps:	286/911 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   215 YFNNNTNMGQSITTGR-NYTNFIKVLKDRFDQHGSSSQSIAWATFPKMPRLVELDISNCSIEYVS 278
            |.|.:.|..|::..|. .:..|::.|:...:|    .|.:....|..:..|.:|.:|:..|..:|
Frog    59 YLNISYNNIQTLHQGSFGHMPFLRTLRLNHNQ----LQRLDPGAFENLTMLEKLHLSSNKISNLS 119

  Fly   279 KEAFRNVSNLRRLFMSDNKIMTISHDTFYYVQGVQYLDLSFTNFLTYSYQLQ-------LPTLEM 336
            ||.|..:.|:..||:.||.:.:|..:.|.::..:|.|:||..|...:...:|       |.||.:
Frog   120 KEVFCGLQNVSWLFLDDNLLSSIHPEAFSHLTNLQNLNLSMNNLHNFEKVVQSIHPLQKLNTLML 184

  Fly   337 ALSLIYGLK-----------------------IQQNVFKYLPELIYLDLSHSKMTRNSA------ 372
            ..:.|..|.                       .||:.|.   .:.:||||::.:..:|.
Frog   185 CSNQISSLNHTHRLPSTLRWLFLCKNQLATLDCQQDFFL---NISWLDLSYNNIATSSLQTMDLR 246

  Fly   373 ------VAFAHLGDKLKFLS--------LCYTAIPMVSSTIFKN--TVLEG-----LDLSGNPYL 416
                  |||....|.|.|:.        :.|:.:.:.:.:..|.  ..|:|     |.||||...
Frog   247 KVIYLNVAFNGNFDILIFIKNPTVPINRIDYSGLNLNNDSKLKTMCRYLKGFNINTLYLSGNKIK 311

  Fly   417 SYN-------IIDDAFDGIANTLKYL----YFERSNIKDLEWSKSL------------------- 451
            :.|       .::...|...|.||.|    :..::|:::|....:|
Frog   312 TLNRGTLTDCPLNKTLDLSRNRLKGLGCLEFMSKTNVENLIVEHNLLKELINCSKKSHFPRLRHI 376

  Fly   452 ------------------KNLQVLGLAGNNINALTPAMFQSLESLEILDLSSNHVGNWYRSAFHN 498
                              .|||.|.|..|||..|....|..|..|..|.|.:|.:.:.|.::|.|
Frog   377 SFRYNRIWIVKGNAFHFAPNLQTLYLNINNIVFLERYSFSGLGKLRELRLDNNLITDLYENSFAN 441

  Fly   499 NSALRVLNLRSNTINMLSNEMLKDFERLDYLSLGDNDFICDCHLRAVVEVAAANNKDADCSYRLL 563
            .:.||:||||:|.::::.:::..:..:|..|.||.|            ::....|:.   .|.|.
Frog   442 LTELRILNLRNNRVSVIFSKVFYNLGKLTTLDLGGN------------KITQLKNQS---FYGLR 491

  Fly   564 NYSQ--------NAVGEEVISLAES--LIIDRKLWQSRYIPWLQRSYSNIREFNRANHIIKLRFS 618
            :.|:        ..:...|.|..||  |::|.|....|| ...:.:||.....::...:
Frog   492 SLSKLYLDGNQIKEISRYVFSHVESTLLVLDLKSNHLRY-NTTRETYSPFLTLSKLYDL------ 549

  Fly   619 SEDYMVAKCSAAQPYHL-----GDLDGDLTLK--------------------------------- 645
                   |..|.|||.|     |...|..:||
Frog   550 -------KLQAQQPYGLTAIPQGFFKGLKSLKALYLAQNRISSLSSDAFNELGQLTYLSLAEDCN 607

  Fly   646 ---------------FQLLDYE--ASQYY---------------------------CFNNTDQLQ 666
                           .|:||.|  ..||.                           .|.|..||:
Frog   608 GIQRLPPGIFKNLKNLQILDLENICLQYMRMEVFSSLTNLKRLLLTKNALTHINIKVFENMTQLK 672

  Fly   667 -VDELNCQIRSMSDLAE-------------------------ELHHVTNTVIAVMGSLVG----- 700
             :|...|.:....:.||                         ...|..:|.:..|...:.
Frog   673 YLDLRKCPLSCTCNNAELQMWFKKGPVQIVLPYNLTCPANENSYFHDFDTHVCDMEIKIKLFCSS 737

  Fly   701 -ACILGFII----YLK-RWHIHYYYSSLKSAALLSSASKESVNKFTNISQRDPSAVYDIFISYCQ 759
             ..||.|||    |.| .|.|.|.|  ....|.|....|.....:.          ||.|:||..
Frog   738 FTSILLFIIIPIVYSKFYWMIKYNY--FLFVAWLHERWKSEKELYK----------YDAFVSYNT 790

  Fly   760 NDRTWVLNELLPNVEETGDVSICLHERDFQIGVTILDNIISCMDRSYSLMLIISSKFLLSHWCQF 824
            :|..||...:|| |.||..:.:|||.||||:|..|:|||:..:..|...:.::|..:|.|.||..
Frog   791 HDEEWVYKIMLP-VLETSALRLCLHHRDFQLGRDIIDNIVDSIHNSRKTICVVSRSYLQSEWCSL 854

  Fly   825 EMYLAQHRIFEVSKEHLILVFLEDIPRRKRP--KTLQYLMDVKTYIKWPTAKEDRKLFWKRLKRS 887
            ||.||.:::|:..::.|:|:.|::||.|:..  ..::.||..||||.|||..|.::|||.:::.:
Frog   855 EMQLASYKLFDEMRDVLVLILLDNIPDRELSTYHRMRKLMLKKTYITWPTEPEAQQLFWAKVQEA 919

  Fly   888 L 888
            :
Frog   920 V 920

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-9	NP_001246846.1	leucine-rich repeat	157..185	CDD:275380
		LRR_8	262..322	CDD:290566	19/59 (32%)
		leucine-rich repeat	264..287	CDD:275380	8/22 (36%)
		leucine-rich repeat	288..311	CDD:275380	6/22 (27%)
		leucine-rich repeat	312..356	CDD:275380	14/73 (19%)
		LRR_8	<344..387	CDD:290566	15/85 (18%)
		leucine-rich repeat	357..381	CDD:275380	8/35 (23%)
		leucine-rich repeat	382..397	CDD:275380	3/22 (14%)
		leucine-rich repeat	405..430	CDD:275380	9/36 (25%)
		LRR_8	431..488	CDD:290566	21/97 (22%)
		leucine-rich repeat	432..453	CDD:275380	6/61 (10%)
		LRR_RI	<449..536	CDD:238064	31/123 (25%)
		leucine-rich repeat	454..477	CDD:275380	10/22 (45%)
		LRR_8	477..536	CDD:290566	19/58 (33%)
		leucine-rich repeat	478..501	CDD:275380	7/22 (32%)
		leucine-rich repeat	502..525	CDD:275380	7/22 (32%)
		TIR	751..891	CDD:214587	55/140 (39%)
tlr21	XP_002936443.3	PLN00113	<46..>528	CDD:215061	109/490 (22%)
		leucine-rich repeat	59..80	CDD:275380	5/20 (25%)
		leucine-rich repeat	81..104	CDD:275380	4/26 (15%)
		leucine-rich repeat	105..128	CDD:275380	8/22 (36%)
		leucine-rich repeat	129..152	CDD:275380	6/22 (27%)
		leucine-rich repeat	153..224	CDD:275380	14/73 (19%)
		leucine-rich repeat	225..299	CDD:275380	15/73 (21%)
		leucine-rich repeat	300..323	CDD:275380	6/22 (27%)
		leucine-rich repeat	348..363	CDD:275378	2/14 (14%)
		leucine-rich repeat	373..396	CDD:275380	0/22 (0%)
		inl_like_NEAT_1	<397..>652	CDD:411101	60/283 (21%)
		leucine-rich repeat	397..420	CDD:275380	10/22 (45%)
		leucine-rich repeat	421..444	CDD:275380	7/22 (32%)
		leucine-rich repeat	445..468	CDD:275380	7/22 (32%)
		leucine-rich repeat	469..492	CDD:275380	8/37 (22%)
		leucine-rich repeat	493..516	CDD:275380	3/22 (14%)
		leucine-rich repeat	518..572	CDD:275380	15/67 (22%)
		leucine-rich repeat	573..596	CDD:275380	2/22 (9%)
		leucine-rich repeat	597..622	CDD:275380	0/24 (0%)
		leucine-rich repeat	623..646	CDD:275380	6/22 (27%)
		leucine-rich repeat	647..668	CDD:275380	1/20 (5%)
		TIR	781..923	CDD:214587	55/151 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010