DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-9 and tlr6

DIOPT Version :9

Sequence 1:	NP_001246846.1	Gene:	Toll-9 / 40245	FlyBaseID:	FBgn0036978	Length:	900	Species:	Drosophila melanogaster
Sequence 2:	XP_017950845.1	Gene:	tlr6 / 100493946	XenbaseID:	XB-GENE-492949	Length:	842	Species:	Xenopus tropicalis

Alignment Length:	879	Identity:	209/879 - (23%)
Similarity:	340/879 - (38%)	Gaps:	265/879 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 LRDSTKKYAHKL-YLDLSHGNLKDDSDLFRE--AKLSRKVTIWRTEVFSAAFNTLTAAPF----- 147
            |..|..|:..:| |||.||..|::.|..|..  ..|......::|....:.|..:....:
Frog    83 LNSSIFKFNTQLQYLDFSHNVLRNISGTFPSHIQHLDISFNNFQTLSVCSGFGNMVLLEYLGLGA 147

  Fly   148 -RTLYSMRESLKLLSLRGNNFAEL--IPDAE--------------DFARFVNESR----LEASNS 191
             :.|.|..|.:..|.|: ..|.||  :.|.|              ||....||.|    .:|.|:
Frog   148 DQILKSDFEGIVHLHLK-EVFIELNSLNDYENGSLLLLNTKKLTLDFGVLSNEDRYNVLFDAVNT 211

  Fly   192 VP----HHCELLLLHNTTDLYDRECYLYFNNNTNMGQSITTGRNYTNFIK--VLKDRFDQHGSSS 250
            ..    .|.:...:|     .|.:.|: ||...|...:..|.|:.....|  ||..::..| ||.
Frog   212 TSVLELSHLQRWNIH-----IDPKKYI-FNIVQNSKVTDLTMRHVNVEWKMIVLALQYIWH-SSV 269

  Fly   251 QSIAWATFPKMPRLV---ELDISNCSIEYVSKEAFRNV-------SNLRRLFMSDNKIMTISHDT 305
            :::.:..| .:..|:   ..|.||.|::.|:.:.. ||       |::.|:|.:.|
Frog   270 ETLTFYDF-SLKGLIAKTSFDYSNTSVKAVNVQGV-NVGVFQFDQSSVYRVFSNMN--------- 323

  Fly   306 FYYVQGVQYLDLSFTNFLTYSYQLQLPTLEMALSLIYGLKIQQNVFKYLPELIYLDLSHSKMTRN 370
                  ::.|.|:|.:.|.....|...|.:.                       :|.||:.:|
Frog   324 ------IENLTLNFASLLFMVCPLNSSTFQS-----------------------IDFSHNALT-- 357

  Fly   371 SAVAFAHLGDKLKFLSLCYTAIPMVSSTIFKNTVLEGLDLS----GNPYLSYNIIDDAFDGIANT 431
                     |.|  ...|:|.|.:....:.||.:.:...||    ..|.|.|      .|...|.
Frog   358 ---------DDL--FKDCFTLINLKRLKLRKNKLEKIYKLSAMTENMPSLEY------LDASHNL 405

  Fly   432 LKYLYFERSNIKDLEWSKSLKNLQVLGLAGNNINALTPAMFQSLE-SLEILDLSSNHVGNWYRSA 495
            |.|      :.:|..||   :|:..|.||.   |.||.::|:.|. |::||.|.||.:.:.....
Frog   406 LAY------DEEDCHWS---QNIVELNLAS---NFLTASIFKCLPISIKILILESNDITHVPSGV 458

  Fly   496 FH---------------------NNSALRVLNLRSNTINMLSNEMLKDFERLDYLSLGDNDFICD 539
            .|                     |.|:|.:|.:..|.|...|.|.::...|:.::|.|.|.|.|:
Frog   459 THLDDLVELNLSFNRLGDLPDCSNISSLSLLGVEGNQILYPSIESIESCSRVKHISAGQNPFQCN 523

  Fly   540 CHLRAVVEVAAANNKDADCSYRLLNYSQNAVGEEVISLAESLIIDRKLWQSRYIPWLQRSYSNIR 604
            |.||                 |.:|..:.|.|        :||    .|...|:
Frog   524 CELR-----------------RFINQEKEAPG--------TLI----GWPEAYV----------- 548

  Fly   605 EFNRANHIIKLRFSSEDYMVAKCSAAQPYHL-GDLDGDLTLKFQLLDYEASQYYCFNNTDQLQVD 668
                                  |.  .|.|| |.:         |.|:              .:.
Frog   549 ----------------------CK--YPDHLRGTM---------LKDF--------------YIS 566

  Fly   669 ELNCQIRSMSDLAEELHHVTNTVIAVMGSLVGACILGFIIYLK-RWHIH--YYYSSLKSAALLSS 730
            |:.|.:..:         :...::.::.|:  |.|:|...||. .|.:.  :.|:..|.....|.
Frog   567 EITCNVFIL---------IPVIILPIIISI--ALIIGLCKYLDGPWFLKMIWQYTRTKQRTRTSK 620

  Fly   731 ASKESVNKFTNISQRDPSAVYDIFISYCQNDRTWVLNELLPNVEETGD-VSICLHERDFQIGVTI 794
            ...:|:       |||..  ::.||||.::|.:||.|..||::|.:.| :.||.|||:|..|.:|
Frog   621 QGYQSL-------QRDFD--FNAFISYSEHDASWVKNIFLPSIERSNDCIRICQHERNFIPGKSI 676

  Fly   795 LDNIISCMDRSYSLMLIISSKFLLSHWCQFEMYLAQHRIFEVSKEHLILVFLEDIPRRKRPK--- 856
            ::|||:|:::||..:.|:|..|:.|.||.:|:|.|.|:::..:.::|||:.||.||:...|.
Frog   677 IENIINCIEKSYKSIFILSPNFVQSEWCHYELYFAHHKLYTENNDNLILILLEPIPQYLIPSKYY 741

  Fly   857 TLQYLMDVKTYIKWPTAKEDRKLFWKRLKRSLEV 890
            .|:.||..:||::||:.|....|||..|:.::.:
Frog   742 KLKTLMAQRTYLEWPSEKSKHGLFWANLRAAISI 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-9	NP_001246846.1	leucine-rich repeat	157..185	CDD:275380	11/43 (26%)
		LRR_8	262..322	CDD:290566	15/69 (22%)
		leucine-rich repeat	264..287	CDD:275380	8/32 (25%)
		leucine-rich repeat	288..311	CDD:275380	3/22 (14%)
		leucine-rich repeat	312..356	CDD:275380	6/43 (14%)
		LRR_8	<344..387	CDD:290566	6/42 (14%)
		leucine-rich repeat	357..381	CDD:275380	4/23 (17%)
		leucine-rich repeat	382..397	CDD:275380	4/14 (29%)
		leucine-rich repeat	405..430	CDD:275380	6/28 (21%)
		LRR_8	431..488	CDD:290566	20/57 (35%)
		leucine-rich repeat	432..453	CDD:275380	5/20 (25%)
		LRR_RI	<449..536	CDD:238064	28/108 (26%)
		leucine-rich repeat	454..477	CDD:275380	8/23 (35%)
		LRR_8	477..536	CDD:290566	19/79 (24%)
		leucine-rich repeat	478..501	CDD:275380	7/43 (16%)
		leucine-rich repeat	502..525	CDD:275380	6/22 (27%)
		TIR	751..891	CDD:214587	56/144 (39%)
tlr6	XP_017950845.1	leucine-rich repeat	46..69	CDD:275378
		LRR_8	70..125	CDD:404697	13/41 (32%)
		leucine-rich repeat	70..93	CDD:275378	3/9 (33%)
		leucine-rich repeat	94..114	CDD:275378	9/19 (47%)
		leucine-rich repeat	115..139	CDD:275378	3/23 (13%)
		LRR_RI	311..>478	CDD:423007	49/235 (21%)
		leucine-rich repeat	347..369	CDD:275380	8/57 (14%)
		leucine-rich repeat	370..395	CDD:275380	4/24 (17%)
		leucine-rich repeat	396..418	CDD:275380	9/36 (25%)
		leucine-rich repeat	419..440	CDD:275380	8/23 (35%)
		leucine-rich repeat	441..463	CDD:275380	6/21 (29%)
		leucine-rich repeat	464..485	CDD:275380	1/20 (5%)
		leucine-rich repeat	486..509	CDD:275380	6/22 (27%)
		LRRCT	518..570	CDD:214507	22/138 (16%)
		TIR	632..775	CDD:214587	56/142 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	125	1.000	Domainoid score	I5392
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	182	1.000	Inparanoid score	I3846
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.070