DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Toll-9 and cd180

DIOPT Version :9

Sequence 1:	NP_001246846.1	Gene:	Toll-9 / 40245	FlyBaseID:	FBgn0036978	Length:	900	Species:	Drosophila melanogaster
Sequence 2:	XP_031762487.1	Gene:	cd180 / 100489673	XenbaseID:	XB-GENE-489949	Length:	571	Species:	Xenopus tropicalis

Alignment Length:	430	Identity:	94/430 - (21%)
Similarity:	167/430 - (38%)	Gaps:	106/430 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   177 FARFVNESRLEASNSVPHHCELLLLHNTTDLYDRECYLYFNNNTNMGQSITTGRNYTNFIKVLKD 241
            |.|.::.:||     .|....|.|::...|.    .::.|.:..::.....:.|.|. .:|.:..
Frog    66 FQRAISAARL-----FPGPLALELINVKVDW----AHVQFRSMKHLRPLPVSHRQYC-LVKEINS 120

  Fly   242 RFDQHGSSSQSIAWATFPKMPRLVELDISNCSIEYVSKEAFRNVSNLRRLFMSDNKIMTI----- 301
            .|        ::...||.::..:..||::.|:|..:.::.|:|..:|..|.:..|.|:.|
Frog   121 LF--------ALYHTTFMRLKCISPLDLTRCNINLLYEDVFQNNIHLNTLVLIGNPILYIAASAF 177

  Fly   302 ----------------SHDTFYYVQGVQYLD-LSF-TNFLTYSYQLQLPTLEMALSLIYGLKIQQ 348
                            ::.||..::.:|:|: ||| .||::   .||||. ...:..:..|..|.
Frog   178 NGPLALKHLFLQQIPLTNVTFIPLEHLQHLETLSFGNNFIS---SLQLPH-NFPIKNLRVLDFQS 238

  Fly   349 NVFKYLPELIYLDLSHSKMTRNSAVAFAHLGDKLKFLSLCYTAIPMVSSTIFKNTVLEGLDLSGN 413
            |. |    ::..|:...|.:.|.::...  |:.:::          :....|.:..|..|||.||
Frog   239 NCXK----ILAADVEILKQSNNLSLILK--GNDIEY----------IEPNSFDSVNLYSLDLKGN 287

  Fly   414 PYLSYNIIDD-AFDGIAN---------------TLKYLYFERSNI--------KDLEWSKSLKN- 453
            .....|::.. ||..:..               .||||...|.||        |.|| |::..|
Frog   288 RGDLANLLSSTAFSCLTTIQRLDLTGTHVESLPLLKYLNLSRMNINASNENLLKGLE-SQTFLNM 351

  Fly   454 ------------------LQVLGLAGNNINALTPAMFQSLESLEILDLSSNHVGNWYRSAFHNNS 500
                              |:||.|...|:.|:....|..|..|:..||..|.:..:..:||.:.|
Frog   352 ERPPSIWELYNIFLQALHLEVLILLSCNLTAIEHRAFHKLAKLQYEDLRHNKITIFSSNAFRDLS 416

  Fly   501 ALRVLNLRSNTINMLSNEMLKDFERLDYLSLGDNDFICDC 540
            .:. ||..||.|:.:::.:|.:......::|..|...|.|
Frog   417 HIH-LNFASNMISDIASHLLHNISGTSAINLSHNPIDCLC 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-9	NP_001246846.1	leucine-rich repeat	157..185	CDD:275380	2/7 (29%)
		LRR_8	262..322	CDD:290566	18/82 (22%)
		leucine-rich repeat	264..287	CDD:275380	6/22 (27%)
		leucine-rich repeat	288..311	CDD:275380	7/43 (16%)
		leucine-rich repeat	312..356	CDD:275380	15/45 (33%)
		LRR_8	<344..387	CDD:290566	8/42 (19%)
		leucine-rich repeat	357..381	CDD:275380	4/23 (17%)
		leucine-rich repeat	382..397	CDD:275380	0/14 (0%)
		leucine-rich repeat	405..430	CDD:275380	9/25 (36%)
		LRR_8	431..488	CDD:290566	24/83 (29%)
		leucine-rich repeat	432..453	CDD:275380	11/28 (39%)
		LRR_RI	<449..536	CDD:238064	24/105 (23%)
		leucine-rich repeat	454..477	CDD:275380	8/22 (36%)
		LRR_8	477..536	CDD:290566	15/58 (26%)
		leucine-rich repeat	478..501	CDD:275380	6/22 (27%)
		leucine-rich repeat	502..525	CDD:275380	6/22 (27%)
		TIR	751..891	CDD:214587
cd180	XP_031762487.1	inl_like_NEAT_1	<71..>326	CDD:411101	58/292 (20%)
		leucine-rich repeat	138..158	CDD:275380	6/19 (32%)
		leucine-rich repeat	159..182	CDD:275380	5/22 (23%)
		leucine-rich repeat	183..206	CDD:275380	2/22 (9%)
		leucine-rich repeat	207..230	CDD:275380	10/26 (38%)
		leucine-rich repeat	231..256	CDD:275380	6/28 (21%)
		leucine-rich repeat	257..278	CDD:275380	2/32 (6%)
		leucine-rich repeat	279..305	CDD:275380	9/25 (36%)
		leucine-rich repeat	322..345	CDD:275380	10/23 (43%)
		LRR_8	369..427	CDD:404697	19/58 (33%)
		leucine-rich repeat	370..393	CDD:275380	8/22 (36%)
		leucine-rich repeat	394..417	CDD:275380	6/22 (27%)
		leucine-rich repeat	418..440	CDD:275380	6/22 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010