DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-9 and tlrs5

DIOPT Version :9

Sequence 1:	NP_001246846.1	Gene:	Toll-9 / 40245	FlyBaseID:	FBgn0036978	Length:	900	Species:	Drosophila melanogaster
Sequence 2:	XP_002937550.2	Gene:	tlrs5 / 100489423	XenbaseID:	XB-GENE-22201327	Length:	653	Species:	Xenopus tropicalis

Alignment Length:	533	Identity:	125/533 - (23%)
Similarity:	196/533 - (36%)	Gaps:	155/533 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 LSHGNLKD---DSDLFREAKLSRKVTIWRTEVFSAAFNTLTAAPFRTLYSMRESLKLLSLRGNNF 167
            |.|..|.:   :|.:|::....:|:.:        :||.:........:....|:..|.|:.|..
Frog   137 LDHNGLDESVLESGMFKDLTSLKKLDL--------SFNNIRRVRPDPTFLKLSSISFLLLKFNKV 193

  Fly   168 AELIPDAEDFARFVNESRLE----ASN-----SVPHHCELLLLHNTTDLYDRECYLYFNNNT--- 220
            :.|.  .||... :...||:    :||     |.||                 |...|||.|
Frog   194 SMLC--GEDLQN-LQGRRLQLLDMSSNPLQLSSTPH-----------------CTNPFNNITLGT 238

  Fly   221 ----NMGQSITTGRNY--------TNFIKVL------------------KDRFDQHGSSSQSIAW 255
                :||.:.....|:        .::||:.                  ||.|....||:..|..
Frog   239 LDVSSMGWNAEMVENFVRTISGTQVDYIKMRHTAGLGSGFGFHNLKDPNKDTFSGLNSSNVQILD 303

  Fly   256 AT-----------FPKMPRLVELDISNCSIEYVSKEAFRNVSNLRRLFMSDNKIMTISHDTFY-- 307
            .:           |...|:|:.||:|:..|..:|..||..:..|..|.:|.|.:..:...:|.
Frog   304 LSNGFISHLVPQLFSAFPKLLSLDLSSNQINRMSSGAFSGLGELVSLNLSGNLLGELMGSSFQGL 368

  Fly   308 -------------YVQGVQY--LDLSFTNFLTYSYQLQLPTLEMALSLIYGLKIQ---------- 347
                         ::..|||  || |||...:.:.:      :.||:.|...|:|
Frog   369 GATSLKTLDLSSNHIGAVQYGALD-SFTALTSLNLR------DNALNKIPPTKLQGVTFVLLKQN 426

  Fly   348 -----QNVFKYLPELIYLDLSHSKMTR-NSAVAFAHLGDKLKFLSLCYTAIPMVS----STIFKN 402
                 .|:..:.|....||||.:::|. .|......| ..||:|||...::...|    |.|.:.
Frog   427 RISDIYNIISFCPHATILDLSSNRLTDFRSLWQILEL-QSLKYLSLASNSLYRCSLPHTSNITRT 490

  Fly   403 TVLEGLDLSGN---PYLSYNIIDDAFDGIANTLKYLYFERSNIKDLEWSKSLKNLQVLGLAGNNI 464
            :.|..||||.|   |.|......|.|                       ..|.:|:.|.||.|.:
Frog   491 SGLVYLDLSDNALGPVLKSGECGDIF-----------------------MHLGSLKSLNLARNQL 532

  Fly   465 NALTPAMFQSLESLEILDLSSNHVGNWYRSAFHNNSALRVLNLRSNTINMLSNEMLKDFERLDYL 529
            :.:...||:||.||:.||||.|.......:.|...:||:.|||..:.:..||:.:|.....|:.:
Frog   533 SNIPDTMFRSLSSLQTLDLSGNGFKEIQSNLFTGLTALKTLNLGKSNLVTLSSSVLDPLGSLESI 597

  Fly   530 SLGDNDFICDCHL 542
            .|.:...:|||.|
Frog   598 DLSEVTLVCDCSL 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-9	NP_001246846.1	leucine-rich repeat	157..185	CDD:275380	6/27 (22%)
		LRR_8	262..322	CDD:290566	22/76 (29%)
		leucine-rich repeat	264..287	CDD:275380	8/22 (36%)
		leucine-rich repeat	288..311	CDD:275380	5/37 (14%)
		leucine-rich repeat	312..356	CDD:275380	14/60 (23%)
		LRR_8	<344..387	CDD:290566	14/58 (24%)
		leucine-rich repeat	357..381	CDD:275380	7/24 (29%)
		leucine-rich repeat	382..397	CDD:275380	6/18 (33%)
		leucine-rich repeat	405..430	CDD:275380	10/27 (37%)
		LRR_8	431..488	CDD:290566	17/56 (30%)
		leucine-rich repeat	432..453	CDD:275380	1/20 (5%)
		LRR_RI	<449..536	CDD:238064	28/86 (33%)
		leucine-rich repeat	454..477	CDD:275380	9/22 (41%)
		LRR_8	477..536	CDD:290566	18/58 (31%)
		leucine-rich repeat	478..501	CDD:275380	7/22 (32%)
		leucine-rich repeat	502..525	CDD:275380	7/22 (32%)
		TIR	751..891	CDD:214587
tlrs5	XP_002937550.2	PLN00113	100..>597	CDD:215061	120/518 (23%)
		leucine-rich repeat	108..131	CDD:275380
		leucine-rich repeat	132..157	CDD:275380	5/19 (26%)
		leucine-rich repeat	158..182	CDD:275380	3/31 (10%)
		leucine-rich repeat	183..208	CDD:275380	6/27 (22%)
		leucine-rich repeat	209..232	CDD:275380	7/39 (18%)
		leucine-rich repeat	299..322	CDD:275380	2/22 (9%)
		leucine-rich repeat	323..346	CDD:275380	8/22 (36%)
		leucine-rich repeat	347..372	CDD:275380	5/24 (21%)
		leucine-rich repeat	373..396	CDD:275380	7/23 (30%)
		leucine-rich repeat	397..440	CDD:275380	6/48 (13%)
		leucine-rich repeat	418..431	CDD:275378	0/12 (0%)
		leucine-rich repeat	441..492	CDD:275380	15/51 (29%)
		leucine-rich repeat	493..521	CDD:275380	11/50 (22%)
		leucine-rich repeat	522..545	CDD:275380	9/22 (41%)
		leucine-rich repeat	546..569	CDD:275380	7/22 (32%)
		leucine-rich repeat	570..591	CDD:275380	7/20 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920