DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-9 and tlr3

DIOPT Version :9

Sequence 1:	NP_001246846.1	Gene:	Toll-9 / 40245	FlyBaseID:	FBgn0036978	Length:	900	Species:	Drosophila melanogaster
Sequence 2:	XP_002934448.3	Gene:	tlr3 / 100486223	XenbaseID:	XB-GENE-491049	Length:	897	Species:	Xenopus tropicalis

Alignment Length:	964	Identity:	222/964 - (23%)
Similarity:	358/964 - (37%)	Gaps:	308/964 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 LDLSHGNLKDDSDLFREAKL-SRKVTIW-RTEVFSAAFNTLTAAPFR-TLYSMRESLKLLSLRGN 165
            |||||..||         || :..:::: :.|...|.||||  ..|. .|......||.|:|..|
Frog    54 LDLSHNQLK---------KLPAANLSVYDQLERLDAGFNTL--HQFEPALCKQLLMLKTLNLEHN 107

  Fly   166 NFAELIPDAEDFARFVNESRLE-ASNSVPH------------------HCELL--------LLHN 203
            .|.::  ...||...|:.|.|. |||.:.:                  |.:::        .|:|
Frog   108 EFTKI--SENDFTFCVHLSELHLASNGISNIDGNPFEKLENLLFLDMSHNKMISTALGNKQQLNN 170

  Fly   204 TTDLY---------DRECYLYFNN---------------------------------NTNMGQSI 226
            ..:||         ::|.:.:..|                                 ||.:....
Frog   171 LKELYLNSNKISKLNKEAFEFLANTSLQKLDLSSNPLTEINPGCFQAIGSFAALVIQNTQLDPQR 235

  Fly   227 T---------TG-RNYT-NFIKVLKDR--------------FDQHGSSSQSIAWATFPKMPRLVE 266
            |         || ||.| |.|::.|.|              .|..|:|...|...:|..:..|..
Frog   236 TEQVCSELAHTGVRNLTLNNIRLSKIRNTTFKGLADTNLTVLDLSGNSLSQIDNDSFVSLGALEI 300

  Fly   267 LDISNCSIEYVSKEAFRNVS-----NLRRLFMSDNKIMTISHDTFYYVQGVQYLDL--------- 317
            |::.|..|.:|:.:.|..:|     |||:...|:.|:..:|   |..:..||||::
Frog   301 LNLENNDISHVNPKTFNGLSKVRVLNLRKSLSSNLKLDDLS---FQSLHNVQYLNMEANKIISIT 362

  Fly   318 --------SFTNFLTYSYQLQLPT------LEMALSLIYGL--------KIQQNVFKYLPELIYL 360
                    |.||.......||..|      |.::.|.:|.|        ||:...|..|..|..|
Frog   363 EHTFIGLTSLTNLSLSDSTLQQHTLTNRTFLSLSKSPLYHLNLTKTGLTKIENGAFLCLKHLQLL 427

  Fly   361 DLSHSKMTR-----------NSAVAFAHLGDKLKFLSLCYTAIPMVSSTIFKNTVLEGLDLSGNP 414
            |:..:::.:           |..:.:.....::...|..:...|.:|....:.|.|...||:.:|
Frog   428 DMGLNQIDQEVSGNELEGLANIEMIYLSYNRRITLTSNSFIFAPSLSKLYLRKTALTFRDLNPSP 492

  Fly   415 Y----------LS----YNIIDDAFDGIANTLKYLYFERSNIKDLEWS-----------KSLKNL 454
            :          ||    .||.:|.|:.::| |:.|.||.:|:..| |.           |.||||
Frog   493 FKVLQNLTVLDLSNNNIANIQEDVFESLSN-LRILSFEHNNLARL-WKEANPGGPVLFLKGLKNL 555

  Fly   455 QVLGLAGNNINALTPAMFQSLESLEILDLSSNHVGNWYRSAFHNNSALRVLNLRSNTINMLSNEM 519
            :.|.|..|..:.:....|:.|..|::||:..|:|.....|.|.:..:|.:|:|..|.|..:..::
Frog   556 EKLSLLSNGFDEIPANAFKGLCKLKVLDIGENNVYILPPSVFDDQHSLTLLDLHKNLITSVEQDL 620

  Fly   520 LKD-FERLDYLSLGDNDFICDCHLRAVVEVAAANNKDADCSYRLLNYSQNAVGEEVISLAESLII 583
            .|: |..|.||::|.|.:.|.|                                      ||:
Frog   621 FKNVFSSLKYLNMGGNPYDCTC--------------------------------------ESI-- 645

  Fly   584 DRKLWQSRYIPWLQRSYSNIREFNRANHIIKLRFSSEDYMVAKCSAAQPYHLGDLDGDLTLKFQL 648
               .|   :..||          |..|..:.|..|  .|:   |:....||...:|
Frog   646 ---AW---FASWL----------NTTNTSVPLAHS--QYI---CNTPARYHGNPVD--------- 680

  Fly   649 LDYEASQYYCFNNTDQLQVDELNCQIRSMSDLAEELHHVTNTVIAVMGSLVGACILG-FIIYLKR 712
                             ..|...|:     :||.....|:..      ||:...||. .:|..:.
Frog   681 -----------------NFDSSPCK-----ELAPFRLFVSTF------SLMLVFILSVLLIQFQG 717

  Fly   713 WHIHYYYSSLKSAALLSSASKESVNKFTNISQRDP---SAVYDIFISYCQNDRTWVLNELLPNVE 774
            |.||:|::             .|:|:.....:.||   :..||.:|.:.|||.:||.|.|:|..:
Frog   718 WRIHFYWT-------------VSINRILGFKEIDPRKRNFDYDAYIIHAQNDVSWVENHLIPLEK 769

  Fly   775 ETGD-VSICLHERDFQIGVTILDNIISCMDRSYSLMLIISSKFLLSHWC-QFEMYLAQHRIFEVS 837
            ..|. :..|..|||.:.|.:.|...:.|::||..::.:::...|...|| :|::..|..:..|.:
Frog   770 NAGSKLQFCFEERDLEAGTSTLSAFVDCINRSRKIIFVVTRNLLNDSWCRRFKVQHAFQQAIEQN 834

  Fly   838 KEHLILVFLEDIPRRKRPKTLQY---LMDVKTYIKWPTAKEDRKLFWKRLKRSL 888
            ::.:||:||||||..|...|:..   :...:..:.||...|..|.|::|||.:|
Frog   835 RDSIILIFLEDIPDYKLYHTIHLRRGMFKSRCILDWPDQMERIKTFYQRLKIAL 888

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-9	NP_001246846.1	leucine-rich repeat	157..185	CDD:275380	9/27 (33%)
		LRR_8	262..322	CDD:290566	20/81 (25%)
		leucine-rich repeat	264..287	CDD:275380	7/27 (26%)
		leucine-rich repeat	288..311	CDD:275380	6/22 (27%)
		leucine-rich repeat	312..356	CDD:275380	18/74 (24%)
		LRR_8	<344..387	CDD:290566	9/61 (15%)
		leucine-rich repeat	357..381	CDD:275380	4/34 (12%)
		leucine-rich repeat	382..397	CDD:275380	2/14 (14%)
		leucine-rich repeat	405..430	CDD:275380	10/38 (26%)
		LRR_8	431..488	CDD:290566	21/67 (31%)
		leucine-rich repeat	432..453	CDD:275380	9/31 (29%)
		LRR_RI	<449..536	CDD:238064	29/87 (33%)
		leucine-rich repeat	454..477	CDD:275380	6/22 (27%)
		LRR_8	477..536	CDD:290566	19/59 (32%)
		leucine-rich repeat	478..501	CDD:275380	7/22 (32%)
		leucine-rich repeat	502..525	CDD:275380	7/23 (30%)
		TIR	751..891	CDD:214587	46/143 (32%)
tlr3	XP_002934448.3	PLN00113	26..>507	CDD:215061	101/468 (22%)
		leucine-rich repeat	54..74	CDD:275380	9/28 (32%)
		leucine-rich repeat	75..98	CDD:275380	8/24 (33%)
		leucine-rich repeat	99..122	CDD:275380	8/24 (33%)
		leucine-rich repeat	123..146	CDD:275380	5/22 (23%)
		leucine-rich repeat	147..170	CDD:275380	2/22 (9%)
		leucine-rich repeat	171..196	CDD:275380	4/24 (17%)
		leucine-rich repeat	197..230	CDD:275380	1/32 (3%)
		leucine-rich repeat	231..273	CDD:275380	10/41 (24%)
		leucine-rich repeat	274..297	CDD:275380	5/22 (23%)
		leucine-rich repeat	298..319	CDD:275380	6/20 (30%)
		leucine-rich repeat	322..347	CDD:275380	7/27 (26%)
		leucine-rich repeat	348..371	CDD:275380	4/22 (18%)
		leucine-rich repeat	424..448	CDD:275380	3/23 (13%)
		PPP1R42	446..637	CDD:411060	51/192 (27%)
		leucine-rich repeat	449..472	CDD:275380	1/22 (5%)
		leucine-rich repeat	473..498	CDD:275380	6/24 (25%)
		leucine-rich repeat	499..522	CDD:275380	6/22 (27%)
		leucine-rich repeat	523..554	CDD:275380	9/31 (29%)
		leucine-rich repeat	555..578	CDD:275380	6/22 (27%)
		leucine-rich repeat	579..602	CDD:275380	7/22 (32%)
		leucine-rich repeat	603..623	CDD:275380	5/19 (26%)
		PCC	607..>689	CDD:188093	28/173 (16%)
		Tlr3_TMD	691..720	CDD:407816	8/34 (24%)
		TIR	746..890	CDD:214587	46/143 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920