DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-9 and tlr2

DIOPT Version :9

Sequence 1:	NP_001246846.1	Gene:	Toll-9 / 40245	FlyBaseID:	FBgn0036978	Length:	900	Species:	Drosophila melanogaster
Sequence 2:	XP_002933537.2	Gene:	tlr2 / 100485771	XenbaseID:	XB-GENE-481145	Length:	780	Species:	Xenopus tropicalis

Alignment Length:	954	Identity:	207/954 - (21%)
Similarity:	346/954 - (36%)	Gaps:	311/954 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 SIQDGLIIEPDSATTSSEEAEEVSKERTD------LKSLMLKYES----DDGNSCLLDLIKDEVI 82
            :|..||..:......||...:.|::  ||      |::|:|:|.:    :||:
Frog    43 AIPSGLPRDVRGLNLSSNAIQIVTE--TDLQPYDQLQTLLLQYNAIHTINDGS------------ 93

  Fly    83 WWQFPNGTLRDSTKKYAHKLYLDLSHGNLKD-DSDLFREAKLSRKVTIWRTEVFSAAFNTLTAAP 146
             :| |.|.|.:          ||||:.||.. .|..||.....:.:.:...:..:...|:|
Frog    94 -FQ-PLGNLEE----------LDLSYNNLSHLSSAWFRNLYNLKHLNLLGNQYLTLGNNSL---- 142

  Fly   147 FRTLYSMR-----------------ESLKLLSLRGNNFAEL----------IPDAEDFARFVNES 184
            |.:|.|:|                 |||:.|::.....|:|          |.........||..
Frog   143 FASLSSLRSLQFGNQDFSAIQKLHFESLERLNILEIKAAQLGLYEEGSLAAIKQINHAVLTVNIQ 207

  Fly   185 RLEA-SNSVPHHCELL-----------------LLHNTTDLY--DRECYLYFNNNTNMGQSITTG 229
            .|.| .|...|...||                 :|::|:..|  .|.|.:...:.:.:.:...|.
Frog   208 NLRALLNDFIHSVTLLEMKDMQFGDAADVKAMVILNDTSIKYLVFRNCIITDQSASRLLEIFQTY 272

  Fly   230 RNYTNFIKVLKDRFDQHGSSSQSIAWATFPKMPRLVELDISNCSIEYVSKEAFRNVSNLRRLFMS 294
            ||.|:||   .|....:|:.:.|......|                :....|..|..::.:.|:
Frog   273 RNITDFI---LDDSTLYGTGTASPVIGDDP----------------FSVTTAIINKLHIPKFFL- 317

  Fly   295 DNKIMTISHDTFYYVQGVQYLDLSFTNFLTYSYQLQLPTLEMALSLIYGLKIQQNVFKYLPELIY 359
                       |..:||:..|..:|.|......::.|  :..|.|            :....|.|
Frog   318 -----------FSDLQGIYKLASNFKNIACIDSKVFL--MPCAFS------------RSFSSLQY 357

  Fly   360 LDLSHSKMTRN----SAVAFAHLGDKLKFLSLCYTAIPMVSSTIFKNTVLEGLDLSGNPYLSYNI 420
            ||||.:.::.|    ||.||...|           |.|          :|:.|::|.|...|...
Frog   358 LDLSGNLLSDNLLASSACAFEGGG-----------AWP----------ILQTLNVSRNLLTSLRR 401

  Fly   421 IDDAFDGIANTLKYLY---FERSNIKDL-----EWSKSLKNLQVLGLAGNNINALTPAMFQSLES 477
            :..    |.:.||||.   ..::|..:|     :|.||||.|.:.....:||..:.|       :
Frog   402 LAQ----ITSGLKYLTNLDVSQNNFGELSTSTCQWPKSLKYLNISSSQMSNITCIPP-------T 455

  Fly   478 LEILDLSSNH-------VGNWYRSAFHNN-----------SALRVLNLRSNTINMLSNEMLKDFE 524
            |:|||:|||:       :.|.......||           ..|.:|::..|.:|......|..|.
Frog   456 LQILDVSSNYLTVFTIKMPNLTELYISNNRLSKLPEGMYFPRLFMLSIDRNKLNDFYQSDLDLFP 520

  Fly   525 RLDYLSLGDNDFICDCHLRAVVEVAAANNKDADCSYRLLNYSQNAVGEEVISLAESLIIDRKLWQ 589
            :|..|...||:::|.|                                :.:|...|
Frog   521 QLTTLDGRDNNYLCSC--------------------------------QFLSFMHS--------- 544

  Fly   590 SRYIPWLQRSYSNIREFNRANHIIKLRFSSEDYMVAKCSAAQPYHLGDLDGDLTLKFQLLDYEAS 654
                                 |.|.|....:||:....|:.:...:.|.:             ..
Frog   545 ---------------------HTIALVGWPDDYICDSPSSVRGKRIQDAN-------------LP 575

  Fly   655 QYYCFNNTDQLQVDELNCQIRSMSDLAEELHHVTNTVIAVMGSLVGACILGFIIYLKRWHIHYYY 719
            ...|....    :..|:|.:                :||::.::...|....::    |:....:
Frog   576 PLVCHKTL----IVTLSCIL----------------LIALVAAIAALCHFLHVV----WYAKMTW 616

  Fly   720 SSLKSAALLSSASKESVNKFTNISQRDPSAVYDIFISYCQNDRTWVLNELLPNVEE-TGDVSICL 783
            :.||:             |...:...|....|:.|:||.:.|..||.|.::|.:|. ...:.:||
Frog   617 AWLKA-------------KRKPLKNCDREICYNGFVSYSERDSEWVENMMVPKLENAVPPMKLCL 668

  Fly   784 HERDFQIGVTILDNIISCMDRSYSLMLIISSKFLLSHWCQFEMYLAQHRIFEVSKEHLILVFLED 848
            |:|||..|..|:||||..|::||..:.::|..|:.|.||::|:..:..|:|:.:.:..||:.||.
Frog   669 HKRDFVPGKWIIDNIIDAMEKSYKTVFVLSEHFVRSEWCKYELEFSHFRLFDENNDTAILILLEP 733

  Fly   849 IPRRKRPK---TLQYLMDVKTYIKWPTAKEDRKLFWKRLKRSLE 889
            |.....||   .|:.||:.|||::|||.:|.:::||..||.:|:
Frog   734 IENETVPKRFCKLRKLMNTKTYLEWPTDEEQQEVFWDNLKTALQ 777

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-9	NP_001246846.1	leucine-rich repeat	157..185	CDD:275380	7/37 (19%)
		LRR_8	262..322	CDD:290566	8/59 (14%)
		leucine-rich repeat	264..287	CDD:275380	2/22 (9%)
		leucine-rich repeat	288..311	CDD:275380	2/22 (9%)
		leucine-rich repeat	312..356	CDD:275380	6/43 (14%)
		LRR_8	<344..387	CDD:290566	12/46 (26%)
		leucine-rich repeat	357..381	CDD:275380	12/27 (44%)
		leucine-rich repeat	382..397	CDD:275380	2/14 (14%)
		leucine-rich repeat	405..430	CDD:275380	6/24 (25%)
		LRR_8	431..488	CDD:290566	22/71 (31%)
		leucine-rich repeat	432..453	CDD:275380	10/28 (36%)
		LRR_RI	<449..536	CDD:238064	28/104 (27%)
		leucine-rich repeat	454..477	CDD:275380	4/22 (18%)
		LRR_8	477..536	CDD:290566	20/76 (26%)
		leucine-rich repeat	478..501	CDD:275380	10/40 (25%)
		leucine-rich repeat	502..525	CDD:275380	6/22 (27%)
		TIR	751..891	CDD:214587	55/143 (38%)
tlr2	XP_002933537.2	internalin_A	55..>247	CDD:380193	47/221 (21%)
		leucine-rich repeat	55..75	CDD:275378	5/21 (24%)
		LRR_8	75..133	CDD:404697	19/81 (23%)
		leucine-rich repeat	76..99	CDD:275378	8/36 (22%)
		leucine-rich repeat	100..123	CDD:275378	10/32 (31%)
		leucine-rich repeat	124..148	CDD:275378	4/27 (15%)
		leucine-rich repeat	149..162	CDD:275378	1/12 (8%)
		leucine-rich repeat	322..352	CDD:275378	8/43 (19%)
		PRK15370	<353..>508	CDD:185268	48/186 (26%)
		leucine-rich repeat	355..382	CDD:275380	12/37 (32%)
		leucine-rich repeat	386..411	CDD:275380	7/28 (25%)
		leucine-rich repeat	412..435	CDD:275380	4/22 (18%)
		leucine-rich repeat	436..455	CDD:275380	6/25 (24%)
		leucine-rich repeat	456..475	CDD:275380	7/18 (39%)
		leucine-rich repeat	476..497	CDD:275380	2/20 (10%)
		leucine-rich repeat	498..521	CDD:275380	6/22 (27%)
		TIR	634..779	CDD:214587	55/144 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	125	1.000	Domainoid score	I5392
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	182	1.000	Inparanoid score	I3846
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.070