DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-9 and tlr14.2

DIOPT Version :9

Sequence 1:	NP_001246846.1	Gene:	Toll-9 / 40245	FlyBaseID:	FBgn0036978	Length:	900	Species:	Drosophila melanogaster
Sequence 2:	XP_012810129.1	Gene:	tlr14.2 / 100485512	XenbaseID:	XB-GENE-5824915	Length:	844	Species:	Xenopus tropicalis

Alignment Length:	941	Identity:	220/941 - (23%)
Similarity:	366/941 - (38%)	Gaps:	288/941 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 LLDLIKDEVIWWQFPNGTLRDSTKKYAHKLYLDLSHGNLKDDSDLFREAKLSRKVTIWRTEVFSA 137
            ||:|:|    |....|...||||.:||:....||    ::...||        .||:   :....
Frog    37 LLNLLK----WTSCQNPCQRDSTNRYANCQGQDL----VEVPQDL--------PVTL---QSLDL 82

  Fly   138 AFNTLTAAPFRTLYSMRESLKLLSLRGNNFAELIPDAEDFARFVNESRLEASNSVPHHCELLLLH 202
            ::|.|....:.. :|...:|:.|:|..||.:.:            |....|||::..:  |.|.:
Frog    83 SYNRLFHIRYED-FSSYTNLRALNLSFNNISTI------------ECGSFASNTLLRN--LTLFN 132

  Fly   203 NT-----TDLYDRECYLYF-NNNTNMGQSITTGRNYTNFI-------------KVLKDRFDQ-HG 247
            |:     :.|::....|.| :.:.|:....|.|:.:.|.:             |||||.|.. ..
Frog   133 NSLTEMPSTLFEPLLLLEFLDVSNNLYNYSTLGKVFENLVNLQNLAIGGPLVSKVLKDDFAPIKN 197

  Fly   248 SSSQSIAWATFPKM------------PRLVELDIS---NC-SIEYVSKE-AFRNVSNL--RRLFM 293
            .|.:..:..|..|:            .|::.||||   |. ::..:.|: |.:.:.:|  ||||
Frog   198 RSLKKFSLKTMSKLGFYEPGALEVLNTRVLWLDISLDTNAQALPLILKDLAGKTIDSLRFRRLF- 261

  Fly   294 SDNKIMTISHDTFYYVQGVQYLDL-----SFTNFLTYS--YQLQLPTLE--MALSLIYGLKIQQN 349
             ::...|.:.|.|..:..:...:|     .||..|.:.  :.:|..|::  :.||:.:...:..|
Frog   262 -ESSYYTDTMDLFCGLVDINIRELIFFRGMFTENLLHQALHSIQKSTIQDLLLLSVKFDRSLNTN 325

  Fly   350 ----VFK--YLPELIYLDLS-------------HSKMTRNSAVAFAHLGDKLKFLSLCYTAIPMV 395
                :|.  ||..|:..|::             .||: ||..::..|||           ::|.:
Frog   326 NTHILFDRLYLNSLVIRDIAGPHIFKYDWTFTWFSKV-RNLQLSRVHLG-----------SLPCI 378

  Fly   396 SSTIFKNTVLEGLDLSGNPYLSYNIID-DAFDGIANTLKYLYFERSNIKDL--------EWSKSL 451
            :.....|  :|.||:|.|..:..|:.: ..:||....|.......:|::.|        :|.|..
Frog   379 AWRQMGN--IECLDVSDNRLIGSNLYNPSCWDGGLPKLDTFIAANNNLQSLRLISLLTAKWPKLT 441

  Fly   452 KNLQVLGLAGNNI--------------------NALTPAMFQSL-ESLEILDLSSNHVG----NW 491
            |    |.|:.|::                    |.|...:||.| .|:|:||||.:.:.    |:
Frog   442 K----LDLSSNDLGVYNEVCTWIPNITTLILKGNTLKMCVFQCLPTSVELLDLSYSQLEQLDLNY 502

  Fly   492 YRSA--------FHN----------NSALRVLNLRSNTINMLSNEMLKDFERLDYLSLGDNDFIC 538
            :..|        .||          :..|:||:|..|:|:::.....||...|..|:.|:|.:.|
Frog   503 FNRATNLKELVLSHNKLNFISSDWRSPNLQVLHLEGNSISLIDKGTFKDLPSLRRLTAGNNPYDC 567

  Fly   539 DCHLRAVVEVAAANNKDADCSYRLLNYSQNAVGEEVISLAESLIIDRKLWQSRYIPWLQRSYSNI 603
            .|.|.|.......|:                         |.|:.|   |     |:
Frog   568 TCDLYAFFSTLQNND-------------------------EMLLAD---W-----PY-------- 591

  Fly   604 REFNRANHIIKLRFSSEDYMVAKCSAAQPYHLGDLDGDLTLKFQLLDYEASQYYCFNNTDQLQVD 668
                             ||   :|  ..|.||.|.|.:        ||...:..|
Frog   592 -----------------DY---QC--FHPQHLRDTDVE--------DYTPWRVEC---------- 616

  Fly   669 ELNCQIRSMSDLAEELHHVTNTVIAVMGSLVGACILGFIIYLKRWHIHYYYSSLKSAALLSSASK 733
                          ::..|....::...:::..|:|....:...|::...:..:||    ...||
Frog   617 --------------DVSLVITISVSTTAAIIILCMLVCWRFDVPWYLRMTWRIVKS----KYRSK 663

  Fly   734 ESVNKFTNISQRDPSAVYDIFISYCQNDRTWVLNELLPNVEE-TGDVSICLHERDFQIGVTILDN 797
            :| ||....:       |..||||..:|..||..|||..:|. :....:|:|||||..|..|:||
Frog   664 KS-NKSREYN-------YHAFISYSYSDADWVRGELLYRLESCSPPYRVCIHERDFLPGRWIIDN 720

  Fly   798 IISCMDRSYSLMLIISSKFLLSHWCQFEMYLAQHRIFEVSKEHLILVF-----LEDIPRRKRPKT 857
            ||..::.|..::.::||.|:.|.||.:|:|.|..|....|.|.:|||.     :||:|  ||...
Frog   721 IIENIENSRKIIFVLSSNFINSEWCNYELYFAHQRAIGHSLEDIILVVKEKVTMEDLP--KRFHK 783

  Fly   858 LQYLMDVKTYIKWPTAKEDRKLFWKRLKRSL 888
            |:.::..|||::||:....:..||.:||..|
Frog   784 LRKMLRTKTYLEWPSEPSKQHFFWIQLKSIL 814

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-9	NP_001246846.1	leucine-rich repeat	157..185	CDD:275380	6/27 (22%)
		LRR_8	262..322	CDD:290566	19/71 (27%)
		leucine-rich repeat	264..287	CDD:275380	7/27 (26%)
		leucine-rich repeat	288..311	CDD:275380	8/24 (33%)
		leucine-rich repeat	312..356	CDD:275380	12/58 (21%)
		LRR_8	<344..387	CDD:290566	13/61 (21%)
		leucine-rich repeat	357..381	CDD:275380	9/36 (25%)
		leucine-rich repeat	382..397	CDD:275380	1/14 (7%)
		leucine-rich repeat	405..430	CDD:275380	8/25 (32%)
		LRR_8	431..488	CDD:290566	20/85 (24%)
		leucine-rich repeat	432..453	CDD:275380	5/28 (18%)
		LRR_RI	<449..536	CDD:238064	32/129 (25%)
		leucine-rich repeat	454..477	CDD:275380	8/43 (19%)
		LRR_8	477..536	CDD:290566	22/80 (28%)
		leucine-rich repeat	478..501	CDD:275380	9/44 (20%)
		leucine-rich repeat	502..525	CDD:275380	8/22 (36%)
		TIR	751..891	CDD:214587	56/144 (39%)
tlr14.2	XP_012810129.1	LRR_8	76..135	CDD:338972	16/76 (21%)
		leucine-rich repeat	77..100	CDD:275378	3/26 (12%)
		leucine-rich repeat	101..124	CDD:275378	9/34 (26%)
		leucine-rich repeat	125..148	CDD:275378	4/24 (17%)
		leucine-rich repeat	149..173	CDD:275378	6/23 (26%)
		leucine-rich repeat	219..280	CDD:275380	16/62 (26%)
		leucine-rich repeat	281..321	CDD:275380	8/39 (21%)
		LRR	299..>558	CDD:227223	60/276 (22%)
		leucine-rich repeat	365..385	CDD:275380	4/30 (13%)
		leucine-rich repeat	386..413	CDD:275380	8/26 (31%)
		leucine-rich repeat	414..435	CDD:275380	3/20 (15%)
		leucine-rich repeat	440..484	CDD:275380	9/47 (19%)
		leucine-rich repeat	485..508	CDD:275380	7/22 (32%)
		LRR_8	508..564	CDD:338972	13/55 (24%)
		leucine-rich repeat	509..530	CDD:275380	2/20 (10%)
		leucine-rich repeat	531..554	CDD:275380	8/22 (36%)
		TPKR_C2	563..>603	CDD:387596	17/102 (17%)
		TIR	673..810	CDD:214587	53/138 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	125	1.000	Domainoid score	I5392
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	182	1.000	Inparanoid score	I3846
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.060