DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-9 and LOC100485358

DIOPT Version :9

Sequence 1:	NP_001246846.1	Gene:	Toll-9 / 40245	FlyBaseID:	FBgn0036978	Length:	900	Species:	Drosophila melanogaster
Sequence 2:	XP_002943096.1	Gene:	LOC100485358 / 100485358	-ID:	-	Length:	837	Species:	Xenopus tropicalis

Alignment Length:	1022	Identity:	230/1022 - (22%)
Similarity:	361/1022 - (35%)	Gaps:	365/1022 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IWDVIVLVCLFLGNVREAYTE----------FSIQDG--LIIEPDSATTSSEEAEEVSKER---- 54
            :|.|:|     ||.|||.:.:          |....|  |:..|.:.:.:.||. ::|..|
Frog    12 LWCVLV-----LGLVRELWCQTPCLVDESRRFVSCSGRNLVEIPKNFSVTLEEL-DMSFNRIFQI 70

  Fly    55 --------TDLKSLMLKYE--------SDDGNSCLLDLIKDEVIWWQFPNGTLRDSTKKYAHKL- 102
                    |:|::|.|.|.        |.:.|:.|..|........:.|:..|..     .|.|
Frog    71 KSDDFSAYTNLRALNLSYNQIATIENGSFNSNTQLRSLTLFNNSLTEMPSALLEP-----LHLLE 130

  Fly   103 YLDLSHG---------------NL--------------KDDSDLFREAKLSR-------KVTIWR 131
            :||:|:.               ||              |||....|...|.:       .:|::.
Frog   131 FLDMSNNFYNKSTLGDVFQTLVNLQTLSIGGPLVSKVQKDDFVPIRNIGLQKFALKTMSSLTLYE 195

  Fly   132 TEVFSAAFNT--------LTAAPFRTLYSMRESLKLLSLRGNNFAELIPDAEDFARFVNESRLEA 188
            ...|| ..||        |...|...|      |.|..|:|.:|        |..||.|
Frog   196 EGAFS-VLNTHVLWFDIALDTNPQALL------LILKDLKGKSF--------DVLRFRN------ 239

  Fly   189 SNSVPHHCELLLLHNTTDLYD-------RECYLY---FNNN-------------------TNMGQ 224
                  ..|:....:|.|::.       ||...|   ||.|                   .::..
Frog   240 ------LFEITYYTDTVDIFSWLPSISTRELVFYRGKFNENLLWIMLENIQRSSILDLSLLSVDF 298

  Fly   225 SITTGRNYTNF------IKVL--KD-------RFDQHGSSSQSIAWATFPKMPRLVELDISNCSI 274
            |.:...|.||.      ::.|  ||       |||          | ||....::..|.|.|.:.
Frog   299 SRSHSANKTNVSIDDLRLRTLRVKDVTNPDILRFD----------W-TFTWFRKISNLYIINVNF 352

  Fly   275 EYVSKEAFRNVSNLRRLFMSDNKIMTISHDTFYYVQGVQYLDLSFTNFLTYSYQLQLPTLEMALS 339
            ..|..:|:..:|||.:|.||.::::    ||:.|....|.:.|..|:....:|. .|.:|.| ||
Frog   353 NSVPCDAWSEMSNLEKLDMSTDELV----DTYLYNPWCQDVALPTTDTFILAYN-NLQSLRM-LS 411

  Fly   340 LIYGLKIQQNVFKYLPELIYLDLSHSKMTRNSAVAFAHLGDKLKFLSLCYTAIPMVSSTIFKNTV 404
            |:        ..|: |:|..|||..:.:..|.              .:| |..|.:.:.|.|:.:
Frog   412 LL--------TAKW-PKLATLDLRSNSLGSND--------------EMC-TWTPSIRTVILKDNM 452

  Fly   405 LE-GLDLSGNPYLSYNIIDDAFDGIANTLKYLYFERSNIK--DLEWSKSLKNLQVLGLAGNNINA 466
            |: |:                |..:..|:::|....|.::  |:::.....||:.|.|:.|.|..
Frog   453 LKVGV----------------FQCLPTTVEFLDLSHSQLEQLDMDYFNKATNLKQLILSHNKIKF 501

  Fly   467 LTPAMFQSLESLEILDLSSNHVGNWYRSAFHNNSALRVLNLRSNTINMLSNEMLKDFERLDYLSL 531
            ::                    ..|      .:..|:||.|..|:..:::....||..:|..|:.
Frog   502 IS--------------------SEW------KSPNLQVLALEDNSFGVINVGSFKDLPKLRNLTA 540

  Fly   532 GDNDFICDCHLRAVVEVAAANNKDADCSYRLLNYSQNAVGEEVISLAESLIIDRKLWQSRYIPWL 596
            |||.:.|.|.|                 ||.
Frog   541 GDNPYGCTCDL-----------------YRF---------------------------------- 554

  Fly   597 QRSYSNIREFNRANHIIKLRFSSEDYMVAKCSAAQPYHLGDLDGDLTLKFQLLDYEASQYYCFNN 661
               :|.|||..|    |.|....:.|   ||     |...|          |||.:..    |.|
Frog   555 ---FSQIREEGR----IVLADWPQAY---KC-----YSPPD----------LLDTKVE----FYN 590

  Fly   662 TDQLQVDELNCQIRSMSDLAEELHHVTNTVIAVMGSLVGACILGFIIYLKRWHIHYYYSSLKSAA 726
            ..::|     |.:|              .|:|:..|.....::..::...|:.:.:|..::.:..
Frog   591 PGKVQ-----CDVR--------------LVVAISVSTTAVVVILSMLLCWRFDVLWYVQTMFAIV 636

  Fly   727 LLSSASKESVNKFTNISQRDPSAVYDIFISYCQNDRTWVLNELLPNVEE-TGDVSICLHERDFQI 790
            .....|:...|        ....:|..||||..:|..||..|||..:|. :....:|:|||||..
Frog   637 QSKYRSRNMGN--------TKEYLYHAFISYSHSDADWVRGELLHQLESCSPPYRVCIHERDFLP 693

  Fly   791 GVTILDNIISCMDRSYSLMLIISSKFLLSHWCQFEMYLAQHRIFEVSKEHLILVF-----LEDIP 850
            |..|:||||..::.|..::.::|..|:.|.||.:|:|.|..|....:.|.:|||.     :||:|
Frog   694 GRWIIDNIIENIENSRKIIFVLSRNFVNSEWCNYELYFAHQRAVGHALEDVILVVKEKVTMEDLP 758

  Fly   851 RRKRPKTLQYLMDVKTYIKWPTAKEDRKLFWKRL-----KRSLEVIG 892
              ||.:.|:.|:..|||::||.....:..||.:|     |.|..|||
Frog   759 --KRFQKLRKLLRTKTYLEWPLEHTRQHFFWIQLRSILGKVSSPVIG 803

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-9	NP_001246846.1	leucine-rich repeat	157..185	CDD:275380	9/27 (33%)
		LRR_8	262..322	CDD:290566	17/59 (29%)
		leucine-rich repeat	264..287	CDD:275380	5/22 (23%)
		leucine-rich repeat	288..311	CDD:275380	7/22 (32%)
		leucine-rich repeat	312..356	CDD:275380	11/43 (26%)
		LRR_8	<344..387	CDD:290566	7/42 (17%)
		leucine-rich repeat	357..381	CDD:275380	5/23 (22%)
		leucine-rich repeat	382..397	CDD:275380	3/14 (21%)
		leucine-rich repeat	405..430	CDD:275380	3/25 (12%)
		LRR_8	431..488	CDD:290566	10/58 (17%)
		leucine-rich repeat	432..453	CDD:275380	3/22 (14%)
		LRR_RI	<449..536	CDD:238064	19/86 (22%)
		leucine-rich repeat	454..477	CDD:275380	5/22 (23%)
		LRR_8	477..536	CDD:290566	13/58 (22%)
		leucine-rich repeat	478..501	CDD:275380	1/22 (5%)
		leucine-rich repeat	502..525	CDD:275380	7/22 (32%)
		TIR	751..891	CDD:214587	55/150 (37%)
LOC100485358	XP_002943096.1	PRK15370	<39..>160	CDD:185268	25/126 (20%)
		leucine-rich repeat	39..55	CDD:275380	3/15 (20%)
		LRR_8	56..115	CDD:338972	13/59 (22%)
		leucine-rich repeat	57..80	CDD:275378	4/23 (17%)
		leucine-rich repeat	81..104	CDD:275378	6/22 (27%)
		leucine-rich repeat	105..128	CDD:275378	4/27 (15%)
		leucine-rich repeat	129..153	CDD:275378	4/23 (17%)
		LRR	<340..>500	CDD:227223	48/205 (23%)
		leucine-rich repeat	345..365	CDD:275380	5/19 (26%)
		leucine-rich repeat	366..419	CDD:275380	18/67 (27%)
		leucine-rich repeat	420..442	CDD:275380	7/36 (19%)
		leucine-rich repeat	443..464	CDD:275378	5/36 (14%)
		leucine-rich repeat	465..488	CDD:275378	3/22 (14%)
		LRR_8	488..544	CDD:338972	18/81 (22%)
		leucine-rich repeat	489..510	CDD:275378	6/46 (13%)
		leucine-rich repeat	511..534	CDD:275378	7/22 (32%)
		PCC	516..>581	CDD:188093	26/140 (19%)
		TIR	653..791	CDD:214587	52/139 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	125	1.000	Domainoid score	I5392
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	182	1.000	Inparanoid score	I3846
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.060